ATF3 protects pulmonary resident cells from acute and ventilator-induced lung injury by preventing Nrf2 degradation.
Identifieur interne : 000540 ( PubMed/Corpus ); précédent : 000539; suivant : 000541ATF3 protects pulmonary resident cells from acute and ventilator-induced lung injury by preventing Nrf2 degradation.
Auteurs : Yuexin Shan ; Ali Akram ; Hajera Amatullah ; Dun Yuan Zhou ; Patricia L. Gali ; Tatiana Maron-Gutierrez ; Adrian González-L Pez ; Louis Zhou ; Patricia R M. Rocco ; David Hwang ; Guillermo M. Albaiceta ; Jack J. Haitsma ; Claudia C. Dos SantosSource :
- Antioxidants & redox signaling [ 1557-7716 ] ; 2015.
English descriptors
- KwdEn :
- Activating Transcription Factor 3 (genetics), Activating Transcription Factor 3 (metabolism), Animals, Cell Line, Cell Membrane Permeability, Chimera, Epithelial Cells, Female, Humans, Inflammation (metabolism), Lung (cytology), Lung (metabolism), Macrophages (immunology), Macrophages (metabolism), Male, Mice, Mice, Knockout, NF-E2-Related Factor 2 (metabolism), Oxidative Stress, Signal Transduction, Ventilator-Induced Lung Injury (metabolism).
- MESH :
- chemical , genetics : Activating Transcription Factor 3.
- chemical , metabolism : Activating Transcription Factor 3, NF-E2-Related Factor 2.
- cytology : Lung.
- immunology : Macrophages.
- metabolism : Inflammation, Lung, Macrophages, Ventilator-Induced Lung Injury.
- Animals, Cell Line, Cell Membrane Permeability, Chimera, Epithelial Cells, Female, Humans, Male, Mice, Mice, Knockout, Oxidative Stress, Signal Transduction.
Abstract
Ventilator-induced lung injury (VILI) contributes to mortality in patients with acute respiratory distress syndrome, the most severe form of acute lung injury (ALI). Absence of activating transcription factor 3 (ATF3) confers susceptibility to ALI/VILI. To identify cell-specific ATF3-dependent mechanisms of susceptibility to ALI/VILI, we generated ATF3 chimera by adoptive bone marrow (BM) transfer and randomized to inhaled saline or lipopolysacharide (LPS) in the presence of mechanical ventilation (MV). Adenovirus vectors to silence or overexpress ATF3 were used in primary human bronchial epithelial cells and murine BM-derived macrophages from wild-type or ATF3-deficient mice.
DOI: 10.1089/ars.2014.5987
PubMed: 25401197
Links to Exploration step
pubmed:25401197Le document en format XML
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Gali</name></author><author><name sortKey="Maron Gutierrez, Tatiana" sort="Maron Gutierrez, Tatiana" uniqKey="Maron Gutierrez T" first="Tatiana" last="Maron-Gutierrez">Tatiana Maron-Gutierrez</name></author><author><name sortKey="Gonzalez L Pez, Adrian" sort="Gonzalez L Pez, Adrian" uniqKey="Gonzalez L Pez A" first="Adrian" last="González-L Pez">Adrian González-L Pez</name></author><author><name sortKey="Zhou, Louis" sort="Zhou, Louis" uniqKey="Zhou L" first="Louis" last="Zhou">Louis Zhou</name></author><author><name sortKey="Rocco, Patricia R M" sort="Rocco, Patricia R M" uniqKey="Rocco P" first="Patricia R M" last="Rocco">Patricia R M. Rocco</name></author><author><name sortKey="Hwang, David" sort="Hwang, David" uniqKey="Hwang D" first="David" last="Hwang">David Hwang</name></author><author><name sortKey="Albaiceta, Guillermo M" sort="Albaiceta, Guillermo M" uniqKey="Albaiceta G" first="Guillermo M" last="Albaiceta">Guillermo M. 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Dos Santos</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25401197</idno><idno type="pmid">25401197</idno><idno type="doi">10.1089/ars.2014.5987</idno><idno type="wicri:Area/PubMed/Corpus">000540</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000540</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">ATF3 protects pulmonary resident cells from acute and ventilator-induced lung injury by preventing Nrf2 degradation.</title><author><name sortKey="Shan, Yuexin" sort="Shan, Yuexin" uniqKey="Shan Y" first="Yuexin" last="Shan">Yuexin Shan</name><affiliation><nlm:affiliation>1 Interdepartmental Division of Critical Care, The Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto , Toronto, Canada .</nlm:affiliation></affiliation></author><author><name sortKey="Akram, Ali" sort="Akram, Ali" uniqKey="Akram A" first="Ali" last="Akram">Ali Akram</name></author><author><name sortKey="Amatullah, Hajera" sort="Amatullah, Hajera" uniqKey="Amatullah H" first="Hajera" last="Amatullah">Hajera Amatullah</name></author><author><name sortKey="Zhou, Dun Yuan" sort="Zhou, Dun Yuan" uniqKey="Zhou D" first="Dun Yuan" last="Zhou">Dun Yuan Zhou</name></author><author><name sortKey="Gali, Patricia L" sort="Gali, Patricia L" uniqKey="Gali P" first="Patricia L" last="Gali">Patricia L. Gali</name></author><author><name sortKey="Maron Gutierrez, Tatiana" sort="Maron Gutierrez, Tatiana" uniqKey="Maron Gutierrez T" first="Tatiana" last="Maron-Gutierrez">Tatiana Maron-Gutierrez</name></author><author><name sortKey="Gonzalez L Pez, Adrian" sort="Gonzalez L Pez, Adrian" uniqKey="Gonzalez L Pez A" first="Adrian" last="González-L Pez">Adrian González-L Pez</name></author><author><name sortKey="Zhou, Louis" sort="Zhou, Louis" uniqKey="Zhou L" first="Louis" last="Zhou">Louis Zhou</name></author><author><name sortKey="Rocco, Patricia R M" sort="Rocco, Patricia R M" uniqKey="Rocco P" first="Patricia R M" last="Rocco">Patricia R M. Rocco</name></author><author><name sortKey="Hwang, David" sort="Hwang, David" uniqKey="Hwang D" first="David" last="Hwang">David Hwang</name></author><author><name sortKey="Albaiceta, Guillermo M" sort="Albaiceta, Guillermo M" uniqKey="Albaiceta G" first="Guillermo M" last="Albaiceta">Guillermo M. Albaiceta</name></author><author><name sortKey="Haitsma, Jack J" sort="Haitsma, Jack J" uniqKey="Haitsma J" first="Jack J" last="Haitsma">Jack J. Haitsma</name></author><author><name sortKey="Dos Santos, Claudia C" sort="Dos Santos, Claudia C" uniqKey="Dos Santos C" first="Claudia C" last="Dos Santos">Claudia C. Dos Santos</name></author></analytic><series><title level="j">Antioxidants & redox signaling</title><idno type="eISSN">1557-7716</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activating Transcription Factor 3 (genetics)</term><term>Activating Transcription Factor 3 (metabolism)</term><term>Animals</term><term>Cell Line</term><term>Cell Membrane Permeability</term><term>Chimera</term><term>Epithelial Cells</term><term>Female</term><term>Humans</term><term>Inflammation (metabolism)</term><term>Lung (cytology)</term><term>Lung (metabolism)</term><term>Macrophages (immunology)</term><term>Macrophages (metabolism)</term><term>Male</term><term>Mice</term><term>Mice, Knockout</term><term>NF-E2-Related Factor 2 (metabolism)</term><term>Oxidative Stress</term><term>Signal Transduction</term><term>Ventilator-Induced Lung Injury (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Activating Transcription Factor 3</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Activating Transcription Factor 3</term><term>NF-E2-Related Factor 2</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Inflammation</term><term>Lung</term><term>Macrophages</term><term>Ventilator-Induced Lung Injury</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Cell Membrane Permeability</term><term>Chimera</term><term>Epithelial Cells</term><term>Female</term><term>Humans</term><term>Male</term><term>Mice</term><term>Mice, Knockout</term><term>Oxidative Stress</term><term>Signal Transduction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ventilator-induced lung injury (VILI) contributes to mortality in patients with acute respiratory distress syndrome, the most severe form of acute lung injury (ALI). Absence of activating transcription factor 3 (ATF3) confers susceptibility to ALI/VILI. To identify cell-specific ATF3-dependent mechanisms of susceptibility to ALI/VILI, we generated ATF3 chimera by adoptive bone marrow (BM) transfer and randomized to inhaled saline or lipopolysacharide (LPS) in the presence of mechanical ventilation (MV). Adenovirus vectors to silence or overexpress ATF3 were used in primary human bronchial epithelial cells and murine BM-derived macrophages from wild-type or ATF3-deficient mice.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25401197</PMID><DateCreated><Year>2015</Year><Month>02</Month><Day>27</Day></DateCreated><DateCompleted><Year>2015</Year><Month>10</Month><Day>21</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1557-7716</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>8</Issue><PubDate><Year>2015</Year><Month>Mar</Month><Day>10</Day></PubDate></JournalIssue><Title>Antioxidants & redox signaling</Title><ISOAbbreviation>Antioxid. Redox Signal.</ISOAbbreviation></Journal><ArticleTitle>ATF3 protects pulmonary resident cells from acute and ventilator-induced lung injury by preventing Nrf2 degradation.</ArticleTitle><Pagination><MedlinePgn>651-68</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1089/ars.2014.5987</ELocationID><Abstract><AbstractText Label="AIMS" NlmCategory="OBJECTIVE">Ventilator-induced lung injury (VILI) contributes to mortality in patients with acute respiratory distress syndrome, the most severe form of acute lung injury (ALI). Absence of activating transcription factor 3 (ATF3) confers susceptibility to ALI/VILI. To identify cell-specific ATF3-dependent mechanisms of susceptibility to ALI/VILI, we generated ATF3 chimera by adoptive bone marrow (BM) transfer and randomized to inhaled saline or lipopolysacharide (LPS) in the presence of mechanical ventilation (MV). Adenovirus vectors to silence or overexpress ATF3 were used in primary human bronchial epithelial cells and murine BM-derived macrophages from wild-type or ATF3-deficient mice.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Absence of ATF3 in myeloid-derived cells caused increased pulmonary cellular infiltration. In contrast, absence of ATF3 in parenchymal cells resulted in loss of alveolar-capillary membrane integrity and increased exudative edema. ATF3-deficient macrophages were unable to limit the expression of pro-inflammatory mediators. Knockdown of ATF3 in resident cells resulted in decreased junctional protein expression and increased paracellular leak. ATF3 overexpression abrogated LPS induced membrane permeability. Despite release of ATF3-dependent Nrf2 transcriptional inhibition, mice that lacked ATF3 expression in resident cells had increased Nrf2 protein degradation.</AbstractText><AbstractText Label="INNOVATION" NlmCategory="METHODS">In our model, in the absence of ATF3 in parenchymal cells increased Nrf2 degradation is the result of increased Keap-1 expression and loss of DJ-1 (Parkinson disease [autosomal recessive, early onset] 7), previously not known to play a role in lung injury.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Results suggest that ATF3 confers protection to lung injury by preventing inflammatory cell recruitment and barrier disruption in a cell-specific manner, opening novel opportunities for cell specific therapy for ALI/VILI.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shan</LastName><ForeName>Yuexin</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>1 Interdepartmental Division of Critical Care, The Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto , Toronto, Canada .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akram</LastName><ForeName>Ali</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Amatullah</LastName><ForeName>Hajera</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Dun Yuan</ForeName><Initials>DY</Initials></Author><Author ValidYN="Y"><LastName>Gali</LastName><ForeName>Patricia L</ForeName><Initials>PL</Initials></Author><Author ValidYN="Y"><LastName>Maron-Gutierrez</LastName><ForeName>Tatiana</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>González-López</LastName><ForeName>Adrian</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Louis</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Rocco</LastName><ForeName>Patricia R M</ForeName><Initials>PR</Initials></Author><Author ValidYN="Y"><LastName>Hwang</LastName><ForeName>David</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Albaiceta</LastName><ForeName>Guillermo M</ForeName><Initials>GM</Initials></Author><Author ValidYN="Y"><LastName>Haitsma</LastName><ForeName>Jack J</ForeName><Initials>JJ</Initials></Author><Author ValidYN="Y"><LastName>dos Santos</LastName><ForeName>Claudia C</ForeName><Initials>CC</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>MOP-106545</GrantID><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>01</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Antioxid Redox Signal</MedlineTA><NlmUniqueID>100888899</NlmUniqueID><ISSNLinking>1523-0864</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051700">Activating Transcription Factor 3</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C103002">Atf3 protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051267">NF-E2-Related Factor 2</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C495636">Nfe2l2 protein, mouse</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 2007 May 15;67(10):4630-7</RefSource><PMID Version="1">17510388</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Respir Crit Care Med. 2008 Sep 15;178(6):592-604</RefSource><PMID Version="1">18556627</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>FEBS Lett. 2008 Jul 23;582(17):2643-9</RefSource><PMID Version="1">18586035</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Antioxid Redox Signal. 2007 Nov;9(11):1991-2002</RefSource><PMID Version="1">17760509</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>FASEB J. 2007 Jul;21(9):2237-46</RefSource><PMID Version="1">17384144</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem Biophys Res Commun. 2004 May 7;317(3):722-8</RefSource><PMID Version="1">15081400</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2005 Oct 20;353(16):1685-93</RefSource><PMID Version="1">16236739</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Respir Crit Care Med. 2001 Mar;163(3 Pt 1):762-9</RefSource><PMID Version="1">11254536</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Respir Crit Care Med. 2010 Aug 15;182(4):489-500</RefSource><PMID Version="1">20413626</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Respir Crit Care Med. 2007 Dec 15;176(12):1222-35</RefSource><PMID Version="1">17901416</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Biochem Cell Biol. 2012 Jan;44(1):65-71</RefSource><PMID Version="1">22024154</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Immunol. 1996 Aug;33(11-12):989-98</RefSource><PMID Version="1">8960123</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Respirology. 2008 May;13(3):333-40</RefSource><PMID Version="1">18399853</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Prostate. 2006 Aug 1;66(11):1177-93</RefSource><PMID Version="1">16652386</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2001 Aug 3;276(31):29507-14</RefSource><PMID Version="1">11371557</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Toxicol Sci. 2009 Feb;107(2):451-60</RefSource><PMID Version="1">19033392</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosci Lett. 2006 Oct 9;406(3):165-8</RefSource><PMID Version="1">16935423</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 2002 Nov;161(5):1783-96</RefSource><PMID Version="1">12414525</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>CSH Protoc. 2008 Dec 01;2008:pdb.prot5080</RefSource><PMID Version="1">21356739</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2544-9</RefSource><PMID Version="1">18268321</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>EMBO Rep. 2004 Feb;5(2):213-8</RefSource><PMID Version="1">14749723</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9103-8</RefSource><PMID Version="1">15181200</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9691-6</RefSource><PMID Version="1">15983381</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur Respir J. 2002 Oct;20(4):946-56</RefSource><PMID Version="1">12412688</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2000 May 4;342(18):1334-49</RefSource><PMID Version="1">10793167</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2005 Jul 15;14(14):2063-73</RefSource><PMID Version="1">15944198</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Oncol. 2009 Dec;35(6):1331-41</RefSource><PMID Version="1">19885556</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2012 Jan;18(1):128-34</RefSource><PMID Version="1">22179317</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosci Lett. 2005 Dec 16;390(1):54-9</RefSource><PMID Version="1">16115732</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2006 May 11;441(7090):173-8</RefSource><PMID Version="1">16688168</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2005 Sep 1;175(5):3369-76</RefSource><PMID Version="1">16116230</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Free Radic Biol Med. 2005 Feb 1;38(3):375-87</RefSource><PMID Version="1">15629866</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem Soc Trans. 2007 Nov;35(Pt 5):1156-60</RefSource><PMID Version="1">17956300</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5215-20</RefSource><PMID Version="1">15784737</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Physiol. 2006;68:585-618</RefSource><PMID Version="1">16460285</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cold Spring Harb Perspect Med. 2012 Sep;2(9):a009415</RefSource><PMID Version="1">22951446</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Mol Med (Berl). 2009 Nov;87(11):1053-60</RefSource><PMID Version="1">19705082</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem Biophys Res Commun. 2004 Jul 23;320(2):389-97</RefSource><PMID Version="1">15219840</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 2008 Jan 15;68(2):364-8</RefSource><PMID Version="1">18199529</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Med. 2011 Mar-Apr;17(3-4):293-307</RefSource><PMID Version="1">21046059</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2005 Sep 15;175(6):4069-75</RefSource><PMID Version="1">16148156</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2003 Jun 13;278(24):21592-600</RefSource><PMID Version="1">12682069</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Physiol Lung Cell Mol Physiol. 2005 Feb;288(2):L333-41</RefSource><PMID Version="1">15475380</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Crit Care Med. 2003 Jun;31(6):1607-11</RefSource><PMID Version="1">12794394</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosci Lett. 2006 Aug 14;404(1-2):166-9</RefSource><PMID Version="1">16781058</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Biol. 2004 Nov;2(11):e327</RefSource><PMID Version="1">15502868</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Immunol. 2007 Mar;44(7):1598-605</RefSource><PMID Version="1">16982098</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Respir Cell Mol Biol. 2009 May;40(5):519-35</RefSource><PMID Version="1">18978300</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Crit Care. 2005 Feb;11(1):29-36</RefSource><PMID Version="1">15659942</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Physiol Lung Cell Mol Physiol. 2002 May;282(5):L892-6</RefSource><PMID Version="1">11943651</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol Methods. 2004 Sep;292(1-2):25-34</RefSource><PMID Version="1">15350509</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15091-6</RefSource><PMID Version="1">17015834</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biochem Mol Biol. 2004 Mar 31;37(2):139-43</RefSource><PMID Version="1">15469687</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Neurosci. 2010 Mar;31(6):967-77</RefSource><PMID Version="1">20377612</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12517-22</RefSource><PMID Version="1">16894167</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2012;7(5):e38144</RefSource><PMID Version="1">22666465</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2005 Dec 30;280(52):43150-8</RefSource><PMID Version="1">16227205</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2010;25 Suppl 1:S44-8</RefSource><PMID Version="1">20187230</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2008 Feb 15;283(7):4022-30</RefSource><PMID Version="1">18042550</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochemistry (Mosc). 2006 Sep;71(9):962-74</RefSource><PMID Version="1">17009949</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Appl Physiol (1985). 2000 Oct;89(4):1645-55</RefSource><PMID Version="1">11007607</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Inflamm Allergy Drug Targets. 2007 Sep;6(3):168-73</RefSource><PMID Version="1">17897053</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18748-53</RefSource><PMID Version="1">18003894</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cell Biol. 2004 Aug;24(16):7130-9</RefSource><PMID Version="1">15282312</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D051700" MajorTopicYN="N">Activating Transcription Factor 3</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002463" MajorTopicYN="N">Cell Membrane 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MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4346377</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>11</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>11</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>10</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25401197</ArticleId><ArticleId IdType="doi">10.1089/ars.2014.5987</ArticleId><ArticleId IdType="pmc">PMC4346377</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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