Short-latency afferent inhibition in patients with Parkinson's disease and freezing of gait.
Identifieur interne : 000377 ( PubMed/Corpus ); précédent : 000376; suivant : 000378Short-latency afferent inhibition in patients with Parkinson's disease and freezing of gait.
Auteurs : Marina Picillo ; Raffaele Dubbioso ; Rosa Iodice ; Alessandro Iavarone ; Chiara Pisciotta ; Emanuele Spina ; Lucio Santoro ; Paolo Barone ; Marianna Amboni ; Fiore ManganelliSource :
- Journal of neural transmission (Vienna, Austria : 1996) [ 1435-1463 ] ; 2015.
English descriptors
- KwdEn :
- Afferent Pathways (physiopathology), Aged, Electric Stimulation (methods), Evoked Potentials, Motor (physiology), Female, Fingers (physiopathology), Gait (physiology), Gait Disorders, Neurologic (physiopathology), Gait Disorders, Neurologic (psychology), Humans, Male, Median Nerve (physiopathology), Middle Aged, Motor Cortex (physiopathology), Muscle, Skeletal (physiopathology), Neural Inhibition (physiology), Neuropsychological Tests, Parkinson Disease (physiopathology), Parkinson Disease (psychology), Somatosensory Cortex (physiopathology), Time, Transcranial Magnetic Stimulation (methods).
- MESH :
- methods : Electric Stimulation, Transcranial Magnetic Stimulation.
- physiology : Evoked Potentials, Motor, Gait, Neural Inhibition.
- physiopathology : Afferent Pathways, Fingers, Gait Disorders, Neurologic, Median Nerve, Motor Cortex, Muscle, Skeletal, Parkinson Disease, Somatosensory Cortex.
- psychology : Gait Disorders, Neurologic, Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Time.
Abstract
Freezing of gait (FOG) is one of the most common gait disturbances in patients with Parkinson's disease (PD). Recently, a PET study has documented that PD patients with FOG display cholinergic deficits selectively driven by nucleus basalis of Meynert (nbM)-neocortical denervation and not by peduncolopontine nucleus (PPN)-thalamic degeneration. Short-latency afferent inhibition (SAI) is a neurophysiological technique that allows evaluating major cholinergic sources in the central nervous system in vivo. We sought to determine whether central cholinergic circuits, evaluated by means of SAI testing, are impaired in patients with PD with FOG (FOG+) as compared to those without (FOG-). SAI and neuropsychological data were collected in 14 FOG+ and 10 FOG-. SAI was also performed in 11 healthy control subjects. Demographic, clinical, and cognitive data were compared by using non-parametric tests. Parametric tests were used to compare electrophysiological results among groups. FOG+ and FOG- had similar SAI without significant differences with controls (p = 0.207). None of the PD patients had SAI values outside the normal range (>72 %). FOG+ presented poorer executive and visuospatial performances as compared to FOG-. Despite the presence of cognitive deficits, SAI failed to detect any significant decrease of cholinergic activity in FOG+. However, nbM-related cholinergic dysfunction cannot be ruled out. In fact, integrity or even increased activation of PPN-related cholinergic circuits may mask an eventual nbM dysfunction thus resulting in normal SAI findings. Indeed, selective PPN cholinergic neurons sparing maybe a distinctive features of FOG. Alternatively or complementary, FOG pathophysiology is underpinned by non-cholinergic neurotransmitters dysfunction.
DOI: 10.1007/s00702-015-1428-y
PubMed: 26228625
Links to Exploration step
pubmed:26228625Le document en format XML
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when="2015">2015</date><idno type="RBID">pubmed:26228625</idno><idno type="pmid">26228625</idno><idno type="doi">10.1007/s00702-015-1428-y</idno><idno type="wicri:Area/PubMed/Corpus">000377</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000377</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Short-latency afferent inhibition in patients with Parkinson's disease and freezing of gait.</title><author><name sortKey="Picillo, Marina" sort="Picillo, Marina" uniqKey="Picillo M" first="Marina" last="Picillo">Marina Picillo</name><affiliation><nlm:affiliation>Department of Medicine and Surgery, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, 84131, Salerno, Italy. maripici@libero.it.</nlm:affiliation></affiliation></author><author><name sortKey="Dubbioso, Raffaele" sort="Dubbioso, Raffaele" uniqKey="Dubbioso R" first="Raffaele" last="Dubbioso">Raffaele Dubbioso</name><affiliation><nlm:affiliation>Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy. rafdubbioso@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Iodice, Rosa" sort="Iodice, Rosa" uniqKey="Iodice R" first="Rosa" last="Iodice">Rosa Iodice</name><affiliation><nlm:affiliation>Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy. rosaiodice@libero.it.</nlm:affiliation></affiliation></author><author><name sortKey="Iavarone, Alessandro" sort="Iavarone, Alessandro" uniqKey="Iavarone A" first="Alessandro" last="Iavarone">Alessandro Iavarone</name><affiliation><nlm:affiliation>Neurological and Stroke Unit, CTO Hospital, AORN Ospedale dei Colli, Naples, Italy. aleiavarone@libero.it.</nlm:affiliation></affiliation></author><author><name sortKey="Pisciotta, Chiara" sort="Pisciotta, Chiara" uniqKey="Pisciotta C" first="Chiara" last="Pisciotta">Chiara Pisciotta</name><affiliation><nlm:affiliation>Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy. chiara.pisciotta@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Spina, Emanuele" sort="Spina, Emanuele" uniqKey="Spina E" first="Emanuele" last="Spina">Emanuele Spina</name><affiliation><nlm:affiliation>Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy. ema.spina@libero.it.</nlm:affiliation></affiliation></author><author><name sortKey="Santoro, Lucio" sort="Santoro, Lucio" uniqKey="Santoro L" first="Lucio" last="Santoro">Lucio Santoro</name><affiliation><nlm:affiliation>Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy. lusantor@unina.it.</nlm:affiliation></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation><nlm:affiliation>Department of Medicine and Surgery, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, 84131, Salerno, Italy. pbarone@unisa.it.</nlm:affiliation></affiliation></author><author><name sortKey="Amboni, Marianna" sort="Amboni, Marianna" uniqKey="Amboni M" first="Marianna" last="Amboni">Marianna Amboni</name><affiliation><nlm:affiliation>Department of Medicine and Surgery, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, 84131, Salerno, Italy. marianna.amboni@libero.it.</nlm:affiliation></affiliation></author><author><name sortKey="Manganelli, Fiore" sort="Manganelli, Fiore" uniqKey="Manganelli F" first="Fiore" last="Manganelli">Fiore Manganelli</name><affiliation><nlm:affiliation>Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy. fiore.manganelli@unina.it.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of neural transmission (Vienna, Austria : 1996)</title><idno type="eISSN">1435-1463</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Afferent Pathways (physiopathology)</term><term>Aged</term><term>Electric Stimulation (methods)</term><term>Evoked Potentials, Motor (physiology)</term><term>Female</term><term>Fingers (physiopathology)</term><term>Gait (physiology)</term><term>Gait Disorders, Neurologic (physiopathology)</term><term>Gait Disorders, Neurologic (psychology)</term><term>Humans</term><term>Male</term><term>Median Nerve (physiopathology)</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Muscle, Skeletal (physiopathology)</term><term>Neural Inhibition (physiology)</term><term>Neuropsychological Tests</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Somatosensory Cortex (physiopathology)</term><term>Time</term><term>Transcranial Magnetic Stimulation (methods)</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electric Stimulation</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Motor</term><term>Gait</term><term>Neural Inhibition</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Afferent Pathways</term><term>Fingers</term><term>Gait Disorders, Neurologic</term><term>Median Nerve</term><term>Motor Cortex</term><term>Muscle, Skeletal</term><term>Parkinson Disease</term><term>Somatosensory Cortex</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Gait Disorders, Neurologic</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Time</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Freezing of gait (FOG) is one of the most common gait disturbances in patients with Parkinson's disease (PD). Recently, a PET study has documented that PD patients with FOG display cholinergic deficits selectively driven by nucleus basalis of Meynert (nbM)-neocortical denervation and not by peduncolopontine nucleus (PPN)-thalamic degeneration. Short-latency afferent inhibition (SAI) is a neurophysiological technique that allows evaluating major cholinergic sources in the central nervous system in vivo. We sought to determine whether central cholinergic circuits, evaluated by means of SAI testing, are impaired in patients with PD with FOG (FOG+) as compared to those without (FOG-). SAI and neuropsychological data were collected in 14 FOG+ and 10 FOG-. SAI was also performed in 11 healthy control subjects. Demographic, clinical, and cognitive data were compared by using non-parametric tests. Parametric tests were used to compare electrophysiological results among groups. FOG+ and FOG- had similar SAI without significant differences with controls (p = 0.207). None of the PD patients had SAI values outside the normal range (>72 %). FOG+ presented poorer executive and visuospatial performances as compared to FOG-. Despite the presence of cognitive deficits, SAI failed to detect any significant decrease of cholinergic activity in FOG+. However, nbM-related cholinergic dysfunction cannot be ruled out. In fact, integrity or even increased activation of PPN-related cholinergic circuits may mask an eventual nbM dysfunction thus resulting in normal SAI findings. Indeed, selective PPN cholinergic neurons sparing maybe a distinctive features of FOG. Alternatively or complementary, FOG pathophysiology is underpinned by non-cholinergic neurotransmitters dysfunction.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26228625</PMID><DateCreated><Year>2015</Year><Month>10</Month><Day>21</Day></DateCreated><DateCompleted><Year>2016</Year><Month>08</Month><Day>30</Day></DateCompleted><DateRevised><Year>2015</Year><Month>10</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1435-1463</ISSN><JournalIssue CitedMedium="Internet"><Volume>122</Volume><Issue>11</Issue><PubDate><Year>2015</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Journal of neural transmission (Vienna, Austria : 1996)</Title><ISOAbbreviation>J Neural Transm (Vienna)</ISOAbbreviation></Journal><ArticleTitle>Short-latency afferent inhibition in patients with Parkinson's disease and freezing of gait.</ArticleTitle><Pagination><MedlinePgn>1533-40</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00702-015-1428-y</ELocationID><Abstract><AbstractText>Freezing of gait (FOG) is one of the most common gait disturbances in patients with Parkinson's disease (PD). Recently, a PET study has documented that PD patients with FOG display cholinergic deficits selectively driven by nucleus basalis of Meynert (nbM)-neocortical denervation and not by peduncolopontine nucleus (PPN)-thalamic degeneration. Short-latency afferent inhibition (SAI) is a neurophysiological technique that allows evaluating major cholinergic sources in the central nervous system in vivo. We sought to determine whether central cholinergic circuits, evaluated by means of SAI testing, are impaired in patients with PD with FOG (FOG+) as compared to those without (FOG-). SAI and neuropsychological data were collected in 14 FOG+ and 10 FOG-. SAI was also performed in 11 healthy control subjects. Demographic, clinical, and cognitive data were compared by using non-parametric tests. Parametric tests were used to compare electrophysiological results among groups. FOG+ and FOG- had similar SAI without significant differences with controls (p = 0.207). None of the PD patients had SAI values outside the normal range (>72 %). FOG+ presented poorer executive and visuospatial performances as compared to FOG-. Despite the presence of cognitive deficits, SAI failed to detect any significant decrease of cholinergic activity in FOG+. However, nbM-related cholinergic dysfunction cannot be ruled out. In fact, integrity or even increased activation of PPN-related cholinergic circuits may mask an eventual nbM dysfunction thus resulting in normal SAI findings. Indeed, selective PPN cholinergic neurons sparing maybe a distinctive features of FOG. Alternatively or complementary, FOG pathophysiology is underpinned by non-cholinergic neurotransmitters dysfunction.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Picillo</LastName><ForeName>Marina</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine and Surgery, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, 84131, Salerno, Italy. maripici@libero.it.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital and Division of Neurology, University of Toronto, Toronto, ON, Canada. maripici@libero.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dubbioso</LastName><ForeName>Raffaele</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy. rafdubbioso@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iodice</LastName><ForeName>Rosa</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy. rosaiodice@libero.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iavarone</LastName><ForeName>Alessandro</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Neurological and Stroke Unit, CTO Hospital, AORN Ospedale dei Colli, Naples, Italy. aleiavarone@libero.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pisciotta</LastName><ForeName>Chiara</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy. chiara.pisciotta@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spina</LastName><ForeName>Emanuele</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy. ema.spina@libero.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Santoro</LastName><ForeName>Lucio</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy. lusantor@unina.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barone</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Medicine and Surgery, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, 84131, Salerno, Italy. pbarone@unisa.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amboni</LastName><ForeName>Marianna</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine and Surgery, Center for Neurodegenerative Diseases (CEMAND), University of Salerno, 84131, Salerno, Italy. marianna.amboni@libero.it.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>IDC Hermitage-Capodimonte, Naples, Italy. marianna.amboni@libero.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manganelli</LastName><ForeName>Fiore</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy. fiore.manganelli@unina.it.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>07</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>Austria</Country><MedlineTA>J Neural Transm (Vienna)</MedlineTA><NlmUniqueID>9702341</NlmUniqueID><ISSNLinking>0300-9564</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000344" MajorTopicYN="N">Afferent Pathways</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004558" MajorTopicYN="N">Electric Stimulation</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019054" MajorTopicYN="N">Evoked Potentials, Motor</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005385" MajorTopicYN="N">Fingers</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005684" MajorTopicYN="N">Gait</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020233" MajorTopicYN="N">Gait Disorders, Neurologic</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008475" MajorTopicYN="N">Median Nerve</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009044" MajorTopicYN="N">Motor Cortex</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018482" MajorTopicYN="N">Muscle, Skeletal</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009433" MajorTopicYN="N">Neural Inhibition</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009483" MajorTopicYN="N">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013003" MajorTopicYN="N">Somatosensory Cortex</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013995" MajorTopicYN="N">Time</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D050781" MajorTopicYN="N">Transcranial Magnetic Stimulation</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cholinergic activity</Keyword><Keyword MajorTopicYN="N">Cognition</Keyword><Keyword MajorTopicYN="N">Freezing</Keyword><Keyword MajorTopicYN="N">Gait</Keyword><Keyword MajorTopicYN="N">PPN</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">SAI</Keyword><Keyword MajorTopicYN="N">TMS</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>04</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>07</Month><Day>14</Day></PubMedPubDate><PubMedPubDate 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