Functional expression and localization of P-glycoprotein in the central nervous system: relevance to the pathogenesis and treatment of neurological disorders.
Identifieur interne : 001333 ( PubMed/Corpus ); précédent : 001332; suivant : 001334Functional expression and localization of P-glycoprotein in the central nervous system: relevance to the pathogenesis and treatment of neurological disorders.
Auteurs : Gloria Lee ; Reina BendayanSource :
- Pharmaceutical research [ 0724-8741 ] ; 2004.
English descriptors
- KwdEn :
- AIDS Dementia Complex (metabolism), Alzheimer Disease (metabolism), Animals, Blood-Brain Barrier (metabolism), Blood-Brain Barrier (ultrastructure), Brain (metabolism), Brain Neoplasms (metabolism), Central Nervous System Diseases (drug therapy), Central Nervous System Diseases (etiology), Central Nervous System Diseases (metabolism), Drug Resistance, Multiple, Humans, P-Glycoprotein (metabolism), Parkinson Disease (metabolism).
- MESH :
- chemical , metabolism : P-Glycoprotein.
- drug therapy : Central Nervous System Diseases.
- etiology : Central Nervous System Diseases.
- metabolism : AIDS Dementia Complex, Alzheimer Disease, Blood-Brain Barrier, Brain, Brain Neoplasms, Central Nervous System Diseases, Parkinson Disease.
- ultrastructure : Blood-Brain Barrier.
- Animals, Drug Resistance, Multiple, Humans.
Abstract
The expression of membrane drug transport systems in the central nervous system plays an important role in the brain disposition and efficacy of many pharmacological agents used in the treatment of neurological disorders such as neoplasia, epilepsy, and HIV-associated dementia. Of particular interest is P-glycoprotein, a membrane-associated, energy-dependent, efflux transporter that confers the multidrug resistance phenotype to many cells by extruding a broad range of xenobiotics from the cell, resulting in poor clinical outcomes. In addition, the expression pattern of P-glycoprotein has recently been suggested to play a key role in the etiology and pathogenesis of certain diseases such as Alzheimer's and Parkinson's diseases. This review will focus on the cellular localization, molecular expression, and functional activity of P-glycoprotein in several compartments of the central nervous system and address its relevance in the pathogenesis and pharmacological treatment of neurological disorders.
PubMed: 15359566
Links to Exploration step
pubmed:15359566Le document en format XML
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<author><name sortKey="Lee, Gloria" sort="Lee, Gloria" uniqKey="Lee G" first="Gloria" last="Lee">Gloria Lee</name>
<affiliation><nlm:affiliation>Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario M5S 2S2, Canada.</nlm:affiliation>
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<author><name sortKey="Bendayan, Reina" sort="Bendayan, Reina" uniqKey="Bendayan R" first="Reina" last="Bendayan">Reina Bendayan</name>
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<author><name sortKey="Lee, Gloria" sort="Lee, Gloria" uniqKey="Lee G" first="Gloria" last="Lee">Gloria Lee</name>
<affiliation><nlm:affiliation>Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario M5S 2S2, Canada.</nlm:affiliation>
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<author><name sortKey="Bendayan, Reina" sort="Bendayan, Reina" uniqKey="Bendayan R" first="Reina" last="Bendayan">Reina Bendayan</name>
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<series><title level="j">Pharmaceutical research</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS Dementia Complex (metabolism)</term>
<term>Alzheimer Disease (metabolism)</term>
<term>Animals</term>
<term>Blood-Brain Barrier (metabolism)</term>
<term>Blood-Brain Barrier (ultrastructure)</term>
<term>Brain (metabolism)</term>
<term>Brain Neoplasms (metabolism)</term>
<term>Central Nervous System Diseases (drug therapy)</term>
<term>Central Nervous System Diseases (etiology)</term>
<term>Central Nervous System Diseases (metabolism)</term>
<term>Drug Resistance, Multiple</term>
<term>Humans</term>
<term>P-Glycoprotein (metabolism)</term>
<term>Parkinson Disease (metabolism)</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>P-Glycoprotein</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>AIDS Dementia Complex</term>
<term>Alzheimer Disease</term>
<term>Blood-Brain Barrier</term>
<term>Brain</term>
<term>Brain Neoplasms</term>
<term>Central Nervous System Diseases</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Blood-Brain Barrier</term>
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<front><div type="abstract" xml:lang="en">The expression of membrane drug transport systems in the central nervous system plays an important role in the brain disposition and efficacy of many pharmacological agents used in the treatment of neurological disorders such as neoplasia, epilepsy, and HIV-associated dementia. Of particular interest is P-glycoprotein, a membrane-associated, energy-dependent, efflux transporter that confers the multidrug resistance phenotype to many cells by extruding a broad range of xenobiotics from the cell, resulting in poor clinical outcomes. In addition, the expression pattern of P-glycoprotein has recently been suggested to play a key role in the etiology and pathogenesis of certain diseases such as Alzheimer's and Parkinson's diseases. This review will focus on the cellular localization, molecular expression, and functional activity of P-glycoprotein in several compartments of the central nervous system and address its relevance in the pathogenesis and pharmacological treatment of neurological disorders.</div>
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<Title>Pharmaceutical research</Title>
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<Abstract><AbstractText>The expression of membrane drug transport systems in the central nervous system plays an important role in the brain disposition and efficacy of many pharmacological agents used in the treatment of neurological disorders such as neoplasia, epilepsy, and HIV-associated dementia. Of particular interest is P-glycoprotein, a membrane-associated, energy-dependent, efflux transporter that confers the multidrug resistance phenotype to many cells by extruding a broad range of xenobiotics from the cell, resulting in poor clinical outcomes. In addition, the expression pattern of P-glycoprotein has recently been suggested to play a key role in the etiology and pathogenesis of certain diseases such as Alzheimer's and Parkinson's diseases. This review will focus on the cellular localization, molecular expression, and functional activity of P-glycoprotein in several compartments of the central nervous system and address its relevance in the pathogenesis and pharmacological treatment of neurological disorders.</AbstractText>
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<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
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<NumberOfReferences>279</NumberOfReferences>
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