ParkinsonCanadaV1, PubMed, Corpus, bibRecord, 000976

Management of neuropsychiatric symptoms in long-term care residents with Parkinson's disease: a retrospective cohort study.

Identifieur interne : 000976 ( PubMed/Corpus ); précédent : 000975; suivant : 000977

Management of neuropsychiatric symptoms in long-term care residents with Parkinson's disease: a retrospective cohort study.

Auteurs : Nathan Herrmann ; Connie Marras ; Hadas D. Fischer ; Xuesong Wang ; Geoff M. Anderson ; Paula A. Rochon

Source :

Drugs & aging [ 1179-1969 ] ; 2013.

RBID : pubmed:23188751

English descriptors

KwdEn :
- Aged, 80 and over, Antiparkinson Agents (therapeutic use), Cohort Studies, Drug Dosage Calculations, Drug Prescriptions (statistics & numerical data), Female, Humans, Levodopa (therapeutic use), Long-Term Care (psychology), Long-Term Care (statistics & numerical data), Male, Medication Adherence (statistics & numerical data), Neuropsychiatry, Parkinson Disease (drug therapy), Parkinson Disease (psychology), Retrospective Studies.
MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- drug therapy : Parkinson Disease.
- psychology : Long-Term Care, Parkinson Disease.
- statistics & numerical data : Drug Prescriptions, Long-Term Care, Medication Adherence.
- Aged, 80 and over, Cohort Studies, Drug Dosage Calculations, Female, Humans, Male, Neuropsychiatry, Retrospective Studies.

Abstract

The management of neuropsychiatric symptoms, including psychosis, in Parkinson's Disease (PD) is complicated by the fact that treatment with antipsychotics can worsen the movement disorder, which may necessitate changes to antiparkinsonian medications.

DOI: 10.1007/s40266-012-0038-8
PubMed: 23188751

Links to Exploration step

pubmed:23188751

Le document en format XML

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<author><name sortKey="Herrmann, Nathan" sort="Herrmann, Nathan" uniqKey="Herrmann N" first="Nathan" last="Herrmann">Nathan Herrmann</name>
<affiliation><nlm:affiliation>Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada. nathan.herrmann@sunnybrook.ca</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name>
</author>
<author><name sortKey="Fischer, Hadas D" sort="Fischer, Hadas D" uniqKey="Fischer H" first="Hadas D" last="Fischer">Hadas D. Fischer</name>
</author>
<author><name sortKey="Wang, Xuesong" sort="Wang, Xuesong" uniqKey="Wang X" first="Xuesong" last="Wang">Xuesong Wang</name>
</author>
<author><name sortKey="Anderson, Geoff M" sort="Anderson, Geoff M" uniqKey="Anderson G" first="Geoff M" last="Anderson">Geoff M. Anderson</name>
</author>
<author><name sortKey="Rochon, Paula A" sort="Rochon, Paula A" uniqKey="Rochon P" first="Paula A" last="Rochon">Paula A. Rochon</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Management of neuropsychiatric symptoms in long-term care residents with Parkinson's disease: a retrospective cohort study.</title>
<author><name sortKey="Herrmann, Nathan" sort="Herrmann, Nathan" uniqKey="Herrmann N" first="Nathan" last="Herrmann">Nathan Herrmann</name>
<affiliation><nlm:affiliation>Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada. nathan.herrmann@sunnybrook.ca</nlm:affiliation>
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<author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name>
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<author><name sortKey="Fischer, Hadas D" sort="Fischer, Hadas D" uniqKey="Fischer H" first="Hadas D" last="Fischer">Hadas D. Fischer</name>
</author>
<author><name sortKey="Wang, Xuesong" sort="Wang, Xuesong" uniqKey="Wang X" first="Xuesong" last="Wang">Xuesong Wang</name>
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<author><name sortKey="Anderson, Geoff M" sort="Anderson, Geoff M" uniqKey="Anderson G" first="Geoff M" last="Anderson">Geoff M. Anderson</name>
</author>
<author><name sortKey="Rochon, Paula A" sort="Rochon, Paula A" uniqKey="Rochon P" first="Paula A" last="Rochon">Paula A. Rochon</name>
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<series><title level="j">Drugs & aging</title>
<idno type="eISSN">1179-1969</idno>
<imprint><date when="2013" type="published">2013</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged, 80 and over</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Cohort Studies</term>
<term>Drug Dosage Calculations</term>
<term>Drug Prescriptions (statistics & numerical data)</term>
<term>Female</term>
<term>Humans</term>
<term>Levodopa (therapeutic use)</term>
<term>Long-Term Care (psychology)</term>
<term>Long-Term Care (statistics & numerical data)</term>
<term>Male</term>
<term>Medication Adherence (statistics & numerical data)</term>
<term>Neuropsychiatry</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (psychology)</term>
<term>Retrospective Studies</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Long-Term Care</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Drug Prescriptions</term>
<term>Long-Term Care</term>
<term>Medication Adherence</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged, 80 and over</term>
<term>Cohort Studies</term>
<term>Drug Dosage Calculations</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Neuropsychiatry</term>
<term>Retrospective Studies</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">The management of neuropsychiatric symptoms, including psychosis, in Parkinson's Disease (PD) is complicated by the fact that treatment with antipsychotics can worsen the movement disorder, which may necessitate changes to antiparkinsonian medications.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23188751</PMID>
<DateCreated><Year>2013</Year>
<Month>01</Month>
<Day>18</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>01</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>05</Month>
<Day>29</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1179-1969</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>30</Volume>
<Issue>1</Issue>
<PubDate><Year>2013</Year>
<Month>Jan</Month>
</PubDate>
</JournalIssue>
<Title>Drugs & aging</Title>
<ISOAbbreviation>Drugs Aging</ISOAbbreviation>
</Journal>
<ArticleTitle>Management of neuropsychiatric symptoms in long-term care residents with Parkinson's disease: a retrospective cohort study.</ArticleTitle>
<Pagination><MedlinePgn>19-22</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s40266-012-0038-8</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The management of neuropsychiatric symptoms, including psychosis, in Parkinson's Disease (PD) is complicated by the fact that treatment with antipsychotics can worsen the movement disorder, which may necessitate changes to antiparkinsonian medications.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The objectives of this study were to determine what antipsychotics are prescribed to residents in long-term care with PD and document subsequent changes in levodopa dosage.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">A retrospective cohort study using administrative health database information from Ontario, Canada, was conducted. PD diagnostic codes were obtained from the Ontario Health Insurance Plan (physician diagnostic codes) and the Canadian Institute of Health Information (hospitalization discharge diagnoses). The Ontario Drug Benefit database provided information on the use of antiparkinsonian medications and antipsychotics. Residents diagnosed with PD in long-term care were included if they were treated with stable doses of levodopa monotherapy and received a new prescription for an antipsychotic. The type of antipsychotic and the changes in levodopa dosage were determined.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">There were 479 residents who met inclusion criteria. The prescribed antipsychotics were quetiapine (n = 192; 40 %), risperidone (n = 185; 39 %) and olanzapine (n = 81; 17 %), and only 21 (4 %) received a prescription for a typical antipsychotic. The first levodopa dosage change was a dose reduction in 469 (98 %) patients, and a dose increase in ten (2 %) patients.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Many PD patients in long-term care are treated with potentially inappropriate antipsychotic medications. However, there is no evidence that this treatment results in a prescribing cascade that leads to inappropriate increases in levodopa dosage.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Herrmann</LastName>
<ForeName>Nathan</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada. nathan.herrmann@sunnybrook.ca</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Marras</LastName>
<ForeName>Connie</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Fischer</LastName>
<ForeName>Hadas D</ForeName>
<Initials>HD</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Xuesong</ForeName>
<Initials>X</Initials>
</Author>
<Author ValidYN="Y"><LastName>Anderson</LastName>
<ForeName>Geoff M</ForeName>
<Initials>GM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Rochon</LastName>
<ForeName>Paula A</ForeName>
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</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>OTG-88591</GrantID>
<Agency>Canadian Institutes of Health Research</Agency>
<Country>Canada</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<MedlineJournalInfo><Country>New Zealand</Country>
<MedlineTA>Drugs Aging</MedlineTA>
<NlmUniqueID>9102074</NlmUniqueID>
<ISSNLinking>1170-229X</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>46627O600J</RegistryNumber>
<NameOfSubstance UI="D007980">Levodopa</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000978" MajorTopicYN="N">Antiparkinson Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054796" MajorTopicYN="N">Drug Dosage Calculations</DescriptorName>
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<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
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<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007980" MajorTopicYN="N">Levodopa</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008134" MajorTopicYN="Y">Long-Term Care</DescriptorName>
<QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055118" MajorTopicYN="N">Medication Adherence</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058027" MajorTopicYN="Y">Neuropsychiatry</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
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<Month>11</Month>
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Management of neuropsychiatric symptoms in long-term care residents with Parkinson's disease: a retrospective cohort study.

Management of neuropsychiatric symptoms in long-term care residents with Parkinson's disease: a retrospective cohort study.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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