Impairments and compensatory adjustments in spontaneous movement after unilateral dopamine depletion in rats.
Identifieur interne : 001918 ( PubMed/Corpus ); précédent : 001917; suivant : 001919Impairments and compensatory adjustments in spontaneous movement after unilateral dopamine depletion in rats.
Auteurs : E I Miklyaeva ; D J Martens ; I Q WhishawSource :
- Brain research [ 0006-8993 ] ; 1995.
English descriptors
- KwdEn :
- Animals, Behavior, Animal (physiology), Brain Chemistry (drug effects), Brain Chemistry (physiology), Dopamine (physiology), Feeding Behavior (physiology), Female, Functional Laterality (physiology), Gait (physiology), Grooming (physiology), Locomotion (physiology), Movement (physiology), Oxidopamine (pharmacology), Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (psychology), Posture, Rats, Videotape Recording.
- MESH :
- chemical , pharmacology : Oxidopamine.
- chemical , physiology : Dopamine.
- chemically induced : Parkinson Disease, Secondary.
- drug effects : Brain Chemistry.
- physiology : Behavior, Animal, Brain Chemistry, Feeding Behavior, Functional Laterality, Gait, Grooming, Locomotion, Movement.
- psychology : Parkinson Disease, Secondary.
- Animals, Female, Posture, Rats, Videotape Recording.
Abstract
Rats with unilateral dopamine (DA) depletions (hemi-Parkinson rats) display directional biases in their locomotion in spontaneous and drug induced tests. These biases have been explained as being due either to changed responsiveness to sensory stimulation, changes in motor ability, or to central changes, but as yet their basis is not fully understood. The purpose of the present experiment is to examine the posture of immobility and the posture and strategies of locomotion in rats with unilateral DA depletions. The rats are found to display impairments in their bad limbs (contralateral-to-lesion limbs) in adjusting posture and moving. They compensate by supporting themselves mainly on their good hindlimb, using the bad hindlimb and tail for balance and by disproportionately relying upon their good limbs to turn and to walk. Thus, their center of gravity is shifted to the good side and movement is preferentially directed toward the good side, in part to maintain equilibrium and in part to remove weight from the bad limbs so that they can enter the swing phase of the stepping cycle. It is proposed that the bad limbs may be unable to apply force to adjust posture and produce movement. These results provide a basis for predicting the movements that the animals will use in various situations and they expand the test repertoire this hemi-Parkinson model provides for studying recovery processes after loss of dopamine.
PubMed: 7552288
Links to Exploration step
pubmed:7552288Le document en format XML
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These biases have been explained as being due either to changed responsiveness to sensory stimulation, changes in motor ability, or to central changes, but as yet their basis is not fully understood. The purpose of the present experiment is to examine the posture of immobility and the posture and strategies of locomotion in rats with unilateral DA depletions. The rats are found to display impairments in their bad limbs (contralateral-to-lesion limbs) in adjusting posture and moving. They compensate by supporting themselves mainly on their good hindlimb, using the bad hindlimb and tail for balance and by disproportionately relying upon their good limbs to turn and to walk. Thus, their center of gravity is shifted to the good side and movement is preferentially directed toward the good side, in part to maintain equilibrium and in part to remove weight from the bad limbs so that they can enter the swing phase of the stepping cycle. It is proposed that the bad limbs may be unable to apply force to adjust posture and produce movement. These results provide a basis for predicting the movements that the animals will use in various situations and they expand the test repertoire this hemi-Parkinson model provides for studying recovery processes after loss of dopamine.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">7552288</PMID><DateCreated><Year>1995</Year><Month>11</Month><Day>06</Day></DateCreated><DateCompleted><Year>1995</Year><Month>11</Month><Day>06</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0006-8993</ISSN><JournalIssue CitedMedium="Print"><Volume>681</Volume><Issue>1-2</Issue><PubDate><Year>1995</Year><Month>May</Month><Day>29</Day></PubDate></JournalIssue><Title>Brain research</Title><ISOAbbreviation>Brain Res.</ISOAbbreviation></Journal><ArticleTitle>Impairments and compensatory adjustments in spontaneous movement after unilateral dopamine depletion in rats.</ArticleTitle><Pagination><MedlinePgn>23-40</MedlinePgn></Pagination><Abstract><AbstractText>Rats with unilateral dopamine (DA) depletions (hemi-Parkinson rats) display directional biases in their locomotion in spontaneous and drug induced tests. These biases have been explained as being due either to changed responsiveness to sensory stimulation, changes in motor ability, or to central changes, but as yet their basis is not fully understood. The purpose of the present experiment is to examine the posture of immobility and the posture and strategies of locomotion in rats with unilateral DA depletions. The rats are found to display impairments in their bad limbs (contralateral-to-lesion limbs) in adjusting posture and moving. They compensate by supporting themselves mainly on their good hindlimb, using the bad hindlimb and tail for balance and by disproportionately relying upon their good limbs to turn and to walk. Thus, their center of gravity is shifted to the good side and movement is preferentially directed toward the good side, in part to maintain equilibrium and in part to remove weight from the bad limbs so that they can enter the swing phase of the stepping cycle. It is proposed that the bad limbs may be unable to apply force to adjust posture and produce movement. These results provide a basis for predicting the movements that the animals will use in various situations and they expand the test repertoire this hemi-Parkinson model provides for studying recovery processes after loss of dopamine.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Miklyaeva</LastName><ForeName>E I</ForeName><Initials>EI</Initials><AffiliationInfo><Affiliation>Department of Psychology, University of Lethbridge, Alta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martens</LastName><ForeName>D J</ForeName><Initials>DJ</Initials></Author><Author ValidYN="Y"><LastName>Whishaw</LastName><ForeName>I Q</ForeName><Initials>IQ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Brain Res</MedlineTA><NlmUniqueID>0045503</NlmUniqueID><ISSNLinking>0006-8993</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>8HW4YBZ748</RegistryNumber><NameOfSubstance UI="D016627">Oxidopamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>VTD58H1Z2X</RegistryNumber><NameOfSubstance UI="D004298">Dopamine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001522" MajorTopicYN="N">Behavior, Animal</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001923" MajorTopicYN="N">Brain Chemistry</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004298" MajorTopicYN="N">Dopamine</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005247" MajorTopicYN="N">Feeding Behavior</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007839" MajorTopicYN="N">Functional Laterality</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005684" MajorTopicYN="N">Gait</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006120" MajorTopicYN="N">Grooming</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008124" MajorTopicYN="N">Locomotion</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009068" MajorTopicYN="N">Movement</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016627" MajorTopicYN="N">Oxidopamine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010302" MajorTopicYN="N">Parkinson Disease, Secondary</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011187" MajorTopicYN="N">Posture</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014743" MajorTopicYN="N">Videotape Recording</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1995</Year><Month>5</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1995</Year><Month>5</Month><Day>29</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1995</Year><Month>5</Month><Day>29</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">7552288</ArticleId><ArticleId IdType="pii">0006-8993(95)00277-W</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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