Gamma knife thalamotomy for disabling tremor: a blinded evaluation.
Identifieur interne : 000D52 ( PubMed/Corpus ); précédent : 000D51; suivant : 000D53Gamma knife thalamotomy for disabling tremor: a blinded evaluation.
Auteurs : Shen-Yang Lim ; Mojgan Hodaie ; Melanie Fallis ; Yu-Yan Poon ; Filomena Mazzella ; Elena MoroSource :
- Archives of neurology [ 1538-3687 ] ; 2010.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Brain Edema (etiology), Brain Edema (pathology), Brain Edema (physiopathology), Essential Tremor (pathology), Essential Tremor (physiopathology), Essential Tremor (surgery), Female, Humans, Intracranial Hemorrhages (etiology), Intracranial Hemorrhages (pathology), Intracranial Hemorrhages (physiopathology), Male, Middle Aged, Ontario, Outcome Assessment (Health Care), Paresis (etiology), Paresis (pathology), Paresis (physiopathology), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson Disease (surgery), Postoperative Complications, Prospective Studies, Radiosurgery (adverse effects), Radiosurgery (methods), Radiosurgery (statistics & numerical data), Single-Blind Method, Thalamus (pathology), Thalamus (physiopathology), Thalamus (surgery), Treatment Outcome.
- MESH :
- geographic : Ontario.
- adverse effects : Radiosurgery.
- etiology : Brain Edema, Intracranial Hemorrhages, Paresis.
- methods : Radiosurgery.
- pathology : Brain Edema, Essential Tremor, Intracranial Hemorrhages, Paresis, Parkinson Disease, Thalamus.
- physiopathology : Brain Edema, Essential Tremor, Intracranial Hemorrhages, Paresis, Parkinson Disease, Thalamus.
- statistics & numerical data : Radiosurgery.
- surgery : Essential Tremor, Parkinson Disease, Thalamus.
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Outcome Assessment (Health Care), Postoperative Complications, Prospective Studies, Single-Blind Method, Treatment Outcome.
Abstract
Gamma knife thalamotomy (GKT) has been used as a therapeutic option for patients with disabling tremor refractory to medications. Impressive improvement of tremor has been reported in the neurosurgical literature, but the reliability of such data has been questioned.
DOI: 10.1001/archneurol.2010.69
PubMed: 20457958
Links to Exploration step
pubmed:20457958Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Gamma knife thalamotomy for disabling tremor: a blinded evaluation.</title><author><name sortKey="Lim, Shen Yang" sort="Lim, Shen Yang" uniqKey="Lim S" first="Shen-Yang" last="Lim">Shen-Yang Lim</name><affiliation><nlm:affiliation>Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation></affiliation></author><author><name sortKey="Hodaie, Mojgan" sort="Hodaie, Mojgan" uniqKey="Hodaie M" first="Mojgan" last="Hodaie">Mojgan Hodaie</name></author><author><name sortKey="Fallis, Melanie" sort="Fallis, Melanie" uniqKey="Fallis M" first="Melanie" last="Fallis">Melanie Fallis</name></author><author><name sortKey="Poon, Yu Yan" sort="Poon, Yu Yan" uniqKey="Poon Y" first="Yu-Yan" last="Poon">Yu-Yan Poon</name></author><author><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20457958</idno><idno type="pmid">20457958</idno><idno type="doi">10.1001/archneurol.2010.69</idno><idno type="wicri:Area/PubMed/Corpus">000D52</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D52</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Gamma knife thalamotomy for disabling tremor: a blinded evaluation.</title><author><name sortKey="Lim, Shen Yang" sort="Lim, Shen Yang" uniqKey="Lim S" first="Shen-Yang" last="Lim">Shen-Yang Lim</name><affiliation><nlm:affiliation>Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation></affiliation></author><author><name sortKey="Hodaie, Mojgan" sort="Hodaie, Mojgan" uniqKey="Hodaie M" first="Mojgan" last="Hodaie">Mojgan Hodaie</name></author><author><name sortKey="Fallis, Melanie" sort="Fallis, Melanie" uniqKey="Fallis M" first="Melanie" last="Fallis">Melanie Fallis</name></author><author><name sortKey="Poon, Yu Yan" sort="Poon, Yu Yan" uniqKey="Poon Y" first="Yu-Yan" last="Poon">Yu-Yan Poon</name></author><author><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author></analytic><series><title level="j">Archives of neurology</title><idno type="eISSN">1538-3687</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Brain Edema (etiology)</term><term>Brain Edema (pathology)</term><term>Brain Edema (physiopathology)</term><term>Essential Tremor (pathology)</term><term>Essential Tremor (physiopathology)</term><term>Essential Tremor (surgery)</term><term>Female</term><term>Humans</term><term>Intracranial Hemorrhages (etiology)</term><term>Intracranial Hemorrhages (pathology)</term><term>Intracranial Hemorrhages (physiopathology)</term><term>Male</term><term>Middle Aged</term><term>Ontario</term><term>Outcome Assessment (Health Care)</term><term>Paresis (etiology)</term><term>Paresis (pathology)</term><term>Paresis (physiopathology)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (surgery)</term><term>Postoperative Complications</term><term>Prospective Studies</term><term>Radiosurgery (adverse effects)</term><term>Radiosurgery (methods)</term><term>Radiosurgery (statistics & numerical data)</term><term>Single-Blind Method</term><term>Thalamus (pathology)</term><term>Thalamus (physiopathology)</term><term>Thalamus (surgery)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Ontario</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Radiosurgery</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Brain Edema</term><term>Intracranial Hemorrhages</term><term>Paresis</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Radiosurgery</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain Edema</term><term>Essential Tremor</term><term>Intracranial Hemorrhages</term><term>Paresis</term><term>Parkinson Disease</term><term>Thalamus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain Edema</term><term>Essential Tremor</term><term>Intracranial Hemorrhages</term><term>Paresis</term><term>Parkinson Disease</term><term>Thalamus</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Radiosurgery</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Essential Tremor</term><term>Parkinson Disease</term><term>Thalamus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Outcome Assessment (Health Care)</term><term>Postoperative Complications</term><term>Prospective Studies</term><term>Single-Blind Method</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Gamma knife thalamotomy (GKT) has been used as a therapeutic option for patients with disabling tremor refractory to medications. Impressive improvement of tremor has been reported in the neurosurgical literature, but the reliability of such data has been questioned.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20457958</PMID><DateCreated><Year>2010</Year><Month>05</Month><Day>11</Day></DateCreated><DateCompleted><Year>2010</Year><Month>07</Month><Day>01</Day></DateCompleted><DateRevised><Year>2010</Year><Month>05</Month><Day>11</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1538-3687</ISSN><JournalIssue CitedMedium="Internet"><Volume>67</Volume><Issue>5</Issue><PubDate><Year>2010</Year><Month>May</Month></PubDate></JournalIssue><Title>Archives of neurology</Title><ISOAbbreviation>Arch. Neurol.</ISOAbbreviation></Journal><ArticleTitle>Gamma knife thalamotomy for disabling tremor: a blinded evaluation.</ArticleTitle><Pagination><MedlinePgn>584-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1001/archneurol.2010.69</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Gamma knife thalamotomy (GKT) has been used as a therapeutic option for patients with disabling tremor refractory to medications. Impressive improvement of tremor has been reported in the neurosurgical literature, but the reliability of such data has been questioned.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To prospectively evaluate clinical outcomes after GKT for disabling tremor with blinded assessments.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Prospective study with blinded independent neurologic evaluations.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">University hospital.</AbstractText><AbstractText Label="PATIENTS" NlmCategory="METHODS">Consecutive patients who underwent unilateral GKT for essential tremor and Parkinson disease tremor at our center. These patients were unwilling or deemed unsuitable candidates for deep brain stimulation or other surgical procedures.</AbstractText><AbstractText Label="INTERVENTIONS" NlmCategory="METHODS">Unilateral GKT and regular follow-up evaluations for up to 30 months, with blinded video evaluations by a movement disorders neurologist.</AbstractText><AbstractText Label="MAIN OUTCOME MEASURES" NlmCategory="METHODS">Clinical outcomes, as measured by the Fahn-Tolosa-Marin Tremor Rating Scale and activities of daily living scores, and incidence of adverse events.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">From September 1, 2006, to November 30, 2008, 18 patients underwent unilateral GKT for essential tremor and Parkinson disease tremor at our center. Videos for 14 patients (11 with essential tremor, 3 with Parkinson disease tremor) with at least 6 months' postoperative follow-up were available for analysis (mean [SD] follow-up duration, 19.2 [7.3] months; range, 7-30 months). The Fahn-Tolosa-Marin Tremor Rating Scale activities of daily living scores improved significantly after GKT (P = .03; median and mean change scores, 2.5 and 2.7 points, respectively [range of scale was 0-27]), but there was no significant improvement in other Fahn-Tolosa-Marin Tremor Rating Scale items (P = .53 for resting tremor, P = .24 for postural tremor, P = .62 for action tremor, P = .40 for drawing, P > .99 for pouring water, P = .89 for head tremor). Handwriting and Unified Parkinson's Disease Rating Scale activities of daily living scores tended to improve (P = .07 and .11, respectively). Three patients developed delayed neurologic adverse events.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Overall, we found that GKT provided only modest antitremor efficacy. Of the 2 patients with essential tremor who experienced marked improvement in tremor, 1 subsequently experienced a serious adverse event. Further prospective studies with careful neurologic evaluation of outcomes are necessary before GKT can be recommended for disabling tremor on a routine clinical basis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lim</LastName><ForeName>Shen-Yang</ForeName><Initials>SY</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hodaie</LastName><ForeName>Mojgan</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Fallis</LastName><ForeName>Melanie</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Poon</LastName><ForeName>Yu-Yan</ForeName><Initials>YY</Initials></Author><Author ValidYN="Y"><LastName>Mazzella</LastName><ForeName>Filomena</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Moro</LastName><ForeName>Elena</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D023362">Evaluation Studies</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Arch Neurol</MedlineTA><NlmUniqueID>0372436</NlmUniqueID><ISSNLinking>0003-9942</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001929" MajorTopicYN="N">Brain Edema</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020329" MajorTopicYN="N">Essential Tremor</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020300" MajorTopicYN="N">Intracranial Hemorrhages</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009864" MajorTopicYN="N" Type="Geographic">Ontario</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017063" MajorTopicYN="N">Outcome Assessment (Health Care)</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010291" MajorTopicYN="N">Paresis</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011183" MajorTopicYN="N">Postoperative Complications</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016634" MajorTopicYN="N">Radiosurgery</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016037" MajorTopicYN="N">Single-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013788" MajorTopicYN="N">Thalamus</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>5</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>5</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>7</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20457958</ArticleId><ArticleId IdType="pii">67/5/584</ArticleId><ArticleId IdType="doi">10.1001/archneurol.2010.69</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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