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The Effect of Endogenous Adenosine on Neuronal Activity in Rats: An FDG PET Study.

Identifieur interne : 000206 ( PubMed/Corpus ); précédent : 000205; suivant : 000207

The Effect of Endogenous Adenosine on Neuronal Activity in Rats: An FDG PET Study.

Auteurs : Fiona E. Parkinson ; Soumen Paul ; Dali Zhang ; Shadreck Mzengeza ; Ji Hyun Ko

Source :

Journal of neuroimaging : official journal of the American Society of Neuroimaging [ 1552-6569 ] ; 2016.

RBID : pubmed:27082948

Abstract

2-(18) F-fluorodeoxy-D-glucose (FDG) is a glucose analog that is taken up by cells and phosphorylated. The amount of FDG accumulated by cells is a measure of the rate of glycolysis, which reflects cellular activity. As the levels and actions of the neuromodulator adenosine are dynamically regulated by neuronal activity, this study was designed to test whether endogenous adenosine affects tissue accumulation of FDG as assessed by positron emission tomography (PET) or by postmortem analysis of tissue radioactivity. Rats were given an intraperitoneal injection of the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropyl-xanthine (DPCPX, 3 mg/kg), the adenosine kinase inhibitor ABT-702 (3 mg/kg), or vehicle 10 minutes prior to an intravenous injection of FDG (15.4 ± 0.7 MBq per rat). Rats were then subjected to a 15 minute static PET scan. Reconstructed images were normalized to FDG PET template for rats and standard uptake values (SUVs) were calculated. To examine the regional effect of active treatment compared to vehicle, statistical parametric mapping analysis was performed. Whole-brain FDG uptake was not affected by drug treatment. Significant regional hypometabolism was detected, particularly in cerebellum, of DPCPX- and ABT-702 treated rats, relative to vehicle-treated rats. Thus, endogenous adenosine can affect FDG accumulation although this effect is modest in quiescent rats.

DOI: 10.1111/jon.12349
PubMed: 27082948

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Le document en format XML

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<author><name sortKey="Parkinson, Fiona E" sort="Parkinson, Fiona E" uniqKey="Parkinson F" first="Fiona E" last="Parkinson">Fiona E. Parkinson</name>
<affiliation><nlm:affiliation>Departments of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Paul, Soumen" sort="Paul, Soumen" uniqKey="Paul S" first="Soumen" last="Paul">Soumen Paul</name>
<affiliation><nlm:affiliation>Departments of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhang, Dali" sort="Zhang, Dali" uniqKey="Zhang D" first="Dali" last="Zhang">Dali Zhang</name>
<affiliation><nlm:affiliation>Departments of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mzengeza, Shadreck" sort="Mzengeza, Shadreck" uniqKey="Mzengeza S" first="Shadreck" last="Mzengeza">Shadreck Mzengeza</name>
<affiliation><nlm:affiliation>Departments of Radiology, University of Manitoba, Winnipeg, MB, Canada.</nlm:affiliation>
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<author><name sortKey="Ko, Ji Hyun" sort="Ko, Ji Hyun" uniqKey="Ko J" first="Ji Hyun" last="Ko">Ji Hyun Ko</name>
<affiliation><nlm:affiliation>Departments of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB, Canada.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">The Effect of Endogenous Adenosine on Neuronal Activity in Rats: An FDG PET Study.</title>
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<front><div type="abstract" xml:lang="en">2-(18) F-fluorodeoxy-D-glucose (FDG) is a glucose analog that is taken up by cells and phosphorylated. The amount of FDG accumulated by cells is a measure of the rate of glycolysis, which reflects cellular activity. As the levels and actions of the neuromodulator adenosine are dynamically regulated by neuronal activity, this study was designed to test whether endogenous adenosine affects tissue accumulation of FDG as assessed by positron emission tomography (PET) or by postmortem analysis of tissue radioactivity. Rats were given an intraperitoneal injection of the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropyl-xanthine (DPCPX, 3 mg/kg), the adenosine kinase inhibitor ABT-702 (3 mg/kg), or vehicle 10 minutes prior to an intravenous injection of FDG (15.4 ± 0.7 MBq per rat). Rats were then subjected to a 15 minute static PET scan. Reconstructed images were normalized to FDG PET template for rats and standard uptake values (SUVs) were calculated. To examine the regional effect of active treatment compared to vehicle, statistical parametric mapping analysis was performed. Whole-brain FDG uptake was not affected by drug treatment. Significant regional hypometabolism was detected, particularly in cerebellum, of DPCPX- and ABT-702 treated rats, relative to vehicle-treated rats. Thus, endogenous adenosine can affect FDG accumulation although this effect is modest in quiescent rats.</div>
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<Abstract><AbstractText>2-(18) F-fluorodeoxy-D-glucose (FDG) is a glucose analog that is taken up by cells and phosphorylated. The amount of FDG accumulated by cells is a measure of the rate of glycolysis, which reflects cellular activity. As the levels and actions of the neuromodulator adenosine are dynamically regulated by neuronal activity, this study was designed to test whether endogenous adenosine affects tissue accumulation of FDG as assessed by positron emission tomography (PET) or by postmortem analysis of tissue radioactivity. Rats were given an intraperitoneal injection of the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropyl-xanthine (DPCPX, 3 mg/kg), the adenosine kinase inhibitor ABT-702 (3 mg/kg), or vehicle 10 minutes prior to an intravenous injection of FDG (15.4 ± 0.7 MBq per rat). Rats were then subjected to a 15 minute static PET scan. Reconstructed images were normalized to FDG PET template for rats and standard uptake values (SUVs) were calculated. To examine the regional effect of active treatment compared to vehicle, statistical parametric mapping analysis was performed. Whole-brain FDG uptake was not affected by drug treatment. Significant regional hypometabolism was detected, particularly in cerebellum, of DPCPX- and ABT-702 treated rats, relative to vehicle-treated rats. Thus, endogenous adenosine can affect FDG accumulation although this effect is modest in quiescent rats.</AbstractText>
<CopyrightInformation>© 2016 The Authors. Journal of Neuroimaging published by Wiley Periodicals, Inc. on behalf of American Society of Neuroimaging.</CopyrightInformation>
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<CommentsCorrections RefType="Cites"><RefSource>Int Rev Neurobiol. 2014;119:1-49</RefSource>
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The Effect of Endogenous Adenosine on Neuronal Activity in Rats: An FDG PET Study.

The Effect of Endogenous Adenosine on Neuronal Activity in Rats: An FDG PET Study.

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