Altered protein expression pattern in skin fibroblasts from parkin-mutant early-onset Parkinson's disease patients.
Identifieur interne : 000419 ( PubMed/Corpus ); précédent : 000418; suivant : 000420Altered protein expression pattern in skin fibroblasts from parkin-mutant early-onset Parkinson's disease patients.
Auteurs : Rosa Lippolis ; Rosa Anna Siciliano ; Consiglia Pacelli ; Anna Ferretta ; Maria Fiorella Mazzeo ; Salvatore Scacco ; Francesco Papa ; Antonio Gaballo ; Claudia Dell'Aquila ; Michele De Mari ; Sergio Papa ; Tiziana CoccoSource :
- Biochimica et biophysica acta [ 0006-3002 ] ; 2015.
Abstract
Parkinson's disease (PD) is the most common neurodegenerative movement disorder caused primarily by selective degeneration of the dopaminergic neurons in substantia nigra. In this work the proteomes extracted from primary fibroblasts of two unrelated, hereditary cases of PD patients, with different parkin mutations, were compared with the proteomes extracted from commercial adult normal human dermal fibroblasts (NHDF) and primary fibroblasts from the healthy mother of one of the two patients. The results show that the fibroblasts from the two different cases of parkin-mutant patients display analogous alterations in the expression level of proteins involved in different cellular functions, like cytoskeleton structure-dynamics, calcium homeostasis, oxidative stress response, protein and RNA processing.
DOI: 10.1016/j.bbadis.2015.06.015
PubMed: 26096686
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Altered protein expression pattern in skin fibroblasts from parkin-mutant early-onset Parkinson's disease patients.</title><author><name sortKey="Lippolis, Rosa" sort="Lippolis, Rosa" uniqKey="Lippolis R" first="Rosa" last="Lippolis">Rosa Lippolis</name><affiliation><nlm:affiliation>Institute of Biomembranes and Bioenergetics, Italian National Research Council (CNR), Via G. Amendola 165/A, Bari, Italy. Electronic address: r.lippolis@ibbe.cnr.it.</nlm:affiliation></affiliation></author><author><name sortKey="Siciliano, Rosa Anna" sort="Siciliano, Rosa Anna" uniqKey="Siciliano R" first="Rosa Anna" last="Siciliano">Rosa Anna Siciliano</name><affiliation><nlm:affiliation>Institute of Food Sciences, Italian National Research Council (CNR), Via Roma, 64, Avellino, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Pacelli, Consiglia" sort="Pacelli, Consiglia" uniqKey="Pacelli C" first="Consiglia" last="Pacelli">Consiglia Pacelli</name><affiliation><nlm:affiliation>Department of Pharmacology, Faculty of Medicine, Universitè de Montreal, 2900 Boulevard Edouard-Montpetit, Montreal QCH3T1J4, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Ferretta, Anna" sort="Ferretta, Anna" uniqKey="Ferretta A" first="Anna" last="Ferretta">Anna Ferretta</name><affiliation><nlm:affiliation>Department of Basic Medical Sciences, Neurosciences and Sense Organs, University 'A. Moro', Bari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Mazzeo, Maria Fiorella" sort="Mazzeo, Maria Fiorella" uniqKey="Mazzeo M" first="Maria Fiorella" last="Mazzeo">Maria Fiorella Mazzeo</name><affiliation><nlm:affiliation>Institute of Food Sciences, Italian National Research Council (CNR), Via Roma, 64, Avellino, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Scacco, Salvatore" sort="Scacco, Salvatore" uniqKey="Scacco S" first="Salvatore" last="Scacco">Salvatore Scacco</name><affiliation><nlm:affiliation>Department of Basic Medical Sciences, Neurosciences and Sense Organs, University 'A. Moro', Bari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Papa, Francesco" sort="Papa, Francesco" uniqKey="Papa F" first="Francesco" last="Papa">Francesco Papa</name><affiliation><nlm:affiliation>Department of Basic Medical Sciences, Neurosciences and Sense Organs, University 'A. Moro', Bari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gaballo, Antonio" sort="Gaballo, Antonio" uniqKey="Gaballo A" first="Antonio" last="Gaballo">Antonio Gaballo</name><affiliation><nlm:affiliation>CNR NANOTEC-Istituto di Nanotecnologia, Polo di Nanotecnologia c/o Campus Ecotekne, via Monteroni, 73100 Lecce, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Dell Aquila, Claudia" sort="Dell Aquila, Claudia" uniqKey="Dell Aquila C" first="Claudia" last="Dell'Aquila">Claudia Dell'Aquila</name><affiliation><nlm:affiliation>Neurology Unit, Bonomo Hospital, Andria, BA, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="De Mari, Michele" sort="De Mari, Michele" uniqKey="De Mari M" first="Michele" last="De Mari">Michele De Mari</name><affiliation><nlm:affiliation>Neurology Unit, Bonomo Hospital, Andria, BA, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Papa, Sergio" sort="Papa, Sergio" uniqKey="Papa S" first="Sergio" last="Papa">Sergio Papa</name><affiliation><nlm:affiliation>Institute of Biomembranes and Bioenergetics, Italian National Research Council (CNR), Via G. Amendola 165/A, Bari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cocco, Tiziana" sort="Cocco, Tiziana" uniqKey="Cocco T" first="Tiziana" last="Cocco">Tiziana Cocco</name><affiliation><nlm:affiliation>Department of Basic Medical Sciences, Neurosciences and Sense Organs, University 'A. Moro', Bari, Italy. Electronic address: tizianamaria.cocco@uniba.it.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26096686</idno><idno type="pmid">26096686</idno><idno type="doi">10.1016/j.bbadis.2015.06.015</idno><idno type="wicri:Area/PubMed/Corpus">000419</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000419</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Altered protein expression pattern in skin fibroblasts from parkin-mutant early-onset Parkinson's disease patients.</title><author><name sortKey="Lippolis, Rosa" sort="Lippolis, Rosa" uniqKey="Lippolis R" first="Rosa" last="Lippolis">Rosa Lippolis</name><affiliation><nlm:affiliation>Institute of Biomembranes and Bioenergetics, Italian National Research Council (CNR), Via G. Amendola 165/A, Bari, Italy. Electronic address: r.lippolis@ibbe.cnr.it.</nlm:affiliation></affiliation></author><author><name sortKey="Siciliano, Rosa Anna" sort="Siciliano, Rosa Anna" uniqKey="Siciliano R" first="Rosa Anna" last="Siciliano">Rosa Anna Siciliano</name><affiliation><nlm:affiliation>Institute of Food Sciences, Italian National Research Council (CNR), Via Roma, 64, Avellino, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Pacelli, Consiglia" sort="Pacelli, Consiglia" uniqKey="Pacelli C" first="Consiglia" last="Pacelli">Consiglia Pacelli</name><affiliation><nlm:affiliation>Department of Pharmacology, Faculty of Medicine, Universitè de Montreal, 2900 Boulevard Edouard-Montpetit, Montreal QCH3T1J4, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Ferretta, Anna" sort="Ferretta, Anna" uniqKey="Ferretta A" first="Anna" last="Ferretta">Anna Ferretta</name><affiliation><nlm:affiliation>Department of Basic Medical Sciences, Neurosciences and Sense Organs, University 'A. Moro', Bari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Mazzeo, Maria Fiorella" sort="Mazzeo, Maria Fiorella" uniqKey="Mazzeo M" first="Maria Fiorella" last="Mazzeo">Maria Fiorella Mazzeo</name><affiliation><nlm:affiliation>Institute of Food Sciences, Italian National Research Council (CNR), Via Roma, 64, Avellino, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Scacco, Salvatore" sort="Scacco, Salvatore" uniqKey="Scacco S" first="Salvatore" last="Scacco">Salvatore Scacco</name><affiliation><nlm:affiliation>Department of Basic Medical Sciences, Neurosciences and Sense Organs, University 'A. Moro', Bari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Papa, Francesco" sort="Papa, Francesco" uniqKey="Papa F" first="Francesco" last="Papa">Francesco Papa</name><affiliation><nlm:affiliation>Department of Basic Medical Sciences, Neurosciences and Sense Organs, University 'A. Moro', Bari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gaballo, Antonio" sort="Gaballo, Antonio" uniqKey="Gaballo A" first="Antonio" last="Gaballo">Antonio Gaballo</name><affiliation><nlm:affiliation>CNR NANOTEC-Istituto di Nanotecnologia, Polo di Nanotecnologia c/o Campus Ecotekne, via Monteroni, 73100 Lecce, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Dell Aquila, Claudia" sort="Dell Aquila, Claudia" uniqKey="Dell Aquila C" first="Claudia" last="Dell'Aquila">Claudia Dell'Aquila</name><affiliation><nlm:affiliation>Neurology Unit, Bonomo Hospital, Andria, BA, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="De Mari, Michele" sort="De Mari, Michele" uniqKey="De Mari M" first="Michele" last="De Mari">Michele De Mari</name><affiliation><nlm:affiliation>Neurology Unit, Bonomo Hospital, Andria, BA, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Papa, Sergio" sort="Papa, Sergio" uniqKey="Papa S" first="Sergio" last="Papa">Sergio Papa</name><affiliation><nlm:affiliation>Institute of Biomembranes and Bioenergetics, Italian National Research Council (CNR), Via G. Amendola 165/A, Bari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cocco, Tiziana" sort="Cocco, Tiziana" uniqKey="Cocco T" first="Tiziana" last="Cocco">Tiziana Cocco</name><affiliation><nlm:affiliation>Department of Basic Medical Sciences, Neurosciences and Sense Organs, University 'A. Moro', Bari, Italy. Electronic address: tizianamaria.cocco@uniba.it.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Biochimica et biophysica acta</title><idno type="ISSN">0006-3002</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is the most common neurodegenerative movement disorder caused primarily by selective degeneration of the dopaminergic neurons in substantia nigra. In this work the proteomes extracted from primary fibroblasts of two unrelated, hereditary cases of PD patients, with different parkin mutations, were compared with the proteomes extracted from commercial adult normal human dermal fibroblasts (NHDF) and primary fibroblasts from the healthy mother of one of the two patients. The results show that the fibroblasts from the two different cases of parkin-mutant patients display analogous alterations in the expression level of proteins involved in different cellular functions, like cytoskeleton structure-dynamics, calcium homeostasis, oxidative stress response, protein and RNA processing.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">26096686</PMID><DateCreated><Year>2015</Year><Month>08</Month><Day>03</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0006-3002</ISSN><JournalIssue CitedMedium="Print"><Volume>1852</Volume><Issue>9</Issue><PubDate><Year>2015</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Biochimica et biophysica acta</Title><ISOAbbreviation>Biochim. Biophys. Acta</ISOAbbreviation></Journal><ArticleTitle>Altered protein expression pattern in skin fibroblasts from parkin-mutant early-onset Parkinson's disease patients.</ArticleTitle><Pagination><MedlinePgn>1960-70</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbadis.2015.06.015</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0925-4439(15)00181-7</ELocationID><Abstract><AbstractText>Parkinson's disease (PD) is the most common neurodegenerative movement disorder caused primarily by selective degeneration of the dopaminergic neurons in substantia nigra. In this work the proteomes extracted from primary fibroblasts of two unrelated, hereditary cases of PD patients, with different parkin mutations, were compared with the proteomes extracted from commercial adult normal human dermal fibroblasts (NHDF) and primary fibroblasts from the healthy mother of one of the two patients. The results show that the fibroblasts from the two different cases of parkin-mutant patients display analogous alterations in the expression level of proteins involved in different cellular functions, like cytoskeleton structure-dynamics, calcium homeostasis, oxidative stress response, protein and RNA processing.</AbstractText><CopyrightInformation>Copyright © 2015. Published by Elsevier B.V.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lippolis</LastName><ForeName>Rosa</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Institute of Biomembranes and Bioenergetics, Italian National Research Council (CNR), Via G. Amendola 165/A, Bari, Italy. Electronic address: r.lippolis@ibbe.cnr.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siciliano</LastName><ForeName>Rosa Anna</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>Institute of Food Sciences, Italian National Research Council (CNR), Via Roma, 64, Avellino, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pacelli</LastName><ForeName>Consiglia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, Faculty of Medicine, Universitè de Montreal, 2900 Boulevard Edouard-Montpetit, Montreal QCH3T1J4, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferretta</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Basic Medical Sciences, Neurosciences and Sense Organs, University 'A. Moro', Bari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mazzeo</LastName><ForeName>Maria Fiorella</ForeName><Initials>MF</Initials><AffiliationInfo><Affiliation>Institute of Food Sciences, Italian National Research Council (CNR), Via Roma, 64, Avellino, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scacco</LastName><ForeName>Salvatore</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Basic Medical Sciences, Neurosciences and Sense Organs, University 'A. Moro', Bari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Papa</LastName><ForeName>Francesco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Basic Medical Sciences, Neurosciences and Sense Organs, University 'A. Moro', Bari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gaballo</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>CNR NANOTEC-Istituto di Nanotecnologia, Polo di Nanotecnologia c/o Campus Ecotekne, via Monteroni, 73100 Lecce, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dell'Aquila</LastName><ForeName>Claudia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Neurology Unit, Bonomo Hospital, Andria, BA, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Mari</LastName><ForeName>Michele</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Neurology Unit, Bonomo Hospital, Andria, BA, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Papa</LastName><ForeName>Sergio</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Biomembranes and Bioenergetics, Italian National Research Council (CNR), Via G. Amendola 165/A, Bari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cocco</LastName><ForeName>Tiziana</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Basic Medical Sciences, Neurosciences and Sense Organs, University 'A. Moro', Bari, Italy. Electronic address: tizianamaria.cocco@uniba.it.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>06</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Biochim Biophys Acta</MedlineTA><NlmUniqueID>0217513</NlmUniqueID><ISSNLinking>0006-3002</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Human skin fibroblasts</Keyword><Keyword MajorTopicYN="N">Mass spectrometry</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">Proteomics</Keyword><Keyword MajorTopicYN="N">Two-dimensional gel electrophoresis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>02</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>06</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>06</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>6</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>6</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>6</Month><Day>23</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26096686</ArticleId><ArticleId IdType="pii">S0925-4439(15)00181-7</ArticleId><ArticleId IdType="doi">10.1016/j.bbadis.2015.06.015</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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