Early-onset vs. Late-onset Parkinson's disease: A Clinical-pathological Study.
Identifieur interne : 000318 ( PubMed/Curation ); précédent : 000317; suivant : 000319Early-onset vs. Late-onset Parkinson's disease: A Clinical-pathological Study.
Auteurs : Leslie Wayne Ferguson [Canada] ; Ali H. Rajput [Canada] ; Alexander Rajput [Canada]Source :
- The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques [ 0317-1671 ] ; 2016.
English descriptors
- KwdEn :
- Adult, Age Factors, Age of Onset, Aged, Aged, 80 and over, Antiparkinson Agents, Disease Progression, Dyskinesias (drug therapy), Dyskinesias (epidemiology), Dyskinesias (etiology), Dyskinesias (physiopathology), Female, Humans, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (epidemiology), Parkinson Disease (physiopathology), Severity of Illness Index.
- MESH :
- chemical : Antiparkinson Agents.
- complications : Parkinson Disease.
- drug therapy : Dyskinesias, Parkinson Disease.
- epidemiology : Dyskinesias, Parkinson Disease.
- etiology : Dyskinesias.
- physiopathology : Dyskinesias, Parkinson Disease.
- Adult, Age Factors, Age of Onset, Aged, Aged, 80 and over, Disease Progression, Female, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
Several studies have compared early-onset Parkinson disease (EOPD) and late-onset Parkinson disease (LOPD) but most are not based on autopsy confirmed cases.
DOI: 10.1017/cjn.2015.244
PubMed: 26189779
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Rajput</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology,University of Saskatchewan,Saskatoon,Saskatchewan,Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology,University of Saskatchewan,Saskatoon,Saskatchewan</wicri:regionArea></affiliation></author><author><name sortKey="Rajput, Alexander" sort="Rajput, Alexander" uniqKey="Rajput A" first="Alexander" last="Rajput">Alexander Rajput</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology,University of Saskatchewan,Saskatoon,Saskatchewan,Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology,University of Saskatchewan,Saskatoon,Saskatchewan</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26189779</idno><idno type="pmid">26189779</idno><idno type="doi">10.1017/cjn.2015.244</idno><idno type="wicri:Area/PubMed/Corpus">000318</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000318</idno><idno type="wicri:Area/PubMed/Curation">000318</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000318</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Early-onset vs. Late-onset Parkinson's disease: A Clinical-pathological Study.</title><author><name sortKey="Ferguson, Leslie Wayne" sort="Ferguson, Leslie Wayne" uniqKey="Ferguson L" first="Leslie Wayne" last="Ferguson">Leslie Wayne Ferguson</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology,University of Saskatchewan,Saskatoon,Saskatchewan,Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology,University of Saskatchewan,Saskatoon,Saskatchewan</wicri:regionArea></affiliation></author><author><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H" last="Rajput">Ali H. Rajput</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology,University of Saskatchewan,Saskatoon,Saskatchewan,Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology,University of Saskatchewan,Saskatoon,Saskatchewan</wicri:regionArea></affiliation></author><author><name sortKey="Rajput, Alexander" sort="Rajput, Alexander" uniqKey="Rajput A" first="Alexander" last="Rajput">Alexander Rajput</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology,University of Saskatchewan,Saskatoon,Saskatchewan,Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology,University of Saskatchewan,Saskatoon,Saskatchewan</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques</title><idno type="ISSN">0317-1671</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Age of Onset</term><term>Aged</term><term>Aged, 80 and over</term><term>Antiparkinson Agents</term><term>Disease Progression</term><term>Dyskinesias (drug therapy)</term><term>Dyskinesias (epidemiology)</term><term>Dyskinesias (etiology)</term><term>Dyskinesias (physiopathology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (physiopathology)</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dyskinesias</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Dyskinesias</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesias</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dyskinesias</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Age of Onset</term><term>Aged</term><term>Aged, 80 and over</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several studies have compared early-onset Parkinson disease (EOPD) and late-onset Parkinson disease (LOPD) but most are not based on autopsy confirmed cases.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26189779</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>20</Day></DateCreated><DateCompleted><Year>2016</Year><Month>10</Month><Day>31</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0317-1671</ISSN><JournalIssue CitedMedium="Internet"><Volume>43</Volume><Issue>1</Issue><PubDate><Year>2016</Year><Month>Jan</Month></PubDate></JournalIssue><Title>The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques</Title><ISOAbbreviation>Can J Neurol Sci</ISOAbbreviation></Journal><ArticleTitle>Early-onset vs. Late-onset Parkinson's disease: A Clinical-pathological Study.</ArticleTitle><Pagination><MedlinePgn>113-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1017/cjn.2015.244</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Several studies have compared early-onset Parkinson disease (EOPD) and late-onset Parkinson disease (LOPD) but most are not based on autopsy confirmed cases.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We compared clinical and pharmacological profiles, time to reach irreversible Hoehn and Yahr (H&Y) Stage 3 and levodopa motor complications in autopsy confirmed EOPD and LOPD cases.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">At first clinic visit EOPD cases were younger but had longer disease duration and they died at a younger age (all p<0.0001). Anti-Parkinsonian drug use, including levodopa, was significantly delayed in EOPD. Lifetime use of amantadine (p<0.05) and dopamine agonists (p<0.01) were higher in EOPD. While lifetime use of levodopa was similar in the two groups, levodopa was used for a significantly longer period by EOPD (p< 0.0001). EOPD had a higher cumulative incidence of dyskinesias (p<0.01), wearing-off (p<0.01), and on-off (p<0.01). However, the time to dyskinesia onset was similar in the two groups. The threshold to wearing-off was much longer in EOPD (p<0.01). H&Y stage profile at first visit was similar in the two groups. The duration from disease onset to reach irreversible H&Y stage 3 was significantly longer in EOPD.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our observations indicate that progression of PD is slower in EOPD and suggest that the pre-clinical interval in this group is longer. These findings can be used for case selection for drug trials and studies of the pathogenesis of PD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ferguson</LastName><ForeName>Leslie Wayne</ForeName><Initials>LW</Initials><AffiliationInfo><Affiliation>Division of Neurology,University of Saskatchewan,Saskatoon,Saskatchewan,Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rajput</LastName><ForeName>Ali H</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Division of Neurology,University of Saskatchewan,Saskatoon,Saskatchewan,Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rajput</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Neurology,University of Saskatchewan,Saskatoon,Saskatchewan,Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>07</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Can J Neurol Sci</MedlineTA><NlmUniqueID>0415227</NlmUniqueID><ISSNLinking>0317-1671</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017668" MajorTopicYN="N">Age of Onset</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000978" MajorTopicYN="N">Antiparkinson Agents</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="Y">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020820" MajorTopicYN="N">Dyskinesias</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Age of Onset</Keyword><Keyword MajorTopicYN="N">Early-onset</Keyword><Keyword MajorTopicYN="N">Late-Onset</Keyword><Keyword MajorTopicYN="N">Parkinson disease</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>7</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>7</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>11</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26189779</ArticleId><ArticleId IdType="pii">S0317167115002449</ArticleId><ArticleId IdType="doi">10.1017/cjn.2015.244</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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