ON-OFF Effects of Dopaminergic Therapy on Psychiatric Symptoms in Parkinson's Disease.
Identifieur interne : 000601 ( PubMed/Corpus ); précédent : 000600; suivant : 000602ON-OFF Effects of Dopaminergic Therapy on Psychiatric Symptoms in Parkinson's Disease.
Auteurs : Hooman Ganjavi ; Penny A. MacdonaldSource :
- The Journal of neuropsychiatry and clinical neurosciences [ 1545-7222 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antipsychotic Agents, Dopamine Agents.
- complications : Parkinson Disease.
- drug therapy : Psychotic Disorders.
- etiology : Psychotic Disorders.
- Aged, Analysis of Variance, Case-Control Studies, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales.
Abstract
Psychiatric manifestations of Parkinson's disease (PD) are a cause of significant disability and the impact of dopaminergic medications is unclear. Using standardized rating scales, the authors tested the hypothesis that anxiety, depression, and apathy vary in the ON versus OFF states in PD in 33 PD patients and 29 healthy age- and education-matched controls. PD patients had significantly higher anxiety, depression, and apathy scores than control participants, regardless of ON-OFF state. Anxiety scores were higher in PD patients on relative to off dopaminergic medication. The ON-OFF difference in anxiety related to degree of improvement in motor function but not illness duration.
DOI: 10.1176/appi.neuropsych.14030055
PubMed: 25923857
Links to Exploration step
pubmed:25923857Le document en format XML
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<affiliation><nlm:affiliation>From the Dept. of Psychiatry, University of Western Ontario, London, Ontario, Canada (HG); The Brain and Mind Institute, University of Western Ontario, London, Ontario, Canada (PAM); and Clinical Neurological Sciences, London Health Sciences Centre, London, Ontario, Canada (PAM).</nlm:affiliation>
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<front><div type="abstract" xml:lang="en">Psychiatric manifestations of Parkinson's disease (PD) are a cause of significant disability and the impact of dopaminergic medications is unclear. Using standardized rating scales, the authors tested the hypothesis that anxiety, depression, and apathy vary in the ON versus OFF states in PD in 33 PD patients and 29 healthy age- and education-matched controls. PD patients had significantly higher anxiety, depression, and apathy scores than control participants, regardless of ON-OFF state. Anxiety scores were higher in PD patients on relative to off dopaminergic medication. The ON-OFF difference in anxiety related to degree of improvement in motor function but not illness duration.</div>
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