A neural model of working memory processes in normal subjects, Parkinson's disease and schizophrenia for fMRI design and predictions.
Identifieur interne : 001617 ( PubMed/Corpus ); précédent : 001616; suivant : 001618A neural model of working memory processes in normal subjects, Parkinson's disease and schizophrenia for fMRI design and predictions.
Auteurs : O. Monchi ; J G Taylor ; A. DagherSource :
- Neural networks : the official journal of the International Neural Network Society [ 0893-6080 ]
English descriptors
- KwdEn :
- Basal Ganglia (physiology), Basal Ganglia (physiopathology), Brain (physiology), Brain (physiopathology), Brain Mapping (methods), Cerebral Cortex (physiology), Cerebral Cortex (physiopathology), Computer Simulation, Data Interpretation, Statistical, Humans, Magnetic Resonance Imaging, Memory (physiology), Models, Neurological, Parkinson Disease (physiopathology), Parkinson Disease (psychology), Predictive Value of Tests, Reference Values, Schizophrenia (physiopathology), Schizophrenic Psychology.
- MESH :
- methods : Brain Mapping.
- physiology : Basal Ganglia, Brain, Cerebral Cortex, Memory.
- physiopathology : Basal Ganglia, Brain, Cerebral Cortex, Parkinson Disease, Schizophrenia.
- psychology : Parkinson Disease.
- Computer Simulation, Data Interpretation, Statistical, Humans, Magnetic Resonance Imaging, Models, Neurological, Predictive Value of Tests, Reference Values, Schizophrenic Psychology.
Abstract
A computational model was previously developed to investigate the role of parallel basal ganglia-thalamocortical loops in solving tasks that rely on working memory. Different lesions are applied to the model in order to investigate the working memory deficits observed in Parkinson's disease and schizophrenia. The simulations predict that the working memory deficits observed in Parkinson's disease result from a local dysfunction within the brain due to a problem in the disinhibitory process arising from the basal ganglia. They also predict that the working memory deficits observed in schizophrenia involve many cortical and subcortical areas and result from a problem in selecting items in working memory which are stored in basal ganglia-thalamocortical loops. The simulations predict the temporal unfolding of neuronal activity in different brain regions, both in the normal case and in the two disease states. A specific event-related functional magnetic resonance imaging study was elaborated to test some of those predictions.
PubMed: 11156204
Links to Exploration step
pubmed:11156204Le document en format XML
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Dagher</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2000 Oct-Nov</MedlineDate></PubDate></date><idno type="RBID">pubmed:11156204</idno><idno type="pmid">11156204</idno><idno type="wicri:Area/PubMed/Corpus">001617</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001617</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A neural model of working memory processes in normal subjects, Parkinson's disease and schizophrenia for fMRI design and predictions.</title><author><name sortKey="Monchi, O" sort="Monchi, O" uniqKey="Monchi O" first="O" last="Monchi">O. Monchi</name><affiliation><nlm:affiliation>McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Que, Canada. oury@bic.mni.mcgill.ca</nlm:affiliation></affiliation></author><author><name sortKey="Taylor, J G" sort="Taylor, J G" uniqKey="Taylor J" first="J G" last="Taylor">J G Taylor</name></author><author><name sortKey="Dagher, A" sort="Dagher, A" uniqKey="Dagher A" first="A" last="Dagher">A. Dagher</name></author></analytic><series><title level="j">Neural networks : the official journal of the International Neural Network Society</title><idno type="ISSN">0893-6080</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal Ganglia (physiology)</term><term>Basal Ganglia (physiopathology)</term><term>Brain (physiology)</term><term>Brain (physiopathology)</term><term>Brain Mapping (methods)</term><term>Cerebral Cortex (physiology)</term><term>Cerebral Cortex (physiopathology)</term><term>Computer Simulation</term><term>Data Interpretation, Statistical</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Memory (physiology)</term><term>Models, Neurological</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Predictive Value of Tests</term><term>Reference Values</term><term>Schizophrenia (physiopathology)</term><term>Schizophrenic Psychology</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Brain Mapping</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Basal Ganglia</term><term>Brain</term><term>Cerebral Cortex</term><term>Memory</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term><term>Brain</term><term>Cerebral Cortex</term><term>Parkinson Disease</term><term>Schizophrenia</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Computer Simulation</term><term>Data Interpretation, Statistical</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Models, Neurological</term><term>Predictive Value of Tests</term><term>Reference Values</term><term>Schizophrenic Psychology</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A computational model was previously developed to investigate the role of parallel basal ganglia-thalamocortical loops in solving tasks that rely on working memory. Different lesions are applied to the model in order to investigate the working memory deficits observed in Parkinson's disease and schizophrenia. The simulations predict that the working memory deficits observed in Parkinson's disease result from a local dysfunction within the brain due to a problem in the disinhibitory process arising from the basal ganglia. They also predict that the working memory deficits observed in schizophrenia involve many cortical and subcortical areas and result from a problem in selecting items in working memory which are stored in basal ganglia-thalamocortical loops. The simulations predict the temporal unfolding of neuronal activity in different brain regions, both in the normal case and in the two disease states. A specific event-related functional magnetic resonance imaging study was elaborated to test some of those predictions.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11156204</PMID><DateCreated><Year>2001</Year><Month>01</Month><Day>11</Day></DateCreated><DateCompleted><Year>2001</Year><Month>03</Month><Day>15</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0893-6080</ISSN><JournalIssue CitedMedium="Print"><Volume>13</Volume><Issue>8-9</Issue><PubDate><MedlineDate>2000 Oct-Nov</MedlineDate></PubDate></JournalIssue><Title>Neural networks : the official journal of the International Neural Network Society</Title><ISOAbbreviation>Neural Netw</ISOAbbreviation></Journal><ArticleTitle>A neural model of working memory processes in normal subjects, Parkinson's disease and schizophrenia for fMRI design and predictions.</ArticleTitle><Pagination><MedlinePgn>953-73</MedlinePgn></Pagination><Abstract><AbstractText>A computational model was previously developed to investigate the role of parallel basal ganglia-thalamocortical loops in solving tasks that rely on working memory. Different lesions are applied to the model in order to investigate the working memory deficits observed in Parkinson's disease and schizophrenia. The simulations predict that the working memory deficits observed in Parkinson's disease result from a local dysfunction within the brain due to a problem in the disinhibitory process arising from the basal ganglia. They also predict that the working memory deficits observed in schizophrenia involve many cortical and subcortical areas and result from a problem in selecting items in working memory which are stored in basal ganglia-thalamocortical loops. The simulations predict the temporal unfolding of neuronal activity in different brain regions, both in the normal case and in the two disease states. A specific event-related functional magnetic resonance imaging study was elaborated to test some of those predictions.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Monchi</LastName><ForeName>O</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Que, Canada. oury@bic.mni.mcgill.ca</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taylor</LastName><ForeName>J G</ForeName><Initials>JG</Initials></Author><Author ValidYN="Y"><LastName>Dagher</LastName><ForeName>A</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neural Netw</MedlineTA><NlmUniqueID>8805018</NlmUniqueID><ISSNLinking>0893-6080</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001479" MajorTopicYN="N">Basal Ganglia</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001931" MajorTopicYN="N">Brain Mapping</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002540" MajorTopicYN="N">Cerebral Cortex</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003198" MajorTopicYN="N">Computer Simulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003627" MajorTopicYN="N">Data Interpretation, Statistical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008568" MajorTopicYN="N">Memory</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008959" MajorTopicYN="N">Models, Neurological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011237" MajorTopicYN="N">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012016" MajorTopicYN="N">Reference Values</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012559" MajorTopicYN="N">Schizophrenia</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012565" MajorTopicYN="N">Schizophrenic Psychology</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>1</Month><Day>13</Day><Hour>11</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>3</Month><Day>17</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>1</Month><Day>13</Day><Hour>11</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11156204</ArticleId><ArticleId IdType="pii">S0893-6080(00)00058-7</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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