Ident. | Authors (with country if any) | Title |
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000577 (2015) |
Dianbo Qu ; Ali Hage ; Katie Don-Carolis ; En Huang ; Alvin Joselin ; Farzaneh Safarpour ; Paul C. Marcogliese ; Maxime W C. Rousseaux ; Sarah J. Hewitt ; Tianwen Huang ; Doo-Soon Im ; Steve Callaghan ; Danielle Dewar-Darch [Canada] ; Daniel Figeys [Canada] ; Ruth S. Slack ; David S. Park [Canada] | BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival. |
000664 (2014) |
Mohammad Parsanejad ; Yi Zhang ; Dianbo Qu ; Isabella Irrcher [Canada] ; Maxime W C. Rousseaux ; Hossein Aleyasin ; Fatemeh Kamkar ; Steve Callaghan ; Ruth S. Slack ; Tak W. Mak ; Stephen Lee ; Daniel Figeys [Canada] ; David S. Park [Canada] | Regulation of the VHL/HIF-1 pathway by DJ-1. |
000766 (2014) |
Mohammad Parsanejad [Canada] ; Noam Bourquard [États-Unis] ; Dianbo Qu [Canada] ; Yi Zhang [Canada] ; En Huang [Canada] ; Maxime W C. Rousseaux [États-Unis] ; Hossein Aleyasin [États-Unis] ; Isabella Irrcher [Canada] ; Steve Callaghan [Canada] ; Dominique C. Vaillant [Canada] ; Raymond H. Kim [Canada] ; Ruth S. Slack [Canada] ; Tak W. Mak [Canada] ; Srinivasa T. Reddy [États-Unis] ; Daniel Figeys [Canada] ; David S. Park [Corée du Sud] | DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress. |
000865 (2013) |
Matthew P. Mount [Canada] ; Yi Zhang ; Mandana Amini ; Steve Callaghan ; Jerzy Kulczycki ; Zixu Mao ; Ruth S. Slack ; Hymie Anisman ; David S. Park | Perturbation of transcription factor Nur77 expression mediated by myocyte enhancer factor 2D (MEF2D) regulates dopaminergic neuron loss in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). |
000998 (2012) |
Maria Xilouri [Grèce] ; Elli Kyratzi ; Pothitos M. Pitychoutis ; Zoi Papadopoulou-Daifoti ; Celine Perier ; Miquel Vila ; Matina Maniati ; Ayse Ulusoy ; Deniz Kirik ; David S. Park ; Keiji Wada ; Leonidas Stefanis | Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system. |
000A09 (2012) |
Maxime W C. Rousseaux [Canada] ; Paul C. Marcogliese ; Dianbo Qu ; Sarah J. Hewitt ; Sarah Seang ; Raymond H. Kim ; Ruth S. Slack ; Michael G. Schlossmacher ; Diane C. Lagace ; Tak W. Mak ; David S. Park | Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease. |
000A35 (2012) |
Andrew W. Greene [Canada] ; Karl Grenier ; Miguel A. Aguileta ; Stephanie Muise ; Rasoul Farazifard ; M Emdadul Haque ; Heidi M. Mcbride ; David S. Park ; Edward A. Fon | Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment. |
000A56 (2012) |
M Emdadul Haque [Canada] ; Matthew P. Mount ; Farzaneh Safarpour ; Elizabeth Abdel-Messih ; Steve Callaghan ; Chantal Mazerolle ; Tohru Kitada ; Ruth S. Slack ; Valerie Wallace ; Jie Shen ; Hymie Anisman ; David S. Park | Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1. |
000B76 (2011) |
Mansoureh Hakimi [Canada] ; Thirumahal Selvanantham ; Erika Swinton ; Ruth F. Padmore ; Youren Tong ; Ghassan Kabbach ; Katerina Venderova ; Stephen E. Girardin ; Dennis E. Bulman ; Clemens R. Scherzer ; Matthew J. Lavoie ; Denis Gris ; David S. Park ; Jonathan B. Angel ; Jie Shen ; Dana J. Philpott ; Michael G. Schlossmacher | Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures. |
000B90 (2011) |
Arman Lira [Canada] ; Jerzy Kulczycki ; Ruth Slack ; Hymie Anisman ; David S. Park | Involvement of the Fc gamma receptor in a chronic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of dopaminergic loss. |
000D40 (2010) |
Hossein Aleyasin [Canada] ; Maxime W C. Rousseaux ; Paul C. Marcogliese ; Sarah J. Hewitt ; Isabella Irrcher ; Alvin P. Joselin ; Mohammad Parsanejad ; Raymond H. Kim ; Patrizia Rizzu ; Steve M. Callaghan ; Ruth S. Slack ; Tak W. Mak ; David S. Park | DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway. |
000E15 (2009) |
Isabella Irrcher [Canada] ; David S. Park | Parkinson's disease: to live or die by autophagy. |
000E40 (2009) |
Katerina Venderova [Canada] ; Ghassan Kabbach ; Elizabeth Abdel-Messih ; Yi Zhang ; Robin J. Parks ; Yuzuru Imai ; Stephan Gehrke ; Johnny Ngsee ; Matthew J. Lavoie ; Ruth S. Slack ; Yong Rao ; Zhuohua Zhang ; Bingwei Lu ; M Emdadul Haque ; David S. Park | Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. |
000F76 (2008) |
M Emdadul Haque [Canada] ; Kelly J. Thomas ; Cheryl D'Souza ; Steve Callaghan ; Tohru Kitada ; Ruth S. Slack ; Paul Fraser ; Mark R. Cookson ; Anurag Tandon ; David S. Park | Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP. |
001008 (2007) |
Hossein Aleyasin [Canada] ; Maxime W C. Rousseaux ; Maryam Phillips ; Raymond H. Kim ; Ross J. Bland ; Steve Callaghan ; Ruth S. Slack ; Matthew J. During ; Tak W. Mak ; David S. Park | The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage. |
001018 (2007) |
Dianbo Qu [Canada] ; Juliet Rashidian ; Matthew P. Mount ; Hossein Aleyasin ; Mohammad Parsanejad ; Arman Lira ; Emdadul Haque ; Yi Zhang ; Steve Callaghan ; Mireille Daigle ; Maxime W C. Rousseaux ; Ruth S. Slack ; Paul R. Albert ; Inez Vincent ; John M. Woulfe ; David S. Park | Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease. |
001044 (2007) |
Matthew P. Mount [Canada] ; Arman Lira ; David Grimes ; Patrice D. Smith ; Sylvie Faucher ; Ruth Slack ; Hymie Anisman ; Shawn Hayley ; David S. Park | Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons. |
001219 (2005) |
Raymond H. Kim [Canada] ; Patrice D. Smith ; Hossein Aleyasin ; Shawn Hayley ; Matthew P. Mount ; Scott Pownall ; Andrew Wakeham ; Annick J. You-Ten ; Suneil K. Kalia ; Patrick Horne ; David Westaway ; Andres M. Lozano ; Hymie Anisman ; David S. Park ; Tak W. Mak | Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. |
001327 (2004) |
Patrice D. Smith [Canada] ; Michael J. O'Hare ; David S. Park | CDKs: taking on a role as mediators of dopaminergic loss in Parkinson's disease. |
001330 (2004) |
Suneil K. Kalia [Canada] ; Sang Lee ; Patrice D. Smith ; Li Liu ; Stephen J. Crocker ; Thorhildur E. Thorarinsdottir ; John R. Glover ; Edward A. Fon ; David S. Park ; Andres M. Lozano | BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. |
001387 (2003) |
Stephen J. Crocker [Canada] ; Patrice D. Smith ; Vernice Jackson-Lewis ; Wiplore R. Lamba ; Shawn P. Hayley ; Erich Grimm ; Steve M. Callaghan ; Ruth S. Slack ; Edon Melloni ; Serge Przedborski ; George S. Robertson ; Hymie Anisman ; Zul Merali ; David S. Park | Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease. |