Manganese neurotoxicity: a review of clinical features, imaging and pathology.
Identifieur interne : 001720 ( PubMed/Corpus ); précédent : 001719; suivant : 001721Manganese neurotoxicity: a review of clinical features, imaging and pathology.
Auteurs : P K Pal ; A. Samii ; D B CalneSource :
- Neurotoxicology [ 0161-813X ]
English descriptors
- KwdEn :
- Animals, Clinical Trials as Topic, Diagnosis, Differential, Globus Pallidus (drug effects), Humans, Magnetic Resonance Imaging, Manganese Poisoning, Nervous System Diseases (chemically induced), Nervous System Diseases (diagnosis), Nervous System Diseases (drug therapy), Parkinson Disease (diagnosis), Tomography, Emission-Computed.
- MESH :
- chemically induced : Nervous System Diseases.
- diagnosis : Nervous System Diseases, Parkinson Disease.
- drug effects : Globus Pallidus.
- drug therapy : Nervous System Diseases.
- Animals, Clinical Trials as Topic, Diagnosis, Differential, Humans, Magnetic Resonance Imaging, Manganese Poisoning, Tomography, Emission-Computed.
Abstract
Manganese intoxication can result in a syndrome of parkinsonism and dystonia. If these extrapyramidal findings are present, they are likely to be irreversible and even progress after termination of the exposure to manganese. Clinical features are usually sufficient to distinguish these patients from those with Parkinson's disease. The neurological syndrome does not respond to levodopa. Imaging of the brain may reveal MRI signal changes in the globus pallidus, striatum, and midbrain. Positron emission tomography reveals normal presynaptic and postsynaptic nigrostriatal dopaminergic function. The primary site of neurological damage has been shown by pathological studies to be the globus pallidus. The mechanism of toxicity is not clear.
PubMed: 10385886
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pubmed:10385886Le document en format XML
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<author><name sortKey="Samii, A" sort="Samii, A" uniqKey="Samii A" first="A" last="Samii">A. Samii</name>
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<author><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D B" last="Calne">D B Calne</name>
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<affiliation><nlm:affiliation>Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, Canada.</nlm:affiliation>
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<author><name sortKey="Samii, A" sort="Samii, A" uniqKey="Samii A" first="A" last="Samii">A. Samii</name>
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<author><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D B" last="Calne">D B Calne</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Clinical Trials as Topic</term>
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<term>Globus Pallidus (drug effects)</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Manganese Poisoning</term>
<term>Nervous System Diseases (chemically induced)</term>
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<term>Nervous System Diseases (drug therapy)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Tomography, Emission-Computed</term>
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<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Nervous System Diseases</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Nervous System Diseases</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Globus Pallidus</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Nervous System Diseases</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Clinical Trials as Topic</term>
<term>Diagnosis, Differential</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
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<front><div type="abstract" xml:lang="en">Manganese intoxication can result in a syndrome of parkinsonism and dystonia. If these extrapyramidal findings are present, they are likely to be irreversible and even progress after termination of the exposure to manganese. Clinical features are usually sufficient to distinguish these patients from those with Parkinson's disease. The neurological syndrome does not respond to levodopa. Imaging of the brain may reveal MRI signal changes in the globus pallidus, striatum, and midbrain. Positron emission tomography reveals normal presynaptic and postsynaptic nigrostriatal dopaminergic function. The primary site of neurological damage has been shown by pathological studies to be the globus pallidus. The mechanism of toxicity is not clear.</div>
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<Title>Neurotoxicology</Title>
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<Abstract><AbstractText>Manganese intoxication can result in a syndrome of parkinsonism and dystonia. If these extrapyramidal findings are present, they are likely to be irreversible and even progress after termination of the exposure to manganese. Clinical features are usually sufficient to distinguish these patients from those with Parkinson's disease. The neurological syndrome does not respond to levodopa. Imaging of the brain may reveal MRI signal changes in the globus pallidus, striatum, and midbrain. Positron emission tomography reveals normal presynaptic and postsynaptic nigrostriatal dopaminergic function. The primary site of neurological damage has been shown by pathological studies to be the globus pallidus. The mechanism of toxicity is not clear.</AbstractText>
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<NumberOfReferences>139</NumberOfReferences>
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