Conditional Epistatic Interaction Maps Reveal Global Functional Rewiring of Genome Integrity Pathways in Escherichia coli.
Identifieur interne : 000304 ( PubMed/Corpus ); précédent : 000303; suivant : 000305Conditional Epistatic Interaction Maps Reveal Global Functional Rewiring of Genome Integrity Pathways in Escherichia coli.
Auteurs : Ashwani Kumar ; Natalia Beloglazova ; Cedoljub Bundalovic-Torma ; Sadhna Phanse ; Viktor Deineko ; Alla Gagarinova ; Gabriel Musso ; James Vlasblom ; Sofia Lemak ; Mohsen Hooshyar ; Zoran Minic ; Omar Wagih ; Roberto Mosca ; Patrick Aloy ; Ashkan Golshani ; John Parkinson ; Andrew Emili ; Alexander F. Yakunin ; Mohan BabuSource :
- Cell reports [ 2211-1247 ] ; 2016.
English descriptors
- KwdEn :
- Catalytic Domain, DNA (metabolism), DNA Repair, Deoxyribonucleases (chemistry), Deoxyribonucleases (genetics), Deoxyribonucleases (metabolism), Endodeoxyribonucleases (chemistry), Endodeoxyribonucleases (genetics), Endodeoxyribonucleases (metabolism), Epistasis, Genetic, Escherichia coli (genetics), Escherichia coli (metabolism), Escherichia coli Proteins (chemistry), Escherichia coli Proteins (genetics), Escherichia coli Proteins (metabolism), Gene Regulatory Networks, Mutagenesis, RNA (metabolism).
- MESH :
- chemical , chemistry : Deoxyribonucleases, Endodeoxyribonucleases, Escherichia coli Proteins.
- chemical , genetics : Deoxyribonucleases, Endodeoxyribonucleases, Escherichia coli Proteins.
- chemical , metabolism : DNA, Deoxyribonucleases, Endodeoxyribonucleases, Escherichia coli Proteins, RNA.
- genetics : Escherichia coli.
- metabolism : Escherichia coli.
- Catalytic Domain, DNA Repair, Epistasis, Genetic, Gene Regulatory Networks, Mutagenesis.
Abstract
As antibiotic resistance is increasingly becoming a public health concern, an improved understanding of the bacterial DNA damage response (DDR), which is commonly targeted by antibiotics, could be of tremendous therapeutic value. Although the genetic components of the bacterial DDR have been studied extensively in isolation, how the underlying biological pathways interact functionally remains unclear. Here, we address this by performing systematic, unbiased, quantitative synthetic genetic interaction (GI) screens and uncover widespread changes in the GI network of the entire genomic integrity apparatus of Escherichia coli under standard and DNA-damaging growth conditions. The GI patterns of untreated cultures implicated two previously uncharacterized proteins (YhbQ and YqgF) as nucleases, whereas reorganization of the GI network after DNA damage revealed DDR roles for both annotated and uncharacterized genes. Analyses of pan-bacterial conservation patterns suggest that DDR mechanisms and functional relationships are near universal, highlighting a modular and highly adaptive genomic stress response.
DOI: 10.1016/j.celrep.2015.12.060
PubMed: 26774489
Links to Exploration step
pubmed:26774489Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Conditional Epistatic Interaction Maps Reveal Global Functional Rewiring of Genome Integrity Pathways in Escherichia coli.</title><author><name sortKey="Kumar, Ashwani" sort="Kumar, Ashwani" uniqKey="Kumar A" first="Ashwani" last="Kumar">Ashwani Kumar</name><affiliation><nlm:affiliation>Department of Computer Science, University of Regina, Regina, SK S4S 0A2, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Beloglazova, Natalia" sort="Beloglazova, Natalia" uniqKey="Beloglazova N" first="Natalia" last="Beloglazova">Natalia Beloglazova</name><affiliation><nlm:affiliation>Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Bundalovic Torma, Cedoljub" sort="Bundalovic Torma, Cedoljub" uniqKey="Bundalovic Torma C" first="Cedoljub" last="Bundalovic-Torma">Cedoljub Bundalovic-Torma</name><affiliation><nlm:affiliation>Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G OX4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Phanse, Sadhna" sort="Phanse, Sadhna" uniqKey="Phanse S" first="Sadhna" last="Phanse">Sadhna Phanse</name><affiliation><nlm:affiliation>Terrence Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Deineko, Viktor" sort="Deineko, Viktor" uniqKey="Deineko V" first="Viktor" last="Deineko">Viktor Deineko</name><affiliation><nlm:affiliation>Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Gagarinova, Alla" sort="Gagarinova, Alla" uniqKey="Gagarinova A" first="Alla" last="Gagarinova">Alla Gagarinova</name><affiliation><nlm:affiliation>Terrence Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Biochemistry, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Musso, Gabriel" sort="Musso, Gabriel" uniqKey="Musso G" first="Gabriel" last="Musso">Gabriel Musso</name><affiliation><nlm:affiliation>Department of Medicine, Harvard Medical School and Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Vlasblom, James" sort="Vlasblom, James" uniqKey="Vlasblom J" first="James" last="Vlasblom">James Vlasblom</name><affiliation><nlm:affiliation>Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Lemak, Sofia" sort="Lemak, Sofia" uniqKey="Lemak S" first="Sofia" last="Lemak">Sofia Lemak</name><affiliation><nlm:affiliation>Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Hooshyar, Mohsen" sort="Hooshyar, Mohsen" uniqKey="Hooshyar M" first="Mohsen" last="Hooshyar">Mohsen Hooshyar</name><affiliation><nlm:affiliation>Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Minic, Zoran" sort="Minic, Zoran" uniqKey="Minic Z" first="Zoran" last="Minic">Zoran Minic</name><affiliation><nlm:affiliation>Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Wagih, Omar" sort="Wagih, Omar" uniqKey="Wagih O" first="Omar" last="Wagih">Omar Wagih</name><affiliation><nlm:affiliation>Terrence Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Mosca, Roberto" sort="Mosca, Roberto" uniqKey="Mosca R" first="Roberto" last="Mosca">Roberto Mosca</name><affiliation><nlm:affiliation>Joint IRB-BSC-CRG Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, c/Baldiri i Reixac 10-12, Barcelona, 08028, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Aloy, Patrick" sort="Aloy, Patrick" uniqKey="Aloy P" first="Patrick" last="Aloy">Patrick Aloy</name><affiliation><nlm:affiliation>Joint IRB-BSC-CRG Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, c/Baldiri i Reixac 10-12, Barcelona, 08028, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg. Lluís Companys 23, Barcelona, 08010, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Golshani, Ashkan" sort="Golshani, Ashkan" uniqKey="Golshani A" first="Ashkan" last="Golshani">Ashkan Golshani</name><affiliation><nlm:affiliation>Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name><affiliation><nlm:affiliation>Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G OX4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Emili, Andrew" sort="Emili, Andrew" uniqKey="Emili A" first="Andrew" last="Emili">Andrew Emili</name><affiliation><nlm:affiliation>Terrence Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Yakunin, Alexander F" sort="Yakunin, Alexander F" uniqKey="Yakunin A" first="Alexander F" last="Yakunin">Alexander F. Yakunin</name><affiliation><nlm:affiliation>Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Babu, Mohan" sort="Babu, Mohan" uniqKey="Babu M" first="Mohan" last="Babu">Mohan Babu</name><affiliation><nlm:affiliation>Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada. Electronic address: mohan.babu@uregina.ca.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26774489</idno><idno type="pmid">26774489</idno><idno type="doi">10.1016/j.celrep.2015.12.060</idno><idno type="wicri:Area/PubMed/Corpus">000304</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000304</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Conditional Epistatic Interaction Maps Reveal Global Functional Rewiring of Genome Integrity Pathways in Escherichia coli.</title><author><name sortKey="Kumar, Ashwani" sort="Kumar, Ashwani" uniqKey="Kumar A" first="Ashwani" last="Kumar">Ashwani Kumar</name><affiliation><nlm:affiliation>Department of Computer Science, University of Regina, Regina, SK S4S 0A2, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Beloglazova, Natalia" sort="Beloglazova, Natalia" uniqKey="Beloglazova N" first="Natalia" last="Beloglazova">Natalia Beloglazova</name><affiliation><nlm:affiliation>Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Bundalovic Torma, Cedoljub" sort="Bundalovic Torma, Cedoljub" uniqKey="Bundalovic Torma C" first="Cedoljub" last="Bundalovic-Torma">Cedoljub Bundalovic-Torma</name><affiliation><nlm:affiliation>Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G OX4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Phanse, Sadhna" sort="Phanse, Sadhna" uniqKey="Phanse S" first="Sadhna" last="Phanse">Sadhna Phanse</name><affiliation><nlm:affiliation>Terrence Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Deineko, Viktor" sort="Deineko, Viktor" uniqKey="Deineko V" first="Viktor" last="Deineko">Viktor Deineko</name><affiliation><nlm:affiliation>Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Gagarinova, Alla" sort="Gagarinova, Alla" uniqKey="Gagarinova A" first="Alla" last="Gagarinova">Alla Gagarinova</name><affiliation><nlm:affiliation>Terrence Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Biochemistry, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Musso, Gabriel" sort="Musso, Gabriel" uniqKey="Musso G" first="Gabriel" last="Musso">Gabriel Musso</name><affiliation><nlm:affiliation>Department of Medicine, Harvard Medical School and Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Vlasblom, James" sort="Vlasblom, James" uniqKey="Vlasblom J" first="James" last="Vlasblom">James Vlasblom</name><affiliation><nlm:affiliation>Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Lemak, Sofia" sort="Lemak, Sofia" uniqKey="Lemak S" first="Sofia" last="Lemak">Sofia Lemak</name><affiliation><nlm:affiliation>Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Hooshyar, Mohsen" sort="Hooshyar, Mohsen" uniqKey="Hooshyar M" first="Mohsen" last="Hooshyar">Mohsen Hooshyar</name><affiliation><nlm:affiliation>Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Minic, Zoran" sort="Minic, Zoran" uniqKey="Minic Z" first="Zoran" last="Minic">Zoran Minic</name><affiliation><nlm:affiliation>Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Wagih, Omar" sort="Wagih, Omar" uniqKey="Wagih O" first="Omar" last="Wagih">Omar Wagih</name><affiliation><nlm:affiliation>Terrence Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Mosca, Roberto" sort="Mosca, Roberto" uniqKey="Mosca R" first="Roberto" last="Mosca">Roberto Mosca</name><affiliation><nlm:affiliation>Joint IRB-BSC-CRG Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, c/Baldiri i Reixac 10-12, Barcelona, 08028, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Aloy, Patrick" sort="Aloy, Patrick" uniqKey="Aloy P" first="Patrick" last="Aloy">Patrick Aloy</name><affiliation><nlm:affiliation>Joint IRB-BSC-CRG Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, c/Baldiri i Reixac 10-12, Barcelona, 08028, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg. Lluís Companys 23, Barcelona, 08010, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Golshani, Ashkan" sort="Golshani, Ashkan" uniqKey="Golshani A" first="Ashkan" last="Golshani">Ashkan Golshani</name><affiliation><nlm:affiliation>Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name><affiliation><nlm:affiliation>Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G OX4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Emili, Andrew" sort="Emili, Andrew" uniqKey="Emili A" first="Andrew" last="Emili">Andrew Emili</name><affiliation><nlm:affiliation>Terrence Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Yakunin, Alexander F" sort="Yakunin, Alexander F" uniqKey="Yakunin A" first="Alexander F" last="Yakunin">Alexander F. Yakunin</name><affiliation><nlm:affiliation>Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Babu, Mohan" sort="Babu, Mohan" uniqKey="Babu M" first="Mohan" last="Babu">Mohan Babu</name><affiliation><nlm:affiliation>Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada. Electronic address: mohan.babu@uregina.ca.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cell reports</title><idno type="eISSN">2211-1247</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Catalytic Domain</term><term>DNA (metabolism)</term><term>DNA Repair</term><term>Deoxyribonucleases (chemistry)</term><term>Deoxyribonucleases (genetics)</term><term>Deoxyribonucleases (metabolism)</term><term>Endodeoxyribonucleases (chemistry)</term><term>Endodeoxyribonucleases (genetics)</term><term>Endodeoxyribonucleases (metabolism)</term><term>Epistasis, Genetic</term><term>Escherichia coli (genetics)</term><term>Escherichia coli (metabolism)</term><term>Escherichia coli Proteins (chemistry)</term><term>Escherichia coli Proteins (genetics)</term><term>Escherichia coli Proteins (metabolism)</term><term>Gene Regulatory Networks</term><term>Mutagenesis</term><term>RNA (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Deoxyribonucleases</term><term>Endodeoxyribonucleases</term><term>Escherichia coli Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Deoxyribonucleases</term><term>Endodeoxyribonucleases</term><term>Escherichia coli Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>DNA</term><term>Deoxyribonucleases</term><term>Endodeoxyribonucleases</term><term>Escherichia coli Proteins</term><term>RNA</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Escherichia coli</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Escherichia coli</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Catalytic Domain</term><term>DNA Repair</term><term>Epistasis, Genetic</term><term>Gene Regulatory Networks</term><term>Mutagenesis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">As antibiotic resistance is increasingly becoming a public health concern, an improved understanding of the bacterial DNA damage response (DDR), which is commonly targeted by antibiotics, could be of tremendous therapeutic value. Although the genetic components of the bacterial DDR have been studied extensively in isolation, how the underlying biological pathways interact functionally remains unclear. Here, we address this by performing systematic, unbiased, quantitative synthetic genetic interaction (GI) screens and uncover widespread changes in the GI network of the entire genomic integrity apparatus of Escherichia coli under standard and DNA-damaging growth conditions. The GI patterns of untreated cultures implicated two previously uncharacterized proteins (YhbQ and YqgF) as nucleases, whereas reorganization of the GI network after DNA damage revealed DDR roles for both annotated and uncharacterized genes. Analyses of pan-bacterial conservation patterns suggest that DDR mechanisms and functional relationships are near universal, highlighting a modular and highly adaptive genomic stress response.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26774489</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>28</Day></DateCreated><DateCompleted><Year>2016</Year><Month>10</Month><Day>20</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2211-1247</ISSN><JournalIssue CitedMedium="Internet"><Volume>14</Volume><Issue>3</Issue><PubDate><Year>2016</Year><Month>Jan</Month><Day>26</Day></PubDate></JournalIssue><Title>Cell reports</Title><ISOAbbreviation>Cell Rep</ISOAbbreviation></Journal><ArticleTitle>Conditional Epistatic Interaction Maps Reveal Global Functional Rewiring of Genome Integrity Pathways in Escherichia coli.</ArticleTitle><Pagination><MedlinePgn>648-61</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.celrep.2015.12.060</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S2211-1247(15)01501-6</ELocationID><Abstract><AbstractText>As antibiotic resistance is increasingly becoming a public health concern, an improved understanding of the bacterial DNA damage response (DDR), which is commonly targeted by antibiotics, could be of tremendous therapeutic value. Although the genetic components of the bacterial DDR have been studied extensively in isolation, how the underlying biological pathways interact functionally remains unclear. Here, we address this by performing systematic, unbiased, quantitative synthetic genetic interaction (GI) screens and uncover widespread changes in the GI network of the entire genomic integrity apparatus of Escherichia coli under standard and DNA-damaging growth conditions. The GI patterns of untreated cultures implicated two previously uncharacterized proteins (YhbQ and YqgF) as nucleases, whereas reorganization of the GI network after DNA damage revealed DDR roles for both annotated and uncharacterized genes. Analyses of pan-bacterial conservation patterns suggest that DDR mechanisms and functional relationships are near universal, highlighting a modular and highly adaptive genomic stress response.</AbstractText><CopyrightInformation>Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kumar</LastName><ForeName>Ashwani</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Computer Science, University of Regina, Regina, SK S4S 0A2, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beloglazova</LastName><ForeName>Natalia</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bundalovic-Torma</LastName><ForeName>Cedoljub</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G OX4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Phanse</LastName><ForeName>Sadhna</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Terrence Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deineko</LastName><ForeName>Viktor</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gagarinova</LastName><ForeName>Alla</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Terrence Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Biochemistry, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Musso</LastName><ForeName>Gabriel</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Medicine, Harvard Medical School and Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vlasblom</LastName><ForeName>James</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lemak</LastName><ForeName>Sofia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hooshyar</LastName><ForeName>Mohsen</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Minic</LastName><ForeName>Zoran</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wagih</LastName><ForeName>Omar</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Terrence Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mosca</LastName><ForeName>Roberto</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Joint IRB-BSC-CRG Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, c/Baldiri i Reixac 10-12, Barcelona, 08028, Catalonia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aloy</LastName><ForeName>Patrick</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Joint IRB-BSC-CRG Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, c/Baldiri i Reixac 10-12, Barcelona, 08028, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg. Lluís Companys 23, Barcelona, 08010, Catalonia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Golshani</LastName><ForeName>Ashkan</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Biology, Carleton University, Ottawa, ON K1S 5B6, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parkinson</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G OX4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Emili</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Terrence Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yakunin</LastName><ForeName>Alexander F</ForeName><Initials>AF</Initials><AffiliationInfo><Affiliation>Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Babu</LastName><ForeName>Mohan</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Regina, Regina, SK S4S 0A2, Canada. Electronic address: mohan.babu@uregina.ca.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>MOP-82852</GrantID><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>01</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cell Rep</MedlineTA><NlmUniqueID>101573691</NlmUniqueID></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029968">Escherichia coli Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>63231-63-0</RegistryNumber><NameOfSubstance UI="D012313">RNA</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-49-2</RegistryNumber><NameOfSubstance UI="D004247">DNA</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.-</RegistryNumber><NameOfSubstance UI="D003851">Deoxyribonucleases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.-</RegistryNumber><NameOfSubstance UI="D004706">Endodeoxyribonucleases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.21.-</RegistryNumber><NameOfSubstance UI="C470945">YqgF protein, E coli</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D020134" MajorTopicYN="N">Catalytic Domain</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004247" MajorTopicYN="N">DNA</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004260" MajorTopicYN="N">DNA Repair</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003851" MajorTopicYN="N">Deoxyribonucleases</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004706" MajorTopicYN="N">Endodeoxyribonucleases</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004843" MajorTopicYN="Y">Epistasis, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004926" MajorTopicYN="N">Escherichia coli</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029968" MajorTopicYN="N">Escherichia coli Proteins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053263" MajorTopicYN="Y">Gene Regulatory Networks</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016296" MajorTopicYN="N">Mutagenesis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012313" MajorTopicYN="N">RNA</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>09</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>11</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>12</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>1</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>1</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>10</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26774489</ArticleId><ArticleId IdType="pii">S2211-1247(15)01501-6</ArticleId><ArticleId IdType="doi">10.1016/j.celrep.2015.12.060</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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