Genetic and Clinical Predictors of Deep Brain Stimulation in Young-Onset Parkinson's Disease.
Identifieur interne : 000172 ( PubMed/Corpus ); précédent : 000171; suivant : 000173Genetic and Clinical Predictors of Deep Brain Stimulation in Young-Onset Parkinson's Disease.
Auteurs : Gian D. Pal ; Deborah Hall ; Bichun Ouyang ; Jessica Phelps ; Roy Alcalay ; Michael W. Pauciulo ; William C. Nichols ; Lorraine Clark ; Helen Mejia-Santana ; Lucia Blasucci ; Christopher G. Goetz ; Cynthia Comella ; Amy Colcher ; Ziv Gan-Or ; Guy A. Rouleau ; Karen MarderSource :
- Movement disorders clinical practice
Abstract
In a cohort of patients with young-onset Parkinson's disease (PD), the authors assessed (1) the prevalence of genetic mutations in those who enrolled in deep brain stimulation (DBS) programs compared with those who did not enroll DBS programs and (2) specific genetic and clinical predictors of DBS enrollment.
DOI: 10.1002/mdc3.12309
PubMed: 27709117
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic and Clinical Predictors of Deep Brain Stimulation in Young-Onset Parkinson's Disease.</title><author><name sortKey="Pal, Gian D" sort="Pal, Gian D" uniqKey="Pal G" first="Gian D" last="Pal">Gian D. Pal</name><affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hall, Deborah" sort="Hall, Deborah" uniqKey="Hall D" first="Deborah" last="Hall">Deborah Hall</name><affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ouyang, Bichun" sort="Ouyang, Bichun" uniqKey="Ouyang B" first="Bichun" last="Ouyang">Bichun Ouyang</name><affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Phelps, Jessica" sort="Phelps, Jessica" uniqKey="Phelps J" first="Jessica" last="Phelps">Jessica Phelps</name><affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Alcalay, Roy" sort="Alcalay, Roy" uniqKey="Alcalay R" first="Roy" last="Alcalay">Roy Alcalay</name><affiliation><nlm:affiliation>Department of Neurology and the Taub Institute, Columbia University Medical Center, New York, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pauciulo, Michael W" sort="Pauciulo, Michael W" uniqKey="Pauciulo M" first="Michael W" last="Pauciulo">Michael W. Pauciulo</name><affiliation><nlm:affiliation>Division of Human Genetics, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Nichols, William C" sort="Nichols, William C" uniqKey="Nichols W" first="William C" last="Nichols">William C. Nichols</name><affiliation><nlm:affiliation>Division of Human Genetics, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Clark, Lorraine" sort="Clark, Lorraine" uniqKey="Clark L" first="Lorraine" last="Clark">Lorraine Clark</name><affiliation><nlm:affiliation>Department of Pathology and Cell Biology and the Taub Institute, Columbia University Medical Center, NY, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mejia Santana, Helen" sort="Mejia Santana, Helen" uniqKey="Mejia Santana H" first="Helen" last="Mejia-Santana">Helen Mejia-Santana</name><affiliation><nlm:affiliation>Department of Neurology and the Taub Institute, Columbia University Medical Center, New York, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Blasucci, Lucia" sort="Blasucci, Lucia" uniqKey="Blasucci L" first="Lucia" last="Blasucci">Lucia Blasucci</name><affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G" last="Goetz">Christopher G. Goetz</name><affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Comella, Cynthia" sort="Comella, Cynthia" uniqKey="Comella C" first="Cynthia" last="Comella">Cynthia Comella</name><affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Colcher, Amy" sort="Colcher, Amy" uniqKey="Colcher A" first="Amy" last="Colcher">Amy Colcher</name><affiliation><nlm:affiliation>PRKNson's Disease and Movement Disorders Center, Pennsylvania Hospital, Philadelphia, Pennsylvania, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gan Or, Ziv" sort="Gan Or, Ziv" uniqKey="Gan Or Z" first="Ziv" last="Gan-Or">Ziv Gan-Or</name><affiliation><nlm:affiliation>Department of Human Genetics, McGill University, Montreal, Quebec, Canada; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A" last="Rouleau">Guy A. Rouleau</name><affiliation><nlm:affiliation>Department of Human Genetics, McGill University, Montreal, Quebec, Canada; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; The Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name><affiliation><nlm:affiliation>Department of Neurology and the Taub Institute, Columbia University Medical Center, New York, NY, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2016 Sep-Oct</MedlineDate></PubDate></date><idno type="RBID">pubmed:27709117</idno><idno type="pmid">27709117</idno><idno type="doi">10.1002/mdc3.12309</idno><idno type="wicri:Area/PubMed/Corpus">000172</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000172</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic and Clinical Predictors of Deep Brain Stimulation in Young-Onset Parkinson's Disease.</title><author><name sortKey="Pal, Gian D" sort="Pal, Gian D" uniqKey="Pal G" first="Gian D" last="Pal">Gian D. Pal</name><affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hall, Deborah" sort="Hall, Deborah" uniqKey="Hall D" first="Deborah" last="Hall">Deborah Hall</name><affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ouyang, Bichun" sort="Ouyang, Bichun" uniqKey="Ouyang B" first="Bichun" last="Ouyang">Bichun Ouyang</name><affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Phelps, Jessica" sort="Phelps, Jessica" uniqKey="Phelps J" first="Jessica" last="Phelps">Jessica Phelps</name><affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Alcalay, Roy" sort="Alcalay, Roy" uniqKey="Alcalay R" first="Roy" last="Alcalay">Roy Alcalay</name><affiliation><nlm:affiliation>Department of Neurology and the Taub Institute, Columbia University Medical Center, New York, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pauciulo, Michael W" sort="Pauciulo, Michael W" uniqKey="Pauciulo M" first="Michael W" last="Pauciulo">Michael W. Pauciulo</name><affiliation><nlm:affiliation>Division of Human Genetics, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Nichols, William C" sort="Nichols, William C" uniqKey="Nichols W" first="William C" last="Nichols">William C. Nichols</name><affiliation><nlm:affiliation>Division of Human Genetics, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Clark, Lorraine" sort="Clark, Lorraine" uniqKey="Clark L" first="Lorraine" last="Clark">Lorraine Clark</name><affiliation><nlm:affiliation>Department of Pathology and Cell Biology and the Taub Institute, Columbia University Medical Center, NY, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mejia Santana, Helen" sort="Mejia Santana, Helen" uniqKey="Mejia Santana H" first="Helen" last="Mejia-Santana">Helen Mejia-Santana</name><affiliation><nlm:affiliation>Department of Neurology and the Taub Institute, Columbia University Medical Center, New York, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Blasucci, Lucia" sort="Blasucci, Lucia" uniqKey="Blasucci L" first="Lucia" last="Blasucci">Lucia Blasucci</name><affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G" last="Goetz">Christopher G. Goetz</name><affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Comella, Cynthia" sort="Comella, Cynthia" uniqKey="Comella C" first="Cynthia" last="Comella">Cynthia Comella</name><affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Colcher, Amy" sort="Colcher, Amy" uniqKey="Colcher A" first="Amy" last="Colcher">Amy Colcher</name><affiliation><nlm:affiliation>PRKNson's Disease and Movement Disorders Center, Pennsylvania Hospital, Philadelphia, Pennsylvania, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gan Or, Ziv" sort="Gan Or, Ziv" uniqKey="Gan Or Z" first="Ziv" last="Gan-Or">Ziv Gan-Or</name><affiliation><nlm:affiliation>Department of Human Genetics, McGill University, Montreal, Quebec, Canada; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A" last="Rouleau">Guy A. Rouleau</name><affiliation><nlm:affiliation>Department of Human Genetics, McGill University, Montreal, Quebec, Canada; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; The Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name><affiliation><nlm:affiliation>Department of Neurology and the Taub Institute, Columbia University Medical Center, New York, NY, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Movement disorders clinical practice</title></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In a cohort of patients with young-onset Parkinson's disease (PD), the authors assessed (1) the prevalence of genetic mutations in those who enrolled in deep brain stimulation (DBS) programs compared with those who did not enroll DBS programs and (2) specific genetic and clinical predictors of DBS enrollment.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">27709117</PMID><DateCreated><Year>2016</Year><Month>10</Month><Day>06</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><JournalIssue CitedMedium="Print"><Volume>3</Volume><Issue>5</Issue><PubDate><MedlineDate>2016 Sep-Oct</MedlineDate></PubDate></JournalIssue><Title>Movement disorders clinical practice</Title><ISOAbbreviation>Mov Disord Clin Pract</ISOAbbreviation></Journal><ArticleTitle>Genetic and Clinical Predictors of Deep Brain Stimulation in Young-Onset Parkinson's Disease.</ArticleTitle><Pagination><MedlinePgn>465-471</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">In a cohort of patients with young-onset Parkinson's disease (PD), the authors assessed (1) the prevalence of genetic mutations in those who enrolled in deep brain stimulation (DBS) programs compared with those who did not enroll DBS programs and (2) specific genetic and clinical predictors of DBS enrollment.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Subjects were participants from 3 sites (Columbia University, Rush University, and the University of Pennsylvania) in the Consortium on Risk for Early Onset Parkinson's Disease (CORE-PD) who had an age at onset < 51 years. The analyses presented here focus on glucocerebrosidase (GBA), leucine-rich repeat kinase 2 (LRRK2), and parkin (PRKN) mutation carriers. Mutation carrier status, demographic data, and disease characteristics in individuals who did and did not enroll in DBS were analyzed. The association between mutation status and DBS placement was assessed in logistic regression models.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Patients who had PD with either GBA, LRRK2, or PRKN mutations were more common in the DBS group (n = 99) compared with the non-DBS group (n = 684; 26.5% vs. 16.8%, respectively; P = 0.02). In a multivariate logistic regression model, GBA mutation status (odds ratio, 2.1; 95% confidence interval, 1.0-4.3; P = 0.05) was associated with DBS surgery enrollment. However, when dyskinesia was included in the multivariate logistic regression model, dyskinesia had a strong association with DBS placement (odds ratio, 3.8; 95% confidence interval, 1.9-7.3; P < 0.0001), whereas the association between GBA mutation status and DBS placement did not persist (P = 0.25).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">DBS populations are enriched with genetic mutation carriers. The effect of genetic mutation carriers on DBS outcomes warrants further exploration.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pal</LastName><ForeName>Gian D</ForeName><Initials>GD</Initials><AffiliationInfo><Affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hall</LastName><ForeName>Deborah</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ouyang</LastName><ForeName>Bichun</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Phelps</LastName><ForeName>Jessica</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alcalay</LastName><ForeName>Roy</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neurology and the Taub Institute, Columbia University Medical Center, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pauciulo</LastName><ForeName>Michael W</ForeName><Initials>MW</Initials><AffiliationInfo><Affiliation>Division of Human Genetics, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nichols</LastName><ForeName>William C</ForeName><Initials>WC</Initials><AffiliationInfo><Affiliation>Division of Human Genetics, Cincinnati Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clark</LastName><ForeName>Lorraine</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Pathology and Cell Biology and the Taub Institute, Columbia University Medical Center, NY, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mejia-Santana</LastName><ForeName>Helen</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Neurology and the Taub Institute, Columbia University Medical Center, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blasucci</LastName><ForeName>Lucia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goetz</LastName><ForeName>Christopher G</ForeName><Initials>CG</Initials><AffiliationInfo><Affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Comella</LastName><ForeName>Cynthia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Colcher</LastName><ForeName>Amy</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>PRKNson's Disease and Movement Disorders Center, Pennsylvania Hospital, Philadelphia, Pennsylvania, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gan-Or</LastName><ForeName>Ziv</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Human Genetics, McGill University, Montreal, Quebec, Canada; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rouleau</LastName><ForeName>Guy A</ForeName><Initials>GA</Initials><AffiliationInfo><Affiliation>Department of Human Genetics, McGill University, Montreal, Quebec, Canada; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; The Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marder</LastName><ForeName>Karen</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Neurology and the Taub Institute, Columbia University Medical Center, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Consortium on Risk for Early Onset Parkinson's Disease (CORE-PD) Investigators</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>K02 NS080915</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS036630</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R56 NS036630</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><Agency>United States NINDS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>01</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord Clin Pract</MedlineTA><NlmUniqueID>101630279</NlmUniqueID><ISSNLinking>2330-1619</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2013 Sep;28(10 ):1370-5</RefSource><PMID Version="1">23818421</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2013 Feb 14;368(7):610-22</RefSource><PMID Version="1">23406026</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2010 Sep;67(9):1116-22</RefSource><PMID Version="1">20837857</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2015 Feb;21(2):106-10</RefSource><PMID Version="1">25434972</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2013 Dec;28(14 ):1966-71</RefSource><PMID Version="1">24243757</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2007 Sep 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disease</Keyword><Keyword MajorTopicYN="N">deep brain stimulation (DBS)</Keyword><Keyword MajorTopicYN="N">glucocerebrosidase (GBA)</Keyword><Keyword MajorTopicYN="N">leucine-rich repeat kinase 2 (LRRK2)</Keyword><Keyword MajorTopicYN="N">parkin (PRKN)</Keyword></KeywordList><CoiStatement>The remaining authors report no sources of funding and no conflicts of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>10</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27709117</ArticleId><ArticleId IdType="pmc">PMC5047521</ArticleId><ArticleId IdType="doi">10.1002/mdc3.12309</ArticleId><ArticleId IdType="mid">NIHMS753295</ArticleId></ArticleIdList><pmc-dir>nihms</pmc-dir>
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