ParkinsonCanadaV1, PubMed, Corpus, bibRecord, 000280

Association Between Change in Body Mass Index, Unified Parkinson's Disease Rating Scale Scores, and Survival Among Persons With Parkinson Disease: Secondary Analysis of Longitudinal Data From NINDS Exploratory Trials in Parkinson Disease Long-term Study 1.

Identifieur interne : 000280 ( PubMed/Corpus ); précédent : 000279; suivant : 000281

Association Between Change in Body Mass Index, Unified Parkinson's Disease Rating Scale Scores, and Survival Among Persons With Parkinson Disease: Secondary Analysis of Longitudinal Data From NINDS Exploratory Trials in Parkinson Disease Long-term Study 1.

Auteurs : Anne-Marie A. Wills ; Adriana Pérez ; Jue Wang ; Xiao Su ; John Morgan ; Suja S. Rajan ; Maureen A. Leehey ; Gregory M. Pontone ; Kelvin L. Chou ; Chizoba Umeh ; Zoltan Mari ; James Boyd

Source :

JAMA neurology [ 2168-6157 ] ; 2016.

RBID : pubmed:26751506

English descriptors

KwdEn :
- Aged, Body Mass Index, Disease Progression, Female, Humans, Male, Middle Aged, National Institute of Neurological Disorders and Stroke, Parkinson Disease (mortality), Parkinson Disease (physiopathology), Randomized Controlled Trials as Topic, Severity of Illness Index, United States.
MESH :
- geographic : United States.
- mortality : Parkinson Disease.
- physiopathology : Parkinson Disease.
- Aged, Body Mass Index, Disease Progression, Female, Humans, Male, Middle Aged, National Institute of Neurological Disorders and Stroke, Randomized Controlled Trials as Topic, Severity of Illness Index.

Abstract

Greater body mass index (BMI, calculated as weight in kilograms divided by height in meters squared) is associated with improved survival among persons with Huntington disease or amyotrophic lateral sclerosis. Weight loss is common among persons with Parkinson disease (PD) and is associated with worse quality of life.

DOI: 10.1001/jamaneurol.2015.4265
PubMed: 26751506

Links to Exploration step

pubmed:26751506

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association Between Change in Body Mass Index, Unified Parkinson's Disease Rating Scale Scores, and Survival Among Persons With Parkinson Disease: Secondary Analysis of Longitudinal Data From NINDS Exploratory Trials in Parkinson Disease Long-term Study 1.</title>
<author><name sortKey="Wills, Anne Marie A" sort="Wills, Anne Marie A" uniqKey="Wills A" first="Anne-Marie A" last="Wills">Anne-Marie A. Wills</name>
<affiliation><nlm:affiliation>Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Perez, Adriana" sort="Perez, Adriana" uniqKey="Perez A" first="Adriana" last="Pérez">Adriana Pérez</name>
<affiliation><nlm:affiliation>Department of Biostatistics, The University of Texas Health Science Center at Houston UTHealth, School of Public Health, Austin.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wang, Jue" sort="Wang, Jue" uniqKey="Wang J" first="Jue" last="Wang">Jue Wang</name>
<affiliation><nlm:affiliation>UTHealth, The University of Texas School of Public Health, Houston.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Su, Xiao" sort="Su, Xiao" uniqKey="Su X" first="Xiao" last="Su">Xiao Su</name>
<affiliation><nlm:affiliation>UTHealth, The University of Texas School of Public Health, Houston.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Morgan, John" sort="Morgan, John" uniqKey="Morgan J" first="John" last="Morgan">John Morgan</name>
<affiliation><nlm:affiliation>Department of Neurology, Medical College of Georgia, Georgia Regents University, Augusta.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rajan, Suja S" sort="Rajan, Suja S" uniqKey="Rajan S" first="Suja S" last="Rajan">Suja S. Rajan</name>
<affiliation><nlm:affiliation>Department of Management, Policy and Community Health, The University of Texas Health Science Center at Houston UTHealth, School of Public Health, Houston.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Leehey, Maureen A" sort="Leehey, Maureen A" uniqKey="Leehey M" first="Maureen A" last="Leehey">Maureen A. Leehey</name>
<affiliation><nlm:affiliation>Department of Neurology, University of Colorado Hospital and University of Colorado School of Medicine, Aurora.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pontone, Gregory M" sort="Pontone, Gregory M" uniqKey="Pontone G" first="Gregory M" last="Pontone">Gregory M. Pontone</name>
<affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chou, Kelvin L" sort="Chou, Kelvin L" uniqKey="Chou K" first="Kelvin L" last="Chou">Kelvin L. Chou</name>
<affiliation><nlm:affiliation>Departments of Neurology and Neurosurgery, University of Michigan, Ann Arbor.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Umeh, Chizoba" sort="Umeh, Chizoba" uniqKey="Umeh C" first="Chizoba" last="Umeh">Chizoba Umeh</name>
<affiliation><nlm:affiliation>Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name>
<affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Boyd, James" sort="Boyd, James" uniqKey="Boyd J" first="James" last="Boyd">James Boyd</name>
<affiliation><nlm:affiliation>Department of Neurological Sciences, University of Vermont College of Medicine, Burlington.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:26751506</idno>
<idno type="pmid">26751506</idno>
<idno type="doi">10.1001/jamaneurol.2015.4265</idno>
<idno type="wicri:Area/PubMed/Corpus">000280</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000280</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Association Between Change in Body Mass Index, Unified Parkinson's Disease Rating Scale Scores, and Survival Among Persons With Parkinson Disease: Secondary Analysis of Longitudinal Data From NINDS Exploratory Trials in Parkinson Disease Long-term Study 1.</title>
<author><name sortKey="Wills, Anne Marie A" sort="Wills, Anne Marie A" uniqKey="Wills A" first="Anne-Marie A" last="Wills">Anne-Marie A. Wills</name>
<affiliation><nlm:affiliation>Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Perez, Adriana" sort="Perez, Adriana" uniqKey="Perez A" first="Adriana" last="Pérez">Adriana Pérez</name>
<affiliation><nlm:affiliation>Department of Biostatistics, The University of Texas Health Science Center at Houston UTHealth, School of Public Health, Austin.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wang, Jue" sort="Wang, Jue" uniqKey="Wang J" first="Jue" last="Wang">Jue Wang</name>
<affiliation><nlm:affiliation>UTHealth, The University of Texas School of Public Health, Houston.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Su, Xiao" sort="Su, Xiao" uniqKey="Su X" first="Xiao" last="Su">Xiao Su</name>
<affiliation><nlm:affiliation>UTHealth, The University of Texas School of Public Health, Houston.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Morgan, John" sort="Morgan, John" uniqKey="Morgan J" first="John" last="Morgan">John Morgan</name>
<affiliation><nlm:affiliation>Department of Neurology, Medical College of Georgia, Georgia Regents University, Augusta.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rajan, Suja S" sort="Rajan, Suja S" uniqKey="Rajan S" first="Suja S" last="Rajan">Suja S. Rajan</name>
<affiliation><nlm:affiliation>Department of Management, Policy and Community Health, The University of Texas Health Science Center at Houston UTHealth, School of Public Health, Houston.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Leehey, Maureen A" sort="Leehey, Maureen A" uniqKey="Leehey M" first="Maureen A" last="Leehey">Maureen A. Leehey</name>
<affiliation><nlm:affiliation>Department of Neurology, University of Colorado Hospital and University of Colorado School of Medicine, Aurora.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pontone, Gregory M" sort="Pontone, Gregory M" uniqKey="Pontone G" first="Gregory M" last="Pontone">Gregory M. Pontone</name>
<affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chou, Kelvin L" sort="Chou, Kelvin L" uniqKey="Chou K" first="Kelvin L" last="Chou">Kelvin L. Chou</name>
<affiliation><nlm:affiliation>Departments of Neurology and Neurosurgery, University of Michigan, Ann Arbor.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Umeh, Chizoba" sort="Umeh, Chizoba" uniqKey="Umeh C" first="Chizoba" last="Umeh">Chizoba Umeh</name>
<affiliation><nlm:affiliation>Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name>
<affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Boyd, James" sort="Boyd, James" uniqKey="Boyd J" first="James" last="Boyd">James Boyd</name>
<affiliation><nlm:affiliation>Department of Neurological Sciences, University of Vermont College of Medicine, Burlington.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">JAMA neurology</title>
<idno type="eISSN">2168-6157</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Body Mass Index</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>National Institute of Neurological Disorders and Stroke</term>
<term>Parkinson Disease (mortality)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Severity of Illness Index</term>
<term>United States</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>United States</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Body Mass Index</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>National Institute of Neurological Disorders and Stroke</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Severity of Illness Index</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Greater body mass index (BMI, calculated as weight in kilograms divided by height in meters squared) is associated with improved survival among persons with Huntington disease or amyotrophic lateral sclerosis. Weight loss is common among persons with Parkinson disease (PD) and is associated with worse quality of life.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26751506</PMID>
<DateCreated><Year>2016</Year>
<Month>03</Month>
<Day>15</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>09</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>03</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2168-6157</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>73</Volume>
<Issue>3</Issue>
<PubDate><Year>2016</Year>
<Month>Mar</Month>
</PubDate>
</JournalIssue>
<Title>JAMA neurology</Title>
<ISOAbbreviation>JAMA Neurol</ISOAbbreviation>
</Journal>
<ArticleTitle>Association Between Change in Body Mass Index, Unified Parkinson's Disease Rating Scale Scores, and Survival Among Persons With Parkinson Disease: Secondary Analysis of Longitudinal Data From NINDS Exploratory Trials in Parkinson Disease Long-term Study 1.</ArticleTitle>
<Pagination><MedlinePgn>321-8</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1001/jamaneurol.2015.4265</ELocationID>
<Abstract><AbstractText Label="IMPORTANCE" NlmCategory="OBJECTIVE">Greater body mass index (BMI, calculated as weight in kilograms divided by height in meters squared) is associated with improved survival among persons with Huntington disease or amyotrophic lateral sclerosis. Weight loss is common among persons with Parkinson disease (PD) and is associated with worse quality of life.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To explore the association between change in BMI, Unified Parkinson's Disease Rating Scale (UPDRS) motor and total scores, and survival among persons with PD and to test whether there is a positive association between BMI at randomization and survival.</AbstractText>
<AbstractText Label="DESIGN, SETTING, AND PARTICIPANTS" NlmCategory="METHODS">Secondary analysis (from May 27, 2014, to October 13, 2015) of longitudinal data (3-6 years) from 1673 participants who started the National Institute of Neurological Disorders and Stroke Exploratory Trials in PD Long-term Study-1 (NET-PD LS-1). This was a double-blind randomized placebo-controlled clinical trial of creatine monohydrate (10 g/d) that was performed at 45 sites throughout the United States and Canada. Participants with early (within 5 years of diagnosis) and treated (receiving dopaminergic therapy) PD were enrolled from March 2007 to May 2010 and followed up until September 2013.</AbstractText>
<AbstractText Label="MAIN OUTCOMES AND MEASURES" NlmCategory="METHODS">Change across time in motor UPDRS score, change across time in total UPDRS score, and time to death. Generalized linear mixed models were used to estimate the effect of BMI on the change in motor and total UPDRS scores after controlling for covariates. Survival was analyzed using Cox proportional hazards models of time to death. A participant's BMI was measured at randomization, and BMI trajectory groups were classified according to whether participants experienced weight loss ("decreasing BMI"), weight stability ("stable BMI"), or weight gain ("increasing BMI") during the study.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Of the 1673 participants (mean [SD] age, 61.7 [9.6] years; 1074 [64.2%] were male), 158 (9.4%) experienced weight loss (decreasing BMI), whereas 233 (13.9%) experienced weight gain (increasing BMI). After adjusting for covariates, we found that the weight-loss group's mean (SE) motor UPDRS score increased by 1.48 (0.28) (P < .001) more points per visit than the weight-stable group's mean (SE) motor UPDRS score. The weight-gain group's mean (SE) motor UPDRS score decreased by -0.51 (0.24) (P = .03) points per visit, relative to the weight-stable group. While there was an unadjusted difference in survival between the 3 BMI trajectory groups (log-rank P < .001), this was not significant after adjusting for covariates.</AbstractText>
<AbstractText Label="CONCLUSIONS AND RELEVANCE" NlmCategory="CONCLUSIONS">Change in BMI was inversely associated with change in motor and total UPDRS scores in the NET-PD LS-1. Change in BMI was not associated with survival; however, these results were limited by the low number of deaths in the NET-PD LS-1.</AbstractText>
<AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">clinicaltrials.gov Identifier: NCT00449865.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wills</LastName>
<ForeName>Anne-Marie A</ForeName>
<Initials>AM</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pérez</LastName>
<ForeName>Adriana</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Biostatistics, The University of Texas Health Science Center at Houston UTHealth, School of Public Health, Austin.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Jue</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>UTHealth, The University of Texas School of Public Health, Houston.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Su</LastName>
<ForeName>Xiao</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>UTHealth, The University of Texas School of Public Health, Houston.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Morgan</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Medical College of Georgia, Georgia Regents University, Augusta.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rajan</LastName>
<ForeName>Suja S</ForeName>
<Initials>SS</Initials>
<AffiliationInfo><Affiliation>Department of Management, Policy and Community Health, The University of Texas Health Science Center at Houston UTHealth, School of Public Health, Houston.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leehey</LastName>
<ForeName>Maureen A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, University of Colorado Hospital and University of Colorado School of Medicine, Aurora.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pontone</LastName>
<ForeName>Gregory M</ForeName>
<Initials>GM</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chou</LastName>
<ForeName>Kelvin L</ForeName>
<Initials>KL</Initials>
<AffiliationInfo><Affiliation>Departments of Neurology and Neurosurgery, University of Michigan, Ann Arbor.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Umeh</LastName>
<ForeName>Chizoba</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mari</LastName>
<ForeName>Zoltan</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Boyd</LastName>
<ForeName>James</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Neurological Sciences, University of Vermont College of Medicine, Burlington.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName>
<AccessionNumberList><AccessionNumber>NCT00449865</AccessionNumber>
</AccessionNumberList>
</DataBank>
</DataBankList>
<GrantList CompleteYN="Y"><Grant><GrantID>U01NS043127</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U01NS043128</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS 044474</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS 044545</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044415</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044425</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044426</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044427</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044431</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044437</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044441</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044446</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044448</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044450</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044451</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044453</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044454</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044455</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044458</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044460</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044462</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044464</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044465</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044466</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044469</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044471</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044472</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044475</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044479</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044481</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044482</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044483</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044484</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044501</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044504</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044505</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044547</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS044555</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS053368</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS053369</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS053370</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS053372</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS053377</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS053379</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS053380</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS053381</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10 NS053387</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U10NS44415-44555</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>JAMA Neurol</MedlineTA>
<NlmUniqueID>101589536</NlmUniqueID>
<ISSNLinking>2168-6149</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015992" MajorTopicYN="Y">Body Mass Index</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018450" MajorTopicYN="Y">Disease Progression</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055825" MajorTopicYN="N">National Institute of Neurological Disorders and Stroke</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="Y">Severity of Illness Index</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>1</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>1</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>9</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">26751506</ArticleId>
<ArticleId IdType="pii">2480880</ArticleId>
<ArticleId IdType="doi">10.1001/jamaneurol.2015.4265</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/PubMed/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000280 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000280 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    PubMed
   |étape=   Corpus
   |type=    RBID
   |clé=     pubmed:26751506
   |texte=   Association Between Change in Body Mass Index, Unified Parkinson's Disease Rating Scale Scores, and Survival Among Persons With Parkinson Disease: Secondary Analysis of Longitudinal Data From NINDS Exploratory Trials in Parkinson Disease Long-term Study 1.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i   -Sk "pubmed:26751506" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonCanadaV1

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Association Between Change in Body Mass Index, Unified Parkinson's Disease Rating Scale Scores, and Survival Among Persons With Parkinson Disease: Secondary Analysis of Longitudinal Data From NINDS Exploratory Trials in Parkinson Disease Long-term Study 1.

Association Between Change in Body Mass Index, Unified Parkinson's Disease Rating Scale Scores, and Survival Among Persons With Parkinson Disease: Secondary Analysis of Longitudinal Data From NINDS Exploratory Trials in Parkinson Disease Long-term Study 1.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki