Aging-related increases in behavioral variability: relations to losses of dopamine D1 receptors.
Identifieur interne : 000A55 ( PubMed/Corpus ); précédent : 000A54; suivant : 000A56Aging-related increases in behavioral variability: relations to losses of dopamine D1 receptors.
Auteurs : Stuart W S. Macdonald ; Sari Karlsson ; Anna Rieckmann ; Lars Nyberg ; Lars B CkmanSource :
- The Journal of neuroscience : the official journal of the Society for Neuroscience [ 1529-2401 ] ; 2012.
English descriptors
- KwdEn :
- Adult, Aged, Aging (metabolism), Benzazepines, Brain (diagnostic imaging), Brain (metabolism), Brain (physiology), Carbon Radioisotopes, Female, Humans, Male, Positron-Emission Tomography (methods), Positron-Emission Tomography (psychology), Psychomotor Performance (physiology), Radioligand Assay (methods), Radioligand Assay (psychology), Reaction Time (physiology), Receptors, Dopamine D1 (metabolism), Receptors, Dopamine D1 (physiology).
- MESH :
- chemical , metabolism : Receptors, Dopamine D1.
- chemical , physiology : Receptors, Dopamine D1.
- chemical : Benzazepines, Carbon Radioisotopes.
- diagnostic imaging : Brain.
- metabolism : Aging, Brain.
- methods : Positron-Emission Tomography, Radioligand Assay.
- physiology : Brain, Psychomotor Performance, Reaction Time.
- psychology : Positron-Emission Tomography, Radioligand Assay.
- Adult, Aged, Female, Humans, Male.
Abstract
Intraindividual variability (IIV) reflects within-person changes in performance, such as trial-by-trial fluctuations on a reaction-time (RT) task. The neural underpinnings of IIV remain largely unknown. The neurotransmitter dopamine (DA) is of particular interest here, as human populations that exhibit DA alterations, such as the elderly, attention deficit hyperactivity disorder children, persons with schizophrenia, and Parkinson patients, also show increased behavioral IIV. We examined links between DA D(1) binding potential (BP) in multiple brain regions and IIV for the control and interference conditions of the Multi-Source Interference Task (MSIT), tapping the cingulo-fronto-parietal attention network. Participants were 18 young and 20 healthy old adults. PET and the radioligand [(11)C]SCH23390 were used to determine D(1) BP. The intraindividual standard deviation (ISD) was computed across successful latency trials of the MSIT conditions, independent of mean RT differences due to age, trial, and condition. Increasing ISDs were associated with increasing age and diminished D(1) binding in several brain regions (anterior cingulate gyrus, dorsolateral prefrontal cortex, and parietal cortex) for the interference, but not control, condition. Analyses of partial associations indicate that the association between age and IIV in the interference condition was linked to D(1) receptor losses in task-relevant brain regions. These findings suggest that dysfunctional DA modulation may contribute to increased variability in cognitive performance among older adults.
DOI: 10.1523/JNEUROSCI.5474-11.2012
PubMed: 22699899
Links to Exploration step
pubmed:22699899Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Aging-related increases in behavioral variability: relations to losses of dopamine D1 receptors.</title><author><name sortKey="Macdonald, Stuart W S" sort="Macdonald, Stuart W S" uniqKey="Macdonald S" first="Stuart W S" last="Macdonald">Stuart W S. Macdonald</name><affiliation><nlm:affiliation>Department of Psychology, University of Victoria, Victoria, British Columbia, Canada V8W 3P5. smacd@uvic.ca</nlm:affiliation></affiliation></author><author><name sortKey="Karlsson, Sari" sort="Karlsson, Sari" uniqKey="Karlsson S" first="Sari" last="Karlsson">Sari Karlsson</name></author><author><name sortKey="Rieckmann, Anna" sort="Rieckmann, Anna" uniqKey="Rieckmann A" first="Anna" last="Rieckmann">Anna Rieckmann</name></author><author><name sortKey="Nyberg, Lars" sort="Nyberg, Lars" uniqKey="Nyberg L" first="Lars" last="Nyberg">Lars Nyberg</name></author><author><name sortKey="B Ckman, Lars" sort="B Ckman, Lars" uniqKey="B Ckman L" first="Lars" last="B Ckman">Lars B Ckman</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22699899</idno><idno type="pmid">22699899</idno><idno type="doi">10.1523/JNEUROSCI.5474-11.2012</idno><idno type="wicri:Area/PubMed/Corpus">000A55</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A55</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Aging-related increases in behavioral variability: relations to losses of dopamine D1 receptors.</title><author><name sortKey="Macdonald, Stuart W S" sort="Macdonald, Stuart W S" uniqKey="Macdonald S" first="Stuart W S" last="Macdonald">Stuart W S. Macdonald</name><affiliation><nlm:affiliation>Department of Psychology, University of Victoria, Victoria, British Columbia, Canada V8W 3P5. smacd@uvic.ca</nlm:affiliation></affiliation></author><author><name sortKey="Karlsson, Sari" sort="Karlsson, Sari" uniqKey="Karlsson S" first="Sari" last="Karlsson">Sari Karlsson</name></author><author><name sortKey="Rieckmann, Anna" sort="Rieckmann, Anna" uniqKey="Rieckmann A" first="Anna" last="Rieckmann">Anna Rieckmann</name></author><author><name sortKey="Nyberg, Lars" sort="Nyberg, Lars" uniqKey="Nyberg L" first="Lars" last="Nyberg">Lars Nyberg</name></author><author><name sortKey="B Ckman, Lars" sort="B Ckman, Lars" uniqKey="B Ckman L" first="Lars" last="B Ckman">Lars B Ckman</name></author></analytic><series><title level="j">The Journal of neuroscience : the official journal of the Society for Neuroscience</title><idno type="eISSN">1529-2401</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aging (metabolism)</term><term>Benzazepines</term><term>Brain (diagnostic imaging)</term><term>Brain (metabolism)</term><term>Brain (physiology)</term><term>Carbon Radioisotopes</term><term>Female</term><term>Humans</term><term>Male</term><term>Positron-Emission Tomography (methods)</term><term>Positron-Emission Tomography (psychology)</term><term>Psychomotor Performance (physiology)</term><term>Radioligand Assay (methods)</term><term>Radioligand Assay (psychology)</term><term>Reaction Time (physiology)</term><term>Receptors, Dopamine D1 (metabolism)</term><term>Receptors, Dopamine D1 (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, Dopamine D1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Receptors, Dopamine D1</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Benzazepines</term><term>Carbon Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Aging</term><term>Brain</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Positron-Emission Tomography</term><term>Radioligand Assay</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Brain</term><term>Psychomotor Performance</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Positron-Emission Tomography</term><term>Radioligand Assay</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Intraindividual variability (IIV) reflects within-person changes in performance, such as trial-by-trial fluctuations on a reaction-time (RT) task. The neural underpinnings of IIV remain largely unknown. The neurotransmitter dopamine (DA) is of particular interest here, as human populations that exhibit DA alterations, such as the elderly, attention deficit hyperactivity disorder children, persons with schizophrenia, and Parkinson patients, also show increased behavioral IIV. We examined links between DA D(1) binding potential (BP) in multiple brain regions and IIV for the control and interference conditions of the Multi-Source Interference Task (MSIT), tapping the cingulo-fronto-parietal attention network. Participants were 18 young and 20 healthy old adults. PET and the radioligand [(11)C]SCH23390 were used to determine D(1) BP. The intraindividual standard deviation (ISD) was computed across successful latency trials of the MSIT conditions, independent of mean RT differences due to age, trial, and condition. Increasing ISDs were associated with increasing age and diminished D(1) binding in several brain regions (anterior cingulate gyrus, dorsolateral prefrontal cortex, and parietal cortex) for the interference, but not control, condition. Analyses of partial associations indicate that the association between age and IIV in the interference condition was linked to D(1) receptor losses in task-relevant brain regions. These findings suggest that dysfunctional DA modulation may contribute to increased variability in cognitive performance among older adults.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22699899</PMID><DateCreated><Year>2012</Year><Month>06</Month><Day>15</Day></DateCreated><DateCompleted><Year>2012</Year><Month>09</Month><Day>24</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1529-2401</ISSN><JournalIssue CitedMedium="Internet"><Volume>32</Volume><Issue>24</Issue><PubDate><Year>2012</Year><Month>Jun</Month><Day>13</Day></PubDate></JournalIssue><Title>The Journal of neuroscience : the official journal of the Society for Neuroscience</Title><ISOAbbreviation>J. Neurosci.</ISOAbbreviation></Journal><ArticleTitle>Aging-related increases in behavioral variability: relations to losses of dopamine D1 receptors.</ArticleTitle><Pagination><MedlinePgn>8186-91</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1523/JNEUROSCI.5474-11.2012</ELocationID><Abstract><AbstractText>Intraindividual variability (IIV) reflects within-person changes in performance, such as trial-by-trial fluctuations on a reaction-time (RT) task. The neural underpinnings of IIV remain largely unknown. The neurotransmitter dopamine (DA) is of particular interest here, as human populations that exhibit DA alterations, such as the elderly, attention deficit hyperactivity disorder children, persons with schizophrenia, and Parkinson patients, also show increased behavioral IIV. We examined links between DA D(1) binding potential (BP) in multiple brain regions and IIV for the control and interference conditions of the Multi-Source Interference Task (MSIT), tapping the cingulo-fronto-parietal attention network. Participants were 18 young and 20 healthy old adults. PET and the radioligand [(11)C]SCH23390 were used to determine D(1) BP. The intraindividual standard deviation (ISD) was computed across successful latency trials of the MSIT conditions, independent of mean RT differences due to age, trial, and condition. Increasing ISDs were associated with increasing age and diminished D(1) binding in several brain regions (anterior cingulate gyrus, dorsolateral prefrontal cortex, and parietal cortex) for the interference, but not control, condition. Analyses of partial associations indicate that the association between age and IIV in the interference condition was linked to D(1) receptor losses in task-relevant brain regions. These findings suggest that dysfunctional DA modulation may contribute to increased variability in cognitive performance among older adults.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>MacDonald</LastName><ForeName>Stuart W S</ForeName><Initials>SW</Initials><AffiliationInfo><Affiliation>Department of Psychology, University of Victoria, Victoria, British Columbia, Canada V8W 3P5. smacd@uvic.ca</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karlsson</LastName><ForeName>Sari</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Rieckmann</LastName><ForeName>Anna</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Nyberg</LastName><ForeName>Lars</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Bäckman</LastName><ForeName>Lars</ForeName><Initials>L</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Neurosci</MedlineTA><NlmUniqueID>8102140</NlmUniqueID><ISSNLinking>0270-6474</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001552">Benzazepines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002250">Carbon Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017447">Receptors, Dopamine D1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C534628">SCH 23390</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000375" MajorTopicYN="N">Aging</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001552" MajorTopicYN="N">Benzazepines</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002250" MajorTopicYN="N">Carbon Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049268" MajorTopicYN="N">Positron-Emission Tomography</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011597" MajorTopicYN="N">Psychomotor Performance</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011869" MajorTopicYN="N">Radioligand Assay</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011930" MajorTopicYN="N">Reaction Time</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017447" MajorTopicYN="N">Receptors, Dopamine D1</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>6</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>6</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>9</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22699899</ArticleId><ArticleId IdType="pii">32/24/8186</ArticleId><ArticleId IdType="doi">10.1523/JNEUROSCI.5474-11.2012</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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