Modeling neurodegeneration in zebrafish.
Identifieur interne : 000C09 ( PubMed/Corpus ); précédent : 000C08; suivant : 000C10Modeling neurodegeneration in zebrafish.
Auteurs : Yanwei Xi ; Sandra Noble ; Marc EkkerSource :
- Current neurology and neuroscience reports [ 1534-6293 ] ; 2011.
English descriptors
- KwdEn :
- Alzheimer Disease (genetics), Animals, Disease Models, Animal, Humans, Huntington Disease (genetics), Intracellular Signaling Peptides and Proteins (genetics), LDL-Receptor Related Proteins (genetics), Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Membrane Transport Proteins (genetics), Neurodegenerative Diseases (genetics), Neurodegenerative Diseases (pathology), Neurodegenerative Diseases (physiopathology), Oncogene Proteins (genetics), Parkinson Disease (genetics), Protein Deglycase DJ-1, Protein Kinases (genetics), Protein-Serine-Threonine Kinases (genetics), Ubiquitin-Protein Ligases (genetics), Zebrafish (genetics), tau Proteins (genetics).
- MESH :
- chemical , genetics : Intracellular Signaling Peptides and Proteins, LDL-Receptor Related Proteins, Membrane Transport Proteins, Oncogene Proteins, Protein Kinases, Protein-Serine-Threonine Kinases, Ubiquitin-Protein Ligases, tau Proteins.
- genetics : Alzheimer Disease, Huntington Disease, Neurodegenerative Diseases, Parkinson Disease, Zebrafish.
- pathology : Neurodegenerative Diseases.
- physiopathology : Neurodegenerative Diseases.
- Animals, Disease Models, Animal, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Protein Deglycase DJ-1.
Abstract
The zebrafish, Danio rerio, has been established as an excellent vertebrate model for the study of developmental biology and gene function. It also has proven to be a valuable model to study human diseases. Here, we reviewed recent publications using zebrafish to study the pathology of human neurodegenerative diseases including Parkinson's, Huntington's, and Alzheimer's. These studies indicate that zebrafish genes and their human homologues have conserved functions with respect to the etiology of neurodegenerative diseases. The characteristics of the zebrafish and the experimental approaches to which it is amenable make this species a useful complement to other animal models for the study of pathologic mechanisms of neurodegenerative diseases and for the screening of compounds with therapeutic potential.
DOI: 10.1007/s11910-011-0182-2
PubMed: 21271309
Links to Exploration step
pubmed:21271309Le document en format XML
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It also has proven to be a valuable model to study human diseases. Here, we reviewed recent publications using zebrafish to study the pathology of human neurodegenerative diseases including Parkinson's, Huntington's, and Alzheimer's. These studies indicate that zebrafish genes and their human homologues have conserved functions with respect to the etiology of neurodegenerative diseases. The characteristics of the zebrafish and the experimental approaches to which it is amenable make this species a useful complement to other animal models for the study of pathologic mechanisms of neurodegenerative diseases and for the screening of compounds with therapeutic potential.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21271309</PMID><DateCreated><Year>2011</Year><Month>04</Month><Day>13</Day></DateCreated><DateCompleted><Year>2011</Year><Month>08</Month><Day>05</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1534-6293</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>3</Issue><PubDate><Year>2011</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Current neurology and neuroscience reports</Title><ISOAbbreviation>Curr Neurol Neurosci Rep</ISOAbbreviation></Journal><ArticleTitle>Modeling neurodegeneration in zebrafish.</ArticleTitle><Pagination><MedlinePgn>274-82</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s11910-011-0182-2</ELocationID><Abstract><AbstractText>The zebrafish, Danio rerio, has been established as an excellent vertebrate model for the study of developmental biology and gene function. It also has proven to be a valuable model to study human diseases. Here, we reviewed recent publications using zebrafish to study the pathology of human neurodegenerative diseases including Parkinson's, Huntington's, and Alzheimer's. These studies indicate that zebrafish genes and their human homologues have conserved functions with respect to the etiology of neurodegenerative diseases. The characteristics of the zebrafish and the experimental approaches to which it is amenable make this species a useful complement to other animal models for the study of pathologic mechanisms of neurodegenerative diseases and for the screening of compounds with therapeutic potential.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xi</LastName><ForeName>Yanwei</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Biology, Center for Advanced Research in Environmental Genomics, University of Ottawa, 30 Marie Curie, Ottawa, Ontario K1N6N5, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Noble</LastName><ForeName>Sandra</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Ekker</LastName><ForeName>Marc</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Canadian Institutes of Health 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