Movement patterns of peak-dose levodopa-induced dyskinesias in patients with Parkinson's disease.
Identifieur interne : 001048 ( PubMed/Corpus ); précédent : 001047; suivant : 001049Movement patterns of peak-dose levodopa-induced dyskinesias in patients with Parkinson's disease.
Auteurs : Jackie Gour ; Roderick Edwards ; Sarah Lemieux ; Mehrdad Ghassemi ; Mandar Jog ; Christian DuvalSource :
- Brain research bulletin [ 0361-9230 ] ; 2007.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Antiparkinson Agents (adverse effects), Case-Control Studies, Dyskinesia, Drug-Induced (etiology), Dyskinesia, Drug-Induced (physiopathology), Entropy, Evoked Potentials, Motor, Female, Functional Laterality, Humans, Levodopa (adverse effects), Male, Middle Aged, Movement (physiology), Neurologic Examination, Parkinson Disease (drug therapy), Spectrum Analysis.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- drug therapy : Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- physiology : Movement.
- physiopathology : Dyskinesia, Drug-Induced.
- Aged, Analysis of Variance, Case-Control Studies, Entropy, Evoked Potentials, Motor, Female, Functional Laterality, Humans, Male, Middle Aged, Neurologic Examination, Spectrum Analysis.
Abstract
The present study characterized involuntary movements associated with levodopa-induced dyskinesias (LID) in patients with Parkinson's disease. We used amplitude, proportional energy, frequency dispersion and sample entropy to determine whether LID movement patterns are truly random, as clinical description seems to suggest, or possess some underlying pattern that is not visible to the naked eye. LID was captured using a magnetic tracker system, which provided 3D rendering of whole-body LID. Patients were instructed to maintain a standing position, with arms extended in front of them. We compared the measurements of the dyskinetic PD group (DPD) with 10 patients without dyskinesias (NDPD) and 10 control subjects. In comparison to the other two groups, movement patterns from the DPD group had significantly higher amplitude, confirming the presence of dyskinesias. In addition, higher frequency components in the power spectrum of velocity were detected, suggestive of higher velocity in LID movement. Furthermore, there was a concentration in narrow frequency bands, which suggested stable oscillatory activity. Finally, sample entropy revealed more regularity in the DPD group. Although not statistically significant, we found that the amplitude from the NDPD group had a tendency to be smaller than those of controls. As well, the spectra were often more dispersed for the NDPD group. In conclusion, the present results suggest that LID cannot be considered as purely random movement since they possess some deterministic pattern of motion. This may provide a way for patients to adapt to these involuntary movements while performing voluntary motor acts.
DOI: 10.1016/j.brainresbull.2007.05.005
PubMed: 17683791
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Movement patterns of peak-dose levodopa-induced dyskinesias in patients with Parkinson's disease.</title><author><name sortKey="Gour, Jackie" sort="Gour, Jackie" uniqKey="Gour J" first="Jackie" last="Gour">Jackie Gour</name><affiliation><nlm:affiliation>Department of Mathematics and Statistics, University of Victoria, PO Box 3045 STN CSC, Victoria, BC, Canada V8W 3P4.</nlm:affiliation></affiliation></author><author><name sortKey="Edwards, Roderick" sort="Edwards, Roderick" uniqKey="Edwards R" first="Roderick" last="Edwards">Roderick Edwards</name></author><author><name sortKey="Lemieux, Sarah" sort="Lemieux, Sarah" uniqKey="Lemieux S" first="Sarah" last="Lemieux">Sarah Lemieux</name></author><author><name sortKey="Ghassemi, Mehrdad" sort="Ghassemi, Mehrdad" uniqKey="Ghassemi M" first="Mehrdad" last="Ghassemi">Mehrdad Ghassemi</name></author><author><name sortKey="Jog, Mandar" sort="Jog, Mandar" uniqKey="Jog M" first="Mandar" last="Jog">Mandar Jog</name></author><author><name sortKey="Duval, Christian" sort="Duval, Christian" uniqKey="Duval C" first="Christian" last="Duval">Christian Duval</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17683791</idno><idno type="pmid">17683791</idno><idno type="doi">10.1016/j.brainresbull.2007.05.005</idno><idno type="wicri:Area/PubMed/Corpus">001048</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001048</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Movement patterns of peak-dose levodopa-induced dyskinesias in patients with Parkinson's disease.</title><author><name sortKey="Gour, Jackie" sort="Gour, Jackie" uniqKey="Gour J" first="Jackie" last="Gour">Jackie Gour</name><affiliation><nlm:affiliation>Department of Mathematics and Statistics, University of Victoria, PO Box 3045 STN CSC, Victoria, BC, Canada V8W 3P4.</nlm:affiliation></affiliation></author><author><name sortKey="Edwards, Roderick" sort="Edwards, Roderick" uniqKey="Edwards R" first="Roderick" last="Edwards">Roderick Edwards</name></author><author><name sortKey="Lemieux, Sarah" sort="Lemieux, Sarah" uniqKey="Lemieux S" first="Sarah" last="Lemieux">Sarah Lemieux</name></author><author><name sortKey="Ghassemi, Mehrdad" sort="Ghassemi, Mehrdad" uniqKey="Ghassemi M" first="Mehrdad" last="Ghassemi">Mehrdad Ghassemi</name></author><author><name sortKey="Jog, Mandar" sort="Jog, Mandar" uniqKey="Jog M" first="Mandar" last="Jog">Mandar Jog</name></author><author><name sortKey="Duval, Christian" sort="Duval, Christian" uniqKey="Duval C" first="Christian" last="Duval">Christian Duval</name></author></analytic><series><title level="j">Brain research bulletin</title><idno type="ISSN">0361-9230</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Antiparkinson Agents (adverse effects)</term><term>Case-Control Studies</term><term>Dyskinesia, Drug-Induced (etiology)</term><term>Dyskinesia, Drug-Induced (physiopathology)</term><term>Entropy</term><term>Evoked Potentials, Motor</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Levodopa (adverse effects)</term><term>Male</term><term>Middle Aged</term><term>Movement (physiology)</term><term>Neurologic Examination</term><term>Parkinson Disease (drug therapy)</term><term>Spectrum Analysis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Movement</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Entropy</term><term>Evoked Potentials, Motor</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Spectrum Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present study characterized involuntary movements associated with levodopa-induced dyskinesias (LID) in patients with Parkinson's disease. We used amplitude, proportional energy, frequency dispersion and sample entropy to determine whether LID movement patterns are truly random, as clinical description seems to suggest, or possess some underlying pattern that is not visible to the naked eye. LID was captured using a magnetic tracker system, which provided 3D rendering of whole-body LID. Patients were instructed to maintain a standing position, with arms extended in front of them. We compared the measurements of the dyskinetic PD group (DPD) with 10 patients without dyskinesias (NDPD) and 10 control subjects. In comparison to the other two groups, movement patterns from the DPD group had significantly higher amplitude, confirming the presence of dyskinesias. In addition, higher frequency components in the power spectrum of velocity were detected, suggestive of higher velocity in LID movement. Furthermore, there was a concentration in narrow frequency bands, which suggested stable oscillatory activity. Finally, sample entropy revealed more regularity in the DPD group. Although not statistically significant, we found that the amplitude from the NDPD group had a tendency to be smaller than those of controls. As well, the spectra were often more dispersed for the NDPD group. In conclusion, the present results suggest that LID cannot be considered as purely random movement since they possess some deterministic pattern of motion. This may provide a way for patients to adapt to these involuntary movements while performing voluntary motor acts.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17683791</PMID><DateCreated><Year>2007</Year><Month>08</Month><Day>08</Day></DateCreated><DateCompleted><Year>2007</Year><Month>11</Month><Day>13</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0361-9230</ISSN><JournalIssue CitedMedium="Print"><Volume>74</Volume><Issue>1-3</Issue><PubDate><Year>2007</Year><Month>Sep</Month><Day>14</Day></PubDate></JournalIssue><Title>Brain research bulletin</Title><ISOAbbreviation>Brain Res. Bull.</ISOAbbreviation></Journal><ArticleTitle>Movement patterns of peak-dose levodopa-induced dyskinesias in patients with Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>66-74</MedlinePgn></Pagination><Abstract><AbstractText>The present study characterized involuntary movements associated with levodopa-induced dyskinesias (LID) in patients with Parkinson's disease. We used amplitude, proportional energy, frequency dispersion and sample entropy to determine whether LID movement patterns are truly random, as clinical description seems to suggest, or possess some underlying pattern that is not visible to the naked eye. LID was captured using a magnetic tracker system, which provided 3D rendering of whole-body LID. Patients were instructed to maintain a standing position, with arms extended in front of them. We compared the measurements of the dyskinetic PD group (DPD) with 10 patients without dyskinesias (NDPD) and 10 control subjects. In comparison to the other two groups, movement patterns from the DPD group had significantly higher amplitude, confirming the presence of dyskinesias. In addition, higher frequency components in the power spectrum of velocity were detected, suggestive of higher velocity in LID movement. Furthermore, there was a concentration in narrow frequency bands, which suggested stable oscillatory activity. Finally, sample entropy revealed more regularity in the DPD group. Although not statistically significant, we found that the amplitude from the NDPD group had a tendency to be smaller than those of controls. As well, the spectra were often more dispersed for the NDPD group. In conclusion, the present results suggest that LID cannot be considered as purely random movement since they possess some deterministic pattern of motion. This may provide a way for patients to adapt to these involuntary movements while performing voluntary motor acts.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gour</LastName><ForeName>Jackie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Mathematics and Statistics, University of Victoria, PO Box 3045 STN CSC, Victoria, BC, Canada V8W 3P4.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Edwards</LastName><ForeName>Roderick</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Lemieux</LastName><ForeName>Sarah</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Ghassemi</LastName><ForeName>Mehrdad</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Jog</LastName><ForeName>Mandar</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Duval</LastName><ForeName>Christian</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2007</Year><Month>06</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Brain Res Bull</MedlineTA><NlmUniqueID>7605818</NlmUniqueID><ISSNLinking>0361-9230</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000978" MajorTopicYN="N">Antiparkinson Agents</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004409" MajorTopicYN="N">Dyskinesia, Drug-Induced</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019277" MajorTopicYN="N">Entropy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019054" MajorTopicYN="N">Evoked Potentials, Motor</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" 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