A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit.
Identifieur interne : 000756 ( PubMed/Corpus ); précédent : 000755; suivant : 000757A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit.
Auteurs : M Flint Beal ; David Oakes ; Ira Shoulson ; Claire Henchcliffe ; Wendy R. Galpern ; Richard Haas ; Jorge L. Juncos ; John G. Nutt ; Tiffini Smith Voss ; Bernard Ravina ; Clifford M. Shults ; Karen Helles ; Victoria Snively ; Mark F. Lew ; Brian Griebner ; Arthur Watts ; Shan Gao ; Emmanuelle Pourcher ; Louisette Bond ; Katie Kompoliti ; Pinky Agarwal ; Cherissa Sia ; Mandar Jog ; Linda Cole ; Munira Sultana ; Roger Kurlan ; Irene Richard ; Cheryl Deeley ; Cheryl H. Waters ; Angel Figueroa ; Ani Arkun ; Matthew Brodsky ; William G. Ondo ; Christine B. Hunter ; Joohi Jimenez-Shahed ; Alicia Palao ; Janis M. Miyasaki ; Julie So ; James Tetrud ; Liza Reys ; Katharine Smith ; Carlos Singer ; Anita Blenke ; David S. Russell ; Candace Cotto ; Joseph H. Friedman ; Margaret Lannon ; Lin Zhang ; Edward Drasby ; Rajeev Kumar ; Thyagarajan Subramanian ; Donna Stuppy Ford ; David A. Grimes ; Diane Cote ; Jennifer Conway ; Andrew D. Siderowf ; Marian Leslie Evatt ; Barbara Sommerfeld ; Abraham N. Lieberman ; Michael S. Okun ; Ramon L. Rodriguez ; Stacy Merritt ; Camille Louise Swartz ; W R Wayne Martin ; Pamela King ; Natividad Stover ; Stephanie Guthrie ; Ray L. Watts ; Anwar Ahmed ; Hubert H. Fernandez ; Adrienna Winters ; Zoltan Mari ; Ted M. Dawson ; Becky Dunlop ; Andrew S. Feigin ; Barbara Shannon ; Melissa Jill Nirenberg ; Mattson Ogg ; Samuel A. Ellias ; Cathi-Ann Thomas ; Karen Frei ; Ivan Bodis-Wollner ; Sofya Glazman ; Thomas Mayer ; Robert A. Hauser ; Rajesh Pahwa ; April Langhammer ; Ranjit Ranawaya ; Lorelei Derwent ; Kapil D. Sethi ; Buff Farrow ; Rajan Prakash ; Irene Litvan ; Annette Robinson ; Alok Sahay ; Maureen Gartner ; Vanessa K. Hinson ; Samuel Markind ; Melisa Pelikan ; Joel S. Perlmutter ; Johanna Hartlein ; Eric Molho ; Sharon Evans ; Charles H. Adler ; Amy Duffy ; Marlene Lind ; Lawrence Elmer ; Kathy Davis ; Julia Spears ; Stephanie Wilson ; Maureen A. Leehey ; Neal Hermanowicz ; Shari Niswonger ; Holly A. Shill ; Sanja Obradov ; Alex Rajput ; Marilyn Cowper ; Stephanie Lessig ; David Song ; Deborah Fontaine ; Cindy Zadikoff ; Karen Williams ; Karen A. Blindauer ; Jo Bergholte ; Clara Schindler Propsom ; Mark A. Stacy ; Joanne Field ; Dragos Mihaila ; Mark Chilton ; Ergun Y. Uc ; Jeri Sieren ; David K. Simon ; Lauren Kraics ; Althea Silver ; James T. Boyd ; Robert W. Hamill ; Christopher Ingvoldstad ; Jennifer Young ; Karen Thomas ; Sandra K. Kostyk ; Joanne Wojcieszek ; Ronald F. Pfeiffer ; Michel Panisset ; Monica Beland ; Stephen G. Reich ; Michelle Cines ; Nancy Zappala ; Jean Rivest ; Richard Zweig ; L Pepper Lumina ; Colette Lynn Hilliard ; Stephen Grill ; Marye Kellermann ; Paul Tuite ; Susan Rolandelli ; Un Jung Kang ; Joan Young ; Jayaraman Rao ; Maureen M. Cook ; Lawrence Severt ; Karyn BoyarSource :
- JAMA neurology [ 2168-6157 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Antioxidants (administration & dosage), Antioxidants (metabolism), Dose-Response Relationship, Drug, Double-Blind Method, Early Diagnosis, Female, Humans, Male, Middle Aged, Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Parkinson Disease (enzymology), Prospective Studies, Treatment Outcome, Ubiquinone (administration & dosage), Ubiquinone (analogs & derivatives), Ubiquinone (blood).
- MESH :
- chemical , administration & dosage : Antioxidants, Ubiquinone.
- chemical , analogs & derivatives : Ubiquinone.
- chemical , blood : Ubiquinone.
- chemical , metabolism : Antioxidants.
- diagnosis : Parkinson Disease.
- drug therapy : Parkinson Disease.
- enzymology : Parkinson Disease.
- Aged, Dose-Response Relationship, Drug, Double-Blind Method, Early Diagnosis, Female, Humans, Male, Middle Aged, Prospective Studies, Treatment Outcome.
Abstract
Coenzyme Q10 (CoQ10), an antioxidant that supports mitochondrial function, has been shown in preclinical Parkinson disease (PD) models to reduce the loss of dopamine neurons, and was safe and well tolerated in early-phase human studies. A previous phase II study suggested possible clinical benefit.
DOI: 10.1001/jamaneurol.2014.131
PubMed: 24664227
Links to Exploration step
pubmed:24664227Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit.</title><author><name sortKey="Beal, M Flint" sort="Beal, M Flint" uniqKey="Beal M" first="M Flint" last="Beal">M Flint Beal</name><affiliation><nlm:affiliation>Department of Neurology, Weill Cornell Medical College, New York Hospital, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Oakes, David" sort="Oakes, David" uniqKey="Oakes D" first="David" last="Oakes">David Oakes</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Rochester Medical Center, Rochester, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Shoulson, Ira" sort="Shoulson, Ira" uniqKey="Shoulson I" first="Ira" last="Shoulson">Ira Shoulson</name><affiliation><nlm:affiliation>Department of Neurology, Georgetown University, Washington, DC.</nlm:affiliation></affiliation></author><author><name sortKey="Henchcliffe, Claire" sort="Henchcliffe, Claire" uniqKey="Henchcliffe C" first="Claire" last="Henchcliffe">Claire Henchcliffe</name><affiliation><nlm:affiliation>Department of Neurology, Weill Cornell Medical College, New York Hospital, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Galpern, Wendy R" sort="Galpern, Wendy R" uniqKey="Galpern W" first="Wendy R" last="Galpern">Wendy R. Galpern</name><affiliation><nlm:affiliation>National Institutes of Health, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Haas, Richard" sort="Haas, Richard" uniqKey="Haas R" first="Richard" last="Haas">Richard Haas</name><affiliation><nlm:affiliation>Department of Neurosciences, University of California, San Diego, La Jolla.</nlm:affiliation></affiliation></author><author><name sortKey="Juncos, Jorge L" sort="Juncos, Jorge L" uniqKey="Juncos J" first="Jorge L" last="Juncos">Jorge L. Juncos</name><affiliation><nlm:affiliation>Department of Neurology, Emory University School of Medicine, Wesley Woods Center, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Nutt, John G" sort="Nutt, John G" uniqKey="Nutt J" first="John G" last="Nutt">John G. Nutt</name><affiliation><nlm:affiliation>Department of Neurology, Oregon Health and Science University, Portland.</nlm:affiliation></affiliation></author><author><name sortKey="Voss, Tiffini Smith" sort="Voss, Tiffini Smith" uniqKey="Voss T" first="Tiffini Smith" last="Voss">Tiffini Smith Voss</name><affiliation><nlm:affiliation>Merck, New Jersey.</nlm:affiliation></affiliation></author><author><name sortKey="Ravina, Bernard" sort="Ravina, Bernard" uniqKey="Ravina B" first="Bernard" last="Ravina">Bernard Ravina</name><affiliation><nlm:affiliation>Biogen Idec, Cambridge, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Shults, Clifford M" sort="Shults, Clifford M" uniqKey="Shults C" first="Clifford M" last="Shults">Clifford M. Shults</name><affiliation><nlm:affiliation>Department of Neurosciences, University of California, San Diego, La Jolla10VA Medical Center, San Diego, California.</nlm:affiliation></affiliation></author><author><name sortKey="Helles, Karen" sort="Helles, Karen" uniqKey="Helles K" first="Karen" last="Helles">Karen Helles</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Rochester Medical Center, Rochester, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Snively, Victoria" sort="Snively, Victoria" uniqKey="Snively V" first="Victoria" last="Snively">Victoria Snively</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Rochester Medical Center, Rochester, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F" last="Lew">Mark F. Lew</name><affiliation><nlm:affiliation>Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles.</nlm:affiliation></affiliation></author><author><name sortKey="Griebner, Brian" sort="Griebner, Brian" uniqKey="Griebner B" first="Brian" last="Griebner">Brian Griebner</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Rochester Medical Center, Rochester, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Watts, Arthur" sort="Watts, Arthur" uniqKey="Watts A" first="Arthur" last="Watts">Arthur Watts</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Rochester Medical Center, Rochester, New York12Department of Neurology, University of Rochester, Rochester, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Gao, Shan" sort="Gao, Shan" uniqKey="Gao S" first="Shan" last="Gao">Shan Gao</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Rochester Medical Center, Rochester, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Pourcher, Emmanuelle" sort="Pourcher, Emmanuelle" uniqKey="Pourcher E" first="Emmanuelle" last="Pourcher">Emmanuelle Pourcher</name><affiliation><nlm:affiliation>Québec Memory and Motor Skills Disorders Research Center, Clinique Sainte-Anne, Québec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Bond, Louisette" sort="Bond, Louisette" uniqKey="Bond L" first="Louisette" last="Bond">Louisette Bond</name><affiliation><nlm:affiliation>Québec Memory and Motor Skills Disorders Research Center, Clinique Sainte-Anne, Québec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Kompoliti, Katie" sort="Kompoliti, Katie" uniqKey="Kompoliti K" first="Katie" last="Kompoliti">Katie Kompoliti</name><affiliation><nlm:affiliation>Rush University Medical Center, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Agarwal, Pinky" sort="Agarwal, Pinky" uniqKey="Agarwal P" first="Pinky" last="Agarwal">Pinky Agarwal</name><affiliation><nlm:affiliation>Booth Gardner Parkinson's Care Center, EvergreenHealth, Kirkland, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Sia, Cherissa" sort="Sia, Cherissa" uniqKey="Sia C" first="Cherissa" last="Sia">Cherissa Sia</name><affiliation><nlm:affiliation>Booth Gardner Parkinson's Care Center, EvergreenHealth, Kirkland, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Jog, Mandar" sort="Jog, Mandar" uniqKey="Jog M" first="Mandar" last="Jog">Mandar Jog</name><affiliation><nlm:affiliation>London Health Sciences Centre, London, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Cole, Linda" sort="Cole, Linda" uniqKey="Cole L" first="Linda" last="Cole">Linda Cole</name><affiliation><nlm:affiliation>London Health Sciences Centre, London, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Sultana, Munira" sort="Sultana, Munira" uniqKey="Sultana M" first="Munira" last="Sultana">Munira Sultana</name><affiliation><nlm:affiliation>London Health Sciences Centre, London, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Kurlan, Roger" sort="Kurlan, Roger" uniqKey="Kurlan R" first="Roger" last="Kurlan">Roger Kurlan</name><affiliation><nlm:affiliation>Overlook Medical Center, Atlantic Neuroscience Institute, Summit, New Jersey.</nlm:affiliation></affiliation></author><author><name sortKey="Richard, Irene" sort="Richard, Irene" uniqKey="Richard I" first="Irene" last="Richard">Irene Richard</name><affiliation><nlm:affiliation>Department of Neurology, University of Rochester, Rochester, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Deeley, Cheryl" sort="Deeley, Cheryl" uniqKey="Deeley C" first="Cheryl" last="Deeley">Cheryl Deeley</name><affiliation><nlm:affiliation>Department of Neurology, University of Rochester, Rochester, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Waters, Cheryl H" sort="Waters, Cheryl H" uniqKey="Waters C" first="Cheryl H" last="Waters">Cheryl H. Waters</name><affiliation><nlm:affiliation>Columbia University Medical Center, Neurological Institute, New York, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Figueroa, Angel" sort="Figueroa, Angel" uniqKey="Figueroa A" first="Angel" last="Figueroa">Angel Figueroa</name><affiliation><nlm:affiliation>Columbia University Medical Center, Neurological Institute, New York, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Arkun, Ani" sort="Arkun, Ani" uniqKey="Arkun A" first="Ani" last="Arkun">Ani Arkun</name><affiliation><nlm:affiliation>Department of Neurology, Weill Cornell Medical College, New York Hospital, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Brodsky, Matthew" sort="Brodsky, Matthew" uniqKey="Brodsky M" first="Matthew" last="Brodsky">Matthew Brodsky</name><affiliation><nlm:affiliation>Department of Neurology, Oregon Health and Science University, Portland.</nlm:affiliation></affiliation></author><author><name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William G" last="Ondo">William G. Ondo</name><affiliation><nlm:affiliation>Department of Neurology, University of Texas Health Science Center at Houston.</nlm:affiliation></affiliation></author><author><name sortKey="Hunter, Christine B" sort="Hunter, Christine B" uniqKey="Hunter C" first="Christine B" last="Hunter">Christine B. Hunter</name><affiliation><nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, Texas.</nlm:affiliation></affiliation></author><author><name sortKey="Jimenez Shahed, Joohi" sort="Jimenez Shahed, Joohi" uniqKey="Jimenez Shahed J" first="Joohi" last="Jimenez-Shahed">Joohi Jimenez-Shahed</name><affiliation><nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, Texas.</nlm:affiliation></affiliation></author><author><name sortKey="Palao, Alicia" sort="Palao, Alicia" uniqKey="Palao A" first="Alicia" last="Palao">Alicia Palao</name><affiliation><nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, Texas.</nlm:affiliation></affiliation></author><author><name sortKey="Miyasaki, Janis M" sort="Miyasaki, Janis M" uniqKey="Miyasaki J" first="Janis M" last="Miyasaki">Janis M. Miyasaki</name><affiliation><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="So, Julie" sort="So, Julie" uniqKey="So J" first="Julie" last="So">Julie So</name><affiliation><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Tetrud, James" sort="Tetrud, James" uniqKey="Tetrud J" first="James" last="Tetrud">James Tetrud</name><affiliation><nlm:affiliation>The Parkinson's Institute and Clinical Center, Sunnyvale, California.</nlm:affiliation></affiliation></author><author><name sortKey="Reys, Liza" sort="Reys, Liza" uniqKey="Reys L" first="Liza" last="Reys">Liza Reys</name><affiliation><nlm:affiliation>The Parkinson's Institute and Clinical Center, Sunnyvale, California.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Katharine" sort="Smith, Katharine" uniqKey="Smith K" first="Katharine" last="Smith">Katharine Smith</name><affiliation><nlm:affiliation>The Parkinson's Institute and Clinical Center, Sunnyvale, California.</nlm:affiliation></affiliation></author><author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name><affiliation><nlm:affiliation>Department of Neurology, University of Miami School of Medicine, Miami, Florida.</nlm:affiliation></affiliation></author><author><name sortKey="Blenke, Anita" sort="Blenke, Anita" uniqKey="Blenke A" first="Anita" last="Blenke">Anita Blenke</name><affiliation><nlm:affiliation>Department of Neurology, University of Miami School of Medicine, Miami, Florida.</nlm:affiliation></affiliation></author><author><name sortKey="Russell, David S" sort="Russell, David S" uniqKey="Russell D" first="David S" last="Russell">David S. Russell</name><affiliation><nlm:affiliation>Institute for Neurodegenerative Disorders, New Haven, Connecticut.</nlm:affiliation></affiliation></author><author><name sortKey="Cotto, Candace" sort="Cotto, Candace" uniqKey="Cotto C" first="Candace" last="Cotto">Candace Cotto</name><affiliation><nlm:affiliation>Institute for Neurodegenerative Disorders, New Haven, Connecticut.</nlm:affiliation></affiliation></author><author><name sortKey="Friedman, Joseph H" sort="Friedman, Joseph H" uniqKey="Friedman J" first="Joseph H" last="Friedman">Joseph H. Friedman</name><affiliation><nlm:affiliation>Department of Neurology, Butler Hospital, Providence, Rhode Island26Alpert Medical School, Brown University, Providence, Rhode Island.</nlm:affiliation></affiliation></author><author><name sortKey="Lannon, Margaret" sort="Lannon, Margaret" uniqKey="Lannon M" first="Margaret" last="Lannon">Margaret Lannon</name><affiliation><nlm:affiliation>Department of Neurology, Butler Hospital, Providence, Rhode Island27Port City Neurology, Inc, Scarborough, Maine.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Lin" sort="Zhang, Lin" uniqKey="Zhang L" first="Lin" last="Zhang">Lin Zhang</name><affiliation><nlm:affiliation>Department of Neurology, University of California, Davis, School of Medicine and Sacramento VA Medical Center, Sacramento.</nlm:affiliation></affiliation></author><author><name sortKey="Drasby, Edward" sort="Drasby, Edward" uniqKey="Drasby E" first="Edward" last="Drasby">Edward Drasby</name><affiliation><nlm:affiliation>Port City Neurology, Inc, Scarborough, Maine.</nlm:affiliation></affiliation></author><author><name sortKey="Kumar, Rajeev" sort="Kumar, Rajeev" uniqKey="Kumar R" first="Rajeev" last="Kumar">Rajeev Kumar</name><affiliation><nlm:affiliation>Colorado Neurological Institute, Englewood.</nlm:affiliation></affiliation></author><author><name sortKey="Subramanian, Thyagarajan" sort="Subramanian, Thyagarajan" uniqKey="Subramanian T" first="Thyagarajan" last="Subramanian">Thyagarajan Subramanian</name><affiliation><nlm:affiliation>Milton S. Hershey Medical Center, Department of Neurology, Pennsylvania State Hershey College of Medicine, Hershey.</nlm:affiliation></affiliation></author><author><name sortKey="Ford, Donna Stuppy" sort="Ford, Donna Stuppy" uniqKey="Ford D" first="Donna Stuppy" last="Ford">Donna Stuppy Ford</name><affiliation><nlm:affiliation>Milton S. Hershey Medical Center, Department of Neurology, Pennsylvania State Hershey College of Medicine, Hershey.</nlm:affiliation></affiliation></author><author><name sortKey="Grimes, David A" sort="Grimes, David A" uniqKey="Grimes D" first="David A" last="Grimes">David A. Grimes</name><affiliation><nlm:affiliation>Ottawa Hospital Civic Site, Ottawa, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Cote, Diane" sort="Cote, Diane" uniqKey="Cote D" first="Diane" last="Cote">Diane Cote</name><affiliation><nlm:affiliation>Ottawa Hospital Civic Site, Ottawa, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Conway, Jennifer" sort="Conway, Jennifer" uniqKey="Conway J" first="Jennifer" last="Conway">Jennifer Conway</name><affiliation><nlm:affiliation>Ottawa Hospital Civic Site, Ottawa, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Siderowf, Andrew D" sort="Siderowf, Andrew D" uniqKey="Siderowf A" first="Andrew D" last="Siderowf">Andrew D. Siderowf</name><affiliation><nlm:affiliation>Avid Radiopharmaceuticals, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Evatt, Marian Leslie" sort="Evatt, Marian Leslie" uniqKey="Evatt M" first="Marian Leslie" last="Evatt">Marian Leslie Evatt</name><affiliation><nlm:affiliation>Department of Neurology, Emory University School of Medicine, Wesley Woods Center, Atlanta, Georgia33Atlanta VA Medical Center, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Sommerfeld, Barbara" sort="Sommerfeld, Barbara" uniqKey="Sommerfeld B" first="Barbara" last="Sommerfeld">Barbara Sommerfeld</name><affiliation><nlm:affiliation>Department of Neurology, Emory University School of Medicine, Wesley Woods Center, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Lieberman, Abraham N" sort="Lieberman, Abraham N" uniqKey="Lieberman A" first="Abraham N" last="Lieberman">Abraham N. Lieberman</name><affiliation><nlm:affiliation>Muhammad Ali Parkinson Center, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, Arizona.</nlm:affiliation></affiliation></author><author><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S" last="Okun">Michael S. Okun</name><affiliation><nlm:affiliation>Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville.</nlm:affiliation></affiliation></author><author><name sortKey="Rodriguez, Ramon L" sort="Rodriguez, Ramon L" uniqKey="Rodriguez R" first="Ramon L" last="Rodriguez">Ramon L. Rodriguez</name><affiliation><nlm:affiliation>Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville.</nlm:affiliation></affiliation></author><author><name sortKey="Merritt, Stacy" sort="Merritt, Stacy" uniqKey="Merritt S" first="Stacy" last="Merritt">Stacy Merritt</name><affiliation><nlm:affiliation>Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville.</nlm:affiliation></affiliation></author><author><name sortKey="Swartz, Camille Louise" sort="Swartz, Camille Louise" uniqKey="Swartz C" first="Camille Louise" last="Swartz">Camille Louise Swartz</name><affiliation><nlm:affiliation>Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville.</nlm:affiliation></affiliation></author><author><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W R Wayne" last="Martin">W R Wayne Martin</name><affiliation><nlm:affiliation>Glenrose Rehabilitation Hospital, University of Alberta, Edmonton, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="King, Pamela" sort="King, Pamela" uniqKey="King P" first="Pamela" last="King">Pamela King</name><affiliation><nlm:affiliation>Glenrose Rehabilitation Hospital, University of Alberta, Edmonton, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Stover, Natividad" sort="Stover, Natividad" uniqKey="Stover N" first="Natividad" last="Stover">Natividad Stover</name><affiliation><nlm:affiliation>Department of Neurology, University of Alabama at Birmingham.</nlm:affiliation></affiliation></author><author><name sortKey="Guthrie, Stephanie" sort="Guthrie, Stephanie" uniqKey="Guthrie S" first="Stephanie" last="Guthrie">Stephanie Guthrie</name><affiliation><nlm:affiliation>Department of Neurology, University of Alabama at Birmingham.</nlm:affiliation></affiliation></author><author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L" last="Watts">Ray L. Watts</name><affiliation><nlm:affiliation>Department of Neurology, University of Alabama at Birmingham.</nlm:affiliation></affiliation></author><author><name sortKey="Ahmed, Anwar" sort="Ahmed, Anwar" uniqKey="Ahmed A" first="Anwar" last="Ahmed">Anwar Ahmed</name><affiliation><nlm:affiliation>Center for Neurological Restoration, Department of Neurology, Cleveland Clinic, Cleveland, Ohio.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H" last="Fernandez">Hubert H. Fernandez</name><affiliation><nlm:affiliation>Center for Neurological Restoration, Department of Neurology, Cleveland Clinic, Cleveland, Ohio.</nlm:affiliation></affiliation></author><author><name sortKey="Winters, Adrienna" sort="Winters, Adrienna" uniqKey="Winters A" first="Adrienna" last="Winters">Adrienna Winters</name><affiliation><nlm:affiliation>Center for Neurological Restoration, Department of Neurology, Cleveland Clinic, Cleveland, Ohio.</nlm:affiliation></affiliation></author><author><name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name><affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Dawson, Ted M" sort="Dawson, Ted M" uniqKey="Dawson T" first="Ted M" last="Dawson">Ted M. Dawson</name><affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Dunlop, Becky" sort="Dunlop, Becky" uniqKey="Dunlop B" first="Becky" last="Dunlop">Becky Dunlop</name><affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Feigin, Andrew S" sort="Feigin, Andrew S" uniqKey="Feigin A" first="Andrew S" last="Feigin">Andrew S. Feigin</name><affiliation><nlm:affiliation>Feinstein Institute for Medical Research, Center for Neurosciences, Manhasset, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Shannon, Barbara" sort="Shannon, Barbara" uniqKey="Shannon B" first="Barbara" last="Shannon">Barbara Shannon</name><affiliation><nlm:affiliation>Feinstein Institute for Medical Research, Center for Neurosciences, Manhasset, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Nirenberg, Melissa Jill" sort="Nirenberg, Melissa Jill" uniqKey="Nirenberg M" first="Melissa Jill" last="Nirenberg">Melissa Jill Nirenberg</name><affiliation><nlm:affiliation>Department of Neurology, New York University Langone Medical Center, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Ogg, Mattson" sort="Ogg, Mattson" uniqKey="Ogg M" first="Mattson" last="Ogg">Mattson Ogg</name><affiliation><nlm:affiliation>Department of Neurology, Weill Cornell Medical College, New York Hospital, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Ellias, Samuel A" sort="Ellias, Samuel A" uniqKey="Ellias S" first="Samuel A" last="Ellias">Samuel A. Ellias</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, Cathi Ann" sort="Thomas, Cathi Ann" uniqKey="Thomas C" first="Cathi-Ann" last="Thomas">Cathi-Ann Thomas</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Frei, Karen" sort="Frei, Karen" uniqKey="Frei K" first="Karen" last="Frei">Karen Frei</name><affiliation><nlm:affiliation>The Parkinson's and Movement Disorder Institute, Fountain Valley, California.</nlm:affiliation></affiliation></author><author><name sortKey="Bodis Wollner, Ivan" sort="Bodis Wollner, Ivan" uniqKey="Bodis Wollner I" first="Ivan" last="Bodis-Wollner">Ivan Bodis-Wollner</name><affiliation><nlm:affiliation>State University of New York, Downstate Medical Center, Brooklyn, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Glazman, Sofya" sort="Glazman, Sofya" uniqKey="Glazman S" first="Sofya" last="Glazman">Sofya Glazman</name><affiliation><nlm:affiliation>State University of New York, Downstate Medical Center, Brooklyn, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Mayer, Thomas" sort="Mayer, Thomas" uniqKey="Mayer T" first="Thomas" last="Mayer">Thomas Mayer</name><affiliation><nlm:affiliation>State University of New York, Downstate Medical Center, Brooklyn, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A" last="Hauser">Robert A. Hauser</name><affiliation><nlm:affiliation>Department of Neurology, University of South Florida, Tampa.</nlm:affiliation></affiliation></author><author><name sortKey="Pahwa, Rajesh" sort="Pahwa, Rajesh" uniqKey="Pahwa R" first="Rajesh" last="Pahwa">Rajesh Pahwa</name><affiliation><nlm:affiliation>Department of Neurology, University of Kansas Medical Center, Kansas City.</nlm:affiliation></affiliation></author><author><name sortKey="Langhammer, April" sort="Langhammer, April" uniqKey="Langhammer A" first="April" last="Langhammer">April Langhammer</name><affiliation><nlm:affiliation>Department of Neurology, University of Kansas Medical Center, Kansas City.</nlm:affiliation></affiliation></author><author><name sortKey="Ranawaya, Ranjit" sort="Ranawaya, Ranjit" uniqKey="Ranawaya R" first="Ranjit" last="Ranawaya">Ranjit Ranawaya</name><affiliation><nlm:affiliation>Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Derwent, Lorelei" sort="Derwent, Lorelei" uniqKey="Derwent L" first="Lorelei" last="Derwent">Lorelei Derwent</name><affiliation><nlm:affiliation>Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Sethi, Kapil D" sort="Sethi, Kapil D" uniqKey="Sethi K" first="Kapil D" last="Sethi">Kapil D. Sethi</name><affiliation><nlm:affiliation>Department of Neurology, Georgia Health Science University, Augusta.</nlm:affiliation></affiliation></author><author><name sortKey="Farrow, Buff" sort="Farrow, Buff" uniqKey="Farrow B" first="Buff" last="Farrow">Buff Farrow</name><affiliation><nlm:affiliation>Department of Neurology, Georgia Health Science University, Augusta.</nlm:affiliation></affiliation></author><author><name sortKey="Prakash, Rajan" sort="Prakash, Rajan" uniqKey="Prakash R" first="Rajan" last="Prakash">Rajan Prakash</name><affiliation><nlm:affiliation>Department of Neurology, Georgia Health Science University, Augusta.</nlm:affiliation></affiliation></author><author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name><affiliation><nlm:affiliation>Department of Neurosciences, University of California, San Diego, La Jolla.</nlm:affiliation></affiliation></author><author><name sortKey="Robinson, Annette" sort="Robinson, Annette" uniqKey="Robinson A" first="Annette" last="Robinson">Annette Robinson</name><affiliation><nlm:affiliation>Department of Neurology, University of Louisville, Kentucky.</nlm:affiliation></affiliation></author><author><name sortKey="Sahay, Alok" sort="Sahay, Alok" uniqKey="Sahay A" first="Alok" last="Sahay">Alok Sahay</name><affiliation><nlm:affiliation>University of Cincinnati College of Medicine, Cincinnati, Ohio.</nlm:affiliation></affiliation></author><author><name sortKey="Gartner, Maureen" sort="Gartner, Maureen" uniqKey="Gartner M" first="Maureen" last="Gartner">Maureen Gartner</name><affiliation><nlm:affiliation>University of Cincinnati College of Medicine, Cincinnati, Ohio.</nlm:affiliation></affiliation></author><author><name sortKey="Hinson, Vanessa K" sort="Hinson, Vanessa K" uniqKey="Hinson V" first="Vanessa K" last="Hinson">Vanessa K. Hinson</name><affiliation><nlm:affiliation>Department of Neurology, Medical University of South Carolina, Charleston.</nlm:affiliation></affiliation></author><author><name sortKey="Markind, Samuel" sort="Markind, Samuel" uniqKey="Markind S" first="Samuel" last="Markind">Samuel Markind</name><affiliation><nlm:affiliation>Associated Neurologists, PC, Danbury, Connecticut.</nlm:affiliation></affiliation></author><author><name sortKey="Pelikan, Melisa" sort="Pelikan, Melisa" uniqKey="Pelikan M" first="Melisa" last="Pelikan">Melisa Pelikan</name><affiliation><nlm:affiliation>Associated Neurologists, PC, Danbury, Connecticut.</nlm:affiliation></affiliation></author><author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name><affiliation><nlm:affiliation>Department of Neurology, Washington University in St Louis, Missouri.</nlm:affiliation></affiliation></author><author><name sortKey="Hartlein, Johanna" sort="Hartlein, Johanna" uniqKey="Hartlein J" first="Johanna" last="Hartlein">Johanna Hartlein</name><affiliation><nlm:affiliation>Department of Neurology, Washington University in St Louis, Missouri.</nlm:affiliation></affiliation></author><author><name sortKey="Molho, Eric" sort="Molho, Eric" uniqKey="Molho E" first="Eric" last="Molho">Eric Molho</name><affiliation><nlm:affiliation>Movement Disorders Center, Albany Medical Center, Albany, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Evans, Sharon" sort="Evans, Sharon" uniqKey="Evans S" first="Sharon" last="Evans">Sharon Evans</name><affiliation><nlm:affiliation>Movement Disorders Center, Albany Medical Center, Albany, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H" last="Adler">Charles H. Adler</name><affiliation><nlm:affiliation>Parkinson's Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic, Scottsdale, Arizona.</nlm:affiliation></affiliation></author><author><name sortKey="Duffy, Amy" sort="Duffy, Amy" uniqKey="Duffy A" first="Amy" last="Duffy">Amy Duffy</name><affiliation><nlm:affiliation>Parkinson's Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic, Scottsdale, Arizona.</nlm:affiliation></affiliation></author><author><name sortKey="Lind, Marlene" sort="Lind, Marlene" uniqKey="Lind M" first="Marlene" last="Lind">Marlene Lind</name><affiliation><nlm:affiliation>Parkinson's Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic, Scottsdale, Arizona.</nlm:affiliation></affiliation></author><author><name sortKey="Elmer, Lawrence" sort="Elmer, Lawrence" uniqKey="Elmer L" first="Lawrence" last="Elmer">Lawrence Elmer</name><affiliation><nlm:affiliation>Center for Neurological Health, University of Toledo, Toledo, Ohio.</nlm:affiliation></affiliation></author><author><name sortKey="Davis, Kathy" sort="Davis, Kathy" uniqKey="Davis K" first="Kathy" last="Davis">Kathy Davis</name><affiliation><nlm:affiliation>Department of Neurology, Medical University of Ohio at Toledo.</nlm:affiliation></affiliation></author><author><name sortKey="Spears, Julia" sort="Spears, Julia" uniqKey="Spears J" first="Julia" last="Spears">Julia Spears</name><affiliation><nlm:affiliation>Department of Neurology, Medical University of Ohio at Toledo.</nlm:affiliation></affiliation></author><author><name sortKey="Wilson, Stephanie" sort="Wilson, Stephanie" uniqKey="Wilson S" first="Stephanie" last="Wilson">Stephanie Wilson</name><affiliation><nlm:affiliation>Department of Neurology, Medical University of Ohio at Toledo.</nlm:affiliation></affiliation></author><author><name sortKey="Leehey, Maureen A" sort="Leehey, Maureen A" uniqKey="Leehey M" first="Maureen A" last="Leehey">Maureen A. Leehey</name><affiliation><nlm:affiliation>Department of Neurology, University of Colorado Health Science Center, Denver.</nlm:affiliation></affiliation></author><author><name sortKey="Hermanowicz, Neal" sort="Hermanowicz, Neal" uniqKey="Hermanowicz N" first="Neal" last="Hermanowicz">Neal Hermanowicz</name><affiliation><nlm:affiliation>Department of Neurology, University of California, Irvine Medical Center, Irvine.</nlm:affiliation></affiliation></author><author><name sortKey="Niswonger, Shari" sort="Niswonger, Shari" uniqKey="Niswonger S" first="Shari" last="Niswonger">Shari Niswonger</name><affiliation><nlm:affiliation>Department of Neurology, University of California, Irvine Medical Center, Irvine.</nlm:affiliation></affiliation></author><author><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A" last="Shill">Holly A. Shill</name><affiliation><nlm:affiliation>Banner Sun Health Research Institute, Sun City, Arizona.</nlm:affiliation></affiliation></author><author><name sortKey="Obradov, Sanja" sort="Obradov, Sanja" uniqKey="Obradov S" first="Sanja" last="Obradov">Sanja Obradov</name><affiliation><nlm:affiliation>Banner Sun Health Research Institute, Sun City, Arizona.</nlm:affiliation></affiliation></author><author><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name><affiliation><nlm:affiliation>Department of Neurology, University of Saskatchewan, Royal University Hospital, Saskatchewan, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Cowper, Marilyn" sort="Cowper, Marilyn" uniqKey="Cowper M" first="Marilyn" last="Cowper">Marilyn Cowper</name><affiliation><nlm:affiliation>Department of Neurology, University of Saskatchewan, Royal University Hospital, Saskatchewan, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Lessig, Stephanie" sort="Lessig, Stephanie" uniqKey="Lessig S" first="Stephanie" last="Lessig">Stephanie Lessig</name><affiliation><nlm:affiliation>Department of Neurology, University of California, San Diego, La Jolla.</nlm:affiliation></affiliation></author><author><name sortKey="Song, David" sort="Song, David" uniqKey="Song D" first="David" last="Song">David Song</name><affiliation><nlm:affiliation>Department of Neurology, University of California, San Diego, La Jolla.</nlm:affiliation></affiliation></author><author><name sortKey="Fontaine, Deborah" sort="Fontaine, Deborah" uniqKey="Fontaine D" first="Deborah" last="Fontaine">Deborah Fontaine</name><affiliation><nlm:affiliation>Department of Neurology, University of California, San Diego, La Jolla.</nlm:affiliation></affiliation></author><author><name sortKey="Zadikoff, Cindy" sort="Zadikoff, Cindy" uniqKey="Zadikoff C" first="Cindy" last="Zadikoff">Cindy Zadikoff</name><affiliation><nlm:affiliation>Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Williams, Karen" sort="Williams, Karen" uniqKey="Williams K" first="Karen" last="Williams">Karen Williams</name><affiliation><nlm:affiliation>Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Blindauer, Karen A" sort="Blindauer, Karen A" uniqKey="Blindauer K" first="Karen A" last="Blindauer">Karen A. Blindauer</name><affiliation><nlm:affiliation>Department of Neurology, Medical College of Wisconsin, Milwaukee.</nlm:affiliation></affiliation></author><author><name sortKey="Bergholte, Jo" sort="Bergholte, Jo" uniqKey="Bergholte J" first="Jo" last="Bergholte">Jo Bergholte</name><affiliation><nlm:affiliation>Department of Neurology, Medical College of Wisconsin, Milwaukee.</nlm:affiliation></affiliation></author><author><name sortKey="Propsom, Clara Schindler" sort="Propsom, Clara Schindler" uniqKey="Propsom C" first="Clara Schindler" last="Propsom">Clara Schindler Propsom</name><affiliation><nlm:affiliation>Department of Neurology, Medical College of Wisconsin, Milwaukee.</nlm:affiliation></affiliation></author><author><name sortKey="Stacy, Mark A" sort="Stacy, Mark A" uniqKey="Stacy M" first="Mark A" last="Stacy">Mark A. Stacy</name><affiliation><nlm:affiliation>Department of Neurology, Duke University, Durham, North Carolina.</nlm:affiliation></affiliation></author><author><name sortKey="Field, Joanne" sort="Field, Joanne" uniqKey="Field J" first="Joanne" last="Field">Joanne Field</name><affiliation><nlm:affiliation>Department of Neurology, Duke University, Durham, North Carolina.</nlm:affiliation></affiliation></author><author><name sortKey="Mihaila, Dragos" sort="Mihaila, Dragos" uniqKey="Mihaila D" first="Dragos" last="Mihaila">Dragos Mihaila</name><affiliation><nlm:affiliation>State University of New York Upstate Medical Center and Syracuse VA Medical Center, Syracuse.</nlm:affiliation></affiliation></author><author><name sortKey="Chilton, Mark" sort="Chilton, Mark" uniqKey="Chilton M" first="Mark" last="Chilton">Mark Chilton</name><affiliation><nlm:affiliation>State University of New York Upstate Medical Center and Syracuse VA Medical Center, Syracuse.</nlm:affiliation></affiliation></author><author><name sortKey="Uc, Ergun Y" sort="Uc, Ergun Y" uniqKey="Uc E" first="Ergun Y" last="Uc">Ergun Y. Uc</name><affiliation><nlm:affiliation>Department of Neurology, University of Iowa, Iowa City.</nlm:affiliation></affiliation></author><author><name sortKey="Sieren, Jeri" sort="Sieren, Jeri" uniqKey="Sieren J" first="Jeri" last="Sieren">Jeri Sieren</name><affiliation><nlm:affiliation>Department of Neurology, University of Iowa, Iowa City.</nlm:affiliation></affiliation></author><author><name sortKey="Simon, David K" sort="Simon, David K" uniqKey="Simon D" first="David K" last="Simon">David K. Simon</name><affiliation><nlm:affiliation>Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Kraics, Lauren" sort="Kraics, Lauren" uniqKey="Kraics L" first="Lauren" last="Kraics">Lauren Kraics</name><affiliation><nlm:affiliation>Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Silver, Althea" sort="Silver, Althea" uniqKey="Silver A" first="Althea" last="Silver">Althea Silver</name><affiliation><nlm:affiliation>Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Boyd, James T" sort="Boyd, James T" uniqKey="Boyd J" first="James T" last="Boyd">James T. Boyd</name><affiliation><nlm:affiliation>Department of Neurology, University of Vermont College of Medicine, Burlington.</nlm:affiliation></affiliation></author><author><name sortKey="Hamill, Robert W" sort="Hamill, Robert W" uniqKey="Hamill R" first="Robert W" last="Hamill">Robert W. Hamill</name><affiliation><nlm:affiliation>Department of Neurology, University of Vermont College of Medicine, Burlington.</nlm:affiliation></affiliation></author><author><name sortKey="Ingvoldstad, Christopher" sort="Ingvoldstad, Christopher" uniqKey="Ingvoldstad C" first="Christopher" last="Ingvoldstad">Christopher Ingvoldstad</name><affiliation><nlm:affiliation>Department of Neurology, University of Vermont College of Medicine, Burlington.</nlm:affiliation></affiliation></author><author><name sortKey="Young, Jennifer" sort="Young, Jennifer" uniqKey="Young J" first="Jennifer" last="Young">Jennifer Young</name><affiliation><nlm:affiliation>Department of Neurology, University of Vermont College of Medicine, Burlington.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, Karen" sort="Thomas, Karen" uniqKey="Thomas K" first="Karen" last="Thomas">Karen Thomas</name><affiliation><nlm:affiliation>Department of Neurology, Ohio State University, Columbus.</nlm:affiliation></affiliation></author><author><name sortKey="Kostyk, Sandra K" sort="Kostyk, Sandra K" uniqKey="Kostyk S" first="Sandra K" last="Kostyk">Sandra K. Kostyk</name><affiliation><nlm:affiliation>Department of Neurology, Ohio State University, Columbus.</nlm:affiliation></affiliation></author><author><name sortKey="Wojcieszek, Joanne" sort="Wojcieszek, Joanne" uniqKey="Wojcieszek J" first="Joanne" last="Wojcieszek">Joanne Wojcieszek</name><affiliation><nlm:affiliation>Department of Neurology, Indiana University School of Medicine, Indianapolis.</nlm:affiliation></affiliation></author><author><name sortKey="Pfeiffer, Ronald F" sort="Pfeiffer, Ronald F" uniqKey="Pfeiffer R" first="Ronald F" last="Pfeiffer">Ronald F. Pfeiffer</name><affiliation><nlm:affiliation>Department of Neurology, University of Tennessee Health Science Center, Memphis.</nlm:affiliation></affiliation></author><author><name sortKey="Panisset, Michel" sort="Panisset, Michel" uniqKey="Panisset M" first="Michel" last="Panisset">Michel Panisset</name><affiliation><nlm:affiliation>Department of Neurology, CHUM-Hôpital Notre-Dame, Montréal, Québec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Beland, Monica" sort="Beland, Monica" uniqKey="Beland M" first="Monica" last="Beland">Monica Beland</name><affiliation><nlm:affiliation>Department of Neurology, CHUM-Hôpital Notre-Dame, Montréal, Québec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Reich, Stephen G" sort="Reich, Stephen G" uniqKey="Reich S" first="Stephen G" last="Reich">Stephen G. Reich</name><affiliation><nlm:affiliation>Department of Neurology, University of Maryland School of Science, Baltimore.</nlm:affiliation></affiliation></author><author><name sortKey="Cines, Michelle" sort="Cines, Michelle" uniqKey="Cines M" first="Michelle" last="Cines">Michelle Cines</name><affiliation><nlm:affiliation>Department of Neurology, University of Maryland School of Science, Baltimore.</nlm:affiliation></affiliation></author><author><name sortKey="Zappala, Nancy" sort="Zappala, Nancy" uniqKey="Zappala N" first="Nancy" last="Zappala">Nancy Zappala</name><affiliation><nlm:affiliation>Department of Neurology, University of Maryland School of Science, Baltimore.</nlm:affiliation></affiliation></author><author><name sortKey="Rivest, Jean" sort="Rivest, Jean" uniqKey="Rivest J" first="Jean" last="Rivest">Jean Rivest</name><affiliation><nlm:affiliation>Department of Neurology, University of Sherbrooke, Québec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Zweig, Richard" sort="Zweig, Richard" uniqKey="Zweig R" first="Richard" last="Zweig">Richard Zweig</name><affiliation><nlm:affiliation>Department of Neurology, Louisiana State University Health Science Center, Shreveport.</nlm:affiliation></affiliation></author><author><name sortKey="Lumina, L Pepper" sort="Lumina, L Pepper" uniqKey="Lumina L" first="L Pepper" last="Lumina">L Pepper Lumina</name><affiliation><nlm:affiliation>Department of Neurology, Louisiana State University Health Science Center, Shreveport.</nlm:affiliation></affiliation></author><author><name sortKey="Hilliard, Colette Lynn" sort="Hilliard, Colette Lynn" uniqKey="Hilliard C" first="Colette Lynn" last="Hilliard">Colette Lynn Hilliard</name><affiliation><nlm:affiliation>Lewis Hall Singletary Oncology Center, Thomasville, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Grill, Stephen" sort="Grill, Stephen" uniqKey="Grill S" first="Stephen" last="Grill">Stephen Grill</name><affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Kellermann, Marye" sort="Kellermann, Marye" uniqKey="Kellermann M" first="Marye" last="Kellermann">Marye Kellermann</name><affiliation><nlm:affiliation>Parkinson and Movement Disorders Center of Maryland, Elkridge.</nlm:affiliation></affiliation></author><author><name sortKey="Tuite, Paul" sort="Tuite, Paul" uniqKey="Tuite P" first="Paul" last="Tuite">Paul Tuite</name><affiliation><nlm:affiliation>Department of Neurology, University of Minnesota, Minneapolis.</nlm:affiliation></affiliation></author><author><name sortKey="Rolandelli, Susan" sort="Rolandelli, Susan" uniqKey="Rolandelli S" first="Susan" last="Rolandelli">Susan Rolandelli</name><affiliation><nlm:affiliation>Department of Neurology, University of Minnesota, Minneapolis.</nlm:affiliation></affiliation></author><author><name sortKey="Kang, Un Jung" sort="Kang, Un Jung" uniqKey="Kang U" first="Un Jung" last="Kang">Un Jung Kang</name><affiliation><nlm:affiliation>Department of Neurology, University of Chicago, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Young, Joan" sort="Young, Joan" uniqKey="Young J" first="Joan" last="Young">Joan Young</name><affiliation><nlm:affiliation>Department of Neurology, University of Chicago, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Rao, Jayaraman" sort="Rao, Jayaraman" uniqKey="Rao J" first="Jayaraman" last="Rao">Jayaraman Rao</name><affiliation><nlm:affiliation>Department of Neurology, Ochsner Clinic Foundation, New Orleans, Louisiana.</nlm:affiliation></affiliation></author><author><name sortKey="Cook, Maureen M" sort="Cook, Maureen M" uniqKey="Cook M" first="Maureen M" last="Cook">Maureen M. Cook</name><affiliation><nlm:affiliation>Department of Neurology, Ochsner Clinic Foundation, New Orleans, Louisiana.</nlm:affiliation></affiliation></author><author><name sortKey="Severt, Lawrence" sort="Severt, Lawrence" uniqKey="Severt L" first="Lawrence" last="Severt">Lawrence Severt</name><affiliation><nlm:affiliation>Department of Neurology, Beth Israel Medical Center, New York, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Boyar, Karyn" sort="Boyar, Karyn" uniqKey="Boyar K" first="Karyn" last="Boyar">Karyn Boyar</name><affiliation><nlm:affiliation>Department of Neurology, Beth Israel Medical Center, New York, New York.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24664227</idno><idno type="pmid">24664227</idno><idno type="doi">10.1001/jamaneurol.2014.131</idno><idno type="wicri:Area/PubMed/Corpus">000756</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000756</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit.</title><author><name sortKey="Beal, M Flint" sort="Beal, M Flint" uniqKey="Beal M" first="M Flint" last="Beal">M Flint Beal</name><affiliation><nlm:affiliation>Department of Neurology, Weill Cornell Medical College, New York Hospital, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Oakes, David" sort="Oakes, David" uniqKey="Oakes D" first="David" last="Oakes">David Oakes</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Rochester Medical Center, Rochester, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Shoulson, Ira" sort="Shoulson, Ira" uniqKey="Shoulson I" first="Ira" last="Shoulson">Ira Shoulson</name><affiliation><nlm:affiliation>Department of Neurology, Georgetown University, Washington, DC.</nlm:affiliation></affiliation></author><author><name sortKey="Henchcliffe, Claire" sort="Henchcliffe, Claire" uniqKey="Henchcliffe C" first="Claire" last="Henchcliffe">Claire Henchcliffe</name><affiliation><nlm:affiliation>Department of Neurology, Weill Cornell Medical College, New York Hospital, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Galpern, Wendy R" sort="Galpern, Wendy R" uniqKey="Galpern W" first="Wendy R" last="Galpern">Wendy R. Galpern</name><affiliation><nlm:affiliation>National Institutes of Health, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Haas, Richard" sort="Haas, Richard" uniqKey="Haas R" first="Richard" last="Haas">Richard Haas</name><affiliation><nlm:affiliation>Department of Neurosciences, University of California, San Diego, La Jolla.</nlm:affiliation></affiliation></author><author><name sortKey="Juncos, Jorge L" sort="Juncos, Jorge L" uniqKey="Juncos J" first="Jorge L" last="Juncos">Jorge L. Juncos</name><affiliation><nlm:affiliation>Department of Neurology, Emory University School of Medicine, Wesley Woods Center, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Nutt, John G" sort="Nutt, John G" uniqKey="Nutt J" first="John G" last="Nutt">John G. Nutt</name><affiliation><nlm:affiliation>Department of Neurology, Oregon Health and Science University, Portland.</nlm:affiliation></affiliation></author><author><name sortKey="Voss, Tiffini Smith" sort="Voss, Tiffini Smith" uniqKey="Voss T" first="Tiffini Smith" last="Voss">Tiffini Smith Voss</name><affiliation><nlm:affiliation>Merck, New Jersey.</nlm:affiliation></affiliation></author><author><name sortKey="Ravina, Bernard" sort="Ravina, Bernard" uniqKey="Ravina B" first="Bernard" last="Ravina">Bernard Ravina</name><affiliation><nlm:affiliation>Biogen Idec, Cambridge, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Shults, Clifford M" sort="Shults, Clifford M" uniqKey="Shults C" first="Clifford M" last="Shults">Clifford M. Shults</name><affiliation><nlm:affiliation>Department of Neurosciences, University of California, San Diego, La Jolla10VA Medical Center, San Diego, California.</nlm:affiliation></affiliation></author><author><name sortKey="Helles, Karen" sort="Helles, Karen" uniqKey="Helles K" first="Karen" last="Helles">Karen Helles</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Rochester Medical Center, Rochester, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Snively, Victoria" sort="Snively, Victoria" uniqKey="Snively V" first="Victoria" last="Snively">Victoria Snively</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Rochester Medical Center, Rochester, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F" last="Lew">Mark F. Lew</name><affiliation><nlm:affiliation>Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles.</nlm:affiliation></affiliation></author><author><name sortKey="Griebner, Brian" sort="Griebner, Brian" uniqKey="Griebner B" first="Brian" last="Griebner">Brian Griebner</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Rochester Medical Center, Rochester, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Watts, Arthur" sort="Watts, Arthur" uniqKey="Watts A" first="Arthur" last="Watts">Arthur Watts</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Rochester Medical Center, Rochester, New York12Department of Neurology, University of Rochester, Rochester, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Gao, Shan" sort="Gao, Shan" uniqKey="Gao S" first="Shan" last="Gao">Shan Gao</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Rochester Medical Center, Rochester, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Pourcher, Emmanuelle" sort="Pourcher, Emmanuelle" uniqKey="Pourcher E" first="Emmanuelle" last="Pourcher">Emmanuelle Pourcher</name><affiliation><nlm:affiliation>Québec Memory and Motor Skills Disorders Research Center, Clinique Sainte-Anne, Québec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Bond, Louisette" sort="Bond, Louisette" uniqKey="Bond L" first="Louisette" last="Bond">Louisette Bond</name><affiliation><nlm:affiliation>Québec Memory and Motor Skills Disorders Research Center, Clinique Sainte-Anne, Québec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Kompoliti, Katie" sort="Kompoliti, Katie" uniqKey="Kompoliti K" first="Katie" last="Kompoliti">Katie Kompoliti</name><affiliation><nlm:affiliation>Rush University Medical Center, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Agarwal, Pinky" sort="Agarwal, Pinky" uniqKey="Agarwal P" first="Pinky" last="Agarwal">Pinky Agarwal</name><affiliation><nlm:affiliation>Booth Gardner Parkinson's Care Center, EvergreenHealth, Kirkland, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Sia, Cherissa" sort="Sia, Cherissa" uniqKey="Sia C" first="Cherissa" last="Sia">Cherissa Sia</name><affiliation><nlm:affiliation>Booth Gardner Parkinson's Care Center, EvergreenHealth, Kirkland, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Jog, Mandar" sort="Jog, Mandar" uniqKey="Jog M" first="Mandar" last="Jog">Mandar Jog</name><affiliation><nlm:affiliation>London Health Sciences Centre, London, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Cole, Linda" sort="Cole, Linda" uniqKey="Cole L" first="Linda" last="Cole">Linda Cole</name><affiliation><nlm:affiliation>London Health Sciences Centre, London, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Sultana, Munira" sort="Sultana, Munira" uniqKey="Sultana M" first="Munira" last="Sultana">Munira Sultana</name><affiliation><nlm:affiliation>London Health Sciences Centre, London, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Kurlan, Roger" sort="Kurlan, Roger" uniqKey="Kurlan R" first="Roger" last="Kurlan">Roger Kurlan</name><affiliation><nlm:affiliation>Overlook Medical Center, Atlantic Neuroscience Institute, Summit, New Jersey.</nlm:affiliation></affiliation></author><author><name sortKey="Richard, Irene" sort="Richard, Irene" uniqKey="Richard I" first="Irene" last="Richard">Irene Richard</name><affiliation><nlm:affiliation>Department of Neurology, University of Rochester, Rochester, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Deeley, Cheryl" sort="Deeley, Cheryl" uniqKey="Deeley C" first="Cheryl" last="Deeley">Cheryl Deeley</name><affiliation><nlm:affiliation>Department of Neurology, University of Rochester, Rochester, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Waters, Cheryl H" sort="Waters, Cheryl H" uniqKey="Waters C" first="Cheryl H" last="Waters">Cheryl H. Waters</name><affiliation><nlm:affiliation>Columbia University Medical Center, Neurological Institute, New York, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Figueroa, Angel" sort="Figueroa, Angel" uniqKey="Figueroa A" first="Angel" last="Figueroa">Angel Figueroa</name><affiliation><nlm:affiliation>Columbia University Medical Center, Neurological Institute, New York, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Arkun, Ani" sort="Arkun, Ani" uniqKey="Arkun A" first="Ani" last="Arkun">Ani Arkun</name><affiliation><nlm:affiliation>Department of Neurology, Weill Cornell Medical College, New York Hospital, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Brodsky, Matthew" sort="Brodsky, Matthew" uniqKey="Brodsky M" first="Matthew" last="Brodsky">Matthew Brodsky</name><affiliation><nlm:affiliation>Department of Neurology, Oregon Health and Science University, Portland.</nlm:affiliation></affiliation></author><author><name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William G" last="Ondo">William G. Ondo</name><affiliation><nlm:affiliation>Department of Neurology, University of Texas Health Science Center at Houston.</nlm:affiliation></affiliation></author><author><name sortKey="Hunter, Christine B" sort="Hunter, Christine B" uniqKey="Hunter C" first="Christine B" last="Hunter">Christine B. Hunter</name><affiliation><nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, Texas.</nlm:affiliation></affiliation></author><author><name sortKey="Jimenez Shahed, Joohi" sort="Jimenez Shahed, Joohi" uniqKey="Jimenez Shahed J" first="Joohi" last="Jimenez-Shahed">Joohi Jimenez-Shahed</name><affiliation><nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, Texas.</nlm:affiliation></affiliation></author><author><name sortKey="Palao, Alicia" sort="Palao, Alicia" uniqKey="Palao A" first="Alicia" last="Palao">Alicia Palao</name><affiliation><nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, Texas.</nlm:affiliation></affiliation></author><author><name sortKey="Miyasaki, Janis M" sort="Miyasaki, Janis M" uniqKey="Miyasaki J" first="Janis M" last="Miyasaki">Janis M. Miyasaki</name><affiliation><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="So, Julie" sort="So, Julie" uniqKey="So J" first="Julie" last="So">Julie So</name><affiliation><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Tetrud, James" sort="Tetrud, James" uniqKey="Tetrud J" first="James" last="Tetrud">James Tetrud</name><affiliation><nlm:affiliation>The Parkinson's Institute and Clinical Center, Sunnyvale, California.</nlm:affiliation></affiliation></author><author><name sortKey="Reys, Liza" sort="Reys, Liza" uniqKey="Reys L" first="Liza" last="Reys">Liza Reys</name><affiliation><nlm:affiliation>The Parkinson's Institute and Clinical Center, Sunnyvale, California.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Katharine" sort="Smith, Katharine" uniqKey="Smith K" first="Katharine" last="Smith">Katharine Smith</name><affiliation><nlm:affiliation>The Parkinson's Institute and Clinical Center, Sunnyvale, California.</nlm:affiliation></affiliation></author><author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name><affiliation><nlm:affiliation>Department of Neurology, University of Miami School of Medicine, Miami, Florida.</nlm:affiliation></affiliation></author><author><name sortKey="Blenke, Anita" sort="Blenke, Anita" uniqKey="Blenke A" first="Anita" last="Blenke">Anita Blenke</name><affiliation><nlm:affiliation>Department of Neurology, University of Miami School of Medicine, Miami, Florida.</nlm:affiliation></affiliation></author><author><name sortKey="Russell, David S" sort="Russell, David S" uniqKey="Russell D" first="David S" last="Russell">David S. Russell</name><affiliation><nlm:affiliation>Institute for Neurodegenerative Disorders, New Haven, Connecticut.</nlm:affiliation></affiliation></author><author><name sortKey="Cotto, Candace" sort="Cotto, Candace" uniqKey="Cotto C" first="Candace" last="Cotto">Candace Cotto</name><affiliation><nlm:affiliation>Institute for Neurodegenerative Disorders, New Haven, Connecticut.</nlm:affiliation></affiliation></author><author><name sortKey="Friedman, Joseph H" sort="Friedman, Joseph H" uniqKey="Friedman J" first="Joseph H" last="Friedman">Joseph H. Friedman</name><affiliation><nlm:affiliation>Department of Neurology, Butler Hospital, Providence, Rhode Island26Alpert Medical School, Brown University, Providence, Rhode Island.</nlm:affiliation></affiliation></author><author><name sortKey="Lannon, Margaret" sort="Lannon, Margaret" uniqKey="Lannon M" first="Margaret" last="Lannon">Margaret Lannon</name><affiliation><nlm:affiliation>Department of Neurology, Butler Hospital, Providence, Rhode Island27Port City Neurology, Inc, Scarborough, Maine.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Lin" sort="Zhang, Lin" uniqKey="Zhang L" first="Lin" last="Zhang">Lin Zhang</name><affiliation><nlm:affiliation>Department of Neurology, University of California, Davis, School of Medicine and Sacramento VA Medical Center, Sacramento.</nlm:affiliation></affiliation></author><author><name sortKey="Drasby, Edward" sort="Drasby, Edward" uniqKey="Drasby E" first="Edward" last="Drasby">Edward Drasby</name><affiliation><nlm:affiliation>Port City Neurology, Inc, Scarborough, Maine.</nlm:affiliation></affiliation></author><author><name sortKey="Kumar, Rajeev" sort="Kumar, Rajeev" uniqKey="Kumar R" first="Rajeev" last="Kumar">Rajeev Kumar</name><affiliation><nlm:affiliation>Colorado Neurological Institute, Englewood.</nlm:affiliation></affiliation></author><author><name sortKey="Subramanian, Thyagarajan" sort="Subramanian, Thyagarajan" uniqKey="Subramanian T" first="Thyagarajan" last="Subramanian">Thyagarajan Subramanian</name><affiliation><nlm:affiliation>Milton S. Hershey Medical Center, Department of Neurology, Pennsylvania State Hershey College of Medicine, Hershey.</nlm:affiliation></affiliation></author><author><name sortKey="Ford, Donna Stuppy" sort="Ford, Donna Stuppy" uniqKey="Ford D" first="Donna Stuppy" last="Ford">Donna Stuppy Ford</name><affiliation><nlm:affiliation>Milton S. Hershey Medical Center, Department of Neurology, Pennsylvania State Hershey College of Medicine, Hershey.</nlm:affiliation></affiliation></author><author><name sortKey="Grimes, David A" sort="Grimes, David A" uniqKey="Grimes D" first="David A" last="Grimes">David A. Grimes</name><affiliation><nlm:affiliation>Ottawa Hospital Civic Site, Ottawa, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Cote, Diane" sort="Cote, Diane" uniqKey="Cote D" first="Diane" last="Cote">Diane Cote</name><affiliation><nlm:affiliation>Ottawa Hospital Civic Site, Ottawa, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Conway, Jennifer" sort="Conway, Jennifer" uniqKey="Conway J" first="Jennifer" last="Conway">Jennifer Conway</name><affiliation><nlm:affiliation>Ottawa Hospital Civic Site, Ottawa, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Siderowf, Andrew D" sort="Siderowf, Andrew D" uniqKey="Siderowf A" first="Andrew D" last="Siderowf">Andrew D. Siderowf</name><affiliation><nlm:affiliation>Avid Radiopharmaceuticals, Philadelphia, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Evatt, Marian Leslie" sort="Evatt, Marian Leslie" uniqKey="Evatt M" first="Marian Leslie" last="Evatt">Marian Leslie Evatt</name><affiliation><nlm:affiliation>Department of Neurology, Emory University School of Medicine, Wesley Woods Center, Atlanta, Georgia33Atlanta VA Medical Center, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Sommerfeld, Barbara" sort="Sommerfeld, Barbara" uniqKey="Sommerfeld B" first="Barbara" last="Sommerfeld">Barbara Sommerfeld</name><affiliation><nlm:affiliation>Department of Neurology, Emory University School of Medicine, Wesley Woods Center, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Lieberman, Abraham N" sort="Lieberman, Abraham N" uniqKey="Lieberman A" first="Abraham N" last="Lieberman">Abraham N. Lieberman</name><affiliation><nlm:affiliation>Muhammad Ali Parkinson Center, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, Arizona.</nlm:affiliation></affiliation></author><author><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S" last="Okun">Michael S. Okun</name><affiliation><nlm:affiliation>Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville.</nlm:affiliation></affiliation></author><author><name sortKey="Rodriguez, Ramon L" sort="Rodriguez, Ramon L" uniqKey="Rodriguez R" first="Ramon L" last="Rodriguez">Ramon L. Rodriguez</name><affiliation><nlm:affiliation>Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville.</nlm:affiliation></affiliation></author><author><name sortKey="Merritt, Stacy" sort="Merritt, Stacy" uniqKey="Merritt S" first="Stacy" last="Merritt">Stacy Merritt</name><affiliation><nlm:affiliation>Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville.</nlm:affiliation></affiliation></author><author><name sortKey="Swartz, Camille Louise" sort="Swartz, Camille Louise" uniqKey="Swartz C" first="Camille Louise" last="Swartz">Camille Louise Swartz</name><affiliation><nlm:affiliation>Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville.</nlm:affiliation></affiliation></author><author><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W R Wayne" last="Martin">W R Wayne Martin</name><affiliation><nlm:affiliation>Glenrose Rehabilitation Hospital, University of Alberta, Edmonton, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="King, Pamela" sort="King, Pamela" uniqKey="King P" first="Pamela" last="King">Pamela King</name><affiliation><nlm:affiliation>Glenrose Rehabilitation Hospital, University of Alberta, Edmonton, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Stover, Natividad" sort="Stover, Natividad" uniqKey="Stover N" first="Natividad" last="Stover">Natividad Stover</name><affiliation><nlm:affiliation>Department of Neurology, University of Alabama at Birmingham.</nlm:affiliation></affiliation></author><author><name sortKey="Guthrie, Stephanie" sort="Guthrie, Stephanie" uniqKey="Guthrie S" first="Stephanie" last="Guthrie">Stephanie Guthrie</name><affiliation><nlm:affiliation>Department of Neurology, University of Alabama at Birmingham.</nlm:affiliation></affiliation></author><author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L" last="Watts">Ray L. Watts</name><affiliation><nlm:affiliation>Department of Neurology, University of Alabama at Birmingham.</nlm:affiliation></affiliation></author><author><name sortKey="Ahmed, Anwar" sort="Ahmed, Anwar" uniqKey="Ahmed A" first="Anwar" last="Ahmed">Anwar Ahmed</name><affiliation><nlm:affiliation>Center for Neurological Restoration, Department of Neurology, Cleveland Clinic, Cleveland, Ohio.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H" last="Fernandez">Hubert H. Fernandez</name><affiliation><nlm:affiliation>Center for Neurological Restoration, Department of Neurology, Cleveland Clinic, Cleveland, Ohio.</nlm:affiliation></affiliation></author><author><name sortKey="Winters, Adrienna" sort="Winters, Adrienna" uniqKey="Winters A" first="Adrienna" last="Winters">Adrienna Winters</name><affiliation><nlm:affiliation>Center for Neurological Restoration, Department of Neurology, Cleveland Clinic, Cleveland, Ohio.</nlm:affiliation></affiliation></author><author><name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name><affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Dawson, Ted M" sort="Dawson, Ted M" uniqKey="Dawson T" first="Ted M" last="Dawson">Ted M. Dawson</name><affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Dunlop, Becky" sort="Dunlop, Becky" uniqKey="Dunlop B" first="Becky" last="Dunlop">Becky Dunlop</name><affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Feigin, Andrew S" sort="Feigin, Andrew S" uniqKey="Feigin A" first="Andrew S" last="Feigin">Andrew S. Feigin</name><affiliation><nlm:affiliation>Feinstein Institute for Medical Research, Center for Neurosciences, Manhasset, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Shannon, Barbara" sort="Shannon, Barbara" uniqKey="Shannon B" first="Barbara" last="Shannon">Barbara Shannon</name><affiliation><nlm:affiliation>Feinstein Institute for Medical Research, Center for Neurosciences, Manhasset, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Nirenberg, Melissa Jill" sort="Nirenberg, Melissa Jill" uniqKey="Nirenberg M" first="Melissa Jill" last="Nirenberg">Melissa Jill Nirenberg</name><affiliation><nlm:affiliation>Department of Neurology, New York University Langone Medical Center, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Ogg, Mattson" sort="Ogg, Mattson" uniqKey="Ogg M" first="Mattson" last="Ogg">Mattson Ogg</name><affiliation><nlm:affiliation>Department of Neurology, Weill Cornell Medical College, New York Hospital, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Ellias, Samuel A" sort="Ellias, Samuel A" uniqKey="Ellias S" first="Samuel A" last="Ellias">Samuel A. Ellias</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, Cathi Ann" sort="Thomas, Cathi Ann" uniqKey="Thomas C" first="Cathi-Ann" last="Thomas">Cathi-Ann Thomas</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Frei, Karen" sort="Frei, Karen" uniqKey="Frei K" first="Karen" last="Frei">Karen Frei</name><affiliation><nlm:affiliation>The Parkinson's and Movement Disorder Institute, Fountain Valley, California.</nlm:affiliation></affiliation></author><author><name sortKey="Bodis Wollner, Ivan" sort="Bodis Wollner, Ivan" uniqKey="Bodis Wollner I" first="Ivan" last="Bodis-Wollner">Ivan Bodis-Wollner</name><affiliation><nlm:affiliation>State University of New York, Downstate Medical Center, Brooklyn, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Glazman, Sofya" sort="Glazman, Sofya" uniqKey="Glazman S" first="Sofya" last="Glazman">Sofya Glazman</name><affiliation><nlm:affiliation>State University of New York, Downstate Medical Center, Brooklyn, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Mayer, Thomas" sort="Mayer, Thomas" uniqKey="Mayer T" first="Thomas" last="Mayer">Thomas Mayer</name><affiliation><nlm:affiliation>State University of New York, Downstate Medical Center, Brooklyn, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A" last="Hauser">Robert A. Hauser</name><affiliation><nlm:affiliation>Department of Neurology, University of South Florida, Tampa.</nlm:affiliation></affiliation></author><author><name sortKey="Pahwa, Rajesh" sort="Pahwa, Rajesh" uniqKey="Pahwa R" first="Rajesh" last="Pahwa">Rajesh Pahwa</name><affiliation><nlm:affiliation>Department of Neurology, University of Kansas Medical Center, Kansas City.</nlm:affiliation></affiliation></author><author><name sortKey="Langhammer, April" sort="Langhammer, April" uniqKey="Langhammer A" first="April" last="Langhammer">April Langhammer</name><affiliation><nlm:affiliation>Department of Neurology, University of Kansas Medical Center, Kansas City.</nlm:affiliation></affiliation></author><author><name sortKey="Ranawaya, Ranjit" sort="Ranawaya, Ranjit" uniqKey="Ranawaya R" first="Ranjit" last="Ranawaya">Ranjit Ranawaya</name><affiliation><nlm:affiliation>Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Derwent, Lorelei" sort="Derwent, Lorelei" uniqKey="Derwent L" first="Lorelei" last="Derwent">Lorelei Derwent</name><affiliation><nlm:affiliation>Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Sethi, Kapil D" sort="Sethi, Kapil D" uniqKey="Sethi K" first="Kapil D" last="Sethi">Kapil D. Sethi</name><affiliation><nlm:affiliation>Department of Neurology, Georgia Health Science University, Augusta.</nlm:affiliation></affiliation></author><author><name sortKey="Farrow, Buff" sort="Farrow, Buff" uniqKey="Farrow B" first="Buff" last="Farrow">Buff Farrow</name><affiliation><nlm:affiliation>Department of Neurology, Georgia Health Science University, Augusta.</nlm:affiliation></affiliation></author><author><name sortKey="Prakash, Rajan" sort="Prakash, Rajan" uniqKey="Prakash R" first="Rajan" last="Prakash">Rajan Prakash</name><affiliation><nlm:affiliation>Department of Neurology, Georgia Health Science University, Augusta.</nlm:affiliation></affiliation></author><author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name><affiliation><nlm:affiliation>Department of Neurosciences, University of California, San Diego, La Jolla.</nlm:affiliation></affiliation></author><author><name sortKey="Robinson, Annette" sort="Robinson, Annette" uniqKey="Robinson A" first="Annette" last="Robinson">Annette Robinson</name><affiliation><nlm:affiliation>Department of Neurology, University of Louisville, Kentucky.</nlm:affiliation></affiliation></author><author><name sortKey="Sahay, Alok" sort="Sahay, Alok" uniqKey="Sahay A" first="Alok" last="Sahay">Alok Sahay</name><affiliation><nlm:affiliation>University of Cincinnati College of Medicine, Cincinnati, Ohio.</nlm:affiliation></affiliation></author><author><name sortKey="Gartner, Maureen" sort="Gartner, Maureen" uniqKey="Gartner M" first="Maureen" last="Gartner">Maureen Gartner</name><affiliation><nlm:affiliation>University of Cincinnati College of Medicine, Cincinnati, Ohio.</nlm:affiliation></affiliation></author><author><name sortKey="Hinson, Vanessa K" sort="Hinson, Vanessa K" uniqKey="Hinson V" first="Vanessa K" last="Hinson">Vanessa K. Hinson</name><affiliation><nlm:affiliation>Department of Neurology, Medical University of South Carolina, Charleston.</nlm:affiliation></affiliation></author><author><name sortKey="Markind, Samuel" sort="Markind, Samuel" uniqKey="Markind S" first="Samuel" last="Markind">Samuel Markind</name><affiliation><nlm:affiliation>Associated Neurologists, PC, Danbury, Connecticut.</nlm:affiliation></affiliation></author><author><name sortKey="Pelikan, Melisa" sort="Pelikan, Melisa" uniqKey="Pelikan M" first="Melisa" last="Pelikan">Melisa Pelikan</name><affiliation><nlm:affiliation>Associated Neurologists, PC, Danbury, Connecticut.</nlm:affiliation></affiliation></author><author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name><affiliation><nlm:affiliation>Department of Neurology, Washington University in St Louis, Missouri.</nlm:affiliation></affiliation></author><author><name sortKey="Hartlein, Johanna" sort="Hartlein, Johanna" uniqKey="Hartlein J" first="Johanna" last="Hartlein">Johanna Hartlein</name><affiliation><nlm:affiliation>Department of Neurology, Washington University in St Louis, Missouri.</nlm:affiliation></affiliation></author><author><name sortKey="Molho, Eric" sort="Molho, Eric" uniqKey="Molho E" first="Eric" last="Molho">Eric Molho</name><affiliation><nlm:affiliation>Movement Disorders Center, Albany Medical Center, Albany, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Evans, Sharon" sort="Evans, Sharon" uniqKey="Evans S" first="Sharon" last="Evans">Sharon Evans</name><affiliation><nlm:affiliation>Movement Disorders Center, Albany Medical Center, Albany, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H" last="Adler">Charles H. Adler</name><affiliation><nlm:affiliation>Parkinson's Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic, Scottsdale, Arizona.</nlm:affiliation></affiliation></author><author><name sortKey="Duffy, Amy" sort="Duffy, Amy" uniqKey="Duffy A" first="Amy" last="Duffy">Amy Duffy</name><affiliation><nlm:affiliation>Parkinson's Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic, Scottsdale, Arizona.</nlm:affiliation></affiliation></author><author><name sortKey="Lind, Marlene" sort="Lind, Marlene" uniqKey="Lind M" first="Marlene" last="Lind">Marlene Lind</name><affiliation><nlm:affiliation>Parkinson's Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic, Scottsdale, Arizona.</nlm:affiliation></affiliation></author><author><name sortKey="Elmer, Lawrence" sort="Elmer, Lawrence" uniqKey="Elmer L" first="Lawrence" last="Elmer">Lawrence Elmer</name><affiliation><nlm:affiliation>Center for Neurological Health, University of Toledo, Toledo, Ohio.</nlm:affiliation></affiliation></author><author><name sortKey="Davis, Kathy" sort="Davis, Kathy" uniqKey="Davis K" first="Kathy" last="Davis">Kathy Davis</name><affiliation><nlm:affiliation>Department of Neurology, Medical University of Ohio at Toledo.</nlm:affiliation></affiliation></author><author><name sortKey="Spears, Julia" sort="Spears, Julia" uniqKey="Spears J" first="Julia" last="Spears">Julia Spears</name><affiliation><nlm:affiliation>Department of Neurology, Medical University of Ohio at Toledo.</nlm:affiliation></affiliation></author><author><name sortKey="Wilson, Stephanie" sort="Wilson, Stephanie" uniqKey="Wilson S" first="Stephanie" last="Wilson">Stephanie Wilson</name><affiliation><nlm:affiliation>Department of Neurology, Medical University of Ohio at Toledo.</nlm:affiliation></affiliation></author><author><name sortKey="Leehey, Maureen A" sort="Leehey, Maureen A" uniqKey="Leehey M" first="Maureen A" last="Leehey">Maureen A. Leehey</name><affiliation><nlm:affiliation>Department of Neurology, University of Colorado Health Science Center, Denver.</nlm:affiliation></affiliation></author><author><name sortKey="Hermanowicz, Neal" sort="Hermanowicz, Neal" uniqKey="Hermanowicz N" first="Neal" last="Hermanowicz">Neal Hermanowicz</name><affiliation><nlm:affiliation>Department of Neurology, University of California, Irvine Medical Center, Irvine.</nlm:affiliation></affiliation></author><author><name sortKey="Niswonger, Shari" sort="Niswonger, Shari" uniqKey="Niswonger S" first="Shari" last="Niswonger">Shari Niswonger</name><affiliation><nlm:affiliation>Department of Neurology, University of California, Irvine Medical Center, Irvine.</nlm:affiliation></affiliation></author><author><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A" last="Shill">Holly A. Shill</name><affiliation><nlm:affiliation>Banner Sun Health Research Institute, Sun City, Arizona.</nlm:affiliation></affiliation></author><author><name sortKey="Obradov, Sanja" sort="Obradov, Sanja" uniqKey="Obradov S" first="Sanja" last="Obradov">Sanja Obradov</name><affiliation><nlm:affiliation>Banner Sun Health Research Institute, Sun City, Arizona.</nlm:affiliation></affiliation></author><author><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name><affiliation><nlm:affiliation>Department of Neurology, University of Saskatchewan, Royal University Hospital, Saskatchewan, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Cowper, Marilyn" sort="Cowper, Marilyn" uniqKey="Cowper M" first="Marilyn" last="Cowper">Marilyn Cowper</name><affiliation><nlm:affiliation>Department of Neurology, University of Saskatchewan, Royal University Hospital, Saskatchewan, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Lessig, Stephanie" sort="Lessig, Stephanie" uniqKey="Lessig S" first="Stephanie" last="Lessig">Stephanie Lessig</name><affiliation><nlm:affiliation>Department of Neurology, University of California, San Diego, La Jolla.</nlm:affiliation></affiliation></author><author><name sortKey="Song, David" sort="Song, David" uniqKey="Song D" first="David" last="Song">David Song</name><affiliation><nlm:affiliation>Department of Neurology, University of California, San Diego, La Jolla.</nlm:affiliation></affiliation></author><author><name sortKey="Fontaine, Deborah" sort="Fontaine, Deborah" uniqKey="Fontaine D" first="Deborah" last="Fontaine">Deborah Fontaine</name><affiliation><nlm:affiliation>Department of Neurology, University of California, San Diego, La Jolla.</nlm:affiliation></affiliation></author><author><name sortKey="Zadikoff, Cindy" sort="Zadikoff, Cindy" uniqKey="Zadikoff C" first="Cindy" last="Zadikoff">Cindy Zadikoff</name><affiliation><nlm:affiliation>Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Williams, Karen" sort="Williams, Karen" uniqKey="Williams K" first="Karen" last="Williams">Karen Williams</name><affiliation><nlm:affiliation>Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Blindauer, Karen A" sort="Blindauer, Karen A" uniqKey="Blindauer K" first="Karen A" last="Blindauer">Karen A. Blindauer</name><affiliation><nlm:affiliation>Department of Neurology, Medical College of Wisconsin, Milwaukee.</nlm:affiliation></affiliation></author><author><name sortKey="Bergholte, Jo" sort="Bergholte, Jo" uniqKey="Bergholte J" first="Jo" last="Bergholte">Jo Bergholte</name><affiliation><nlm:affiliation>Department of Neurology, Medical College of Wisconsin, Milwaukee.</nlm:affiliation></affiliation></author><author><name sortKey="Propsom, Clara Schindler" sort="Propsom, Clara Schindler" uniqKey="Propsom C" first="Clara Schindler" last="Propsom">Clara Schindler Propsom</name><affiliation><nlm:affiliation>Department of Neurology, Medical College of Wisconsin, Milwaukee.</nlm:affiliation></affiliation></author><author><name sortKey="Stacy, Mark A" sort="Stacy, Mark A" uniqKey="Stacy M" first="Mark A" last="Stacy">Mark A. Stacy</name><affiliation><nlm:affiliation>Department of Neurology, Duke University, Durham, North Carolina.</nlm:affiliation></affiliation></author><author><name sortKey="Field, Joanne" sort="Field, Joanne" uniqKey="Field J" first="Joanne" last="Field">Joanne Field</name><affiliation><nlm:affiliation>Department of Neurology, Duke University, Durham, North Carolina.</nlm:affiliation></affiliation></author><author><name sortKey="Mihaila, Dragos" sort="Mihaila, Dragos" uniqKey="Mihaila D" first="Dragos" last="Mihaila">Dragos Mihaila</name><affiliation><nlm:affiliation>State University of New York Upstate Medical Center and Syracuse VA Medical Center, Syracuse.</nlm:affiliation></affiliation></author><author><name sortKey="Chilton, Mark" sort="Chilton, Mark" uniqKey="Chilton M" first="Mark" last="Chilton">Mark Chilton</name><affiliation><nlm:affiliation>State University of New York Upstate Medical Center and Syracuse VA Medical Center, Syracuse.</nlm:affiliation></affiliation></author><author><name sortKey="Uc, Ergun Y" sort="Uc, Ergun Y" uniqKey="Uc E" first="Ergun Y" last="Uc">Ergun Y. Uc</name><affiliation><nlm:affiliation>Department of Neurology, University of Iowa, Iowa City.</nlm:affiliation></affiliation></author><author><name sortKey="Sieren, Jeri" sort="Sieren, Jeri" uniqKey="Sieren J" first="Jeri" last="Sieren">Jeri Sieren</name><affiliation><nlm:affiliation>Department of Neurology, University of Iowa, Iowa City.</nlm:affiliation></affiliation></author><author><name sortKey="Simon, David K" sort="Simon, David K" uniqKey="Simon D" first="David K" last="Simon">David K. Simon</name><affiliation><nlm:affiliation>Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Kraics, Lauren" sort="Kraics, Lauren" uniqKey="Kraics L" first="Lauren" last="Kraics">Lauren Kraics</name><affiliation><nlm:affiliation>Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Silver, Althea" sort="Silver, Althea" uniqKey="Silver A" first="Althea" last="Silver">Althea Silver</name><affiliation><nlm:affiliation>Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Boyd, James T" sort="Boyd, James T" uniqKey="Boyd J" first="James T" last="Boyd">James T. Boyd</name><affiliation><nlm:affiliation>Department of Neurology, University of Vermont College of Medicine, Burlington.</nlm:affiliation></affiliation></author><author><name sortKey="Hamill, Robert W" sort="Hamill, Robert W" uniqKey="Hamill R" first="Robert W" last="Hamill">Robert W. Hamill</name><affiliation><nlm:affiliation>Department of Neurology, University of Vermont College of Medicine, Burlington.</nlm:affiliation></affiliation></author><author><name sortKey="Ingvoldstad, Christopher" sort="Ingvoldstad, Christopher" uniqKey="Ingvoldstad C" first="Christopher" last="Ingvoldstad">Christopher Ingvoldstad</name><affiliation><nlm:affiliation>Department of Neurology, University of Vermont College of Medicine, Burlington.</nlm:affiliation></affiliation></author><author><name sortKey="Young, Jennifer" sort="Young, Jennifer" uniqKey="Young J" first="Jennifer" last="Young">Jennifer Young</name><affiliation><nlm:affiliation>Department of Neurology, University of Vermont College of Medicine, Burlington.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, Karen" sort="Thomas, Karen" uniqKey="Thomas K" first="Karen" last="Thomas">Karen Thomas</name><affiliation><nlm:affiliation>Department of Neurology, Ohio State University, Columbus.</nlm:affiliation></affiliation></author><author><name sortKey="Kostyk, Sandra K" sort="Kostyk, Sandra K" uniqKey="Kostyk S" first="Sandra K" last="Kostyk">Sandra K. Kostyk</name><affiliation><nlm:affiliation>Department of Neurology, Ohio State University, Columbus.</nlm:affiliation></affiliation></author><author><name sortKey="Wojcieszek, Joanne" sort="Wojcieszek, Joanne" uniqKey="Wojcieszek J" first="Joanne" last="Wojcieszek">Joanne Wojcieszek</name><affiliation><nlm:affiliation>Department of Neurology, Indiana University School of Medicine, Indianapolis.</nlm:affiliation></affiliation></author><author><name sortKey="Pfeiffer, Ronald F" sort="Pfeiffer, Ronald F" uniqKey="Pfeiffer R" first="Ronald F" last="Pfeiffer">Ronald F. Pfeiffer</name><affiliation><nlm:affiliation>Department of Neurology, University of Tennessee Health Science Center, Memphis.</nlm:affiliation></affiliation></author><author><name sortKey="Panisset, Michel" sort="Panisset, Michel" uniqKey="Panisset M" first="Michel" last="Panisset">Michel Panisset</name><affiliation><nlm:affiliation>Department of Neurology, CHUM-Hôpital Notre-Dame, Montréal, Québec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Beland, Monica" sort="Beland, Monica" uniqKey="Beland M" first="Monica" last="Beland">Monica Beland</name><affiliation><nlm:affiliation>Department of Neurology, CHUM-Hôpital Notre-Dame, Montréal, Québec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Reich, Stephen G" sort="Reich, Stephen G" uniqKey="Reich S" first="Stephen G" last="Reich">Stephen G. Reich</name><affiliation><nlm:affiliation>Department of Neurology, University of Maryland School of Science, Baltimore.</nlm:affiliation></affiliation></author><author><name sortKey="Cines, Michelle" sort="Cines, Michelle" uniqKey="Cines M" first="Michelle" last="Cines">Michelle Cines</name><affiliation><nlm:affiliation>Department of Neurology, University of Maryland School of Science, Baltimore.</nlm:affiliation></affiliation></author><author><name sortKey="Zappala, Nancy" sort="Zappala, Nancy" uniqKey="Zappala N" first="Nancy" last="Zappala">Nancy Zappala</name><affiliation><nlm:affiliation>Department of Neurology, University of Maryland School of Science, Baltimore.</nlm:affiliation></affiliation></author><author><name sortKey="Rivest, Jean" sort="Rivest, Jean" uniqKey="Rivest J" first="Jean" last="Rivest">Jean Rivest</name><affiliation><nlm:affiliation>Department of Neurology, University of Sherbrooke, Québec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Zweig, Richard" sort="Zweig, Richard" uniqKey="Zweig R" first="Richard" last="Zweig">Richard Zweig</name><affiliation><nlm:affiliation>Department of Neurology, Louisiana State University Health Science Center, Shreveport.</nlm:affiliation></affiliation></author><author><name sortKey="Lumina, L Pepper" sort="Lumina, L Pepper" uniqKey="Lumina L" first="L Pepper" last="Lumina">L Pepper Lumina</name><affiliation><nlm:affiliation>Department of Neurology, Louisiana State University Health Science Center, Shreveport.</nlm:affiliation></affiliation></author><author><name sortKey="Hilliard, Colette Lynn" sort="Hilliard, Colette Lynn" uniqKey="Hilliard C" first="Colette Lynn" last="Hilliard">Colette Lynn Hilliard</name><affiliation><nlm:affiliation>Lewis Hall Singletary Oncology Center, Thomasville, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Grill, Stephen" sort="Grill, Stephen" uniqKey="Grill S" first="Stephen" last="Grill">Stephen Grill</name><affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Kellermann, Marye" sort="Kellermann, Marye" uniqKey="Kellermann M" first="Marye" last="Kellermann">Marye Kellermann</name><affiliation><nlm:affiliation>Parkinson and Movement Disorders Center of Maryland, Elkridge.</nlm:affiliation></affiliation></author><author><name sortKey="Tuite, Paul" sort="Tuite, Paul" uniqKey="Tuite P" first="Paul" last="Tuite">Paul Tuite</name><affiliation><nlm:affiliation>Department of Neurology, University of Minnesota, Minneapolis.</nlm:affiliation></affiliation></author><author><name sortKey="Rolandelli, Susan" sort="Rolandelli, Susan" uniqKey="Rolandelli S" first="Susan" last="Rolandelli">Susan Rolandelli</name><affiliation><nlm:affiliation>Department of Neurology, University of Minnesota, Minneapolis.</nlm:affiliation></affiliation></author><author><name sortKey="Kang, Un Jung" sort="Kang, Un Jung" uniqKey="Kang U" first="Un Jung" last="Kang">Un Jung Kang</name><affiliation><nlm:affiliation>Department of Neurology, University of Chicago, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Young, Joan" sort="Young, Joan" uniqKey="Young J" first="Joan" last="Young">Joan Young</name><affiliation><nlm:affiliation>Department of Neurology, University of Chicago, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Rao, Jayaraman" sort="Rao, Jayaraman" uniqKey="Rao J" first="Jayaraman" last="Rao">Jayaraman Rao</name><affiliation><nlm:affiliation>Department of Neurology, Ochsner Clinic Foundation, New Orleans, Louisiana.</nlm:affiliation></affiliation></author><author><name sortKey="Cook, Maureen M" sort="Cook, Maureen M" uniqKey="Cook M" first="Maureen M" last="Cook">Maureen M. Cook</name><affiliation><nlm:affiliation>Department of Neurology, Ochsner Clinic Foundation, New Orleans, Louisiana.</nlm:affiliation></affiliation></author><author><name sortKey="Severt, Lawrence" sort="Severt, Lawrence" uniqKey="Severt L" first="Lawrence" last="Severt">Lawrence Severt</name><affiliation><nlm:affiliation>Department of Neurology, Beth Israel Medical Center, New York, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Boyar, Karyn" sort="Boyar, Karyn" uniqKey="Boyar K" first="Karyn" last="Boyar">Karyn Boyar</name><affiliation><nlm:affiliation>Department of Neurology, Beth Israel Medical Center, New York, New York.</nlm:affiliation></affiliation></author></analytic><series><title level="j">JAMA neurology</title><idno type="eISSN">2168-6157</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antioxidants (administration & dosage)</term><term>Antioxidants (metabolism)</term><term>Dose-Response Relationship, Drug</term><term>Double-Blind Method</term><term>Early Diagnosis</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (enzymology)</term><term>Prospective Studies</term><term>Treatment Outcome</term><term>Ubiquinone (administration & dosage)</term><term>Ubiquinone (analogs & derivatives)</term><term>Ubiquinone (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antioxidants</term><term>Ubiquinone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Ubiquinone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Ubiquinone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antioxidants</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Dose-Response Relationship, Drug</term><term>Double-Blind Method</term><term>Early Diagnosis</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coenzyme Q10 (CoQ10), an antioxidant that supports mitochondrial function, has been shown in preclinical Parkinson disease (PD) models to reduce the loss of dopamine neurons, and was safe and well tolerated in early-phase human studies. A previous phase II study suggested possible clinical benefit.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24664227</PMID><DateCreated><Year>2014</Year><Month>05</Month><Day>13</Day></DateCreated><DateCompleted><Year>2014</Year><Month>07</Month><Day>07</Day></DateCompleted><DateRevised><Year>2017</Year><Month>01</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2168-6157</ISSN><JournalIssue CitedMedium="Internet"><Volume>71</Volume><Issue>5</Issue><PubDate><Year>2014</Year><Month>May</Month></PubDate></JournalIssue><Title>JAMA neurology</Title><ISOAbbreviation>JAMA Neurol</ISOAbbreviation></Journal><ArticleTitle>A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit.</ArticleTitle><Pagination><MedlinePgn>543-52</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1001/jamaneurol.2014.131</ELocationID><Abstract><AbstractText Label="IMPORTANCE" NlmCategory="OBJECTIVE">Coenzyme Q10 (CoQ10), an antioxidant that supports mitochondrial function, has been shown in preclinical Parkinson disease (PD) models to reduce the loss of dopamine neurons, and was safe and well tolerated in early-phase human studies. A previous phase II study suggested possible clinical benefit.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To examine whether CoQ10 could slow disease progression in early PD.</AbstractText><AbstractText Label="DESIGN, SETTING, AND PARTICIPANTS" NlmCategory="METHODS">A phase III randomized, placebo-controlled, double-blind clinical trial at 67 North American sites consisting of participants 30 years of age or older who received a diagnosis of PD within 5 years and who had the following inclusion criteria: the presence of a rest tremor, bradykinesia, and rigidity; a modified Hoehn and Yahr stage of 2.5 or less; and no anticipated need for dopaminergic therapy within 3 months. Exclusion criteria included the use of any PD medication within 60 days, the use of any symptomatic PD medication for more than 90 days, atypical or drug-induced parkinsonism, a Unified Parkinson's Disease Rating Scale (UPDRS) rest tremor score of 3 or greater for any limb, a Mini-Mental State Examination score of 25 or less, a history of stroke, the use of certain supplements, and substantial recent exposure to CoQ10. Of 696 participants screened, 78 were found to be ineligible, and 18 declined participation.</AbstractText><AbstractText Label="INTERVENTIONS" NlmCategory="METHODS">The remaining 600 participants were randomly assigned to receive placebo, 1200 mg/d of CoQ10, or 2400 mg/d of CoQ10; all participants received 1200 IU/d of vitamin E.</AbstractText><AbstractText Label="MAIN OUTCOMES AND MEASURES" NlmCategory="METHODS">Participants were observed for 16 months or until a disability requiring dopaminergic treatment. The prospectively defined primary outcome measure was the change in total UPDRS score (Parts I-III) from baseline to final visit. The study was powered to detect a 3-point difference between an active treatment and placebo.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The baseline characteristics of the participants were well balanced, the mean age was 62.5 years, 66% of participants were male, and the mean baseline total UPDRS score was 22.7. A total of 267 participants required treatment (94 received placebo, 87 received 1200 mg/d of CoQ10, and 86 received 2400 mg/d of CoQ10), and 65 participants (29 who received placebo, 19 who received 1200 mg/d of CoQ10, and 17 who received 2400 mg/d of CoQ10) withdrew prematurely. Treatments were well tolerated with no safety concerns. The study was terminated after a prespecified futility criterion was reached. At study termination, both active treatment groups showed slight adverse trends relative to placebo. Adjusted mean changes (worsening) in total UPDRS scores from baseline to final visit were 6.9 points (placebo), 7.5 points (1200 mg/d of CoQ10; P = .49 relative to placebo), and 8.0 points (2400 mg/d of CoQ10; P = .21 relative to placebo).</AbstractText><AbstractText Label="CONCLUSIONS AND RELEVANCE" NlmCategory="CONCLUSIONS">Coenzyme Q10 was safe and well tolerated in this population, but showed no evidence of clinical benefit.</AbstractText><AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">clinicaltrials.gov Identifier: NCT00740714.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><CollectiveName>Parkinson Study Group QE3 Investigators</CollectiveName></Author><Author ValidYN="Y"><LastName>Beal</LastName><ForeName>M Flint</ForeName><Initials>MF</Initials><AffiliationInfo><Affiliation>Department of Neurology, Weill Cornell Medical College, New York Hospital, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oakes</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of Rochester Medical Center, Rochester, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shoulson</LastName><ForeName>Ira</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Neurology, Georgetown University, Washington, DC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Henchcliffe</LastName><ForeName>Claire</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Neurology, Weill Cornell Medical College, New York Hospital, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Galpern</LastName><ForeName>Wendy R</ForeName><Initials>WR</Initials><AffiliationInfo><Affiliation>National Institutes of Health, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haas</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neurosciences, University of California, San Diego, La Jolla.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Juncos</LastName><ForeName>Jorge L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Department of Neurology, Emory University School of Medicine, Wesley Woods Center, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nutt</LastName><ForeName>John G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Department of Neurology, Oregon Health and Science University, Portland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Voss</LastName><ForeName>Tiffini Smith</ForeName><Initials>TS</Initials><AffiliationInfo><Affiliation>Merck, New Jersey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ravina</LastName><ForeName>Bernard</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Biogen Idec, Cambridge, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shults</LastName><ForeName>Clifford M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Department of Neurosciences, University of California, San Diego, La Jolla10VA Medical Center, San Diego, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Helles</LastName><ForeName>Karen</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of Rochester Medical Center, Rochester, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Snively</LastName><ForeName>Victoria</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of Rochester Medical Center, Rochester, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lew</LastName><ForeName>Mark F</ForeName><Initials>MF</Initials><AffiliationInfo><Affiliation>Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Griebner</LastName><ForeName>Brian</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of Rochester Medical Center, Rochester, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Watts</LastName><ForeName>Arthur</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of Rochester Medical Center, Rochester, New York12Department of Neurology, University of Rochester, Rochester, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Shan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of Rochester Medical Center, Rochester, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pourcher</LastName><ForeName>Emmanuelle</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Québec Memory and Motor Skills Disorders Research Center, Clinique Sainte-Anne, Québec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bond</LastName><ForeName>Louisette</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Québec Memory and Motor Skills Disorders Research Center, Clinique Sainte-Anne, Québec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kompoliti</LastName><ForeName>Katie</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Rush University Medical Center, Chicago, Illinois.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Agarwal</LastName><ForeName>Pinky</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Booth Gardner Parkinson's Care Center, EvergreenHealth, Kirkland, Washington.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sia</LastName><ForeName>Cherissa</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Booth Gardner Parkinson's Care Center, EvergreenHealth, Kirkland, Washington.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jog</LastName><ForeName>Mandar</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>London Health Sciences Centre, London, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cole</LastName><ForeName>Linda</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>London Health Sciences Centre, London, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sultana</LastName><ForeName>Munira</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>London Health Sciences Centre, London, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kurlan</LastName><ForeName>Roger</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Overlook Medical Center, Atlantic Neuroscience Institute, Summit, New Jersey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richard</LastName><ForeName>Irene</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Rochester, Rochester, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deeley</LastName><ForeName>Cheryl</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Rochester, Rochester, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Waters</LastName><ForeName>Cheryl H</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Columbia University Medical Center, Neurological Institute, New York, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Figueroa</LastName><ForeName>Angel</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Columbia University Medical Center, Neurological Institute, New York, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arkun</LastName><ForeName>Ani</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, Weill Cornell Medical College, New York Hospital, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brodsky</LastName><ForeName>Matthew</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, Oregon Health and Science University, Portland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ondo</LastName><ForeName>William G</ForeName><Initials>WG</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Texas Health Science Center at Houston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hunter</LastName><ForeName>Christine B</ForeName><Initials>CB</Initials><AffiliationInfo><Affiliation>Department of Neurology, Baylor College of Medicine, Houston, Texas.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jimenez-Shahed</LastName><ForeName>Joohi</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurology, Baylor College of Medicine, Houston, Texas.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palao</LastName><ForeName>Alicia</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, Baylor College of Medicine, Houston, Texas.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miyasaki</LastName><ForeName>Janis M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>So</LastName><ForeName>Julie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tetrud</LastName><ForeName>James</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>The Parkinson's Institute and Clinical Center, Sunnyvale, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reys</LastName><ForeName>Liza</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>The Parkinson's Institute and Clinical Center, Sunnyvale, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Katharine</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>The Parkinson's Institute and Clinical Center, Sunnyvale, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Singer</LastName><ForeName>Carlos</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Miami School of Medicine, Miami, Florida.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blenke</LastName><ForeName>Anita</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Miami School of Medicine, Miami, Florida.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Russell</LastName><ForeName>David S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Institute for Neurodegenerative Disorders, New Haven, Connecticut.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cotto</LastName><ForeName>Candace</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute for Neurodegenerative Disorders, New Haven, Connecticut.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Friedman</LastName><ForeName>Joseph H</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Neurology, Butler Hospital, Providence, Rhode Island26Alpert Medical School, Brown University, Providence, Rhode Island.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lannon</LastName><ForeName>Margaret</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, Butler Hospital, Providence, Rhode Island27Port City Neurology, Inc, Scarborough, Maine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Lin</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of California, Davis, School of Medicine and Sacramento VA Medical Center, Sacramento.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drasby</LastName><ForeName>Edward</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Port City Neurology, Inc, Scarborough, Maine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumar</LastName><ForeName>Rajeev</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Colorado Neurological Institute, Englewood.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Subramanian</LastName><ForeName>Thyagarajan</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Milton S. Hershey Medical Center, Department of Neurology, Pennsylvania State Hershey College of Medicine, Hershey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ford</LastName><ForeName>Donna Stuppy</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Milton S. Hershey Medical Center, Department of Neurology, Pennsylvania State Hershey College of Medicine, Hershey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grimes</LastName><ForeName>David A</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>Ottawa Hospital Civic Site, Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cote</LastName><ForeName>Diane</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Ottawa Hospital Civic Site, Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Conway</LastName><ForeName>Jennifer</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Ottawa Hospital Civic Site, Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siderowf</LastName><ForeName>Andrew D</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>Avid Radiopharmaceuticals, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Evatt</LastName><ForeName>Marian Leslie</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Department of Neurology, Emory University School of Medicine, Wesley Woods Center, Atlanta, Georgia33Atlanta VA Medical Center, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sommerfeld</LastName><ForeName>Barbara</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Neurology, Emory University School of Medicine, Wesley Woods Center, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lieberman</LastName><ForeName>Abraham N</ForeName><Initials>AN</Initials><AffiliationInfo><Affiliation>Muhammad Ali Parkinson Center, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, Arizona.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Okun</LastName><ForeName>Michael S</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodriguez</LastName><ForeName>Ramon L</ForeName><Initials>RL</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Merritt</LastName><ForeName>Stacy</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Swartz</LastName><ForeName>Camille Louise</ForeName><Initials>CL</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>W R Wayne</ForeName><Initials>WR</Initials><AffiliationInfo><Affiliation>Glenrose Rehabilitation Hospital, University of Alberta, Edmonton, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>King</LastName><ForeName>Pamela</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Glenrose Rehabilitation Hospital, University of Alberta, Edmonton, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stover</LastName><ForeName>Natividad</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Alabama at Birmingham.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guthrie</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Alabama at Birmingham.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Watts</LastName><ForeName>Ray L</ForeName><Initials>RL</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Alabama at Birmingham.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahmed</LastName><ForeName>Anwar</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Center for Neurological Restoration, Department of Neurology, Cleveland Clinic, Cleveland, Ohio.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernandez</LastName><ForeName>Hubert H</ForeName><Initials>HH</Initials><AffiliationInfo><Affiliation>Center for Neurological Restoration, Department of Neurology, Cleveland Clinic, Cleveland, Ohio.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Winters</LastName><ForeName>Adrienna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Center for Neurological Restoration, Department of Neurology, Cleveland Clinic, Cleveland, Ohio.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mari</LastName><ForeName>Zoltan</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dawson</LastName><ForeName>Ted M</ForeName><Initials>TM</Initials><AffiliationInfo><Affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dunlop</LastName><ForeName>Becky</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feigin</LastName><ForeName>Andrew S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Feinstein Institute for Medical Research, Center for Neurosciences, Manhasset, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shannon</LastName><ForeName>Barbara</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Feinstein Institute for Medical Research, Center for Neurosciences, Manhasset, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nirenberg</LastName><ForeName>Melissa Jill</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Department of Neurology, New York University Langone Medical Center, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ogg</LastName><ForeName>Mattson</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, Weill Cornell Medical College, New York Hospital, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ellias</LastName><ForeName>Samuel A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>Cathi-Ann</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frei</LastName><ForeName>Karen</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>The Parkinson's and Movement Disorder Institute, Fountain Valley, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bodis-Wollner</LastName><ForeName>Ivan</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>State University of New York, Downstate Medical Center, Brooklyn, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Glazman</LastName><ForeName>Sofya</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>State University of New York, Downstate Medical Center, Brooklyn, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mayer</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>State University of New York, Downstate Medical Center, Brooklyn, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hauser</LastName><ForeName>Robert A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of South Florida, Tampa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pahwa</LastName><ForeName>Rajesh</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Kansas Medical Center, Kansas City.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Langhammer</LastName><ForeName>April</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Kansas Medical Center, Kansas City.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ranawaya</LastName><ForeName>Ranjit</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Derwent</LastName><ForeName>Lorelei</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sethi</LastName><ForeName>Kapil D</ForeName><Initials>KD</Initials><AffiliationInfo><Affiliation>Department of Neurology, Georgia Health Science University, Augusta.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farrow</LastName><ForeName>Buff</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Neurology, Georgia Health Science University, Augusta.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prakash</LastName><ForeName>Rajan</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neurology, Georgia Health Science University, Augusta.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Litvan</LastName><ForeName>Irene</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Neurosciences, University of California, San Diego, La Jolla.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robinson</LastName><ForeName>Annette</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Louisville, Kentucky.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sahay</LastName><ForeName>Alok</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University of Cincinnati College of Medicine, Cincinnati, Ohio.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gartner</LastName><ForeName>Maureen</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University of Cincinnati College of Medicine, Cincinnati, Ohio.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hinson</LastName><ForeName>Vanessa K</ForeName><Initials>VK</Initials><AffiliationInfo><Affiliation>Department of Neurology, Medical University of South Carolina, Charleston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Markind</LastName><ForeName>Samuel</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Associated Neurologists, PC, Danbury, Connecticut.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pelikan</LastName><ForeName>Melisa</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Associated Neurologists, PC, Danbury, Connecticut.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perlmutter</LastName><ForeName>Joel S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Department of Neurology, Washington University in St Louis, Missouri.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hartlein</LastName><ForeName>Johanna</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurology, Washington University in St Louis, Missouri.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Molho</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Movement Disorders Center, Albany Medical Center, Albany, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Evans</LastName><ForeName>Sharon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Movement Disorders Center, Albany Medical Center, Albany, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adler</LastName><ForeName>Charles H</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic, Scottsdale, Arizona.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duffy</LastName><ForeName>Amy</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic, Scottsdale, Arizona.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lind</LastName><ForeName>Marlene</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic, Scottsdale, Arizona.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elmer</LastName><ForeName>Lawrence</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Center for Neurological Health, University of Toledo, Toledo, Ohio.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Davis</LastName><ForeName>Kathy</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Neurology, Medical University of Ohio at Toledo.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spears</LastName><ForeName>Julia</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurology, Medical University of Ohio at Toledo.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wilson</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, Medical University of Ohio at Toledo.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leehey</LastName><ForeName>Maureen A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Colorado Health Science Center, Denver.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hermanowicz</LastName><ForeName>Neal</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of California, Irvine Medical Center, Irvine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Niswonger</LastName><ForeName>Shari</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of California, Irvine Medical Center, Irvine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shill</LastName><ForeName>Holly A</ForeName><Initials>HA</Initials><AffiliationInfo><Affiliation>Banner Sun Health Research Institute, Sun City, Arizona.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Obradov</LastName><ForeName>Sanja</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Banner Sun Health Research Institute, Sun City, Arizona.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rajput</LastName><ForeName>Alex</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Saskatchewan, Royal University Hospital, Saskatchewan, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cowper</LastName><ForeName>Marilyn</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Saskatchewan, Royal University Hospital, Saskatchewan, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lessig</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of California, San Diego, La Jolla.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of California, San Diego, La Jolla.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fontaine</LastName><ForeName>Deborah</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of California, San Diego, La Jolla.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zadikoff</LastName><ForeName>Cindy</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Williams</LastName><ForeName>Karen</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blindauer</LastName><ForeName>Karen A</ForeName><Initials>KA</Initials><AffiliationInfo><Affiliation>Department of Neurology, Medical College of Wisconsin, Milwaukee.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bergholte</LastName><ForeName>Jo</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurology, Medical College of Wisconsin, Milwaukee.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Propsom</LastName><ForeName>Clara Schindler</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>Department of Neurology, Medical College of Wisconsin, Milwaukee.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stacy</LastName><ForeName>Mark A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Neurology, Duke University, Durham, North Carolina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Field</LastName><ForeName>Joanne</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurology, Duke University, Durham, North 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