Obstructive sleep apnea in Parkinson's disease patients: effect of Sinemet CR taken at bedtime.
Identifieur interne : 000289 ( PubMed/Corpus ); précédent : 000288; suivant : 000290Obstructive sleep apnea in Parkinson's disease patients: effect of Sinemet CR taken at bedtime.
Auteurs : Priti Gros ; Victoria P. Mery ; Anne-Louise Lafontaine ; Ann Robinson ; Andrea Benedetti ; R John Kimoff ; Marta KaminskaSource :
- Sleep & breathing = Schlaf & Atmung [ 1522-1709 ] ; 2016.
English descriptors
- KwdEn :
- Aged, Arousal (drug effects), Carbidopa (administration & dosage), Drug Administration Schedule, Drug Combinations, Female, Humans, Levodopa (administration & dosage), Male, Middle Aged, Parkinson Disease (drug therapy), Polysomnography (drug effects), Sleep Apnea, Obstructive (drug therapy), Wakefulness (drug effects).
- MESH :
- chemical , administration & dosage : Carbidopa, Levodopa.
- drug effects : Arousal, Polysomnography, Wakefulness.
- drug therapy : Parkinson Disease, Sleep Apnea, Obstructive.
- Aged, Drug Administration Schedule, Drug Combinations, Female, Humans, Male, Middle Aged.
Abstract
Obstructive sleep apnea (OSA) results from upper airway (UA) obstruction. In Parkinson's disease (PD), levodopa improves UA obstruction during wakefulness. We hypothesized that bedtime controlled-release levodopa (Sinemet CR) is associated with less severe OSA (lower apnea-hypopnea index [AHI]) in PD patients.
DOI: 10.1007/s11325-015-1208-9
PubMed: 26070532
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pubmed:26070532Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Obstructive sleep apnea in Parkinson's disease patients: effect of Sinemet CR taken at bedtime.</title><author><name sortKey="Gros, Priti" sort="Gros, Priti" uniqKey="Gros P" first="Priti" last="Gros">Priti Gros</name><affiliation><nlm:affiliation>Respiratory Division & Sleep Laboratory, McGill University Health Centre, 1001 Decarie Blvd, Montreal, Quebec, H4A 3J1, Canada. priti.gros@mail.mcgill.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Mery, Victoria P" sort="Mery, Victoria P" uniqKey="Mery V" first="Victoria P" last="Mery">Victoria P. Mery</name><affiliation><nlm:affiliation>Neurology Department, Clinica Alemana de Santiago, Santiago, Chile.</nlm:affiliation></affiliation></author><author><name sortKey="Lafontaine, Anne Louise" sort="Lafontaine, Anne Louise" uniqKey="Lafontaine A" first="Anne-Louise" last="Lafontaine">Anne-Louise Lafontaine</name><affiliation><nlm:affiliation>Montreal Neurological Hospital, McGill University Health Centre, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Robinson, Ann" sort="Robinson, Ann" uniqKey="Robinson A" first="Ann" last="Robinson">Ann Robinson</name><affiliation><nlm:affiliation>Respiratory Division & Sleep Laboratory, McGill University Health Centre, 1001 Decarie Blvd, Montreal, Quebec, H4A 3J1, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Benedetti, Andrea" sort="Benedetti, Andrea" uniqKey="Benedetti A" first="Andrea" last="Benedetti">Andrea Benedetti</name><affiliation><nlm:affiliation>Department of Medicine and Department of Epidemiology, Biostatistics & Occupational Health, McGill University Health Centre, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Kimoff, R John" sort="Kimoff, R John" uniqKey="Kimoff R" first="R John" last="Kimoff">R John Kimoff</name><affiliation><nlm:affiliation>Respiratory Division & Sleep Laboratory, McGill University Health Centre, 1001 Decarie Blvd, Montreal, Quebec, H4A 3J1, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Kaminska, Marta" sort="Kaminska, Marta" uniqKey="Kaminska M" first="Marta" last="Kaminska">Marta Kaminska</name><affiliation><nlm:affiliation>Respiratory Division & Sleep Laboratory, McGill University Health Centre, 1001 Decarie Blvd, Montreal, Quebec, H4A 3J1, Canada.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26070532</idno><idno type="pmid">26070532</idno><idno type="doi">10.1007/s11325-015-1208-9</idno><idno type="wicri:Area/PubMed/Corpus">000289</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000289</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Obstructive sleep apnea in Parkinson's disease patients: effect of Sinemet CR taken at bedtime.</title><author><name sortKey="Gros, Priti" sort="Gros, Priti" uniqKey="Gros P" first="Priti" last="Gros">Priti Gros</name><affiliation><nlm:affiliation>Respiratory Division & Sleep Laboratory, McGill University Health Centre, 1001 Decarie Blvd, Montreal, Quebec, H4A 3J1, Canada. priti.gros@mail.mcgill.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Mery, Victoria P" sort="Mery, Victoria P" uniqKey="Mery V" first="Victoria P" last="Mery">Victoria P. Mery</name><affiliation><nlm:affiliation>Neurology Department, Clinica Alemana de Santiago, Santiago, Chile.</nlm:affiliation></affiliation></author><author><name sortKey="Lafontaine, Anne Louise" sort="Lafontaine, Anne Louise" uniqKey="Lafontaine A" first="Anne-Louise" last="Lafontaine">Anne-Louise Lafontaine</name><affiliation><nlm:affiliation>Montreal Neurological Hospital, McGill University Health Centre, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Robinson, Ann" sort="Robinson, Ann" uniqKey="Robinson A" first="Ann" last="Robinson">Ann Robinson</name><affiliation><nlm:affiliation>Respiratory Division & Sleep Laboratory, McGill University Health Centre, 1001 Decarie Blvd, Montreal, Quebec, H4A 3J1, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Benedetti, Andrea" sort="Benedetti, Andrea" uniqKey="Benedetti A" first="Andrea" last="Benedetti">Andrea Benedetti</name><affiliation><nlm:affiliation>Department of Medicine and Department of Epidemiology, Biostatistics & Occupational Health, McGill University Health Centre, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Kimoff, R John" sort="Kimoff, R John" uniqKey="Kimoff R" first="R John" last="Kimoff">R John Kimoff</name><affiliation><nlm:affiliation>Respiratory Division & Sleep Laboratory, McGill University Health Centre, 1001 Decarie Blvd, Montreal, Quebec, H4A 3J1, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Kaminska, Marta" sort="Kaminska, Marta" uniqKey="Kaminska M" first="Marta" last="Kaminska">Marta Kaminska</name><affiliation><nlm:affiliation>Respiratory Division & Sleep Laboratory, McGill University Health Centre, 1001 Decarie Blvd, Montreal, Quebec, H4A 3J1, Canada.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Sleep & breathing = Schlaf & Atmung</title><idno type="eISSN">1522-1709</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Arousal (drug effects)</term><term>Carbidopa (administration & dosage)</term><term>Drug Administration Schedule</term><term>Drug Combinations</term><term>Female</term><term>Humans</term><term>Levodopa (administration & dosage)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (drug therapy)</term><term>Polysomnography (drug effects)</term><term>Sleep Apnea, Obstructive (drug therapy)</term><term>Wakefulness (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Carbidopa</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Arousal</term><term>Polysomnography</term><term>Wakefulness</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term><term>Sleep Apnea, Obstructive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Drug Administration Schedule</term><term>Drug Combinations</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Obstructive sleep apnea (OSA) results from upper airway (UA) obstruction. In Parkinson's disease (PD), levodopa improves UA obstruction during wakefulness. We hypothesized that bedtime controlled-release levodopa (Sinemet CR) is associated with less severe OSA (lower apnea-hypopnea index [AHI]) in PD patients.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26070532</PMID><DateCreated><Year>2016</Year><Month>03</Month><Day>16</Day></DateCreated><DateCompleted><Year>2017</Year><Month>01</Month><Day>24</Day></DateCompleted><DateRevised><Year>2017</Year><Month>01</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1522-1709</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>1</Issue><PubDate><Year>2016</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Sleep & breathing = Schlaf & Atmung</Title><ISOAbbreviation>Sleep Breath</ISOAbbreviation></Journal><ArticleTitle>Obstructive sleep apnea in Parkinson's disease patients: effect of Sinemet CR taken at bedtime.</ArticleTitle><Pagination><MedlinePgn>205-12</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s11325-015-1208-9</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">Obstructive sleep apnea (OSA) results from upper airway (UA) obstruction. In Parkinson's disease (PD), levodopa improves UA obstruction during wakefulness. We hypothesized that bedtime controlled-release levodopa (Sinemet CR) is associated with less severe OSA (lower apnea-hypopnea index [AHI]) in PD patients.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Idiopathic PD subjects underwent nocturnal polysomnography (PSG) and were divided into those taking bedtime Sinemet CR (SinCR+) and those not taking Sinemet CR (SinCR-). Outcomes were compared between groups for PSG recordings analyzed in whole and split at their mid-point with each half analyzed separately, using linear regression.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Fifty-seven subjects were studied, eight SinCR+, and 49 SinCR-. They were 65 % male, aged 64.4 ± 10.3 years (mean ± SD), with body mass index 27.26 ± 3.98 kg/m(2). The whole night AHI was 15.6 ± 13.3 and 29.1 ± 20.8 in SinCR+ and SinCR-, respectively (p = 0.07 unadjusted, p = 0.11 adjusted for confounders). A similar trend was observed in the first half of the night. In the second half, the SinCR+ group had significantly lower AHI (beta = -18.8; p = 0.01 adjusted) and respiratory arousal index (beta = -14.2; p = 0.02 adjusted) than the SinCR- group.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Bedtime Sinemet CR appears to reduce OSA in PD patients. There were no significant differences between groups in the first half of the night likely because of residual effects of short-acting levodopa in both groups, while Sinemet CR had residual effect in the second half. These results possibly provide an alternative to help manage OSA and improve sleep quality in PD patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gros</LastName><ForeName>Priti</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Respiratory Division & Sleep Laboratory, McGill University Health Centre, 1001 Decarie Blvd, Montreal, Quebec, H4A 3J1, Canada. priti.gros@mail.mcgill.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mery</LastName><ForeName>Victoria P</ForeName><Initials>VP</Initials><AffiliationInfo><Affiliation>Neurology Department, Clinica Alemana de Santiago, Santiago, Chile.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lafontaine</LastName><ForeName>Anne-Louise</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Montreal Neurological Hospital, McGill University Health Centre, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robinson</LastName><ForeName>Ann</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Respiratory Division & Sleep Laboratory, McGill University Health Centre, 1001 Decarie Blvd, Montreal, Quebec, H4A 3J1, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benedetti</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine and Department of Epidemiology, Biostatistics & Occupational Health, McGill University Health Centre, Montreal, QC, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Respiratory & Epidemiology and Clinical Research Unit, McGill University Health Centre, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kimoff</LastName><ForeName>R John</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Respiratory Division & Sleep Laboratory, McGill University Health Centre, 1001 Decarie Blvd, Montreal, Quebec, H4A 3J1, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaminska</LastName><ForeName>Marta</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Respiratory Division & Sleep Laboratory, McGill University Health Centre, 1001 Decarie Blvd, Montreal, Quebec, H4A 3J1, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Respiratory & Epidemiology and Clinical Research Unit, McGill University Health Centre, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D018848">Controlled Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>06</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Sleep Breath</MedlineTA><NlmUniqueID>9804161</NlmUniqueID><ISSNLinking>1520-9512</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004338">Drug Combinations</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C009265">carbidopa, levodopa drug combination</NameOfSubstance></Chemical><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical><Chemical><RegistryNumber>MNX7R8C5VO</RegistryNumber><NameOfSubstance UI="D002230">Carbidopa</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001143" MajorTopicYN="N">Arousal</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002230" MajorTopicYN="N">Carbidopa</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004334" MajorTopicYN="N">Drug Administration Schedule</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004338" MajorTopicYN="N">Drug Combinations</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007980" MajorTopicYN="N">Levodopa</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017286" MajorTopicYN="N">Polysomnography</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020181" MajorTopicYN="N">Sleep Apnea, Obstructive</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014851" MajorTopicYN="N">Wakefulness</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Long-acting levodopa</Keyword><Keyword MajorTopicYN="N">Obstructive sleep apnea</Keyword><Keyword MajorTopicYN="N">Parkinson’s disease</Keyword><Keyword MajorTopicYN="N">Sinemet CR</Keyword><Keyword MajorTopicYN="N">Sleep disorders</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>01</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>05</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>04</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>6</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>6</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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