ParkinsonCanadaV1, PubMed, Corpus, bibRecord, 000A42

Intact limbic-prefrontal connections and reduced amygdala volumes in Parkinson's disease with mild depressive symptoms.

Identifieur interne : 000A42 ( PubMed/Corpus ); précédent : 000A41; suivant : 000A43

Intact limbic-prefrontal connections and reduced amygdala volumes in Parkinson's disease with mild depressive symptoms.

Auteurs : Ian Surdhar ; Myrlene Gee ; Thomas Bouchard ; Nicholas Coupland ; Nikolai Malykhin ; Richard Camicioli

Source :

Parkinsonism & related disorders [ 1873-5126 ] ; 2012.

RBID : pubmed:22652466

English descriptors

KwdEn :
- Aged, Amygdala (pathology), Atrophy, Corpus Callosum (pathology), Depression (complications), Depression (pathology), Diffusion Magnetic Resonance Imaging (methods), Female, Hippocampus (pathology), Humans, Male, Nerve Net (pathology), Nerve Net (physiopathology), Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Prefrontal Cortex (pathology), Prefrontal Cortex (physiopathology).
MESH :
- complications : Depression, Parkinson Disease.
- methods : Diffusion Magnetic Resonance Imaging.
- pathology : Amygdala, Corpus Callosum, Depression, Hippocampus, Nerve Net, Parkinson Disease, Prefrontal Cortex.
- physiopathology : Nerve Net, Parkinson Disease, Prefrontal Cortex.
- Aged, Atrophy, Female, Humans, Male.

Abstract

Depression is very common in Parkinson's disease (PD). The neuropathological basis for this remains unclear; however, dysfunction in prefrontal and limbic regions may play a role.

DOI: 10.1016/j.parkreldis.2012.03.008
PubMed: 22652466

Links to Exploration step

pubmed:22652466

Le document en format XML

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<author><name sortKey="Surdhar, Ian" sort="Surdhar, Ian" uniqKey="Surdhar I" first="Ian" last="Surdhar">Ian Surdhar</name>
<affiliation><nlm:affiliation>Centre for Neuroscience, University of Alberta, Edmonton, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gee, Myrlene" sort="Gee, Myrlene" uniqKey="Gee M" first="Myrlene" last="Gee">Myrlene Gee</name>
</author>
<author><name sortKey="Bouchard, Thomas" sort="Bouchard, Thomas" uniqKey="Bouchard T" first="Thomas" last="Bouchard">Thomas Bouchard</name>
</author>
<author><name sortKey="Coupland, Nicholas" sort="Coupland, Nicholas" uniqKey="Coupland N" first="Nicholas" last="Coupland">Nicholas Coupland</name>
</author>
<author><name sortKey="Malykhin, Nikolai" sort="Malykhin, Nikolai" uniqKey="Malykhin N" first="Nikolai" last="Malykhin">Nikolai Malykhin</name>
</author>
<author><name sortKey="Camicioli, Richard" sort="Camicioli, Richard" uniqKey="Camicioli R" first="Richard" last="Camicioli">Richard Camicioli</name>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Intact limbic-prefrontal connections and reduced amygdala volumes in Parkinson's disease with mild depressive symptoms.</title>
<author><name sortKey="Surdhar, Ian" sort="Surdhar, Ian" uniqKey="Surdhar I" first="Ian" last="Surdhar">Ian Surdhar</name>
<affiliation><nlm:affiliation>Centre for Neuroscience, University of Alberta, Edmonton, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gee, Myrlene" sort="Gee, Myrlene" uniqKey="Gee M" first="Myrlene" last="Gee">Myrlene Gee</name>
</author>
<author><name sortKey="Bouchard, Thomas" sort="Bouchard, Thomas" uniqKey="Bouchard T" first="Thomas" last="Bouchard">Thomas Bouchard</name>
</author>
<author><name sortKey="Coupland, Nicholas" sort="Coupland, Nicholas" uniqKey="Coupland N" first="Nicholas" last="Coupland">Nicholas Coupland</name>
</author>
<author><name sortKey="Malykhin, Nikolai" sort="Malykhin, Nikolai" uniqKey="Malykhin N" first="Nikolai" last="Malykhin">Nikolai Malykhin</name>
</author>
<author><name sortKey="Camicioli, Richard" sort="Camicioli, Richard" uniqKey="Camicioli R" first="Richard" last="Camicioli">Richard Camicioli</name>
</author>
</analytic>
<series><title level="j">Parkinsonism & related disorders</title>
<idno type="eISSN">1873-5126</idno>
<imprint><date when="2012" type="published">2012</date>
</imprint>
</series>
</biblStruct>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Amygdala (pathology)</term>
<term>Atrophy</term>
<term>Corpus Callosum (pathology)</term>
<term>Depression (complications)</term>
<term>Depression (pathology)</term>
<term>Diffusion Magnetic Resonance Imaging (methods)</term>
<term>Female</term>
<term>Hippocampus (pathology)</term>
<term>Humans</term>
<term>Male</term>
<term>Nerve Net (pathology)</term>
<term>Nerve Net (physiopathology)</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Prefrontal Cortex (pathology)</term>
<term>Prefrontal Cortex (physiopathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Depression</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Diffusion Magnetic Resonance Imaging</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Amygdala</term>
<term>Corpus Callosum</term>
<term>Depression</term>
<term>Hippocampus</term>
<term>Nerve Net</term>
<term>Parkinson Disease</term>
<term>Prefrontal Cortex</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Nerve Net</term>
<term>Parkinson Disease</term>
<term>Prefrontal Cortex</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Atrophy</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Depression is very common in Parkinson's disease (PD). The neuropathological basis for this remains unclear; however, dysfunction in prefrontal and limbic regions may play a role.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22652466</PMID>
<DateCreated><Year>2012</Year>
<Month>08</Month>
<Day>21</Day>
</DateCreated>
<DateCompleted><Year>2013</Year>
<Month>03</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2012</Year>
<Month>08</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5126</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>18</Volume>
<Issue>7</Issue>
<PubDate><Year>2012</Year>
<Month>Aug</Month>
</PubDate>
</JournalIssue>
<Title>Parkinsonism & related disorders</Title>
<ISOAbbreviation>Parkinsonism Relat. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Intact limbic-prefrontal connections and reduced amygdala volumes in Parkinson's disease with mild depressive symptoms.</ArticleTitle>
<Pagination><MedlinePgn>809-13</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.parkreldis.2012.03.008</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Depression is very common in Parkinson's disease (PD). The neuropathological basis for this remains unclear; however, dysfunction in prefrontal and limbic regions may play a role.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We examined non-demented PD patients with and without depression and healthy controls (n = 6 per group) for differences in limbic structures and connections between these structures and the prefrontal cortex. Depressed individuals were selected from a representative sample of 33 PD patients using scores from the 15 question geriatric depression scale (GDS). Magnetic resonance diffusion tensor imaging (DTI) tractography was used to examine the structural integrity of the uncinate fasciculus (UF), a white matter tract that projects from the hippocampus, amygdala and temporal pole to the orbitofrontal cortex, and the corpus callosum. Integrity of the UF and corpus callosum was established through measures of mean diffusivity (MD), fractional anisotropy (FA) and tract length. A volumetric analysis of the hippocampal head, body and tail, as well as the amygdala was performed to determine whether volume differences in these structures in PD relate to depression.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The depressed PD group showed smaller amygdala volumes compared to healthy controls, but the groups did not differ on any other measure.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The present study found intact limbic connectivity but suggests that amygdala atrophy may be present in Parkinson's disease with depression. Further work is needed to replicate these findings.</AbstractText>
<CopyrightInformation>Copyright © 2012. Published by Elsevier Ltd.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Surdhar</LastName>
<ForeName>Ian</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Centre for Neuroscience, University of Alberta, Edmonton, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gee</LastName>
<ForeName>Myrlene</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Bouchard</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
</Author>
<Author ValidYN="Y"><LastName>Coupland</LastName>
<ForeName>Nicholas</ForeName>
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<Author ValidYN="Y"><LastName>Malykhin</LastName>
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<Author ValidYN="Y"><LastName>Camicioli</LastName>
<ForeName>Richard</ForeName>
<Initials>R</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><Agency>Canadian Institutes of Health Research</Agency>
<Country>Canada</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2012</Year>
<Month>05</Month>
<Day>29</Day>
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</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Parkinsonism Relat Disord</MedlineTA>
<NlmUniqueID>9513583</NlmUniqueID>
<ISSNLinking>1353-8020</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D000679" MajorTopicYN="N">Amygdala</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001284" MajorTopicYN="N">Atrophy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003337" MajorTopicYN="N">Corpus Callosum</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003863" MajorTopicYN="N">Depression</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D038524" MajorTopicYN="N">Diffusion Magnetic Resonance Imaging</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
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<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006624" MajorTopicYN="N">Hippocampus</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009415" MajorTopicYN="N">Nerve Net</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017397" MajorTopicYN="N">Prefrontal Cortex</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
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<Day>16</Day>
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<PubMedPubDate PubStatus="revised"><Year>2012</Year>
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Intact limbic-prefrontal connections and reduced amygdala volumes in Parkinson's disease with mild depressive symptoms.

Intact limbic-prefrontal connections and reduced amygdala volumes in Parkinson's disease with mild depressive symptoms.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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