A Placebo-Controlled Trial of AQW051 in Patients With Moderate to Severe Levodopa-Induced Dyskinesia.
Identifieur interne : 000211 ( PubMed/Corpus ); précédent : 000210; suivant : 000212A Placebo-Controlled Trial of AQW051 in Patients With Moderate to Severe Levodopa-Induced Dyskinesia.
Auteurs : Claudia Trenkwalder ; Daniela Berg ; Olivier Rascol ; Karla Eggert ; Andres Ceballos-Baumann ; Jean-Christophe Corvol ; Alexander Storch ; Lin Zhang ; Jean-Philippe Azulay ; Emmanuel Broussolle ; Luc Defebvre ; Christian Geny ; Michal Gostkowski ; Fabrizio Stocchi ; Christine Tranchant ; Pascal Derkinderen ; Franck Durif ; Alberto J. Espay ; Andrew Feigin ; Jean-Luc Houeto ; Johannes Schwarz ; Thérèse Di Paolo ; Dominik Feuerbach ; Hans-Ulrich Hockey ; Judith Jaeger ; Annamaria Jakab ; Donald Johns ; Gurutz Linazasoro ; Paul Maruff ; Izabela Rozenberg ; Judit Sovago ; Markus Weiss ; Baltazar Gomez-MancillaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2016.
Abstract
This phase 2 randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of the nicotinic acetylcholine receptor α7 agonist AQW051 in patients with Parkinson's disease and levodopa-induced dyskinesia.
DOI: 10.1002/mds.26569
PubMed: 26990766
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Placebo-Controlled Trial of AQW051 in Patients With Moderate to Severe Levodopa-Induced Dyskinesia.</title><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name><affiliation><nlm:affiliation>Paracelsus-Elena Hospital, Kassel, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><affiliation><nlm:affiliation>German Parkinson Study Group, Marburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><affiliation><nlm:affiliation>Department of Clinical Pharmacology and Neurosciences, NeuroToul Excellence Center for Neurodegenerative Disorders, University UPS of Toulouse III, CIC-9302/INSERM UMR825, Hôpital Purpan - Pavillon Riser, Toulouse, France.</nlm:affiliation></affiliation></author><author><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name><affiliation><nlm:affiliation>German Parkinson Study Group, Marburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ceballos Baumann, Andres" sort="Ceballos Baumann, Andres" uniqKey="Ceballos Baumann A" first="Andres" last="Ceballos-Baumann">Andres Ceballos-Baumann</name><affiliation><nlm:affiliation>German Parkinson Study Group, Marburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Corvol, Jean Christophe" sort="Corvol, Jean Christophe" uniqKey="Corvol J" first="Jean-Christophe" last="Corvol">Jean-Christophe Corvol</name><affiliation><nlm:affiliation>NS PARK/FCRIN Network, France.</nlm:affiliation></affiliation></author><author><name sortKey="Storch, Alexander" sort="Storch, Alexander" uniqKey="Storch A" first="Alexander" last="Storch">Alexander Storch</name><affiliation><nlm:affiliation>German Parkinson Study Group, Marburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Lin" sort="Zhang, Lin" uniqKey="Zhang L" first="Lin" last="Zhang">Lin Zhang</name><affiliation><nlm:affiliation>Department of Neurology, UC Davis MIND Institute, Sacramento, California, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name><affiliation><nlm:affiliation>NS PARK/FCRIN Network, France.</nlm:affiliation></affiliation></author><author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name><affiliation><nlm:affiliation>NS PARK/FCRIN Network, France.</nlm:affiliation></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation><nlm:affiliation>NS PARK/FCRIN Network, France.</nlm:affiliation></affiliation></author><author><name sortKey="Geny, Christian" sort="Geny, Christian" uniqKey="Geny C" first="Christian" last="Geny">Christian Geny</name><affiliation><nlm:affiliation>NS PARK/FCRIN Network, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gostkowski, Michal" sort="Gostkowski, Michal" uniqKey="Gostkowski M" first="Michal" last="Gostkowski">Michal Gostkowski</name><affiliation><nlm:affiliation>Center for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name><affiliation><nlm:affiliation>Department of Neurology, Institute for Research and Medical Care, IROCS, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tranchant, Christine" sort="Tranchant, Christine" uniqKey="Tranchant C" first="Christine" last="Tranchant">Christine Tranchant</name><affiliation><nlm:affiliation>NS PARK/FCRIN Network, France.</nlm:affiliation></affiliation></author><author><name sortKey="Derkinderen, Pascal" sort="Derkinderen, Pascal" uniqKey="Derkinderen P" first="Pascal" last="Derkinderen">Pascal Derkinderen</name><affiliation><nlm:affiliation>NS PARK/FCRIN Network, France.</nlm:affiliation></affiliation></author><author><name sortKey="Durif, Franck" sort="Durif, Franck" uniqKey="Durif F" first="Franck" last="Durif">Franck Durif</name><affiliation><nlm:affiliation>NS PARK/FCRIN Network, France.</nlm:affiliation></affiliation></author><author><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J" last="Espay">Alberto J. Espay</name><affiliation><nlm:affiliation>Department of Neurology, James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, University of Cincinnati Academic Health Center, Cincinnati, Ohio, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name><affiliation><nlm:affiliation>Feinstein Institute for Medical Research, North Shore - LIJ Health System, Manhasset, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name><affiliation><nlm:affiliation>NS PARK/FCRIN Network, France.</nlm:affiliation></affiliation></author><author><name sortKey="Schwarz, Johannes" sort="Schwarz, Johannes" uniqKey="Schwarz J" first="Johannes" last="Schwarz">Johannes Schwarz</name><affiliation><nlm:affiliation>German Parkinson Study Group, Marburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre de recherche du CHU de Québec, Québec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Feuerbach, Dominik" sort="Feuerbach, Dominik" uniqKey="Feuerbach D" first="Dominik" last="Feuerbach">Dominik Feuerbach</name><affiliation><nlm:affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Hockey, Hans Ulrich" sort="Hockey, Hans Ulrich" uniqKey="Hockey H" first="Hans-Ulrich" last="Hockey">Hans-Ulrich Hockey</name><affiliation><nlm:affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Jaeger, Judith" sort="Jaeger, Judith" uniqKey="Jaeger J" first="Judith" last="Jaeger">Judith Jaeger</name><affiliation><nlm:affiliation>Albert Einstein College of Medicine, New York, NY, USA, and CognitionMetrics, LLC, Wilmington, Delaware, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jakab, Annamaria" sort="Jakab, Annamaria" uniqKey="Jakab A" first="Annamaria" last="Jakab">Annamaria Jakab</name><affiliation><nlm:affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Johns, Donald" sort="Johns, Donald" uniqKey="Johns D" first="Donald" last="Johns">Donald Johns</name><affiliation><nlm:affiliation>Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Linazasoro, Gurutz" sort="Linazasoro, Gurutz" uniqKey="Linazasoro G" first="Gurutz" last="Linazasoro">Gurutz Linazasoro</name><affiliation><nlm:affiliation>Inbiomed, San Sebastian, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Maruff, Paul" sort="Maruff, Paul" uniqKey="Maruff P" first="Paul" last="Maruff">Paul Maruff</name><affiliation><nlm:affiliation>CogState, Inc, New Haven, Connecticut, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rozenberg, Izabela" sort="Rozenberg, Izabela" uniqKey="Rozenberg I" first="Izabela" last="Rozenberg">Izabela Rozenberg</name><affiliation><nlm:affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Sovago, Judit" sort="Sovago, Judit" uniqKey="Sovago J" first="Judit" last="Sovago">Judit Sovago</name><affiliation><nlm:affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Weiss, Markus" sort="Weiss, Markus" uniqKey="Weiss M" first="Markus" last="Weiss">Markus Weiss</name><affiliation><nlm:affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Gomez Mancilla, Baltazar" sort="Gomez Mancilla, Baltazar" uniqKey="Gomez Mancilla B" first="Baltazar" last="Gomez-Mancilla">Baltazar Gomez-Mancilla</name><affiliation><nlm:affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26990766</idno><idno type="pmid">26990766</idno><idno type="doi">10.1002/mds.26569</idno><idno type="wicri:Area/PubMed/Corpus">000211</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000211</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A Placebo-Controlled Trial of AQW051 in Patients With Moderate to Severe Levodopa-Induced Dyskinesia.</title><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name><affiliation><nlm:affiliation>Paracelsus-Elena Hospital, Kassel, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><affiliation><nlm:affiliation>German Parkinson Study Group, Marburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><affiliation><nlm:affiliation>Department of Clinical Pharmacology and Neurosciences, NeuroToul Excellence Center for Neurodegenerative Disorders, University UPS of Toulouse III, CIC-9302/INSERM UMR825, Hôpital Purpan - Pavillon Riser, Toulouse, France.</nlm:affiliation></affiliation></author><author><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name><affiliation><nlm:affiliation>German Parkinson Study Group, Marburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ceballos Baumann, Andres" sort="Ceballos Baumann, Andres" uniqKey="Ceballos Baumann A" first="Andres" last="Ceballos-Baumann">Andres Ceballos-Baumann</name><affiliation><nlm:affiliation>German Parkinson Study Group, Marburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Corvol, Jean Christophe" sort="Corvol, Jean Christophe" uniqKey="Corvol J" first="Jean-Christophe" last="Corvol">Jean-Christophe Corvol</name><affiliation><nlm:affiliation>NS PARK/FCRIN Network, France.</nlm:affiliation></affiliation></author><author><name sortKey="Storch, Alexander" sort="Storch, Alexander" uniqKey="Storch A" first="Alexander" last="Storch">Alexander Storch</name><affiliation><nlm:affiliation>German Parkinson Study Group, Marburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Lin" sort="Zhang, Lin" uniqKey="Zhang L" first="Lin" last="Zhang">Lin Zhang</name><affiliation><nlm:affiliation>Department of Neurology, UC Davis MIND Institute, Sacramento, California, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name><affiliation><nlm:affiliation>NS PARK/FCRIN Network, France.</nlm:affiliation></affiliation></author><author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name><affiliation><nlm:affiliation>NS PARK/FCRIN Network, France.</nlm:affiliation></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation><nlm:affiliation>NS PARK/FCRIN Network, France.</nlm:affiliation></affiliation></author><author><name sortKey="Geny, Christian" sort="Geny, Christian" uniqKey="Geny C" first="Christian" last="Geny">Christian Geny</name><affiliation><nlm:affiliation>NS PARK/FCRIN Network, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gostkowski, Michal" sort="Gostkowski, Michal" uniqKey="Gostkowski M" first="Michal" last="Gostkowski">Michal Gostkowski</name><affiliation><nlm:affiliation>Center for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name><affiliation><nlm:affiliation>Department of Neurology, Institute for Research and Medical Care, IROCS, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tranchant, Christine" sort="Tranchant, Christine" uniqKey="Tranchant C" first="Christine" last="Tranchant">Christine Tranchant</name><affiliation><nlm:affiliation>NS PARK/FCRIN Network, France.</nlm:affiliation></affiliation></author><author><name sortKey="Derkinderen, Pascal" sort="Derkinderen, Pascal" uniqKey="Derkinderen P" first="Pascal" last="Derkinderen">Pascal Derkinderen</name><affiliation><nlm:affiliation>NS PARK/FCRIN Network, France.</nlm:affiliation></affiliation></author><author><name sortKey="Durif, Franck" sort="Durif, Franck" uniqKey="Durif F" first="Franck" last="Durif">Franck Durif</name><affiliation><nlm:affiliation>NS PARK/FCRIN Network, France.</nlm:affiliation></affiliation></author><author><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J" last="Espay">Alberto J. Espay</name><affiliation><nlm:affiliation>Department of Neurology, James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, University of Cincinnati Academic Health Center, Cincinnati, Ohio, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name><affiliation><nlm:affiliation>Feinstein Institute for Medical Research, North Shore - LIJ Health System, Manhasset, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name><affiliation><nlm:affiliation>NS PARK/FCRIN Network, France.</nlm:affiliation></affiliation></author><author><name sortKey="Schwarz, Johannes" sort="Schwarz, Johannes" uniqKey="Schwarz J" first="Johannes" last="Schwarz">Johannes Schwarz</name><affiliation><nlm:affiliation>German Parkinson Study Group, Marburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name><affiliation><nlm:affiliation>Neuroscience Research Unit, Centre de recherche du CHU de Québec, Québec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Feuerbach, Dominik" sort="Feuerbach, Dominik" uniqKey="Feuerbach D" first="Dominik" last="Feuerbach">Dominik Feuerbach</name><affiliation><nlm:affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Hockey, Hans Ulrich" sort="Hockey, Hans Ulrich" uniqKey="Hockey H" first="Hans-Ulrich" last="Hockey">Hans-Ulrich Hockey</name><affiliation><nlm:affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Jaeger, Judith" sort="Jaeger, Judith" uniqKey="Jaeger J" first="Judith" last="Jaeger">Judith Jaeger</name><affiliation><nlm:affiliation>Albert Einstein College of Medicine, New York, NY, USA, and CognitionMetrics, LLC, Wilmington, Delaware, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jakab, Annamaria" sort="Jakab, Annamaria" uniqKey="Jakab A" first="Annamaria" last="Jakab">Annamaria Jakab</name><affiliation><nlm:affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Johns, Donald" sort="Johns, Donald" uniqKey="Johns D" first="Donald" last="Johns">Donald Johns</name><affiliation><nlm:affiliation>Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Linazasoro, Gurutz" sort="Linazasoro, Gurutz" uniqKey="Linazasoro G" first="Gurutz" last="Linazasoro">Gurutz Linazasoro</name><affiliation><nlm:affiliation>Inbiomed, San Sebastian, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Maruff, Paul" sort="Maruff, Paul" uniqKey="Maruff P" first="Paul" last="Maruff">Paul Maruff</name><affiliation><nlm:affiliation>CogState, Inc, New Haven, Connecticut, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rozenberg, Izabela" sort="Rozenberg, Izabela" uniqKey="Rozenberg I" first="Izabela" last="Rozenberg">Izabela Rozenberg</name><affiliation><nlm:affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Sovago, Judit" sort="Sovago, Judit" uniqKey="Sovago J" first="Judit" last="Sovago">Judit Sovago</name><affiliation><nlm:affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Weiss, Markus" sort="Weiss, Markus" uniqKey="Weiss M" first="Markus" last="Weiss">Markus Weiss</name><affiliation><nlm:affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Gomez Mancilla, Baltazar" sort="Gomez Mancilla, Baltazar" uniqKey="Gomez Mancilla B" first="Baltazar" last="Gomez-Mancilla">Baltazar Gomez-Mancilla</name><affiliation><nlm:affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This phase 2 randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of the nicotinic acetylcholine receptor α7 agonist AQW051 in patients with Parkinson's disease and levodopa-induced dyskinesia.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">26990766</PMID><DateCreated><Year>2016</Year><Month>07</Month><Day>04</Day></DateCreated><DateRevised><Year>2016</Year><Month>07</Month><Day>04</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>31</Volume><Issue>7</Issue><PubDate><Year>2016</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>A Placebo-Controlled Trial of AQW051 in Patients With Moderate to Severe Levodopa-Induced Dyskinesia.</ArticleTitle><Pagination><MedlinePgn>1049-54</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26569</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">This phase 2 randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of the nicotinic acetylcholine receptor α7 agonist AQW051 in patients with Parkinson's disease and levodopa-induced dyskinesia.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Patients with idiopathic Parkinson's disease and moderate to severe levodopa-induced dyskinesia were randomized to AQW051 10 mg (n = 24), AQW051 50 mg (n = 24), or placebo (n = 23) once daily for 28 days. Coprimary end points were change in Modified Abnormal Involuntary Movement Scale and Unified Parkinson's Disease Rating Scale part III scores. Secondary outcomes included pharmacokinetics.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In total, 67 patients completed the study. AQW051-treated patients experienced no significant improvements in Modified Abnormal Involuntary Movement Scale or Unified Parkinson's Disease Rating Scale part III scores by day 28. AQW051 was well tolerated; the most common adverse events were dyskinesia, fatigue, nausea, and falls.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">AQW051 did not significantly reduce dyskinesia or parkinsonian severity. © 2016 International Parkinson and Movement Disorder Society.</AbstractText><CopyrightInformation>© 2016 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Trenkwalder</LastName><ForeName>Claudia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Paracelsus-Elena Hospital, Kassel, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurosurgery, University Medical Center, Goettingen, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Parkinson Study Group, Marburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berg</LastName><ForeName>Daniela</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>German Parkinson Study Group, Marburg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurodegeneration, Hertie-Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rascol</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Clinical Pharmacology and Neurosciences, NeuroToul Excellence Center for Neurodegenerative Disorders, University UPS of Toulouse III, CIC-9302/INSERM UMR825, Hôpital Purpan - Pavillon Riser, Toulouse, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>NS PARK/FCRIN Network, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eggert</LastName><ForeName>Karla</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>German Parkinson Study Group, Marburg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology, Philipps-University of Marburg, Marburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ceballos-Baumann</LastName><ForeName>Andres</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>German Parkinson Study Group, Marburg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Schön Klinik München-Schwabing, München, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corvol</LastName><ForeName>Jean-Christophe</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>NS PARK/FCRIN Network, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Sorbonne Universités, UPMC Univ Paris 06, and INSERM UMRS 1127 /CIC-1422, and CNRS UMR 7225, and AP-HP, and ICM, Hôpital Pitié-Salpêtrière, Département des maladies du système nerveux, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Storch</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>German Parkinson Study Group, Marburg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Neurodegenerative Diseases, Department of Neurology, Dresden University of Technology, Dresden, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Lin</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Neurology, UC Davis MIND Institute, Sacramento, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Azulay</LastName><ForeName>Jean-Philippe</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>NS PARK/FCRIN Network, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de Neurologie et pathologie du Mouvement, Hôpital de la Timone, Marseille Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Broussolle</LastName><ForeName>Emmanuel</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>NS PARK/FCRIN Network, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Univisité Lyon 1, Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Service de Neurologie C, Lyon, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS UMR 5229, Centre de Neurosciences Cognitives, Team Basal Ganglia, Bron, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Defebvre</LastName><ForeName>Luc</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>NS PARK/FCRIN Network, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de Neurologie et Pathologie du movement, EA 1046, CHU de Lille, Hôpital Roger Salengro, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Geny</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>NS PARK/FCRIN Network, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Movement to Health (M2H) laboratory, Euromov, University Montpellier 1, Hôpital gui de Chauliac, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gostkowski</LastName><ForeName>Michal</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Center for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stocchi</LastName><ForeName>Fabrizio</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Neurology, Institute for Research and Medical Care, IROCS, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tranchant</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>NS PARK/FCRIN Network, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de Neurologie, Hôpital de Hautepierre, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Derkinderen</LastName><ForeName>Pascal</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>NS PARK/FCRIN Network, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre Investigation Clinique Neurologie, CHU Nantes, Hôpital G&R Laennec, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Durif</LastName><ForeName>Franck</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>NS PARK/FCRIN Network, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de Neurologie, Hôpital Gabriel Montpied, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Espay</LastName><ForeName>Alberto J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Department of Neurology, James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, University of Cincinnati Academic Health Center, Cincinnati, Ohio, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feigin</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Feinstein Institute for Medical Research, North Shore - LIJ Health System, Manhasset, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Houeto</LastName><ForeName>Jean-Luc</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>NS PARK/FCRIN Network, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de Neurologie, CIC-INSERM 1402, CHU de Poitiers, Université de Poitiers, Poitiers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schwarz</LastName><ForeName>Johannes</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>German Parkinson Study Group, Marburg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Klinik Haag, Haag, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Di Paolo</LastName><ForeName>Thérèse</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Neuroscience Research Unit, Centre de recherche du CHU de Québec, Québec, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Pharmacy, Laval University, Québec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feuerbach</LastName><ForeName>Dominik</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hockey</LastName><ForeName>Hans-Ulrich</ForeName><Initials>HU</Initials><AffiliationInfo><Affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Biometrics Matters Ltd, Hamilton, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jaeger</LastName><ForeName>Judith</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Albert Einstein College of Medicine, New York, NY, USA, and CognitionMetrics, LLC, Wilmington, Delaware, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jakab</LastName><ForeName>Annamaria</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johns</LastName><ForeName>Donald</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Linazasoro</LastName><ForeName>Gurutz</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Inbiomed, San Sebastian, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maruff</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>CogState, Inc, New Haven, Connecticut, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rozenberg</LastName><ForeName>Izabela</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sovago</LastName><ForeName>Judit</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weiss</LastName><ForeName>Markus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gomez-Mancilla</LastName><ForeName>Baltazar</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Novartis Institutes for BioMedical Research, Basel, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology and Neurosurgery, McGill University, Montreal, Québec, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>03</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">AQW051</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">dyskinesias</Keyword><Keyword MajorTopicYN="N">levodopa (l-dopa)</Keyword><Keyword MajorTopicYN="N">nicotinic acetylcholine receptor agonist (nAChR) α7</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>11</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>01</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>01</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>3</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26990766</ArticleId><ArticleId IdType="doi">10.1002/mds.26569</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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