Dementia Predictors in Parkinson Disease: A Validation Study.
Identifieur interne : 000098 ( PubMed/Corpus ); précédent : 000097; suivant : 000099Dementia Predictors in Parkinson Disease: A Validation Study.
Auteurs : Julius B M. Anang ; Takashi Nomura ; Silvia Rios Romenets ; Kenji Nakashima ; Jean-Francois Gagnon ; Ronald B. PostumaSource :
- Journal of Parkinson's disease [ 1877-718X ] ; 2017.
Abstract
In a prospective study, we recently discovered 8 clinical predictors of dementia in Parkinson's disease. Here, we validate these dementia predictors using two additional prospective cohorts (n = 134). After a 3.6-year follow-up, 35/134 developed dementia (7.2% per year). When confirming individual variables, 5/8 were significantly associated with dementia in the validation cohort. These included age, male sex, baseline RBD, orthostatic hypotension, and MCI. Bilateral onset, hallucinations and falls/freezing did not significantly predict dementia; however, point estimates of OR were all >1. In all cohorts, the strongest determinant for dementia development was the co-existence of RBD, MCI and orthostatic hypotension at baseline.
DOI: 10.3233/JPD-160925
PubMed: 27911340
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Anang</name><affiliation><nlm:affiliation>Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Nomura, Takashi" sort="Nomura, Takashi" uniqKey="Nomura T" first="Takashi" last="Nomura">Takashi Nomura</name><affiliation><nlm:affiliation>Department of Brain and Neurosciences, Division of Neurology, Faculty of Medicine, Tottori University, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Romenets, Silvia Rios" sort="Romenets, Silvia Rios" uniqKey="Romenets S" first="Silvia Rios" last="Romenets">Silvia Rios Romenets</name><affiliation><nlm:affiliation>Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Nakashima, Kenji" sort="Nakashima, Kenji" uniqKey="Nakashima K" first="Kenji" last="Nakashima">Kenji Nakashima</name><affiliation><nlm:affiliation>Department of Brain and Neurosciences, Division of Neurology, Faculty of Medicine, Tottori University, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-Francois" last="Gagnon">Jean-Francois Gagnon</name><affiliation><nlm:affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B" last="Postuma">Ronald B. Postuma</name><affiliation><nlm:affiliation>Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27911340</idno><idno type="pmid">27911340</idno><idno type="doi">10.3233/JPD-160925</idno><idno type="wicri:Area/PubMed/Corpus">000098</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000098</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Dementia Predictors in Parkinson Disease: A Validation Study.</title><author><name sortKey="Anang, Julius B M" sort="Anang, Julius B M" uniqKey="Anang J" first="Julius B M" last="Anang">Julius B M. Anang</name><affiliation><nlm:affiliation>Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Nomura, Takashi" sort="Nomura, Takashi" uniqKey="Nomura T" first="Takashi" last="Nomura">Takashi Nomura</name><affiliation><nlm:affiliation>Department of Brain and Neurosciences, Division of Neurology, Faculty of Medicine, Tottori University, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Romenets, Silvia Rios" sort="Romenets, Silvia Rios" uniqKey="Romenets S" first="Silvia Rios" last="Romenets">Silvia Rios Romenets</name><affiliation><nlm:affiliation>Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Nakashima, Kenji" sort="Nakashima, Kenji" uniqKey="Nakashima K" first="Kenji" last="Nakashima">Kenji Nakashima</name><affiliation><nlm:affiliation>Department of Brain and Neurosciences, Division of Neurology, Faculty of Medicine, Tottori University, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-Francois" last="Gagnon">Jean-Francois Gagnon</name><affiliation><nlm:affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B" last="Postuma">Ronald B. Postuma</name><affiliation><nlm:affiliation>Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of Parkinson's disease</title><idno type="eISSN">1877-718X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In a prospective study, we recently discovered 8 clinical predictors of dementia in Parkinson's disease. Here, we validate these dementia predictors using two additional prospective cohorts (n = 134). After a 3.6-year follow-up, 35/134 developed dementia (7.2% per year). When confirming individual variables, 5/8 were significantly associated with dementia in the validation cohort. These included age, male sex, baseline RBD, orthostatic hypotension, and MCI. Bilateral onset, hallucinations and falls/freezing did not significantly predict dementia; however, point estimates of OR were all >1. In all cohorts, the strongest determinant for dementia development was the co-existence of RBD, MCI and orthostatic hypotension at baseline.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27911340</PMID><DateCreated><Year>2016</Year><Month>12</Month><Day>02</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>22</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1877-718X</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>1</Issue><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>Journal of Parkinson's disease</Title><ISOAbbreviation>J Parkinsons Dis</ISOAbbreviation></Journal><ArticleTitle>Dementia Predictors in Parkinson Disease: A Validation Study.</ArticleTitle><Pagination><MedlinePgn>159-162</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3233/JPD-160925</ELocationID><Abstract><AbstractText>In a prospective study, we recently discovered 8 clinical predictors of dementia in Parkinson's disease. Here, we validate these dementia predictors using two additional prospective cohorts (n = 134). After a 3.6-year follow-up, 35/134 developed dementia (7.2% per year). When confirming individual variables, 5/8 were significantly associated with dementia in the validation cohort. These included age, male sex, baseline RBD, orthostatic hypotension, and MCI. Bilateral onset, hallucinations and falls/freezing did not significantly predict dementia; however, point estimates of OR were all >1. In all cohorts, the strongest determinant for dementia development was the co-existence of RBD, MCI and orthostatic hypotension at baseline.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Anang</LastName><ForeName>Julius B M</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nomura</LastName><ForeName>Takashi</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Brain and Neurosciences, Division of Neurology, Faculty of Medicine, Tottori University, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Romenets</LastName><ForeName>Silvia Rios</ForeName><Initials>SR</Initials><AffiliationInfo><Affiliation>Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nakashima</LastName><ForeName>Kenji</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Brain and Neurosciences, Division of Neurology, Faculty of Medicine, Tottori University, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gagnon</LastName><ForeName>Jean-Francois</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychology, Université du Québec à Montréal, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Postuma</LastName><ForeName>Ronald B</ForeName><Initials>RB</Initials><AffiliationInfo><Affiliation>Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Parkinsons Dis</MedlineTA><NlmUniqueID>101567362</NlmUniqueID><ISSNLinking>1877-7171</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Dementia</Keyword><Keyword MajorTopicYN="N">REM sleep behavior disorder</Keyword><Keyword MajorTopicYN="N">mild cognitive impairment</Keyword><Keyword MajorTopicYN="N">prediction</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27911340</ArticleId><ArticleId IdType="pii">JPD160925</ArticleId><ArticleId IdType="doi">10.3233/JPD-160925</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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