PINK1 deficiency enhances autophagy and mitophagy induction.
Identifieur interne : 000440 ( PubMed/Corpus ); précédent : 000439; suivant : 000441PINK1 deficiency enhances autophagy and mitophagy induction.
Auteurs : Rubén G Mez-Sánchez ; Sokhna M S. Yakhine-Diop ; José M. Bravo-San Pedro ; Elisa Pizarro-Estrella ; Mario Rodríguez-Arribas ; Vicente Climent ; Francisco E. Martin-Cano ; María E. González-Soltero ; Anurag Tandon ; José M. Fuentes ; Rosa A. González-PoloSource :
- Molecular & cellular oncology ; 2016.
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder with poorly understood etiology. Increasing evidence suggests that age-dependent compromise of the maintenance of mitochondrial function is a key risk factor. Several proteins encoded by PD-related genes are associated with mitochondria including PTEN-induced putative kinase 1 (PINK1), which was first identified as a gene that is upregulated by PTEN. Loss-of-function PINK1 mutations induce mitochondrial dysfunction and, ultimately, neuronal cell death. To mitigate the negative effects of altered cellular functions cells possess a degradation mechanism called autophagy for recycling damaged components; selective elimination of dysfunctional mitochondria by autophagy is termed mitophagy. Our study indicates that autophagy and mitophagy are upregulated in PINK1-deficient cells, and is the first report to demonstrate efficient fluxes by one-step analysis. We propose that autophagy is induced to maintain cellular homeostasis under conditions of non-regulated mitochondrial quality control.
DOI: 10.1080/23723556.2015.1046579
PubMed: 27308585
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pubmed:27308585Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">PINK1 deficiency enhances autophagy and mitophagy induction.</title><author><name sortKey="G Mez Sanchez, Ruben" sort="G Mez Sanchez, Ruben" uniqKey="G Mez Sanchez R" first="Rubén" last="G Mez-Sánchez">Rubén G Mez-Sánchez</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional ; Cáceres, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Yakhine Diop, Sokhna M S" sort="Yakhine Diop, Sokhna M S" uniqKey="Yakhine Diop S" first="Sokhna M S" last="Yakhine-Diop">Sokhna M S. Yakhine-Diop</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional ; Cáceres, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Bravo San Pedro, Jose M" sort="Bravo San Pedro, Jose M" uniqKey="Bravo San Pedro J" first="José M" last="Bravo-San Pedro">José M. Bravo-San Pedro</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional; Cáceres, Spain; Equipe 11 Labellisee pas la Ligue Nationale Contre le Cancer; Center de Recherche des Cordeliers; Paris, France; Sorbonne Paris Cite; Paris, France; Gustave Roussy Cancer Campus; Villejuif, France; Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus; Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pizarro Estrella, Elisa" sort="Pizarro Estrella, Elisa" uniqKey="Pizarro Estrella E" first="Elisa" last="Pizarro-Estrella">Elisa Pizarro-Estrella</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional ; Cáceres, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Rodriguez Arribas, Mario" sort="Rodriguez Arribas, Mario" uniqKey="Rodriguez Arribas M" first="Mario" last="Rodríguez-Arribas">Mario Rodríguez-Arribas</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional ; Cáceres, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Climent, Vicente" sort="Climent, Vicente" uniqKey="Climent V" first="Vicente" last="Climent">Vicente Climent</name><affiliation><nlm:affiliation>Departamento de Anatomía y Embriología Humana; Facultad de Medicina; Universidad de Extremadura ; Badajoz, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Martin Cano, Francisco E" sort="Martin Cano, Francisco E" uniqKey="Martin Cano F" first="Francisco E" last="Martin-Cano">Francisco E. Martin-Cano</name><affiliation><nlm:affiliation>Departamento de Fisiología; Facultad de Enfermería y Terapia Ocupacional; Universidad de Extremadura ; Cáceres, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Gonzalez Soltero, Maria E" sort="Gonzalez Soltero, Maria E" uniqKey="Gonzalez Soltero M" first="María E" last="González-Soltero">María E. González-Soltero</name><affiliation><nlm:affiliation>Sección de Neurología; Hospital Virgen del Puerto ; Plasencia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Tandon, Anurag" sort="Tandon, Anurag" uniqKey="Tandon A" first="Anurag" last="Tandon">Anurag Tandon</name><affiliation><nlm:affiliation>Tanz Center for Research in Neurodegenerative Diseases; University of Toronto ; Toronto, ON Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Fuentes, Jose M" sort="Fuentes, Jose M" uniqKey="Fuentes J" first="José M" last="Fuentes">José M. Fuentes</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional; Cáceres, Spain; These authors contributed equally to this work.</nlm:affiliation></affiliation></author><author><name sortKey="Gonzalez Polo, Rosa A" sort="Gonzalez Polo, Rosa A" uniqKey="Gonzalez Polo R" first="Rosa A" last="González-Polo">Rosa A. González-Polo</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional; Cáceres, Spain; These authors contributed equally to this work.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27308585</idno><idno type="pmid">27308585</idno><idno type="doi">10.1080/23723556.2015.1046579</idno><idno type="wicri:Area/PubMed/Corpus">000440</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000440</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">PINK1 deficiency enhances autophagy and mitophagy induction.</title><author><name sortKey="G Mez Sanchez, Ruben" sort="G Mez Sanchez, Ruben" uniqKey="G Mez Sanchez R" first="Rubén" last="G Mez-Sánchez">Rubén G Mez-Sánchez</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional ; Cáceres, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Yakhine Diop, Sokhna M S" sort="Yakhine Diop, Sokhna M S" uniqKey="Yakhine Diop S" first="Sokhna M S" last="Yakhine-Diop">Sokhna M S. Yakhine-Diop</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional ; Cáceres, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Bravo San Pedro, Jose M" sort="Bravo San Pedro, Jose M" uniqKey="Bravo San Pedro J" first="José M" last="Bravo-San Pedro">José M. Bravo-San Pedro</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional; Cáceres, Spain; Equipe 11 Labellisee pas la Ligue Nationale Contre le Cancer; Center de Recherche des Cordeliers; Paris, France; Sorbonne Paris Cite; Paris, France; Gustave Roussy Cancer Campus; Villejuif, France; Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus; Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pizarro Estrella, Elisa" sort="Pizarro Estrella, Elisa" uniqKey="Pizarro Estrella E" first="Elisa" last="Pizarro-Estrella">Elisa Pizarro-Estrella</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional ; Cáceres, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Rodriguez Arribas, Mario" sort="Rodriguez Arribas, Mario" uniqKey="Rodriguez Arribas M" first="Mario" last="Rodríguez-Arribas">Mario Rodríguez-Arribas</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional ; Cáceres, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Climent, Vicente" sort="Climent, Vicente" uniqKey="Climent V" first="Vicente" last="Climent">Vicente Climent</name><affiliation><nlm:affiliation>Departamento de Anatomía y Embriología Humana; Facultad de Medicina; Universidad de Extremadura ; Badajoz, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Martin Cano, Francisco E" sort="Martin Cano, Francisco E" uniqKey="Martin Cano F" first="Francisco E" last="Martin-Cano">Francisco E. Martin-Cano</name><affiliation><nlm:affiliation>Departamento de Fisiología; Facultad de Enfermería y Terapia Ocupacional; Universidad de Extremadura ; Cáceres, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Gonzalez Soltero, Maria E" sort="Gonzalez Soltero, Maria E" uniqKey="Gonzalez Soltero M" first="María E" last="González-Soltero">María E. González-Soltero</name><affiliation><nlm:affiliation>Sección de Neurología; Hospital Virgen del Puerto ; Plasencia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Tandon, Anurag" sort="Tandon, Anurag" uniqKey="Tandon A" first="Anurag" last="Tandon">Anurag Tandon</name><affiliation><nlm:affiliation>Tanz Center for Research in Neurodegenerative Diseases; University of Toronto ; Toronto, ON Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Fuentes, Jose M" sort="Fuentes, Jose M" uniqKey="Fuentes J" first="José M" last="Fuentes">José M. Fuentes</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional; Cáceres, Spain; These authors contributed equally to this work.</nlm:affiliation></affiliation></author><author><name sortKey="Gonzalez Polo, Rosa A" sort="Gonzalez Polo, Rosa A" uniqKey="Gonzalez Polo R" first="Rosa A" last="González-Polo">Rosa A. González-Polo</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional; Cáceres, Spain; These authors contributed equally to this work.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Molecular & cellular oncology</title><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a neurodegenerative disorder with poorly understood etiology. Increasing evidence suggests that age-dependent compromise of the maintenance of mitochondrial function is a key risk factor. Several proteins encoded by PD-related genes are associated with mitochondria including PTEN-induced putative kinase 1 (PINK1), which was first identified as a gene that is upregulated by PTEN. Loss-of-function PINK1 mutations induce mitochondrial dysfunction and, ultimately, neuronal cell death. To mitigate the negative effects of altered cellular functions cells possess a degradation mechanism called autophagy for recycling damaged components; selective elimination of dysfunctional mitochondria by autophagy is termed mitophagy. Our study indicates that autophagy and mitophagy are upregulated in PINK1-deficient cells, and is the first report to demonstrate efficient fluxes by one-step analysis. We propose that autophagy is induced to maintain cellular homeostasis under conditions of non-regulated mitochondrial quality control.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">27308585</PMID><DateCreated><Year>2016</Year><Month>06</Month><Day>16</Day></DateCreated><DateCompleted><Year>2016</Year><Month>06</Month><Day>16</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><JournalIssue CitedMedium="Print"><Volume>3</Volume><Issue>2</Issue><PubDate><Year>2016</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Molecular & cellular oncology</Title><ISOAbbreviation>Mol Cell Oncol</ISOAbbreviation></Journal><ArticleTitle>PINK1 deficiency enhances autophagy and mitophagy induction.</ArticleTitle><Pagination><MedlinePgn>e1046579</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/23723556.2015.1046579</ELocationID><Abstract><AbstractText>Parkinson's disease (PD) is a neurodegenerative disorder with poorly understood etiology. Increasing evidence suggests that age-dependent compromise of the maintenance of mitochondrial function is a key risk factor. Several proteins encoded by PD-related genes are associated with mitochondria including PTEN-induced putative kinase 1 (PINK1), which was first identified as a gene that is upregulated by PTEN. Loss-of-function PINK1 mutations induce mitochondrial dysfunction and, ultimately, neuronal cell death. To mitigate the negative effects of altered cellular functions cells possess a degradation mechanism called autophagy for recycling damaged components; selective elimination of dysfunctional mitochondria by autophagy is termed mitophagy. Our study indicates that autophagy and mitophagy are upregulated in PINK1-deficient cells, and is the first report to demonstrate efficient fluxes by one-step analysis. We propose that autophagy is induced to maintain cellular homeostasis under conditions of non-regulated mitochondrial quality control.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gómez-Sánchez</LastName><ForeName>Rubén</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional ; Cáceres, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yakhine-Diop</LastName><ForeName>Sokhna M S</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional ; Cáceres, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bravo-San Pedro</LastName><ForeName>José M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional; Cáceres, Spain; Equipe 11 Labellisee pas la Ligue Nationale Contre le Cancer; Center de Recherche des Cordeliers; Paris, France; Sorbonne Paris Cite; Paris, France; Gustave Roussy Cancer Campus; Villejuif, France; Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus; Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pizarro-Estrella</LastName><ForeName>Elisa</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional ; Cáceres, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodríguez-Arribas</LastName><ForeName>Mario</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional ; Cáceres, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Climent</LastName><ForeName>Vicente</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Departamento de Anatomía y Embriología Humana; Facultad de Medicina; Universidad de Extremadura ; Badajoz, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin-Cano</LastName><ForeName>Francisco E</ForeName><Initials>FE</Initials><AffiliationInfo><Affiliation>Departamento de Fisiología; Facultad de Enfermería y Terapia Ocupacional; Universidad de Extremadura ; Cáceres, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>González-Soltero</LastName><ForeName>María E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>Sección de Neurología; Hospital Virgen del Puerto ; Plasencia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tandon</LastName><ForeName>Anurag</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Tanz Center for Research in Neurodegenerative Diseases; University of Toronto ; Toronto, ON Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fuentes</LastName><ForeName>José M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional; Cáceres, Spain; These authors contributed equally to this work.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>González-Polo</LastName><ForeName>Rosa A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Departamento de Bioquímica y Biología Molecular y Genética; Universidad de Extremadura; Facultad de Enfermería y Terapia Ocupacional; Cáceres, Spain; These authors contributed equally to this work.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>08</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mol Cell 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PubStatus="accepted"><Year>2015</Year><Month>04</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>6</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>6</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>6</Month><Day>17</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27308585</ArticleId><ArticleId IdType="doi">10.1080/23723556.2015.1046579</ArticleId><ArticleId IdType="pii">1046579</ArticleId><ArticleId IdType="pmc">PMC4905358</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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