Changes in glutamate receptors in dyskinetic parkinsonian monkeys after unilateral subthalamotomy.
Identifieur interne : 000361 ( PubMed/Curation ); précédent : 000360; suivant : 000362Changes in glutamate receptors in dyskinetic parkinsonian monkeys after unilateral subthalamotomy.
Auteurs : Vincent A. Jourdain ; Nicolas Morin ; Laurent Grégoire ; Marc Morissette ; Thérèse Di PaoloSource :
- Journal of neurosurgery [ 1933-0693 ] ; 2015.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Antiparkinson Agents (adverse effects), Basal Ganglia (metabolism), Disease Models, Animal, Dyskinesia, Drug-Induced (etiology), Dyskinesia, Drug-Induced (metabolism), Dyskinesia, Drug-Induced (surgery), Female, Levodopa (adverse effects), Macaca, Parkinsonian Disorders (drug therapy), Parkinsonian Disorders (metabolism), Parkinsonian Disorders (surgery), Receptors, Glutamate (metabolism), Subthalamic Nucleus (surgery).
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemical , metabolism : Receptors, Glutamate.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- drug therapy : Parkinsonian Disorders.
- etiology : Dyskinesia, Drug-Induced.
- metabolism : Basal Ganglia, Dyskinesia, Drug-Induced, Parkinsonian Disorders.
- surgery : Dyskinesia, Drug-Induced, Parkinsonian Disorders, Subthalamic Nucleus.
- Animals, Disease Models, Animal, Female, Macaca.
Abstract
Unilateral subthalamotomy is a surgical procedure that may be used to alleviate disabling levodopa-induced dyskinesias (LIDs) in patients with Parkinson disease (PD). However, the mechanisms involved in LID remain largely unknown. The subthalamic nucleus (STN) is the sole glutamatergic nucleus within the basal ganglia, and its lesion may produce changes in glutamate receptors in various areas of the basal ganglia. The authors aimed to investigate the biochemical changes in glutamate receptors in striatal and pallidal regions of the basal ganglia after lesion of the STN in parkinsonian macaque monkeys.
DOI: 10.3171/2014.10.JNS141570
PubMed: 25932606
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Vincent A. Jourdain<affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation>Le document en format XML
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Jourdain</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author><author><name sortKey="Morin, Nicolas" sort="Morin, Nicolas" uniqKey="Morin N" first="Nicolas" last="Morin">Nicolas Morin</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author><author><name sortKey="Gregoire, Laurent" sort="Gregoire, Laurent" uniqKey="Gregoire L" first="Laurent" last="Grégoire">Laurent Grégoire</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author><author><name sortKey="Morissette, Marc" sort="Morissette, Marc" uniqKey="Morissette M" first="Marc" last="Morissette">Marc Morissette</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author><author><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25932606</idno><idno type="pmid">25932606</idno><idno type="doi">10.3171/2014.10.JNS141570</idno><idno type="wicri:Area/PubMed/Corpus">000361</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000361</idno><idno type="wicri:Area/PubMed/Curation">000361</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000361</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Changes in glutamate receptors in dyskinetic parkinsonian monkeys after unilateral subthalamotomy.</title><author><name sortKey="Jourdain, Vincent A" sort="Jourdain, Vincent A" uniqKey="Jourdain V" first="Vincent A" last="Jourdain">Vincent A. Jourdain</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author><author><name sortKey="Morin, Nicolas" sort="Morin, Nicolas" uniqKey="Morin N" first="Nicolas" last="Morin">Nicolas Morin</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author><author><name sortKey="Gregoire, Laurent" sort="Gregoire, Laurent" uniqKey="Gregoire L" first="Laurent" last="Grégoire">Laurent Grégoire</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author><author><name sortKey="Morissette, Marc" sort="Morissette, Marc" uniqKey="Morissette M" first="Marc" last="Morissette">Marc Morissette</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author><author><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</nlm:affiliation><wicri:noCountry code="subField">Centre Hospitalier Universitaire de Québec; and</wicri:noCountry></affiliation></author></analytic><series><title level="j">Journal of neurosurgery</title><idno type="eISSN">1933-0693</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Animals</term><term>Antiparkinson Agents (adverse effects)</term><term>Basal Ganglia (metabolism)</term><term>Disease Models, Animal</term><term>Dyskinesia, Drug-Induced (etiology)</term><term>Dyskinesia, Drug-Induced (metabolism)</term><term>Dyskinesia, Drug-Induced (surgery)</term><term>Female</term><term>Levodopa (adverse effects)</term><term>Macaca</term><term>Parkinsonian Disorders (drug therapy)</term><term>Parkinsonian Disorders (metabolism)</term><term>Parkinsonian Disorders (surgery)</term><term>Receptors, Glutamate (metabolism)</term><term>Subthalamic Nucleus (surgery)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, Glutamate</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Basal Ganglia</term><term>Dyskinesia, Drug-Induced</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Parkinsonian Disorders</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Macaca</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Unilateral subthalamotomy is a surgical procedure that may be used to alleviate disabling levodopa-induced dyskinesias (LIDs) in patients with Parkinson disease (PD). However, the mechanisms involved in LID remain largely unknown. The subthalamic nucleus (STN) is the sole glutamatergic nucleus within the basal ganglia, and its lesion may produce changes in glutamate receptors in various areas of the basal ganglia. The authors aimed to investigate the biochemical changes in glutamate receptors in striatal and pallidal regions of the basal ganglia after lesion of the STN in parkinsonian macaque monkeys.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25932606</PMID><DateCreated><Year>2015</Year><Month>12</Month><Day>01</Day></DateCreated><DateCompleted><Year>2016</Year><Month>03</Month><Day>28</Day></DateCompleted><DateRevised><Year>2015</Year><Month>12</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1933-0693</ISSN><JournalIssue CitedMedium="Internet"><Volume>123</Volume><Issue>6</Issue><PubDate><Year>2015</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Journal of neurosurgery</Title><ISOAbbreviation>J. Neurosurg.</ISOAbbreviation></Journal><ArticleTitle>Changes in glutamate receptors in dyskinetic parkinsonian monkeys after unilateral subthalamotomy.</ArticleTitle><Pagination><MedlinePgn>1383-93</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3171/2014.10.JNS141570</ELocationID><Abstract><AbstractText Label="OBJECT" NlmCategory="OBJECTIVE">Unilateral subthalamotomy is a surgical procedure that may be used to alleviate disabling levodopa-induced dyskinesias (LIDs) in patients with Parkinson disease (PD). However, the mechanisms involved in LID remain largely unknown. The subthalamic nucleus (STN) is the sole glutamatergic nucleus within the basal ganglia, and its lesion may produce changes in glutamate receptors in various areas of the basal ganglia. The authors aimed to investigate the biochemical changes in glutamate receptors in striatal and pallidal regions of the basal ganglia after lesion of the STN in parkinsonian macaque monkeys.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The authors treated 12 female ovariectomized monkeys with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to induce PD-like symptoms, treated 8 of these animals with 3,4-dihydroxy-l-phenylalanine (L-DOPA; levodopa) to induce LID, and performed unilateral subthalamotomy in 4 of these 8 monkeys. Four additional monkeys were treated with saline only and were used as controls. The MPTP monkeys had previously been shown to respond behaviorally to lower doses of levodopa after the STN lesion. Autoradiography of slices from postmortem brain tissues was used to visualize changes in the specific binding of striatal and pallidal ionotropic glutamate receptors (that is, of the α-amino-3-hydroxy 5-methyl-4-isoxazole propionate [AMPA] and N-methyl-d-aspartate [NMDA] NR1/NR2B subunit receptors) and of metabotropic glutamate (mGlu) receptors (that is, mGlu2/3 and mGlu5 receptors). The specific binding and distribution of glutamate receptors in the basal ganglia of the levodopa-treated, STN-lesioned MPTP monkeys were compared with those in the saline-treated control monkeys and in the saline-treated and levodopa-treated MPTP monkeys.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The autoradiographic results indicated that none of the pharmacological and surgical treatments produced changes in the specific binding of AMPA receptors in the basal ganglia. Levodopa treatment increased the specific binding of NMDA receptors in the basal ganglia. Subthalamotomy reversed these increases in the striatum, but in the globus pallidus (GP), the subthalamotomy reversed these increases only contralaterally. Levodopa treatment reversed MPTP-induced increases in mGlu2/3 receptors only in the GP. mGlu2/3 receptor-specific binding in the striatum and GP decreased bilaterally in the levodopa-treated, STN-lesioned MPTP monkeys compared with the other 3 groups. Compared with mGlu5 receptor-specific binding in the control monkeys, that of the levodopa-treated MPTP monkeys increased in the dorsal putamen and remained unchanged in the caudate nucleus and in the GP.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These results implicate glutamate receptors in the previously observed benefits of unilateral subthalamotomy to improve motor control.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jourdain</LastName><ForeName>Vincent A</ForeName><Initials>VA</Initials><AffiliationInfo><Affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Pharmacy, Laval University, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morin</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Pharmacy, Laval University, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grégoire</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morissette</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Di Paolo</LastName><ForeName>Thérèse</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec; and.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Pharmacy, Laval University, Quebec, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>05</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Neurosurg</MedlineTA><NlmUniqueID>0253357</NlmUniqueID><ISSNLinking>0022-3085</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017470">Receptors, Glutamate</NameOfSubstance></Chemical><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical><Chemical><RegistryNumber>9P21XSP91P</RegistryNumber><NameOfSubstance UI="D015632">1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D015632" MajorTopicYN="N">1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000978" MajorTopicYN="N">Antiparkinson Agents</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001479" MajorTopicYN="N">Basal Ganglia</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004409" MajorTopicYN="N">Dyskinesia, Drug-Induced</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007980" MajorTopicYN="N">Levodopa</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008251" MajorTopicYN="N">Macaca</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020734" MajorTopicYN="N">Parkinsonian Disorders</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017470" MajorTopicYN="N">Receptors, Glutamate</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020531" MajorTopicYN="N">Subthalamic Nucleus</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">6-OHDA = 6-hydroxydopamine</Keyword><Keyword MajorTopicYN="N">AMPA = α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid</Keyword><Keyword MajorTopicYN="N">GP = globus pallidus</Keyword><Keyword MajorTopicYN="N">GPe = GP externus</Keyword><Keyword MajorTopicYN="N">GPi = GP internus</Keyword><Keyword MajorTopicYN="N">LID = levodopa-induced dyskinesia</Keyword><Keyword MajorTopicYN="N">MPTP = 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine</Keyword><Keyword MajorTopicYN="N">MPTP monkey</Keyword><Keyword MajorTopicYN="N">NMDA = N-methyl-d-aspartate</Keyword><Keyword MajorTopicYN="N">PD = Parkinson disease</Keyword><Keyword MajorTopicYN="N">Parkinson disease</Keyword><Keyword MajorTopicYN="N">STN = subthalamic nucleus</Keyword><Keyword MajorTopicYN="N">functional neurosurgery</Keyword><Keyword MajorTopicYN="N">glutamate receptor</Keyword><Keyword MajorTopicYN="N">levodopa</Keyword><Keyword MajorTopicYN="N">levodopa-induced dyskinesia</Keyword><Keyword MajorTopicYN="N">mGlu = metabotropic glutamate</Keyword><Keyword MajorTopicYN="N">subthalamotomy</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>5</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>5</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>3</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId 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