ParkinsonCanadaV1, PubMed, Corpus, bibRecord, 000995

Identification of a functional connectome for long-term fear memory in mice.

Identifieur interne : 000995 ( PubMed/Corpus ); précédent : 000994; suivant : 000996

Identification of a functional connectome for long-term fear memory in mice.

Auteurs : Anne L. Wheeler ; Cátia M. Teixeira ; Afra H. Wang ; Xuejian Xiong ; Natasa Kovacevic ; Jason P. Lerch ; Anthony R. Mcintosh ; John Parkinson ; Paul W. Frankland

Source :

PLoS computational biology [ 1553-7358 ] ; 2013.

RBID : pubmed:23300432

English descriptors

KwdEn :
- Animals, Brain (physiology), Fear, Immunohistochemistry, Memory, Mice, Mice, Mutant Strains, Nerve Net.
MESH :
- physiology : Brain.
- Animals, Fear, Immunohistochemistry, Memory, Mice, Mice, Mutant Strains, Nerve Net.

Abstract

Long-term memories are thought to depend upon the coordinated activation of a broad network of cortical and subcortical brain regions. However, the distributed nature of this representation has made it challenging to define the neural elements of the memory trace, and lesion and electrophysiological approaches provide only a narrow window into what is appreciated a much more global network. Here we used a global mapping approach to identify networks of brain regions activated following recall of long-term fear memories in mice. Analysis of Fos expression across 84 brain regions allowed us to identify regions that were co-active following memory recall. These analyses revealed that the functional organization of long-term fear memories depends on memory age and is altered in mutant mice that exhibit premature forgetting. Most importantly, these analyses indicate that long-term memory recall engages a network that has a distinct thalamic-hippocampal-cortical signature. This network is concurrently integrated and segregated and therefore has small-world properties, and contains hub-like regions in the prefrontal cortex and thalamus that may play privileged roles in memory expression.

DOI: 10.1371/journal.pcbi.1002853
PubMed: 23300432

Links to Exploration step

pubmed:23300432

Le document en format XML

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<front><div type="abstract" xml:lang="en">Long-term memories are thought to depend upon the coordinated activation of a broad network of cortical and subcortical brain regions. However, the distributed nature of this representation has made it challenging to define the neural elements of the memory trace, and lesion and electrophysiological approaches provide only a narrow window into what is appreciated a much more global network. Here we used a global mapping approach to identify networks of brain regions activated following recall of long-term fear memories in mice. Analysis of Fos expression across 84 brain regions allowed us to identify regions that were co-active following memory recall. These analyses revealed that the functional organization of long-term fear memories depends on memory age and is altered in mutant mice that exhibit premature forgetting. Most importantly, these analyses indicate that long-term memory recall engages a network that has a distinct thalamic-hippocampal-cortical signature. This network is concurrently integrated and segregated and therefore has small-world properties, and contains hub-like regions in the prefrontal cortex and thalamus that may play privileged roles in memory expression.</div>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year>
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<PubMedPubDate PubStatus="accepted"><Year>2012</Year>
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{{Explor lien
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   |area=    ParkinsonCanadaV1
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   |étape=   Corpus
   |type=    RBID
   |clé=     pubmed:23300432
   |texte=   Identification of a functional connectome for long-term fear memory in mice.
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This area was generated with Dilib version V0.6.29.
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	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Identification of a functional connectome for long-term fear memory in mice.

Identification of a functional connectome for long-term fear memory in mice.

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