Inflammatory profile in LRRK2-associated prodromal and clinical PD.
Identifieur interne : 000229 ( PubMed/Curation ); précédent : 000228; suivant : 000230Inflammatory profile in LRRK2-associated prodromal and clinical PD.
Auteurs : Kathrin Brockmann [Allemagne] ; Anja Apel [Allemagne] ; Claudia Schulte [Allemagne] ; Nicole Schneiderhan-Marra [Allemagne] ; Claustre Pont-Sunyer [Espagne] ; Dolores Vilas [Espagne] ; Javier Ruiz-Martinez [Espagne] ; Markus Langkamp [Allemagne] ; Jean-Christophe Corvol [France] ; Florence Cormier [France] ; Thomas Knorpp [Allemagne] ; Thomas O. Joos [Allemagne] ; Thomas Gasser [Allemagne] ; Birgitt Schüle [États-Unis] ; Jan O. Aasly [Norvège] ; Tatiana Foroud [États-Unis] ; Jose Felix Marti-Masso [Espagne] ; Alexis Brice [France] ; Eduardo Tolosa [Espagne] ; Connie Marras [Canada] ; Daniela Berg [Allemagne] ; Walter Maetzler [Allemagne]Source :
- Journal of neuroinflammation [ 1742-2094 ] ; 2016.
Abstract
There is evidence for a relevant role of inflammation in the pathogenesis of Parkinson's disease (PD). Mutations in the LRRK2 gene represent the most frequent genetic cause for autosomal dominant PD. LRRK2 is highly expressed in macrophages and microglia suggesting an involvement in inflammatory pathways. The objectives are to test (1) whether idiopathic PD and LRRK2-associated PD share common inflammatory pathways or present distinct profiles and (2) whether non-manifesting LRRK2 mutation carriers present with similar aspects of inflammatory profiles as seen in PD-affected patients.
DOI: 10.1186/s12974-016-0588-5
PubMed: 27220776
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Kathrin.Brockmann@uni-tuebingen.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Apel, Anja" sort="Apel, Anja" uniqKey="Apel A" first="Anja" last="Apel">Anja Apel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Schulte, Claudia" sort="Schulte, Claudia" uniqKey="Schulte C" first="Claudia" last="Schulte">Claudia Schulte</name><affiliation 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Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa</wicri:regionArea></affiliation></author><author><name sortKey="Langkamp, Markus" sort="Langkamp, Markus" uniqKey="Langkamp M" first="Markus" last="Langkamp">Markus Langkamp</name><affiliation wicri:level="1"><nlm:affiliation>Mediagnost GmbH, Reutlingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mediagnost GmbH, Reutlingen</wicri:regionArea></affiliation></author><author><name sortKey="Corvol, Jean Christophe" sort="Corvol, Jean Christophe" uniqKey="Corvol J" first="Jean-Christophe" last="Corvol">Jean-Christophe Corvol</name><affiliation wicri:level="1"><nlm:affiliation>Département de Génétique et Cytogénétique, INSERM, Sorbonne Universités, Hôpital de la Pitié Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de Génétique et Cytogénétique, INSERM, Sorbonne Universités, Hôpital de la Pitié Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Cormier, Florence" sort="Cormier, Florence" uniqKey="Cormier F" first="Florence" last="Cormier">Florence Cormier</name><affiliation wicri:level="1"><nlm:affiliation>Département de Génétique et Cytogénétique, INSERM, Sorbonne Universités, Hôpital de la Pitié Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de Génétique et Cytogénétique, INSERM, Sorbonne Universités, Hôpital de la Pitié Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Knorpp, Thomas" sort="Knorpp, Thomas" uniqKey="Knorpp T" first="Thomas" last="Knorpp">Thomas Knorpp</name><affiliation wicri:level="1"><nlm:affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen</wicri:regionArea></affiliation></author><author><name sortKey="Joos, Thomas O" sort="Joos, Thomas O" uniqKey="Joos T" first="Thomas O" last="Joos">Thomas O. 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Aasly</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, St. Olavs Hospital, Trondheim, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, St. Olavs Hospital, Trondheim</wicri:regionArea></affiliation></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical and Molecular Genetics, Indiana University, Bloomington, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University, Bloomington, IN</wicri:regionArea></affiliation></author><author><name sortKey="Marti Masso, Jose Felix" sort="Marti Masso, Jose Felix" uniqKey="Marti Masso J" first="Jose Felix" last="Marti-Masso">Jose Felix Marti-Masso</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa</wicri:regionArea></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation wicri:level="1"><nlm:affiliation>Département de Génétique et Cytogénétique, INSERM, Sorbonne Universités, Hôpital de la Pitié Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de Génétique et Cytogénétique, INSERM, Sorbonne Universités, Hôpital de la Pitié Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institutd'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institutd'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name><affiliation wicri:level="1"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's disease, Toronto Western Hospital, University of Toronto, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's disease, Toronto Western Hospital, University of Toronto, Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27220776</idno><idno type="pmid">27220776</idno><idno type="doi">10.1186/s12974-016-0588-5</idno><idno type="wicri:Area/PubMed/Corpus">000229</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000229</idno><idno type="wicri:Area/PubMed/Curation">000229</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000229</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inflammatory profile in LRRK2-associated prodromal and clinical PD.</title><author><name sortKey="Brockmann, Kathrin" sort="Brockmann, Kathrin" uniqKey="Brockmann K" first="Kathrin" last="Brockmann">Kathrin Brockmann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. Kathrin.Brockmann@uni-tuebingen.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Apel, Anja" sort="Apel, Anja" uniqKey="Apel A" first="Anja" last="Apel">Anja Apel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Schulte, Claudia" sort="Schulte, Claudia" uniqKey="Schulte C" first="Claudia" last="Schulte">Claudia Schulte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Schneiderhan Marra, Nicole" sort="Schneiderhan Marra, Nicole" uniqKey="Schneiderhan Marra N" first="Nicole" last="Schneiderhan-Marra">Nicole Schneiderhan-Marra</name><affiliation wicri:level="1"><nlm:affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen</wicri:regionArea></affiliation></author><author><name sortKey="Pont Sunyer, Claustre" sort="Pont Sunyer, Claustre" uniqKey="Pont Sunyer C" first="Claustre" last="Pont-Sunyer">Claustre Pont-Sunyer</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institutd'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institutd'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Vilas, Dolores" sort="Vilas, Dolores" uniqKey="Vilas D" first="Dolores" last="Vilas">Dolores Vilas</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institutd'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institutd'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Ruiz Martinez, Javier" sort="Ruiz Martinez, Javier" uniqKey="Ruiz Martinez J" first="Javier" last="Ruiz-Martinez">Javier Ruiz-Martinez</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa</wicri:regionArea></affiliation></author><author><name sortKey="Langkamp, Markus" sort="Langkamp, Markus" uniqKey="Langkamp M" first="Markus" last="Langkamp">Markus Langkamp</name><affiliation wicri:level="1"><nlm:affiliation>Mediagnost GmbH, Reutlingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mediagnost GmbH, Reutlingen</wicri:regionArea></affiliation></author><author><name sortKey="Corvol, Jean Christophe" sort="Corvol, Jean Christophe" uniqKey="Corvol J" first="Jean-Christophe" last="Corvol">Jean-Christophe Corvol</name><affiliation wicri:level="1"><nlm:affiliation>Département de Génétique et Cytogénétique, INSERM, Sorbonne Universités, Hôpital de la Pitié Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de Génétique et Cytogénétique, INSERM, Sorbonne Universités, Hôpital de la Pitié Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Cormier, Florence" sort="Cormier, Florence" uniqKey="Cormier F" first="Florence" last="Cormier">Florence Cormier</name><affiliation wicri:level="1"><nlm:affiliation>Département de Génétique et Cytogénétique, INSERM, Sorbonne Universités, Hôpital de la Pitié Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de Génétique et Cytogénétique, INSERM, Sorbonne Universités, Hôpital de la Pitié Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Knorpp, Thomas" sort="Knorpp, Thomas" uniqKey="Knorpp T" first="Thomas" last="Knorpp">Thomas Knorpp</name><affiliation wicri:level="1"><nlm:affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen</wicri:regionArea></affiliation></author><author><name sortKey="Joos, Thomas O" sort="Joos, Thomas O" uniqKey="Joos T" first="Thomas O" last="Joos">Thomas O. Joos</name><affiliation wicri:level="1"><nlm:affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen</wicri:regionArea></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Schule, Birgitt" sort="Schule, Birgitt" uniqKey="Schule B" first="Birgitt" last="Schüle">Birgitt Schüle</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson Institute and Clinical Center, 675 Almanor Ave, Sunnyvale, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson Institute and Clinical Center, 675 Almanor Ave, Sunnyvale, CA</wicri:regionArea></affiliation></author><author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O" last="Aasly">Jan O. Aasly</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, St. Olavs Hospital, Trondheim, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, St. Olavs Hospital, Trondheim</wicri:regionArea></affiliation></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical and Molecular Genetics, Indiana University, Bloomington, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University, Bloomington, IN</wicri:regionArea></affiliation></author><author><name sortKey="Marti Masso, Jose Felix" sort="Marti Masso, Jose Felix" uniqKey="Marti Masso J" first="Jose Felix" last="Marti-Masso">Jose Felix Marti-Masso</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa</wicri:regionArea></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation wicri:level="1"><nlm:affiliation>Département de Génétique et Cytogénétique, INSERM, Sorbonne Universités, Hôpital de la Pitié Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de Génétique et Cytogénétique, INSERM, Sorbonne Universités, Hôpital de la Pitié Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institutd'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institutd'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name><affiliation wicri:level="1"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's disease, Toronto Western Hospital, University of Toronto, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's disease, Toronto Western Hospital, University of Toronto, Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of neuroinflammation</title><idno type="eISSN">1742-2094</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is evidence for a relevant role of inflammation in the pathogenesis of Parkinson's disease (PD). Mutations in the LRRK2 gene represent the most frequent genetic cause for autosomal dominant PD. LRRK2 is highly expressed in macrophages and microglia suggesting an involvement in inflammatory pathways. The objectives are to test (1) whether idiopathic PD and LRRK2-associated PD share common inflammatory pathways or present distinct profiles and (2) whether non-manifesting LRRK2 mutation carriers present with similar aspects of inflammatory profiles as seen in PD-affected patients.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27220776</PMID><DateCreated><Year>2016</Year><Month>05</Month><Day>25</Day></DateCreated><DateRevised><Year>2017</Year><Month>03</Month><Day>02</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1742-2094</ISSN><JournalIssue CitedMedium="Internet"><Volume>13</Volume><Issue>1</Issue><PubDate><Year>2016</Year><Month>May</Month><Day>24</Day></PubDate></JournalIssue><Title>Journal of neuroinflammation</Title><ISOAbbreviation>J Neuroinflammation</ISOAbbreviation></Journal><ArticleTitle>Inflammatory profile in LRRK2-associated prodromal and clinical PD.</ArticleTitle><Pagination><MedlinePgn>122</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12974-016-0588-5</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">There is evidence for a relevant role of inflammation in the pathogenesis of Parkinson's disease (PD). Mutations in the LRRK2 gene represent the most frequent genetic cause for autosomal dominant PD. LRRK2 is highly expressed in macrophages and microglia suggesting an involvement in inflammatory pathways. The objectives are to test (1) whether idiopathic PD and LRRK2-associated PD share common inflammatory pathways or present distinct profiles and (2) whether non-manifesting LRRK2 mutation carriers present with similar aspects of inflammatory profiles as seen in PD-affected patients.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We assessed serum profiles of 23 immune-associated markers and the brain-derived neurotrophic factor in 534 individuals from the MJFF LRRK2 consortium.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A large proportion of inflammatory markers were gender-dependent. Both PD-affected cohorts showed increased levels of the pro-inflammatory marker fatty-acid-binding protein. Additionally, idiopathic PD but not LRRK2-associated PD patients showed increased levels of the pro-inflammatory marker interleukin-12-p40 as well as the anti-inflammatory species interleukin-10, brain-derived neurotrophic factor, and stem cell factor. Non-manifesting LRRK2 mutation carriers including those with prodromal characteristics of PD presented with control-like inflammatory profiles.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Concomitant inflammation seems to be associated with idiopathic and LRRK2-associated PD. Identifying PD patients in whom inflammatory processes play a major role in their pathophysiology might offer a new therapeutic window at least for a subgroup of patients. Since non-manifesting LRRK2 mutation carriers with symptoms of the prodromal phase of PD did not show inflammatory profiles, activation of the immune system seems not an early event in the disease cascade.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Brockmann</LastName><ForeName>Kathrin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. Kathrin.Brockmann@uni-tuebingen.de.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. Kathrin.Brockmann@uni-tuebingen.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Apel</LastName><ForeName>Anja</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schulte</LastName><ForeName>Claudia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schneiderhan-Marra</LastName><ForeName>Nicole</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pont-Sunyer</LastName><ForeName>Claustre</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institutd'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vilas</LastName><ForeName>Dolores</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institutd'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ruiz-Martinez</LastName><ForeName>Javier</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Langkamp</LastName><ForeName>Markus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Mediagnost GmbH, Reutlingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corvol</LastName><ForeName>Jean-Christophe</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Département de Génétique et Cytogénétique, INSERM, Sorbonne Universités, Hôpital de la Pitié Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cormier</LastName><ForeName>Florence</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Département de Génétique et Cytogénétique, INSERM, Sorbonne Universités, Hôpital de la Pitié Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Knorpp</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Joos</LastName><ForeName>Thomas O</ForeName><Initials>TO</Initials><AffiliationInfo><Affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gasser</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schüle</LastName><ForeName>Birgitt</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Parkinson Institute and Clinical Center, 675 Almanor Ave, Sunnyvale, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aasly</LastName><ForeName>Jan O</ForeName><Initials>JO</Initials><AffiliationInfo><Affiliation>Department of Neurology, St. Olavs Hospital, Trondheim, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Foroud</LastName><ForeName>Tatiana</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Medical and Molecular Genetics, Indiana University, Bloomington, IN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marti-Masso</LastName><ForeName>Jose Felix</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brice</LastName><ForeName>Alexis</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Département de Génétique et Cytogénétique, INSERM, Sorbonne Universités, Hôpital de la Pitié Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tolosa</LastName><ForeName>Eduardo</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institutd'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marras</LastName><ForeName>Connie</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's disease, Toronto Western Hospital, University of Toronto, Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berg</LastName><ForeName>Daniela</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maetzler</LastName><ForeName>Walter</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Center for Neurodegenerative Diseases (DZNE), Tübingen, 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