The Systemic Synuclein Sampling Study: toward a biomarker for Parkinson's disease.
Identifieur interne : 000023 ( PubMed/Curation ); précédent : 000022; suivant : 000024The Systemic Synuclein Sampling Study: toward a biomarker for Parkinson's disease.
Auteurs : Naomi P. Visanji [Canada] ; Brit Mollenhauer [Allemagne] ; Thomas G. Beach [États-Unis] ; Charles H. Adler [États-Unis] ; Christopher S. Coffey [États-Unis] ; Catherine M. Kopil [États-Unis] ; Kuldip D. Dave [États-Unis] ; Tatiana Foroud [États-Unis] ; Lana Chahine [États-Unis] ; Danna Jennings [États-Unis]Source :
- Biomarkers in medicine [ 1752-0371 ] ; 2017.
Abstract
The search for a biomarker for Parkinson's disease (PD) has led to a surge in literature describing peripheral α-synuclein (aSyn) in both biofluids and biopsy/autopsy tissues. Despite encouraging results, attempts to capitalize on this promise have fallen woefully short. The Systemic Synuclein Sampling Study (S4) is uniquely designed to identify a reproducible diagnostic and progression biomarker for PD. S4 will evaluate aSyn in multiple tissues and biofluids within the same subject and across the disease spectrum to identify the optimal biomarker source and provide vital information on the evolution of peripheral aSyn throughout the disease. Additionally, S4 will correlate the systemic aSyn profile with an objective measure of nigrostriatal dopaminergic function furthering our understanding of the pathophysiological progression of PD.
DOI: 10.2217/bmm-2016-0366
PubMed: 28353371
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Visanji</name><affiliation wicri:level="1"><nlm:affiliation>Morton & Gloria Shulman Movement Disorders Centre & Edmund J Saffra program in Parkinson's disease, Toronto Western Hospital, 399 Bathurst Street, MCl 7, Toronto, Ontario, M5T 2S8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton & Gloria Shulman Movement Disorders Centre & Edmund J Saffra program in Parkinson's disease, Toronto Western Hospital, 399 Bathurst Street, MCl 7, Toronto, Ontario, M5T 2S8</wicri:regionArea></affiliation></author><author><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name><affiliation wicri:level="1"><nlm:affiliation>Paracelsus-Elena-Klinik, Klinikstrasse 16, 34128 Kassel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paracelsus-Elena-Klinik, Klinikstrasse 16, 34128 Kassel</wicri:regionArea></affiliation></author><author><name sortKey="Beach, Thomas G" sort="Beach, Thomas G" uniqKey="Beach T" first="Thomas G" last="Beach">Thomas G. 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Visanji</name><affiliation wicri:level="1"><nlm:affiliation>Morton & Gloria Shulman Movement Disorders Centre & Edmund J Saffra program in Parkinson's disease, Toronto Western Hospital, 399 Bathurst Street, MCl 7, Toronto, Ontario, M5T 2S8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton & Gloria Shulman Movement Disorders Centre & Edmund J Saffra program in Parkinson's disease, Toronto Western Hospital, 399 Bathurst Street, MCl 7, Toronto, Ontario, M5T 2S8</wicri:regionArea></affiliation></author><author><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name><affiliation wicri:level="1"><nlm:affiliation>Paracelsus-Elena-Klinik, Klinikstrasse 16, 34128 Kassel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paracelsus-Elena-Klinik, Klinikstrasse 16, 34128 Kassel</wicri:regionArea></affiliation></author><author><name sortKey="Beach, Thomas G" sort="Beach, Thomas G" uniqKey="Beach T" first="Thomas G" last="Beach">Thomas G. Beach</name><affiliation wicri:level="1"><nlm:affiliation>Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ 85351, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ 85351</wicri:regionArea></affiliation></author><author><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H" last="Adler">Charles H. Adler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259</wicri:regionArea></affiliation></author><author><name sortKey="Coffey, Christopher S" sort="Coffey, Christopher S" uniqKey="Coffey C" first="Christopher S" last="Coffey">Christopher S. Coffey</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biostatistics, University of Iowa, Iowa City, IA 52242-1409, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of Iowa, Iowa City, IA 52242-1409</wicri:regionArea></affiliation></author><author><name sortKey="Kopil, Catherine M" sort="Kopil, Catherine M" uniqKey="Kopil C" first="Catherine M" last="Kopil">Catherine M. Kopil</name><affiliation wicri:level="1"><nlm:affiliation>The Michael J Fox Foundation for Parkinson's Research, Grand Central Station, PO Box 4777, New York, NY 10163-4777, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Michael J Fox Foundation for Parkinson's Research, Grand Central Station, PO Box 4777, New York, NY 10163-4777</wicri:regionArea></affiliation></author><author><name sortKey="Dave, Kuldip D" sort="Dave, Kuldip D" uniqKey="Dave K" first="Kuldip D" last="Dave">Kuldip D. Dave</name><affiliation wicri:level="1"><nlm:affiliation>The Michael J Fox Foundation for Parkinson's Research, Grand Central Station, PO Box 4777, New York, NY 10163-4777, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Michael J Fox Foundation for Parkinson's Research, Grand Central Station, PO Box 4777, New York, NY 10163-4777</wicri:regionArea></affiliation></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical & Molecular Genetics, Indiana University, Bloomington, IN 46202, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical & Molecular Genetics, Indiana University, Bloomington, IN 46202</wicri:regionArea></affiliation></author><author><name sortKey="Chahine, Lana" sort="Chahine, Lana" uniqKey="Chahine L" first="Lana" last="Chahine">Lana Chahine</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Pennsylvania Perelman School of Medicine, 330 South 9th Street, Philadelphia, PA 19107, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Pennsylvania Perelman School of Medicine, 330 South 9th Street, Philadelphia, PA 19107</wicri:regionArea></affiliation></author><author><name sortKey="Jennings, Danna" sort="Jennings, Danna" uniqKey="Jennings D" first="Danna" last="Jennings">Danna Jennings</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Neurodegenerative Disorders, New Haven, CT 06510</wicri:regionArea></affiliation></author></analytic><series><title level="j">Biomarkers in medicine</title><idno type="eISSN">1752-0371</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The search for a biomarker for Parkinson's disease (PD) has led to a surge in literature describing peripheral α-synuclein (aSyn) in both biofluids and biopsy/autopsy tissues. Despite encouraging results, attempts to capitalize on this promise have fallen woefully short. The Systemic Synuclein Sampling Study (S4) is uniquely designed to identify a reproducible diagnostic and progression biomarker for PD. S4 will evaluate aSyn in multiple tissues and biofluids within the same subject and across the disease spectrum to identify the optimal biomarker source and provide vital information on the evolution of peripheral aSyn throughout the disease. Additionally, S4 will correlate the systemic aSyn profile with an objective measure of nigrostriatal dopaminergic function furthering our understanding of the pathophysiological progression of PD.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28353371</PMID><DateCreated><Year>2017</Year><Month>03</Month><Day>29</Day></DateCreated><DateRevised><Year>2017</Year><Month>03</Month><Day>31</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1752-0371</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>4</Issue><PubDate><Year>2017</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Biomarkers in medicine</Title><ISOAbbreviation>Biomark Med</ISOAbbreviation></Journal><ArticleTitle>The Systemic Synuclein Sampling Study: toward a biomarker for Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>359-368</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2217/bmm-2016-0366</ELocationID><Abstract><AbstractText>The search for a biomarker for Parkinson's disease (PD) has led to a surge in literature describing peripheral α-synuclein (aSyn) in both biofluids and biopsy/autopsy tissues. Despite encouraging results, attempts to capitalize on this promise have fallen woefully short. The Systemic Synuclein Sampling Study (S4) is uniquely designed to identify a reproducible diagnostic and progression biomarker for PD. S4 will evaluate aSyn in multiple tissues and biofluids within the same subject and across the disease spectrum to identify the optimal biomarker source and provide vital information on the evolution of peripheral aSyn throughout the disease. Additionally, S4 will correlate the systemic aSyn profile with an objective measure of nigrostriatal dopaminergic function furthering our understanding of the pathophysiological progression of PD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Visanji</LastName><ForeName>Naomi P</ForeName><Initials>NP</Initials><AffiliationInfo><Affiliation>Morton & Gloria Shulman Movement Disorders Centre & Edmund J Saffra program in Parkinson's disease, Toronto Western Hospital, 399 Bathurst Street, MCl 7, Toronto, Ontario, M5T 2S8, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mollenhauer</LastName><ForeName>Brit</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Paracelsus-Elena-Klinik, Klinikstrasse 16, 34128 Kassel, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beach</LastName><ForeName>Thomas G</ForeName><Initials>TG</Initials><AffiliationInfo><Affiliation>Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ 85351, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adler</LastName><ForeName>Charles H</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coffey</LastName><ForeName>Christopher S</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of Iowa, Iowa City, IA 52242-1409, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kopil</LastName><ForeName>Catherine M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>The Michael J Fox Foundation for Parkinson's Research, Grand Central Station, PO Box 4777, New York, NY 10163-4777, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dave</LastName><ForeName>Kuldip D</ForeName><Initials>KD</Initials><AffiliationInfo><Affiliation>The Michael J Fox Foundation for Parkinson's Research, Grand Central Station, PO Box 4777, New York, NY 10163-4777, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Foroud</LastName><ForeName>Tatiana</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Medical & Molecular Genetics, Indiana University, Bloomington, IN 46202, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chahine</LastName><ForeName>Lana</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Pennsylvania Perelman School of Medicine, 330 South 9th Street, Philadelphia, PA 19107, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jennings</LastName><ForeName>Danna</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Systemic Synuclein Sampling Study (S4)</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>03</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Biomark Med</MedlineTA><NlmUniqueID>101312535</NlmUniqueID><ISSNLinking>1752-0363</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">biofluid</Keyword><Keyword MajorTopicYN="N">biomarker</Keyword><Keyword MajorTopicYN="N">tissue</Keyword><Keyword MajorTopicYN="N">α-synuclein</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>3</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>3</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>3</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28353371</ArticleId><ArticleId IdType="doi">10.2217/bmm-2016-0366</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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