Conjugal parkinsonism - Clinical, pathology and genetic study. No evidence of person-to-person transmission.
Identifieur interne : 000149 ( PubMed/Corpus ); précédent : 000148; suivant : 000150Conjugal parkinsonism - Clinical, pathology and genetic study. No evidence of person-to-person transmission.
Auteurs : Ali H. Rajput ; Leslie W. Ferguson ; Christopher A. Robinson ; Ilaria Guella ; Matthew J. Farrer ; Alexander RajputSource :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2016.
Abstract
Neurodegeneration is known basis of several different Parkinson syndromes. The most common Parkinson syndrome is the Parkinson's disease. Distinction between different Parkinson syndromes is based on pathology or genetic findings. Recent studies indicate that several major variants of PS have some characteristics of a prion disease and may therefore be transmissible. Married couples offer a unique opportunity to study person-to-person transmission and the role of shared environments as the cause of parkinsonism.
DOI: 10.1016/j.parkreldis.2016.07.011
PubMed: 27481034
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Conjugal parkinsonism - Clinical, pathology and genetic study. No evidence of person-to-person transmission.</title><author><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H" last="Rajput">Ali H. Rajput</name><affiliation><nlm:affiliation>Saskatchewan Movement Disorders Program, University of Saskatchewan/Saskatoon Health Region, Canada. Electronic address: ali.rajput@saskatoonhealthregion.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Ferguson, Leslie W" sort="Ferguson, Leslie W" uniqKey="Ferguson L" first="Leslie W" last="Ferguson">Leslie W. Ferguson</name><affiliation><nlm:affiliation>Saskatchewan Movement Disorders Program, University of Saskatchewan/Saskatoon Health Region, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Robinson, Christopher A" sort="Robinson, Christopher A" uniqKey="Robinson C" first="Christopher A" last="Robinson">Christopher A. Robinson</name><affiliation><nlm:affiliation>Division of Neuropathology, Department of Pathology, Saskatoon Health Region, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Guella, Ilaria" sort="Guella, Ilaria" uniqKey="Guella I" first="Ilaria" last="Guella">Ilaria Guella</name><affiliation><nlm:affiliation>Centre of Applied Neurogenetics, University of British Columbia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J" last="Farrer">Matthew J. Farrer</name><affiliation><nlm:affiliation>Centre of Applied Neurogenetics, University of British Columbia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Rajput, Alexander" sort="Rajput, Alexander" uniqKey="Rajput A" first="Alexander" last="Rajput">Alexander Rajput</name><affiliation><nlm:affiliation>Saskatchewan Movement Disorders Program, University of Saskatchewan/Saskatoon Health Region, Canada.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27481034</idno><idno type="pmid">27481034</idno><idno type="doi">10.1016/j.parkreldis.2016.07.011</idno><idno type="wicri:Area/PubMed/Corpus">000149</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000149</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Conjugal parkinsonism - Clinical, pathology and genetic study. No evidence of person-to-person transmission.</title><author><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H" last="Rajput">Ali H. Rajput</name><affiliation><nlm:affiliation>Saskatchewan Movement Disorders Program, University of Saskatchewan/Saskatoon Health Region, Canada. Electronic address: ali.rajput@saskatoonhealthregion.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Ferguson, Leslie W" sort="Ferguson, Leslie W" uniqKey="Ferguson L" first="Leslie W" last="Ferguson">Leslie W. Ferguson</name><affiliation><nlm:affiliation>Saskatchewan Movement Disorders Program, University of Saskatchewan/Saskatoon Health Region, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Robinson, Christopher A" sort="Robinson, Christopher A" uniqKey="Robinson C" first="Christopher A" last="Robinson">Christopher A. Robinson</name><affiliation><nlm:affiliation>Division of Neuropathology, Department of Pathology, Saskatoon Health Region, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Guella, Ilaria" sort="Guella, Ilaria" uniqKey="Guella I" first="Ilaria" last="Guella">Ilaria Guella</name><affiliation><nlm:affiliation>Centre of Applied Neurogenetics, University of British Columbia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J" last="Farrer">Matthew J. Farrer</name><affiliation><nlm:affiliation>Centre of Applied Neurogenetics, University of British Columbia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Rajput, Alexander" sort="Rajput, Alexander" uniqKey="Rajput A" first="Alexander" last="Rajput">Alexander Rajput</name><affiliation><nlm:affiliation>Saskatchewan Movement Disorders Program, University of Saskatchewan/Saskatoon Health Region, Canada.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Parkinsonism & related disorders</title><idno type="eISSN">1873-5126</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Neurodegeneration is known basis of several different Parkinson syndromes. The most common Parkinson syndrome is the Parkinson's disease. Distinction between different Parkinson syndromes is based on pathology or genetic findings. Recent studies indicate that several major variants of PS have some characteristics of a prion disease and may therefore be transmissible. Married couples offer a unique opportunity to study person-to-person transmission and the role of shared environments as the cause of parkinsonism.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27481034</PMID><DateCreated><Year>2016</Year><Month>08</Month><Day>02</Day></DateCreated><DateRevised><Year>2016</Year><Month>10</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5126</ISSN><JournalIssue CitedMedium="Internet"><Volume>31</Volume><PubDate><Year>2016</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Parkinsonism & related disorders</Title><ISOAbbreviation>Parkinsonism Relat. Disord.</ISOAbbreviation></Journal><ArticleTitle>Conjugal parkinsonism - Clinical, pathology and genetic study. No evidence of person-to-person transmission.</ArticleTitle><Pagination><MedlinePgn>87-90</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1353-8020(16)30275-9</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.parkreldis.2016.07.011</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Neurodegeneration is known basis of several different Parkinson syndromes. The most common Parkinson syndrome is the Parkinson's disease. Distinction between different Parkinson syndromes is based on pathology or genetic findings. Recent studies indicate that several major variants of PS have some characteristics of a prion disease and may therefore be transmissible. Married couples offer a unique opportunity to study person-to-person transmission and the role of shared environments as the cause of parkinsonism.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Autopsy is offered to patients seen at the Movement Disorders Clinic Saskatchewan at no cost. Five couples seen in our clinic, where each spouse had a clinical diagnosis of parkinsonism, came to autopsy.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Median duration of marriage was 42 years before the Parkinson syndrome first manifested in a spouse. Three couples were pathologically or genetically discordant for Parkinson variant. Each spouse in the other two couples had Parkinson's disease. One couple had onset separated by 20 years and one partner had a strong family history of Parkinson's disease.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Our data indicate that neither of the Parkinson's disease, Progressive Supranuclear Palsy and Multiple System Atrophy are transmitted by sexual or other intimate contact. The data also indicate against shared environments as the cause of these disorders.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rajput</LastName><ForeName>Ali H</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Saskatchewan Movement Disorders Program, University of Saskatchewan/Saskatoon Health Region, Canada. Electronic address: ali.rajput@saskatoonhealthregion.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferguson</LastName><ForeName>Leslie W</ForeName><Initials>LW</Initials><AffiliationInfo><Affiliation>Saskatchewan Movement Disorders Program, University of Saskatchewan/Saskatoon Health Region, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robinson</LastName><ForeName>Christopher A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Division of Neuropathology, Department of Pathology, Saskatoon Health Region, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guella</LastName><ForeName>Ilaria</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Centre of Applied Neurogenetics, University of British Columbia, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farrer</LastName><ForeName>Matthew J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Centre of Applied Neurogenetics, University of British Columbia, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rajput</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Saskatchewan Movement Disorders Program, University of Saskatchewan/Saskatoon Health Region, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>07</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Parkinsonism Relat Disord</MedlineTA><NlmUniqueID>9513583</NlmUniqueID><ISSNLinking>1353-8020</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Autopsy</Keyword><Keyword MajorTopicYN="N">Conjugal</Keyword><Keyword MajorTopicYN="N">Environment</Keyword><Keyword MajorTopicYN="N">Parkinson syndrome</Keyword><Keyword MajorTopicYN="N">Transmission</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>05</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>07</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>07</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>8</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>8</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>8</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27481034</ArticleId><ArticleId IdType="pii">S1353-8020(16)30275-9</ArticleId><ArticleId IdType="doi">10.1016/j.parkreldis.2016.07.011</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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