MRI and PET studies of manganese-intoxicated monkeys.
Identifieur interne : 001842 ( PubMed/Checkpoint ); précédent : 001841; suivant : 001843MRI and PET studies of manganese-intoxicated monkeys.
Auteurs : H. Shinotoh [Canada] ; B J Snow ; K A Hewitt ; B D Pate ; D. Doudet ; R. Nugent ; D P Perl ; W. Olanow ; D B CalneSource :
- Neurology [ 0028-3878 ] ; 1995.
English descriptors
- KwdEn :
- Animals, Carbidopa (administration & dosage), Corpus Striatum (diagnostic imaging), Corpus Striatum (metabolism), Corpus Striatum (pathology), Deoxyglucose (analogs & derivatives), Drug Therapy, Combination, Dystonia (drug therapy), Dystonia (physiopathology), Fluorodeoxyglucose F18, Globus Pallidus (diagnostic imaging), Globus Pallidus (metabolism), Globus Pallidus (pathology), Glucose (metabolism), Levodopa (administration & dosage), Macaca mulatta, Magnetic Resonance Imaging, Male, Manganese Poisoning, Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (diagnostic imaging), Parkinson Disease, Secondary (drug therapy), Parkinson Disease, Secondary (pathology), Raclopride, Salicylamides, Substantia Nigra (diagnostic imaging), Substantia Nigra (metabolism), Substantia Nigra (pathology), Tomography, Emission-Computed.
- MESH :
- chemical , administration & dosage : Carbidopa, Levodopa.
- chemical , analogs & derivatives : Deoxyglucose.
- chemically induced : Parkinson Disease, Secondary.
- diagnostic imaging : Corpus Striatum, Globus Pallidus, Parkinson Disease, Secondary, Substantia Nigra.
- drug therapy : Dystonia, Parkinson Disease, Secondary.
- metabolism : Corpus Striatum, Globus Pallidus, Glucose, Substantia Nigra.
- pathology : Corpus Striatum, Globus Pallidus, Parkinson Disease, Secondary, Substantia Nigra.
- physiopathology : Dystonia.
- Animals, Drug Therapy, Combination, Fluorodeoxyglucose F18, Macaca mulatta, Magnetic Resonance Imaging, Male, Manganese Poisoning, Raclopride, Salicylamides, Tomography, Emission-Computed.
Abstract
Using MRI and PET, we investigated the consequences of manganese intoxication in a primate model of parkinsonism and dystonia. Three rhesus monkeys were injected intravenously with doses of 10 to 14 mg/kg of MnCl2 on seven occasions, each a week apart. Two animals became hypoactive with abnormal extended posturing in the hind limbs. These motor disturbances did not improve with administration of levodopa. In all three monkeys, T1-weighted MRI demonstrated high signal intensities in the regions of the striatum, globus pallidus, and substantia nigra. No significant changes were found on [18F]6-fluoro-L-dopa, [11C]raclopride, or [18F]fluorodeoxyglucose PET. These results are consistent with the pathologic findings, which were primarily confined to the globus pallidus, and indicate that manganese intoxication is associated with preservation of the nigrostriatal dopaminergic pathway, despite clinical evidence of parkinsonian deficits. Chronic manganese intoxication may cause parkinsonism by damaging output pathways downstream to the nigrostriatal dopaminergic pathway. This is consistent with the demonstrated lack of therapeutic response to levodopa.
PubMed: 7783889
Affiliations:
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Shinotoh</name><affiliation wicri:level="1"><nlm:affiliation>Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Neurodegenerative Disorders Centre, University of British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Snow, B J" sort="Snow, B J" uniqKey="Snow B" first="B J" last="Snow">B J Snow</name></author><author><name sortKey="Hewitt, K A" sort="Hewitt, K A" uniqKey="Hewitt K" first="K A" last="Hewitt">K A Hewitt</name></author><author><name sortKey="Pate, B D" sort="Pate, B D" uniqKey="Pate B" first="B D" last="Pate">B D Pate</name></author><author><name sortKey="Doudet, D" sort="Doudet, D" uniqKey="Doudet D" first="D" last="Doudet">D. Doudet</name></author><author><name sortKey="Nugent, R" sort="Nugent, R" uniqKey="Nugent R" first="R" last="Nugent">R. 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Shinotoh</name><affiliation wicri:level="1"><nlm:affiliation>Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Neurodegenerative Disorders Centre, University of British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Snow, B J" sort="Snow, B J" uniqKey="Snow B" first="B J" last="Snow">B J Snow</name></author><author><name sortKey="Hewitt, K A" sort="Hewitt, K A" uniqKey="Hewitt K" first="K A" last="Hewitt">K A Hewitt</name></author><author><name sortKey="Pate, B D" sort="Pate, B D" uniqKey="Pate B" first="B D" last="Pate">B D Pate</name></author><author><name sortKey="Doudet, D" sort="Doudet, D" uniqKey="Doudet D" first="D" last="Doudet">D. Doudet</name></author><author><name sortKey="Nugent, R" sort="Nugent, R" uniqKey="Nugent R" first="R" last="Nugent">R. 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Three rhesus monkeys were injected intravenously with doses of 10 to 14 mg/kg of MnCl2 on seven occasions, each a week apart. Two animals became hypoactive with abnormal extended posturing in the hind limbs. These motor disturbances did not improve with administration of levodopa. In all three monkeys, T1-weighted MRI demonstrated high signal intensities in the regions of the striatum, globus pallidus, and substantia nigra. No significant changes were found on [18F]6-fluoro-L-dopa, [11C]raclopride, or [18F]fluorodeoxyglucose PET. These results are consistent with the pathologic findings, which were primarily confined to the globus pallidus, and indicate that manganese intoxication is associated with preservation of the nigrostriatal dopaminergic pathway, despite clinical evidence of parkinsonian deficits. Chronic manganese intoxication may cause parkinsonism by damaging output pathways downstream to the nigrostriatal dopaminergic pathway. This is consistent with the demonstrated lack of therapeutic response to levodopa.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">7783889</PMID><DateCreated><Year>1995</Year><Month>07</Month><Day>18</Day></DateCreated><DateCompleted><Year>1995</Year><Month>07</Month><Day>18</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0028-3878</ISSN><JournalIssue CitedMedium="Print"><Volume>45</Volume><Issue>6</Issue><PubDate><Year>1995</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Neurology</Title><ISOAbbreviation>Neurology</ISOAbbreviation></Journal><ArticleTitle>MRI and PET studies of manganese-intoxicated monkeys.</ArticleTitle><Pagination><MedlinePgn>1199-204</MedlinePgn></Pagination><Abstract><AbstractText>Using MRI and PET, we investigated the consequences of manganese intoxication in a primate model of parkinsonism and dystonia. Three rhesus monkeys were injected intravenously with doses of 10 to 14 mg/kg of MnCl2 on seven occasions, each a week apart. Two animals became hypoactive with abnormal extended posturing in the hind limbs. These motor disturbances did not improve with administration of levodopa. In all three monkeys, T1-weighted MRI demonstrated high signal intensities in the regions of the striatum, globus pallidus, and substantia nigra. No significant changes were found on [18F]6-fluoro-L-dopa, [11C]raclopride, or [18F]fluorodeoxyglucose PET. These results are consistent with the pathologic findings, which were primarily confined to the globus pallidus, and indicate that manganese intoxication is associated with preservation of the nigrostriatal dopaminergic pathway, despite clinical evidence of parkinsonian deficits. Chronic manganese intoxication may cause parkinsonism by damaging output pathways downstream to the nigrostriatal dopaminergic pathway. This is consistent with the demonstrated lack of therapeutic response to levodopa.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shinotoh</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Snow</LastName><ForeName>B J</ForeName><Initials>BJ</Initials></Author><Author ValidYN="Y"><LastName>Hewitt</LastName><ForeName>K A</ForeName><Initials>KA</Initials></Author><Author ValidYN="Y"><LastName>Pate</LastName><ForeName>B D</ForeName><Initials>BD</Initials></Author><Author ValidYN="Y"><LastName>Doudet</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Nugent</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Perl</LastName><ForeName>D P</ForeName><Initials>DP</Initials></Author><Author ValidYN="Y"><LastName>Olanow</LastName><ForeName>W</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Calne</LastName><ForeName>D B</ForeName><Initials>DB</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurology</MedlineTA><NlmUniqueID>0401060</NlmUniqueID><ISSNLinking>0028-3878</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012457">Salicylamides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0Z5B2CJX4D</RegistryNumber><NameOfSubstance UI="D019788">Fluorodeoxyglucose F18</NameOfSubstance></Chemical><Chemical><RegistryNumber>430K3SOZ7G</RegistryNumber><NameOfSubstance UI="D020891">Raclopride</NameOfSubstance></Chemical><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical><Chemical><RegistryNumber>9G2MP84A8W</RegistryNumber><NameOfSubstance UI="D003847">Deoxyglucose</NameOfSubstance></Chemical><Chemical><RegistryNumber>IY9XDZ35W2</RegistryNumber><NameOfSubstance UI="D005947">Glucose</NameOfSubstance></Chemical><Chemical><RegistryNumber>MNX7R8C5VO</RegistryNumber><NameOfSubstance UI="D002230">Carbidopa</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002230" MajorTopicYN="N">Carbidopa</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003342" MajorTopicYN="N">Corpus Striatum</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003847" MajorTopicYN="N">Deoxyglucose</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="N">analogs & derivatives</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004421" MajorTopicYN="N">Dystonia</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019788" MajorTopicYN="N">Fluorodeoxyglucose F18</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005917" MajorTopicYN="N">Globus Pallidus</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005947" MajorTopicYN="N">Glucose</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007980" MajorTopicYN="N">Levodopa</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008253" MajorTopicYN="N">Macaca mulatta</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020149" MajorTopicYN="Y">Manganese Poisoning</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010302" MajorTopicYN="N">Parkinson Disease, Secondary</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020891" MajorTopicYN="N">Raclopride</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012457" MajorTopicYN="N">Salicylamides</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013378" MajorTopicYN="N">Substantia Nigra</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014055" MajorTopicYN="N">Tomography, Emission-Computed</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1995</Year><Month>6</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1995</Year><Month>6</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1995</Year><Month>6</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">7783889</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D B" last="Calne">D B Calne</name><name sortKey="Doudet, D" sort="Doudet, D" uniqKey="Doudet D" first="D" last="Doudet">D. Doudet</name><name sortKey="Hewitt, K A" sort="Hewitt, K A" uniqKey="Hewitt K" first="K A" last="Hewitt">K A Hewitt</name><name sortKey="Nugent, R" sort="Nugent, R" uniqKey="Nugent R" first="R" last="Nugent">R. Nugent</name><name sortKey="Olanow, W" sort="Olanow, W" uniqKey="Olanow W" first="W" last="Olanow">W. Olanow</name><name sortKey="Pate, B D" sort="Pate, B D" uniqKey="Pate B" first="B D" last="Pate">B D Pate</name><name sortKey="Perl, D P" sort="Perl, D P" uniqKey="Perl D" first="D P" last="Perl">D P Perl</name><name sortKey="Snow, B J" sort="Snow, B J" uniqKey="Snow B" first="B J" last="Snow">B J Snow</name></noCountry><country name="Canada"><noRegion><name sortKey="Shinotoh, H" sort="Shinotoh, H" uniqKey="Shinotoh H" first="H" last="Shinotoh">H. Shinotoh</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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