La maladie de Parkinson au Canada (serveur d'exploration)

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Head injuries and Parkinson's disease in a case-control study.

Identifieur interne : 000834 ( PubMed/Corpus ); précédent : 000833; suivant : 000835

Head injuries and Parkinson's disease in a case-control study.

Auteurs : M Anne Harris ; Hui Shen ; Stephen A. Marion ; Joseph K C. Tsui ; Kay Teschke

Source :

RBID : pubmed:24142978

English descriptors

Abstract

Head injury is a hypothesised risk factor for Parkinson's disease, but there is a knowledge gap concerning the potential effect of injury circumstances (eg, work-related injuries) on risk. The objective of this study is to address this gap while addressing issues of recall bias and potential for reverse causation by prediagnosis symptoms.

DOI: 10.1136/oemed-2013-101444
PubMed: 24142978

Links to Exploration step

pubmed:24142978

Le document en format XML

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<nlm:affiliation>School of Occupational and Public Health, Ryerson University, Toronto, Ontario, Canada.</nlm:affiliation>
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<name sortKey="Shen, Hui" sort="Shen, Hui" uniqKey="Shen H" first="Hui" last="Shen">Hui Shen</name>
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<name sortKey="Marion, Stephen A" sort="Marion, Stephen A" uniqKey="Marion S" first="Stephen A" last="Marion">Stephen A. Marion</name>
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<name sortKey="Tsui, Joseph K C" sort="Tsui, Joseph K C" uniqKey="Tsui J" first="Joseph K C" last="Tsui">Joseph K C. Tsui</name>
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<term>Case-Control Studies</term>
<term>Craniocerebral Trauma (complications)</term>
<term>Craniocerebral Trauma (epidemiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (etiology)</term>
<term>Risk Factors</term>
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<term>British Columbia</term>
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<term>Craniocerebral Trauma</term>
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<term>Parkinson Disease</term>
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<term>Parkinson Disease</term>
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<term>Adult</term>
<term>Aged</term>
<term>Case-Control Studies</term>
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<div type="abstract" xml:lang="en">Head injury is a hypothesised risk factor for Parkinson's disease, but there is a knowledge gap concerning the potential effect of injury circumstances (eg, work-related injuries) on risk. The objective of this study is to address this gap while addressing issues of recall bias and potential for reverse causation by prediagnosis symptoms.</div>
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<Volume>70</Volume>
<Issue>12</Issue>
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<Year>2013</Year>
<Month>Dec</Month>
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<Title>Occupational and environmental medicine</Title>
<ISOAbbreviation>Occup Environ Med</ISOAbbreviation>
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<ArticleTitle>Head injuries and Parkinson's disease in a case-control study.</ArticleTitle>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Head injury is a hypothesised risk factor for Parkinson's disease, but there is a knowledge gap concerning the potential effect of injury circumstances (eg, work-related injuries) on risk. The objective of this study is to address this gap while addressing issues of recall bias and potential for reverse causation by prediagnosis symptoms.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We conducted a population based case-control study of Parkinson's disease in British Columbia, Canada (403 cases, 405 controls). Interviews queried injury history; whether injuries occurred at work, in a motor vehicle accident or during sports. Participants were also asked to report their suspicions about the causes of Parkinson's disease to provide an indicator of potential recall bias. Associations were estimated with logistic regression, adjusted for age, sex and smoking history.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Associations were strongest for injuries involving concussion (OR: 2.08, 95% CI 1.30 to 3.33) and unconsciousness (OR: 2.64, 95% CI 1.39 to 5.03). Effects remained for injuries that occurred long before diagnosis and after adjustment for suspicion of head injury as a cause of Parkinson's disease. Injuries that occurred at work were consistently associated with stronger ORs, although small numbers meant that estimates were not statistically significant.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This study adds to the body of literature suggesting a link between head injury and Parkinson's disease and indicates further scrutiny of workplace incurred head injuries is warranted.</AbstractText>
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