La maladie de Parkinson au Canada (serveur d'exploration)

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b.

Identifieur interne : 000349 ( PubMed/Curation ); précédent : 000348; suivant : 000350

Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b.

Auteurs : Hélène Doucet-Beaupré [Canada] ; Siew-Lan Ang [Royaume-Uni] ; Martin Lévesque [Canada]

Source :

RBID : pubmed:26526610

English descriptors

Abstract

LIM-homeodomain (LIM-HD) proteins are evolutionary conserved developmental transcription factors. LIM-HD Lmx1a and Lmx1b orchestrate complex temporal and spatial gene expression of the dopaminergic pathway, and evidence shows they are also involved in adult neuronal homeostasis. In this review, the multiple roles played by Lmx1a and Lmx1b will be discussed. Controlled Lmx1a and Lmx1b expression and activities ensure the proper formation of critical signaling centers, including the embryonic ventral mesencephalon floor plate and sharp boundaries between lineage-specific cells. Lmx1a and Lmx1b expression persists in mature dopaminergic neurons of the substantia nigra pars compacta and the ventral tegmental area, and their role in the adult brain is beginning to be revealed. Notably, LMX1B expression was lower in brain tissue affected by Parkinson's disease. Actual and future applications of Lmx1a and Lmx1b transcription factors in stem cell production as well as in direct conversion of fibroblast into dopaminergic neurons are also discussed. A thorough understanding of the role of LMX1A and LMX1B in a number of disease states, including developmental diseases, cancer and neurodegenerative diseases, could lead to significant benefits for human healthcare.

DOI: 10.1016/j.febslet.2015.10.020
PubMed: 26526610

Links toward previous steps (curation, corpus...)


Links to Exploration step

pubmed:26526610

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b.</title>
<author>
<name sortKey="Doucet Beaupre, Helene" sort="Doucet Beaupre, Helene" uniqKey="Doucet Beaupre H" first="Hélène" last="Doucet-Beaupré">Hélène Doucet-Beaupré</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval, Québec, QC, Canada; Centre de recherche de l'Institut universitaire en santé mentale de Québec, 2601, chemin de la Canardière, Québec, QC G1J 2G3, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval, Québec, QC, Canada; Centre de recherche de l'Institut universitaire en santé mentale de Québec, 2601, chemin de la Canardière, Québec, QC G1J 2G3</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ang, Siew Lan" sort="Ang, Siew Lan" uniqKey="Ang S" first="Siew-Lan" last="Ang">Siew-Lan Ang</name>
<affiliation wicri:level="1">
<nlm:affiliation>Division of Developmental Neurobiology, MRC-National Institute for Medical Research, London NW7 1AA, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Developmental Neurobiology, MRC-National Institute for Medical Research, London NW7 1AA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Levesque, Martin" sort="Levesque, Martin" uniqKey="Levesque M" first="Martin" last="Lévesque">Martin Lévesque</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval, Québec, QC, Canada; Centre de recherche de l'Institut universitaire en santé mentale de Québec, 2601, chemin de la Canardière, Québec, QC G1J 2G3, Canada. Electronic address: martin.levesque@fmed.ulaval.ca.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval, Québec, QC, Canada; Centre de recherche de l'Institut universitaire en santé mentale de Québec, 2601, chemin de la Canardière, Québec, QC G1J 2G3</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:26526610</idno>
<idno type="pmid">26526610</idno>
<idno type="doi">10.1016/j.febslet.2015.10.020</idno>
<idno type="wicri:Area/PubMed/Corpus">000349</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000349</idno>
<idno type="wicri:Area/PubMed/Curation">000349</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000349</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b.</title>
<author>
<name sortKey="Doucet Beaupre, Helene" sort="Doucet Beaupre, Helene" uniqKey="Doucet Beaupre H" first="Hélène" last="Doucet-Beaupré">Hélène Doucet-Beaupré</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval, Québec, QC, Canada; Centre de recherche de l'Institut universitaire en santé mentale de Québec, 2601, chemin de la Canardière, Québec, QC G1J 2G3, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval, Québec, QC, Canada; Centre de recherche de l'Institut universitaire en santé mentale de Québec, 2601, chemin de la Canardière, Québec, QC G1J 2G3</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ang, Siew Lan" sort="Ang, Siew Lan" uniqKey="Ang S" first="Siew-Lan" last="Ang">Siew-Lan Ang</name>
<affiliation wicri:level="1">
<nlm:affiliation>Division of Developmental Neurobiology, MRC-National Institute for Medical Research, London NW7 1AA, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Developmental Neurobiology, MRC-National Institute for Medical Research, London NW7 1AA</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Levesque, Martin" sort="Levesque, Martin" uniqKey="Levesque M" first="Martin" last="Lévesque">Martin Lévesque</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval, Québec, QC, Canada; Centre de recherche de l'Institut universitaire en santé mentale de Québec, 2601, chemin de la Canardière, Québec, QC G1J 2G3, Canada. Electronic address: martin.levesque@fmed.ulaval.ca.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval, Québec, QC, Canada; Centre de recherche de l'Institut universitaire en santé mentale de Québec, 2601, chemin de la Canardière, Québec, QC G1J 2G3</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">FEBS letters</title>
<idno type="eISSN">1873-3468</idno>
<imprint>
<date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Animals</term>
<term>Brain (metabolism)</term>
<term>Brain (pathology)</term>
<term>Gene Expression Regulation</term>
<term>Homeostasis</term>
<term>Humans</term>
<term>LIM-Homeodomain Proteins (physiology)</term>
<term>Neurogenesis</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (pathology)</term>
<term>Transcription Factors (physiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en">
<term>LIM-Homeodomain Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en">
<term>Brain</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Brain</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Animals</term>
<term>Gene Expression Regulation</term>
<term>Homeostasis</term>
<term>Humans</term>
<term>Neurogenesis</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">LIM-homeodomain (LIM-HD) proteins are evolutionary conserved developmental transcription factors. LIM-HD Lmx1a and Lmx1b orchestrate complex temporal and spatial gene expression of the dopaminergic pathway, and evidence shows they are also involved in adult neuronal homeostasis. In this review, the multiple roles played by Lmx1a and Lmx1b will be discussed. Controlled Lmx1a and Lmx1b expression and activities ensure the proper formation of critical signaling centers, including the embryonic ventral mesencephalon floor plate and sharp boundaries between lineage-specific cells. Lmx1a and Lmx1b expression persists in mature dopaminergic neurons of the substantia nigra pars compacta and the ventral tegmental area, and their role in the adult brain is beginning to be revealed. Notably, LMX1B expression was lower in brain tissue affected by Parkinson's disease. Actual and future applications of Lmx1a and Lmx1b transcription factors in stem cell production as well as in direct conversion of fibroblast into dopaminergic neurons are also discussed. A thorough understanding of the role of LMX1A and LMX1B in a number of disease states, including developmental diseases, cancer and neurodegenerative diseases, could lead to significant benefits for human healthcare.</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="MEDLINE" Owner="NLM">
<PMID Version="1">26526610</PMID>
<DateCreated>
<Year>2015</Year>
<Month>12</Month>
<Day>15</Day>
</DateCreated>
<DateCompleted>
<Year>2016</Year>
<Month>04</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised>
<Year>2015</Year>
<Month>12</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1873-3468</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>589</Volume>
<Issue>24 Pt A</Issue>
<PubDate>
<Year>2015</Year>
<Month>Dec</Month>
<Day>21</Day>
</PubDate>
</JournalIssue>
<Title>FEBS letters</Title>
<ISOAbbreviation>FEBS Lett.</ISOAbbreviation>
</Journal>
<ArticleTitle>Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b.</ArticleTitle>
<Pagination>
<MedlinePgn>3727-38</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.febslet.2015.10.020</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0014-5793(15)00944-8</ELocationID>
<Abstract>
<AbstractText>LIM-homeodomain (LIM-HD) proteins are evolutionary conserved developmental transcription factors. LIM-HD Lmx1a and Lmx1b orchestrate complex temporal and spatial gene expression of the dopaminergic pathway, and evidence shows they are also involved in adult neuronal homeostasis. In this review, the multiple roles played by Lmx1a and Lmx1b will be discussed. Controlled Lmx1a and Lmx1b expression and activities ensure the proper formation of critical signaling centers, including the embryonic ventral mesencephalon floor plate and sharp boundaries between lineage-specific cells. Lmx1a and Lmx1b expression persists in mature dopaminergic neurons of the substantia nigra pars compacta and the ventral tegmental area, and their role in the adult brain is beginning to be revealed. Notably, LMX1B expression was lower in brain tissue affected by Parkinson's disease. Actual and future applications of Lmx1a and Lmx1b transcription factors in stem cell production as well as in direct conversion of fibroblast into dopaminergic neurons are also discussed. A thorough understanding of the role of LMX1A and LMX1B in a number of disease states, including developmental diseases, cancer and neurodegenerative diseases, could lead to significant benefits for human healthcare.</AbstractText>
<CopyrightInformation>Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Doucet-Beaupré</LastName>
<ForeName>Hélène</ForeName>
<Initials>H</Initials>
<AffiliationInfo>
<Affiliation>Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval, Québec, QC, Canada; Centre de recherche de l'Institut universitaire en santé mentale de Québec, 2601, chemin de la Canardière, Québec, QC G1J 2G3, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Ang</LastName>
<ForeName>Siew-Lan</ForeName>
<Initials>SL</Initials>
<AffiliationInfo>
<Affiliation>Division of Developmental Neurobiology, MRC-National Institute for Medical Research, London NW7 1AA, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Lévesque</LastName>
<ForeName>Martin</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval, Québec, QC, Canada; Centre de recherche de l'Institut universitaire en santé mentale de Québec, 2601, chemin de la Canardière, Québec, QC G1J 2G3, Canada. Electronic address: martin.levesque@fmed.ulaval.ca.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic">
<Year>2015</Year>
<Month>10</Month>
<Day>23</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo>
<Country>England</Country>
<MedlineTA>FEBS Lett</MedlineTA>
<NlmUniqueID>0155157</NlmUniqueID>
<ISSNLinking>0014-5793</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C112149">LIM homeobox transcription factor 1 beta</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D060850">LIM-Homeodomain Proteins</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C078021">LMX1A protein, human</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList>
<MeshHeading>
<DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D006706" MajorTopicYN="N">Homeostasis</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D060850" MajorTopicYN="N">LIM-Homeodomain Proteins</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D055495" MajorTopicYN="Y">Neurogenesis</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM">
<Keyword MajorTopicYN="N">Cancer</Keyword>
<Keyword MajorTopicYN="N">Neurodegeneration</Keyword>
<Keyword MajorTopicYN="N">Parkinson’s disease</Keyword>
<Keyword MajorTopicYN="N">Stem cell</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData>
<History>
<PubMedPubDate PubStatus="received">
<Year>2015</Year>
<Month>09</Month>
<Day>07</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised">
<Year>2015</Year>
<Month>10</Month>
<Day>06</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted">
<Year>2015</Year>
<Month>10</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez">
<Year>2015</Year>
<Month>11</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed">
<Year>2015</Year>
<Month>11</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline">
<Year>2016</Year>
<Month>4</Month>
<Day>30</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList>
<ArticleId IdType="pubmed">26526610</ArticleId>
<ArticleId IdType="pii">S0014-5793(15)00944-8</ArticleId>
<ArticleId IdType="doi">10.1016/j.febslet.2015.10.020</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000349 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000349 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    PubMed
   |étape=   Curation
   |type=    RBID
   |clé=     pubmed:26526610
   |texte=   Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i   -Sk "pubmed:26526610" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonCanadaV1 

Wicri

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022