Targeting voltage-gated calcium channels in neurological and psychiatric diseases.
Identifieur interne : 000336 ( PubMed/Curation ); précédent : 000335; suivant : 000337Targeting voltage-gated calcium channels in neurological and psychiatric diseases.
Auteurs : Gerald W. Zamponi [Canada]Source :
- Nature reviews. Drug discovery [ 1474-1784 ] ; 2016.
English descriptors
- KwdEn :
- Animals, Calcium Channel Blockers (pharmacology), Calcium Channel Blockers (therapeutic use), Calcium Channels (metabolism), Humans, Mental Disorders (drug therapy), Mental Disorders (metabolism), Models, Neurological, Molecular Targeted Therapy (methods), Nervous System Diseases (drug therapy), Nervous System Diseases (metabolism).
- MESH :
- chemical , metabolism : Calcium Channels.
- chemical , pharmacology : Calcium Channel Blockers.
- chemical , therapeutic use : Calcium Channel Blockers.
- drug therapy : Mental Disorders, Nervous System Diseases.
- metabolism : Mental Disorders, Nervous System Diseases.
- methods : Molecular Targeted Therapy.
- Animals, Humans, Models, Neurological.
Abstract
Voltage-gated calcium channels are important regulators of brain, heart and muscle functions, and their dysfunction can give rise to pathophysiological conditions ranging from cardiovascular disorders to neurological and psychiatric conditions such as epilepsy, pain and autism. In the nervous system, calcium channel blockers have been used successfully to treat absence seizures, and are emerging as potential therapeutic avenues for pathologies such as pain, Parkinson disease, addiction and anxiety. This Review provides an overview of calcium channels as drug targets for nervous system disorders, and discusses potential challenges and opportunities for the development of new clinically effective calcium channel inhibitors.
DOI: 10.1038/nrd.2015.5
PubMed: 26542451
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pubmed:26542451Le document en format XML
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Zamponi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physiology and Pharmacology, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary T2N 4N1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physiology and Pharmacology, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary T2N 4N1</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature reviews. 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In the nervous system, calcium channel blockers have been used successfully to treat absence seizures, and are emerging as potential therapeutic avenues for pathologies such as pain, Parkinson disease, addiction and anxiety. This Review provides an overview of calcium channels as drug targets for nervous system disorders, and discusses potential challenges and opportunities for the development of new clinically effective calcium channel inhibitors.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26542451</PMID><DateCreated><Year>2015</Year><Month>12</Month><Day>31</Day></DateCreated><DateCompleted><Year>2016</Year><Month>05</Month><Day>02</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-1784</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>1</Issue><PubDate><Year>2016</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Nature reviews. Drug discovery</Title><ISOAbbreviation>Nat Rev Drug Discov</ISOAbbreviation></Journal><ArticleTitle>Targeting voltage-gated calcium channels in neurological and psychiatric diseases.</ArticleTitle><Pagination><MedlinePgn>19-34</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/nrd.2015.5</ELocationID><Abstract><AbstractText>Voltage-gated calcium channels are important regulators of brain, heart and muscle functions, and their dysfunction can give rise to pathophysiological conditions ranging from cardiovascular disorders to neurological and psychiatric conditions such as epilepsy, pain and autism. In the nervous system, calcium channel blockers have been used successfully to treat absence seizures, and are emerging as potential therapeutic avenues for pathologies such as pain, Parkinson disease, addiction and anxiety. This Review provides an overview of calcium channels as drug targets for nervous system disorders, and discusses potential challenges and opportunities for the development of new clinically effective calcium channel inhibitors.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zamponi</LastName><ForeName>Gerald W</ForeName><Initials>GW</Initials><AffiliationInfo><Affiliation>Department of Physiology and Pharmacology, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary T2N 4N1, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType 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