A unique retinal epitheliopathy is associated with amyotrophic lateral sclerosis/Parkinsonism-Dementia complex of Guam.
Identifieur interne : 000456 ( PubMed/Corpus ); précédent : 000455; suivant : 000457A unique retinal epitheliopathy is associated with amyotrophic lateral sclerosis/Parkinsonism-Dementia complex of Guam.
Auteurs : John C. Steele ; Robert Wresch ; Samuel D. Hanlon ; Jay Keystone ; Yoav Ben-ShlomoSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Amyotrophic Lateral Sclerosis (epidemiology), Amyotrophic Lateral Sclerosis (pathology), Cross-Sectional Studies, Dementia (complications), Dementia (pathology), Female, Guam (epidemiology), Humans, Kaplan-Meier Estimate, Linear Models, Male, Middle Aged, Nervous System Diseases (complications), Nervous System Diseases (diagnosis), Parkinson Disease (complications), Parkinson Disease (pathology), Retina (pathology), Retinal Pigment Epithelium (pathology), Retrospective Studies.
- MESH :
- geographic , epidemiology : Guam.
- complications : Dementia, Nervous System Diseases, Parkinson Disease.
- diagnosis : Nervous System Diseases.
- epidemiology : Amyotrophic Lateral Sclerosis.
- pathology : Amyotrophic Lateral Sclerosis, Dementia, Parkinson Disease, Retina, Retinal Pigment Epithelium.
- Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Kaplan-Meier Estimate, Linear Models, Male, Middle Aged, Retrospective Studies.
Abstract
The aim of this work was to examine whether a linear retinal pigment epitheliopathy is associated with the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam.
DOI: 10.1002/mds.26264
PubMed: 26153661
Links to Exploration step
pubmed:26153661Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A unique retinal epitheliopathy is associated with amyotrophic lateral sclerosis/Parkinsonism-Dementia complex of Guam.</title>
<author><name sortKey="Steele, John C" sort="Steele, John C" uniqKey="Steele J" first="John C" last="Steele">John C. Steele</name>
<affiliation><nlm:affiliation>Guam Memorial Hospital, Tamuning, Guam.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wresch, Robert" sort="Wresch, Robert" uniqKey="Wresch R" first="Robert" last="Wresch">Robert Wresch</name>
<affiliation><nlm:affiliation>Seventh-day Adventist Guam Clinic; Guam Memorial Hospital; and Loma Linda University, Loma Linda, California, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hanlon, Samuel D" sort="Hanlon, Samuel D" uniqKey="Hanlon S" first="Samuel D" last="Hanlon">Samuel D. Hanlon</name>
<affiliation><nlm:affiliation>University Eye Institute, University of Houston, Houston, Texas, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Keystone, Jay" sort="Keystone, Jay" uniqKey="Keystone J" first="Jay" last="Keystone">Jay Keystone</name>
<affiliation><nlm:affiliation>Tropical Disease Unit, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name>
<affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">A unique retinal epitheliopathy is associated with amyotrophic lateral sclerosis/Parkinsonism-Dementia complex of Guam.</title>
<author><name sortKey="Steele, John C" sort="Steele, John C" uniqKey="Steele J" first="John C" last="Steele">John C. Steele</name>
<affiliation><nlm:affiliation>Guam Memorial Hospital, Tamuning, Guam.</nlm:affiliation>
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<author><name sortKey="Wresch, Robert" sort="Wresch, Robert" uniqKey="Wresch R" first="Robert" last="Wresch">Robert Wresch</name>
<affiliation><nlm:affiliation>Seventh-day Adventist Guam Clinic; Guam Memorial Hospital; and Loma Linda University, Loma Linda, California, USA.</nlm:affiliation>
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<author><name sortKey="Hanlon, Samuel D" sort="Hanlon, Samuel D" uniqKey="Hanlon S" first="Samuel D" last="Hanlon">Samuel D. Hanlon</name>
<affiliation><nlm:affiliation>University Eye Institute, University of Houston, Houston, Texas, USA.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Keystone, Jay" sort="Keystone, Jay" uniqKey="Keystone J" first="Jay" last="Keystone">Jay Keystone</name>
<affiliation><nlm:affiliation>Tropical Disease Unit, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name>
<affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</nlm:affiliation>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2015" type="published">2015</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Amyotrophic Lateral Sclerosis (epidemiology)</term>
<term>Amyotrophic Lateral Sclerosis (pathology)</term>
<term>Cross-Sectional Studies</term>
<term>Dementia (complications)</term>
<term>Dementia (pathology)</term>
<term>Female</term>
<term>Guam (epidemiology)</term>
<term>Humans</term>
<term>Kaplan-Meier Estimate</term>
<term>Linear Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous System Diseases (complications)</term>
<term>Nervous System Diseases (diagnosis)</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (pathology)</term>
<term>Retina (pathology)</term>
<term>Retinal Pigment Epithelium (pathology)</term>
<term>Retrospective Studies</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Guam</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dementia</term>
<term>Nervous System Diseases</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Nervous System Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Amyotrophic Lateral Sclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Amyotrophic Lateral Sclerosis</term>
<term>Dementia</term>
<term>Parkinson Disease</term>
<term>Retina</term>
<term>Retinal Pigment Epithelium</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Kaplan-Meier Estimate</term>
<term>Linear Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
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<front><div type="abstract" xml:lang="en">The aim of this work was to examine whether a linear retinal pigment epitheliopathy is associated with the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam.</div>
</front>
</TEI>
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<DateCreated><Year>2015</Year>
<Month>09</Month>
<Day>21</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>06</Month>
<Day>08</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>09</Month>
<Day>21</Day>
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<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>30</Volume>
<Issue>9</Issue>
<PubDate><Year>2015</Year>
<Month>Aug</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>A unique retinal epitheliopathy is associated with amyotrophic lateral sclerosis/Parkinsonism-Dementia complex of Guam.</ArticleTitle>
<Pagination><MedlinePgn>1271-5</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26264</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The aim of this work was to examine whether a linear retinal pigment epitheliopathy is associated with the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">A total of 918 Guamanian Chamorros, with and without amyotrophic lateral sclerosis/parkinsonism-dementia complex, were examined cross-sectionally for linear retinal pigment epitheliopathy (LRPE). Overall, 239 Guamanians, who were neurologically asymptomatic, were followed for up to 20 years to determine the risk of developing amyotrophic lateral sclerosis/parkinsonism-dementia complex.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The epitheliopathy was present in 59.7% (117 of 196) patients with amyotrophic lateral sclerosis/parkinsonism-dementia complex, but in only 24.7% (178 of 722) of subjects who were neurologically asymptomatic (age- and sex-adjusted risk difference: 35.0%; 95% confidence interval [CI]: 27.5-42.6; p < 0.0001). Prospectively, 15 of 50 cases with epitheliopathy developed amyotrophic lateral sclerosis/parkinsonism-dementia complex, compared to 4 of 189 cases without epitheliopathy (age- and sex-adjusted hazard ratio: 13.1; 95% CI: 4.0-43.1; P < 0.0001).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Amyotrophic lateral sclerosis/parkinsonism-dementia complex is associated with an LRPE and predicts future neurological disease. Identifying the cause of this retinopathy could provide an understanding about the pathogenesis of amyotrophic lateral sclerosis/parkinsonism-dementia complex and related diseases.</AbstractText>
<CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Steele</LastName>
<ForeName>John C</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>Guam Memorial Hospital, Tamuning, Guam.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wresch</LastName>
<ForeName>Robert</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Seventh-day Adventist Guam Clinic; Guam Memorial Hospital; and Loma Linda University, Loma Linda, California, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hanlon</LastName>
<ForeName>Samuel D</ForeName>
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<AffiliationInfo><Affiliation>University Eye Institute, University of Houston, Houston, Texas, USA.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Keystone</LastName>
<ForeName>Jay</ForeName>
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<AffiliationInfo><Affiliation>Tropical Disease Unit, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Ben-Shlomo</LastName>
<ForeName>Yoav</ForeName>
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<AffiliationInfo><Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</Affiliation>
</AffiliationInfo>
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<Language>eng</Language>
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<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<MeshHeading><DescriptorName UI="D000690" MajorTopicYN="N">Amyotrophic Lateral Sclerosis</DescriptorName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Guam</Keyword>
<Keyword MajorTopicYN="N">Parkinson's disease with dementia</Keyword>
<Keyword MajorTopicYN="N">amyotrophic lateral sclerosis</Keyword>
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