La maladie de Parkinson au Canada (serveur d'exploration)

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External radioactive reference markers in SPECT imaging of the dopamine system.

Identifieur interne : 001711 ( PubMed/Corpus ); précédent : 001710; suivant : 001712

External radioactive reference markers in SPECT imaging of the dopamine system.

Auteurs : D C Vines ; B D Ivo ; J R Ballinger ; M. Ichise

Source :

RBID : pubmed:10353107

English descriptors

Abstract

External radioactive reference markers have been used to localize the canthomeatal (CM) line and correct for head rotation in perfusion brain SPECT. This ensures that regardless of the subject's head position or rotation under the SPECT camera, reconstructed transaxial slices are reoriented parallel to the CM line. This study was undertaken to demonstrate the value of external radioactive reference markers in dopamine SPECT imaging.

PubMed: 10353107

Links to Exploration step

pubmed:10353107

Le document en format XML

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<name sortKey="Vines, D C" sort="Vines, D C" uniqKey="Vines D" first="D C" last="Vines">D C Vines</name>
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<nlm:affiliation>Department of Nuclear Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.</nlm:affiliation>
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<name sortKey="Ivo, B D" sort="Ivo, B D" uniqKey="Ivo B" first="B D" last="Ivo">B D Ivo</name>
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<name sortKey="Ballinger, J R" sort="Ballinger, J R" uniqKey="Ballinger J" first="J R" last="Ballinger">J R Ballinger</name>
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<name sortKey="Ichise, M" sort="Ichise, M" uniqKey="Ichise M" first="M" last="Ichise">M. Ichise</name>
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<term>Dopamine Plasma Membrane Transport Proteins</term>
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<term>Iodine Radioisotopes</term>
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<term>Parkinson Disease (diagnostic imaging)</term>
<term>Radiopharmaceuticals</term>
<term>Receptors, Dopamine (analysis)</term>
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<term>Dopamine Plasma Membrane Transport Proteins</term>
<term>Humans</term>
<term>Iodine Radioisotopes</term>
<term>Membrane Glycoproteins</term>
<term>Membrane Transport Proteins</term>
<term>Nerve Tissue Proteins</term>
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<div type="abstract" xml:lang="en">External radioactive reference markers have been used to localize the canthomeatal (CM) line and correct for head rotation in perfusion brain SPECT. This ensures that regardless of the subject's head position or rotation under the SPECT camera, reconstructed transaxial slices are reoriented parallel to the CM line. This study was undertaken to demonstrate the value of external radioactive reference markers in dopamine SPECT imaging.</div>
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<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">External radioactive reference markers have been used to localize the canthomeatal (CM) line and correct for head rotation in perfusion brain SPECT. This ensures that regardless of the subject's head position or rotation under the SPECT camera, reconstructed transaxial slices are reoriented parallel to the CM line. This study was undertaken to demonstrate the value of external radioactive reference markers in dopamine SPECT imaging.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We compared visual and marker methods of reorienting the transaxial slices between dopamine and perfusion brain SPECT studies, respectively. These consisted of imaging normal controls and patients with Alzheimer's or Parkinson's disease using a triple-head camera. Intra- and interoperator variability of the visual and marker methods of reorientation was determined for both perfusion and dopamine studies.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">In both intra- and interoperator studies, the variability of image reorientation was significantly reduced (P = 0.0066 and 0.014, respectively) by using the marker method on dopamine images. The variability of reorientation using the marker method for a single operator with dopamine images was 3.0% coefficient of variation (CV), and for the interoperator study (5 different operators) this was 7.0% CV.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This study demonstrated that SPECT imaging of the dopamine system with external radioactive reference markers significantly reduced the variability of determining the angle of reorientation. This resulted in a standardized and consistent method of reorienting transaxial slices, allowing comparison within and between subjects of pre- and postsynaptic dopamine SPECT studies.</AbstractText>
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