Investing in the future: stimulation of the medial prefrontal cortex reduces discounting of delayed rewards.
Identifieur interne : 000583 ( PubMed/Corpus ); précédent : 000582; suivant : 000584Investing in the future: stimulation of the medial prefrontal cortex reduces discounting of delayed rewards.
Auteurs : Sang Soo Cho ; Yuko Koshimori ; Kelly Aminian ; Ignacio Obeso ; Pablo Rusjan ; Anthony E. Lang ; Zafiris J. Daskalakis ; Sylvain Houle ; Antonio P. StrafellaSource :
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [ 1740-634X ] ; 2015.
English descriptors
- KwdEn :
- Carbon Radioisotopes (metabolism), Corpus Striatum (metabolism), Delay Discounting (physiology), Dopamine (metabolism), Female, Functional Neuroimaging, Humans, Male, Oxazines (metabolism), Positron-Emission Tomography, Prefrontal Cortex (metabolism), Prefrontal Cortex (physiology), Reward, Transcranial Magnetic Stimulation, Young Adult.
- MESH :
- chemical , metabolism : Carbon Radioisotopes, Dopamine, Oxazines.
- metabolism : Corpus Striatum, Prefrontal Cortex.
- physiology : Delay Discounting, Prefrontal Cortex.
- Female, Functional Neuroimaging, Humans, Male, Positron-Emission Tomography, Reward, Transcranial Magnetic Stimulation, Young Adult.
Abstract
Generally, rewards that are received sooner are often preferred over future rewards, and the time between the choice and the reception of the reward is an important factor that influences our decisions, a phenomenon called delay discounting (DD). In DD, the medial prefrontal cortex (MePFC) and striatal dopamine neurotransmission both play an important role. We used repetitive transcranial magnetic stimulation (rTMS) to transiently activate the MePFC to evaluate its behavioral effect on the DD paradigm, and subsequently to measure its effect on striatal dopamine. Twenty-four right-handed young healthy subjects (11 females; age: 22.1±2.9 years) underwent DD following 10 Hz-rTMS of the MePFC and vertex stimulation (control condition). Thereafter, 11 subjects (5 females; age: 22.2±2.87 years) completed the PET study at rest using [(11)C]-(+)-PHNO following 10 Hz-rTMS of the MePFC and vertex. Modulation of the MePFC excitability influenced the subjective level of DD for delayed rewards and interfered with synaptic dopamine level in the striatum. The present study yielded findings that might reconcile the role of these areas in inter-temporal decision making and dopamine modulation, suggesting that the subjective sense of time and value of reward are critically controlled by these important regions.
DOI: 10.1038/npp.2014.211
PubMed: 25168685
Links to Exploration step
pubmed:25168685Le document en format XML
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Strafella</name><affiliation><nlm:affiliation>1] Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada [2] Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, ON, Canada [3] Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, ON, Canada.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology</title><idno type="eISSN">1740-634X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Carbon Radioisotopes (metabolism)</term><term>Corpus Striatum (metabolism)</term><term>Delay Discounting (physiology)</term><term>Dopamine (metabolism)</term><term>Female</term><term>Functional Neuroimaging</term><term>Humans</term><term>Male</term><term>Oxazines (metabolism)</term><term>Positron-Emission Tomography</term><term>Prefrontal Cortex (metabolism)</term><term>Prefrontal Cortex (physiology)</term><term>Reward</term><term>Transcranial Magnetic Stimulation</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Carbon Radioisotopes</term><term>Dopamine</term><term>Oxazines</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Delay Discounting</term><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Functional Neuroimaging</term><term>Humans</term><term>Male</term><term>Positron-Emission Tomography</term><term>Reward</term><term>Transcranial Magnetic Stimulation</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Generally, rewards that are received sooner are often preferred over future rewards, and the time between the choice and the reception of the reward is an important factor that influences our decisions, a phenomenon called delay discounting (DD). In DD, the medial prefrontal cortex (MePFC) and striatal dopamine neurotransmission both play an important role. We used repetitive transcranial magnetic stimulation (rTMS) to transiently activate the MePFC to evaluate its behavioral effect on the DD paradigm, and subsequently to measure its effect on striatal dopamine. Twenty-four right-handed young healthy subjects (11 females; age: 22.1±2.9 years) underwent DD following 10 Hz-rTMS of the MePFC and vertex stimulation (control condition). Thereafter, 11 subjects (5 females; age: 22.2±2.87 years) completed the PET study at rest using [(11)C]-(+)-PHNO following 10 Hz-rTMS of the MePFC and vertex. Modulation of the MePFC excitability influenced the subjective level of DD for delayed rewards and interfered with synaptic dopamine level in the striatum. The present study yielded findings that might reconcile the role of these areas in inter-temporal decision making and dopamine modulation, suggesting that the subjective sense of time and value of reward are critically controlled by these important regions.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25168685</PMID><DateCreated><Year>2015</Year><Month>01</Month><Day>09</Day></DateCreated><DateCompleted><Year>2016</Year><Month>03</Month><Day>15</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1740-634X</ISSN><JournalIssue CitedMedium="Internet"><Volume>40</Volume><Issue>3</Issue><PubDate><Year>2015</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology</Title><ISOAbbreviation>Neuropsychopharmacology</ISOAbbreviation></Journal><ArticleTitle>Investing in the future: stimulation of the medial prefrontal cortex reduces discounting of delayed rewards.</ArticleTitle><Pagination><MedlinePgn>546-53</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/npp.2014.211</ELocationID><Abstract><AbstractText>Generally, rewards that are received sooner are often preferred over future rewards, and the time between the choice and the reception of the reward is an important factor that influences our decisions, a phenomenon called delay discounting (DD). In DD, the medial prefrontal cortex (MePFC) and striatal dopamine neurotransmission both play an important role. We used repetitive transcranial magnetic stimulation (rTMS) to transiently activate the MePFC to evaluate its behavioral effect on the DD paradigm, and subsequently to measure its effect on striatal dopamine. Twenty-four right-handed young healthy subjects (11 females; age: 22.1±2.9 years) underwent DD following 10 Hz-rTMS of the MePFC and vertex stimulation (control condition). Thereafter, 11 subjects (5 females; age: 22.2±2.87 years) completed the PET study at rest using [(11)C]-(+)-PHNO following 10 Hz-rTMS of the MePFC and vertex. Modulation of the MePFC excitability influenced the subjective level of DD for delayed rewards and interfered with synaptic dopamine level in the striatum. The present study yielded findings that might reconcile the role of these areas in inter-temporal decision making and dopamine modulation, suggesting that the subjective sense of time and value of reward are critically controlled by these important regions.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cho</LastName><ForeName>Sang Soo</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>1] Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada [2] Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koshimori</LastName><ForeName>Yuko</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>1] Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada [2] Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aminian</LastName><ForeName>Kelly</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>1] Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada [2] Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Obeso</LastName><ForeName>Ignacio</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>1] Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada [2] Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rusjan</LastName><ForeName>Pablo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lang</LastName><ForeName>Anthony E</ForeName><Initials>AE</Initials><AffiliationInfo><Affiliation>Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Daskalakis</LastName><ForeName>Zafiris J</ForeName><Initials>ZJ</Initials><AffiliationInfo><Affiliation>Temerty Centre for Therapeutic Brain Intervention, Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Houle</LastName><ForeName>Sylvain</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Strafella</LastName><ForeName>Antonio P</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>1] Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, Ontario, Canada [2] Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, ON, Canada [3] Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>MOP 110962</GrantID><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>08</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Neuropsychopharmacology</MedlineTA><NlmUniqueID>8904907</NlmUniqueID><ISSNLinking>0893-133X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002250">Carbon 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Source="NLM">PMC4289950</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>04</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>07</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>08</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>8</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>8</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>3</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25168685</ArticleId><ArticleId IdType="pii">npp2014211</ArticleId><ArticleId IdType="doi">10.1038/npp.2014.211</ArticleId><ArticleId 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