The placebo effect in Parkinson's disease.
Identifieur interne : 001511 ( PubMed/Corpus ); précédent : 001510; suivant : 001512The placebo effect in Parkinson's disease.
Auteurs : Raúl De La Fuente-Fernández ; A Jon StoesslSource :
- Trends in neurosciences [ 0166-2236 ] ; 2002.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Dopamine.
- metabolism : Corpus Striatum, Parkinson Disease.
- Animals, Humans, Placebo Effect, Randomized Controlled Trials as Topic, Tomography, Emission-Computed.
Abstract
The biochemical bases of the placebo effect are still incompletely known. We show here that the placebo effect in Parkinson's disease is due, at least in part, to the release of dopamine in the striatum. We propose that the placebo effect might be related to reward mechanisms. The expectation of reward (i.e. clinical benefit) seems to be particularly relevant. According to this theory, brain dopamine release could be a common biochemical substrate for the placebo effect encountered in other medical conditions, such as pain and depression. Other neurotransmitters or neuropeptides, however, are also likely to be involved in mediating the placebo effect (e.g. opioids in pain disorders, serotonin in depression).
PubMed: 12086748
Links to Exploration step
pubmed:12086748Le document en format XML
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We show here that the placebo effect in Parkinson's disease is due, at least in part, to the release of dopamine in the striatum. We propose that the placebo effect might be related to reward mechanisms. The expectation of reward (i.e. clinical benefit) seems to be particularly relevant. According to this theory, brain dopamine release could be a common biochemical substrate for the placebo effect encountered in other medical conditions, such as pain and depression. Other neurotransmitters or neuropeptides, however, are also likely to be involved in mediating the placebo effect (e.g. opioids in pain disorders, serotonin in depression).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12086748</PMID><DateCreated><Year>2002</Year><Month>06</Month><Day>27</Day></DateCreated><DateCompleted><Year>2002</Year><Month>07</Month><Day>30</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0166-2236</ISSN><JournalIssue CitedMedium="Print"><Volume>25</Volume><Issue>6</Issue><PubDate><Year>2002</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Trends in neurosciences</Title><ISOAbbreviation>Trends Neurosci.</ISOAbbreviation></Journal><ArticleTitle>The placebo effect in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>302-6</MedlinePgn></Pagination><Abstract><AbstractText>The biochemical bases of the placebo effect are still incompletely known. We show here that the placebo effect in Parkinson's disease is due, at least in part, to the release of dopamine in the striatum. We propose that the placebo effect might be related to reward mechanisms. The expectation of reward (i.e. clinical benefit) seems to be particularly relevant. According to this theory, brain dopamine release could be a common biochemical substrate for the placebo effect encountered in other medical conditions, such as pain and depression. 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