A drug delivery hydrogel system based on activin B for Parkinson's disease.
Identifieur interne : 000158 ( PubMed/Corpus ); précédent : 000157; suivant : 000159A drug delivery hydrogel system based on activin B for Parkinson's disease.
Auteurs : Juan Li ; Mohammadali Darabi ; Jingjing Gu ; Junbin Shi ; Jinhua Xue ; Lu Huang ; Yutong Liu ; Lei Zhang ; N. Liu ; Wen Zhong ; Lin Zhang ; Malcolm Xing ; Lu ZhangSource :
- Biomaterials [ 1878-5905 ] ; 2016.
Abstract
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Activins are members of the superfamily of transforming growth factors and have many potential neuroprotective effects. Herein, at the first place, we verified activin B's neuroprotective role in a PD model, and revealed that activin B's fast release has limited function in the PD therapy. To this end, we developed a multi-functional crosslinker based thermosensitive injectable hydrogels to deliver activin B, and stereotactically injected the activin B-loaded hydrogel into the striatum of a mouse model of PD. The histological evaluation showed that activin B can be detected even 5 weeks post-surgery in PD mice implanted with activin B-loaded hydrogels, and activin B-loaded hydrogels can significantly increase the density of tyrosine hydroxylase positive (TH(+)) nerve fibers and reduce inflammatory responses. The behavioral evaluation demonstrated that activin B-loaded hydrogels significantly improved the performance of the mice in the PD model. Meanwhile, we found that hydrogels can slightly induce the activation of microglia cells and astrocytes, while cannot induce apoptosis in the striatum. Overall, our data demonstrated that the developed activin B-loaded hydrogels provide sustained release of activin B for over 5 weeks and contribute to substantial cellular protection and behavioral improvement, suggesting their potential as a therapeutic strategy for PD.
DOI: 10.1016/j.biomaterials.2016.06.016
PubMed: 27322960
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A drug delivery hydrogel system based on activin B for Parkinson's disease.</title><author><name sortKey="Li, Juan" sort="Li, Juan" uniqKey="Li J" first="Juan" last="Li">Juan Li</name><affiliation><nlm:affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.</nlm:affiliation></affiliation></author><author><name sortKey="Darabi, Mohammadali" sort="Darabi, Mohammadali" uniqKey="Darabi M" first="Mohammadali" last="Darabi">Mohammadali Darabi</name><affiliation><nlm:affiliation>Department of Mechanical Engineering, Biochemistry and Medical Genetics, University of Manitoba, Manitoba Institute of Child Health, Winnipeg, MB, R3T 2N2, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Gu, Jingjing" sort="Gu, Jingjing" uniqKey="Gu J" first="Jingjing" last="Gu">Jingjing Gu</name><affiliation><nlm:affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shi, Junbin" sort="Shi, Junbin" uniqKey="Shi J" first="Junbin" last="Shi">Junbin Shi</name><affiliation><nlm:affiliation>Department of Mechanical Engineering, Biochemistry and Medical Genetics, University of Manitoba, Manitoba Institute of Child Health, Winnipeg, MB, R3T 2N2, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Xue, Jinhua" sort="Xue, Jinhua" uniqKey="Xue J" first="Jinhua" last="Xue">Jinhua Xue</name><affiliation><nlm:affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Lu" sort="Huang, Lu" uniqKey="Huang L" first="Lu" last="Huang">Lu Huang</name><affiliation><nlm:affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Yutong" sort="Liu, Yutong" uniqKey="Liu Y" first="Yutong" last="Liu">Yutong Liu</name><affiliation><nlm:affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Lei" sort="Zhang, Lei" uniqKey="Zhang L" first="Lei" last="Zhang">Lei Zhang</name><affiliation><nlm:affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, N" sort="Liu, N" uniqKey="Liu N" first="N" last="Liu">N. Liu</name><affiliation><nlm:affiliation>Elderly Health Services Research Center, Southern Medical University, Guangzhou, 510515, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhong, Wen" sort="Zhong, Wen" uniqKey="Zhong W" first="Wen" last="Zhong">Wen Zhong</name><affiliation><nlm:affiliation>Department of Textile Sciences, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Lin" sort="Zhang, Lin" uniqKey="Zhang L" first="Lin" last="Zhang">Lin Zhang</name><affiliation><nlm:affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China. Electronic address: zlilyzh@126.com.</nlm:affiliation></affiliation></author><author><name sortKey="Xing, Malcolm" sort="Xing, Malcolm" uniqKey="Xing M" first="Malcolm" last="Xing">Malcolm Xing</name><affiliation><nlm:affiliation>Department of Mechanical Engineering, Biochemistry and Medical Genetics, University of Manitoba, Manitoba Institute of Child Health, Winnipeg, MB, R3T 2N2, Canada. Electronic address: Malcolm.xing@umanitoba.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Lu" sort="Zhang, Lu" uniqKey="Zhang L" first="Lu" last="Zhang">Lu Zhang</name><affiliation><nlm:affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China; Elderly Health Services Research Center, Southern Medical University, Guangzhou, 510515, China. Electronic address: zlulu70@126.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27322960</idno><idno type="pmid">27322960</idno><idno type="doi">10.1016/j.biomaterials.2016.06.016</idno><idno type="wicri:Area/PubMed/Corpus">000158</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000158</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A drug delivery hydrogel system based on activin B for Parkinson's disease.</title><author><name sortKey="Li, Juan" sort="Li, Juan" uniqKey="Li J" first="Juan" last="Li">Juan Li</name><affiliation><nlm:affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.</nlm:affiliation></affiliation></author><author><name sortKey="Darabi, Mohammadali" sort="Darabi, Mohammadali" uniqKey="Darabi M" first="Mohammadali" last="Darabi">Mohammadali Darabi</name><affiliation><nlm:affiliation>Department of Mechanical Engineering, Biochemistry and Medical Genetics, University of Manitoba, Manitoba Institute of Child Health, Winnipeg, MB, R3T 2N2, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Gu, Jingjing" sort="Gu, Jingjing" uniqKey="Gu J" first="Jingjing" last="Gu">Jingjing Gu</name><affiliation><nlm:affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shi, Junbin" sort="Shi, Junbin" uniqKey="Shi J" first="Junbin" last="Shi">Junbin Shi</name><affiliation><nlm:affiliation>Department of Mechanical Engineering, Biochemistry and Medical Genetics, University of Manitoba, Manitoba Institute of Child Health, Winnipeg, MB, R3T 2N2, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Xue, Jinhua" sort="Xue, Jinhua" uniqKey="Xue J" first="Jinhua" last="Xue">Jinhua Xue</name><affiliation><nlm:affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Lu" sort="Huang, Lu" uniqKey="Huang L" first="Lu" last="Huang">Lu Huang</name><affiliation><nlm:affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Yutong" sort="Liu, Yutong" uniqKey="Liu Y" first="Yutong" last="Liu">Yutong Liu</name><affiliation><nlm:affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Lei" sort="Zhang, Lei" uniqKey="Zhang L" first="Lei" last="Zhang">Lei Zhang</name><affiliation><nlm:affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, N" sort="Liu, N" uniqKey="Liu N" first="N" last="Liu">N. Liu</name><affiliation><nlm:affiliation>Elderly Health Services Research Center, Southern Medical University, Guangzhou, 510515, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhong, Wen" sort="Zhong, Wen" uniqKey="Zhong W" first="Wen" last="Zhong">Wen Zhong</name><affiliation><nlm:affiliation>Department of Textile Sciences, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Lin" sort="Zhang, Lin" uniqKey="Zhang L" first="Lin" last="Zhang">Lin Zhang</name><affiliation><nlm:affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China. Electronic address: zlilyzh@126.com.</nlm:affiliation></affiliation></author><author><name sortKey="Xing, Malcolm" sort="Xing, Malcolm" uniqKey="Xing M" first="Malcolm" last="Xing">Malcolm Xing</name><affiliation><nlm:affiliation>Department of Mechanical Engineering, Biochemistry and Medical Genetics, University of Manitoba, Manitoba Institute of Child Health, Winnipeg, MB, R3T 2N2, Canada. Electronic address: Malcolm.xing@umanitoba.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Lu" sort="Zhang, Lu" uniqKey="Zhang L" first="Lu" last="Zhang">Lu Zhang</name><affiliation><nlm:affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China; Elderly Health Services Research Center, Southern Medical University, Guangzhou, 510515, China. Electronic address: zlulu70@126.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Biomaterials</title><idno type="eISSN">1878-5905</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Activins are members of the superfamily of transforming growth factors and have many potential neuroprotective effects. Herein, at the first place, we verified activin B's neuroprotective role in a PD model, and revealed that activin B's fast release has limited function in the PD therapy. To this end, we developed a multi-functional crosslinker based thermosensitive injectable hydrogels to deliver activin B, and stereotactically injected the activin B-loaded hydrogel into the striatum of a mouse model of PD. The histological evaluation showed that activin B can be detected even 5 weeks post-surgery in PD mice implanted with activin B-loaded hydrogels, and activin B-loaded hydrogels can significantly increase the density of tyrosine hydroxylase positive (TH(+)) nerve fibers and reduce inflammatory responses. The behavioral evaluation demonstrated that activin B-loaded hydrogels significantly improved the performance of the mice in the PD model. Meanwhile, we found that hydrogels can slightly induce the activation of microglia cells and astrocytes, while cannot induce apoptosis in the striatum. Overall, our data demonstrated that the developed activin B-loaded hydrogels provide sustained release of activin B for over 5 weeks and contribute to substantial cellular protection and behavioral improvement, suggesting their potential as a therapeutic strategy for PD.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27322960</PMID><DateCreated><Year>2016</Year><Month>07</Month><Day>09</Day></DateCreated><DateRevised><Year>2016</Year><Month>07</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-5905</ISSN><JournalIssue CitedMedium="Internet"><Volume>102</Volume><PubDate><Year>2016</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Biomaterials</Title><ISOAbbreviation>Biomaterials</ISOAbbreviation></Journal><ArticleTitle>A drug delivery hydrogel system based on activin B for Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>72-86</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.biomaterials.2016.06.016</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0142-9612(16)30270-8</ELocationID><Abstract><AbstractText>Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Activins are members of the superfamily of transforming growth factors and have many potential neuroprotective effects. Herein, at the first place, we verified activin B's neuroprotective role in a PD model, and revealed that activin B's fast release has limited function in the PD therapy. To this end, we developed a multi-functional crosslinker based thermosensitive injectable hydrogels to deliver activin B, and stereotactically injected the activin B-loaded hydrogel into the striatum of a mouse model of PD. The histological evaluation showed that activin B can be detected even 5 weeks post-surgery in PD mice implanted with activin B-loaded hydrogels, and activin B-loaded hydrogels can significantly increase the density of tyrosine hydroxylase positive (TH(+)) nerve fibers and reduce inflammatory responses. The behavioral evaluation demonstrated that activin B-loaded hydrogels significantly improved the performance of the mice in the PD model. Meanwhile, we found that hydrogels can slightly induce the activation of microglia cells and astrocytes, while cannot induce apoptosis in the striatum. Overall, our data demonstrated that the developed activin B-loaded hydrogels provide sustained release of activin B for over 5 weeks and contribute to substantial cellular protection and behavioral improvement, suggesting their potential as a therapeutic strategy for PD.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Juan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Darabi</LastName><ForeName>Mohammadali</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Mechanical Engineering, Biochemistry and Medical Genetics, University of Manitoba, Manitoba Institute of Child Health, Winnipeg, MB, R3T 2N2, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gu</LastName><ForeName>Jingjing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Junbin</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Mechanical Engineering, Biochemistry and Medical Genetics, University of Manitoba, Manitoba Institute of Child Health, Winnipeg, MB, R3T 2N2, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xue</LastName><ForeName>Jinhua</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Lu</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yutong</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Lei</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Elderly Health Services Research Center, Southern Medical University, Guangzhou, 510515, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhong</LastName><ForeName>Wen</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Textile Sciences, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Lin</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China. Electronic address: zlilyzh@126.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xing</LastName><ForeName>Malcolm</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Mechanical Engineering, Biochemistry and Medical Genetics, University of Manitoba, Manitoba Institute of Child Health, Winnipeg, MB, R3T 2N2, Canada. Electronic address: Malcolm.xing@umanitoba.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Lu</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Guangdong Provincial Key Laboratory of Proteomics and Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China; Elderly Health Services Research Center, Southern Medical University, Guangzhou, 510515, China. Electronic address: zlulu70@126.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>06</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Biomaterials</MedlineTA><NlmUniqueID>8100316</NlmUniqueID><ISSNLinking>0142-9612</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Activin B</Keyword><Keyword MajorTopicYN="N">Biomaterials</Keyword><Keyword MajorTopicYN="N">Drug release</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">Thermosensitive hydrogel</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>05</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>05</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>06</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>6</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>6</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>6</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27322960</ArticleId><ArticleId IdType="pii">S0142-9612(16)30270-8</ArticleId><ArticleId IdType="doi">10.1016/j.biomaterials.2016.06.016</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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