La maladie de Parkinson au Canada (serveur d'exploration)

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Long-term double-blinded unilateral pedunculopontine area stimulation in Parkinson's disease.

Identifieur interne : 000144 ( PubMed/Curation ); précédent : 000143; suivant : 000145

Long-term double-blinded unilateral pedunculopontine area stimulation in Parkinson's disease.

Auteurs : Tiago A. Mestre [Canada] ; Christos Sidiropoulos [Canada] ; Clement Hamani [Canada] ; Yu-Yan Poon [Canada] ; Andres M. Lozano [Canada] ; Anthony E. Lang [Canada] ; Elena Moro [Canada]

Source :

RBID : pubmed:27392513

Abstract

Gait-related symptoms are often refractory to current available treatment options with a significant reduction in quality of life in Parkinson's disease.

DOI: 10.1002/mds.26710
PubMed: 27392513

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<nlm:affiliation>Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Division of Neurology, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Ontario, Canada. tmestre@toh.on.ca.</nlm:affiliation>
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<nlm:affiliation>Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Division of Neurology, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Ontario, Canada. tmestre@toh.on.ca.</nlm:affiliation>
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<name sortKey="Poon, Yu Yan" sort="Poon, Yu Yan" uniqKey="Poon Y" first="Yu-Yan" last="Poon">Yu-Yan Poon</name>
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<name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name>
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<title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<div type="abstract" xml:lang="en">Gait-related symptoms are often refractory to current available treatment options with a significant reduction in quality of life in Parkinson's disease.</div>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Gait-related symptoms are often refractory to current available treatment options with a significant reduction in quality of life in Parkinson's disease.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The objective of this study was to determine the long-term efficacy and safety of unilateral pedunculopontine area stimulation for refractory gait and balance impairment in Parkinson's disease.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">This study used periodic randomized double-blinded assessments until 4 years postoperatively. The primary outcomes were gait-related items of the UPDRS part II and the MDS-UPDRS part III.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">At baseline, the median age and disease duration was 63 years (interquartile range: 62, 65) and 15 years (interquartile range: 11, 20). At 2 years, patient-reported freezing (UPDRS part II, off-time) was significantly better when compared with baseline (P =.028), with 62.5% of responders. At 4 years, there was no significant change in the used outcomes, but 66.7 % (n = 4 of 6) were responders for off-time patient-reported freezing and falling.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Pedunculopontine area stimulation has an initial but not sustained benefit for gait-related symptoms. © 2016 International Parkinson and Movement Disorder Society.</AbstractText>
<CopyrightInformation>© 2016 International Parkinson and Movement Disorder Society.</CopyrightInformation>
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<ForeName>Tiago A</ForeName>
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<Affiliation>Parkinson's disease and Movement Disorders Center, Division of Neurology, Department of Medicine, University of Ottawa Brain and Mind Institute, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada (current affiliation). tmestre@toh.on.ca.</Affiliation>
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<Affiliation>Parkinson's Disease and Movement Disorders Program, Henry Ford Health System, West Bloomfield, Michigan, USA (current affiliation).</Affiliation>
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</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Université Joseph Fourier, Grenoble, France (current affiliation).</Affiliation>
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<Language>eng</Language>
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<Keyword MajorTopicYN="N">deep brain stimulation</Keyword>
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