Ablative therapy for movement disorders. Does thalamotomy alter the course of Parkinson's disease?
Identifieur interne : 001724 ( PubMed/Checkpoint ); précédent : 001723; suivant : 001725Ablative therapy for movement disorders. Does thalamotomy alter the course of Parkinson's disease?
Auteurs : R R Tasker [Canada]Source :
- Neurosurgery clinics of North America [ 1042-3680 ] ; 1998.
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Abstract
Although there is no confirmed evidence that therapy alters the course of Parkinson's disease, some follow-up of patients who have undergone thalamotomy has suggested it might slow or even halt the progress of the disease. A retrospective semiquantitative assessment of 55 patients undergoing bilateral thalamotomy and 31 undergoing unilateral operation confirms the previously held notion that postencephalitic disease or clinical onset below age 40 may progress so slowly as to appear arrested after thalamotomy. Patients left with no tremor and minimal rigidity after completion of unilateral or bilateral surgery, whether their disease is of youthful onset, postencephalitic or not, may also appear to follow stable courses postoperatively. This occurs in patients whose tremor and rigidity have been controlled by bilateral thalamotomy and also in those in whom unilateral tremor and rigidity have been controlled by unilateral surgery in the absence of significant tremor and rigidity on the other side of the body. Possible explanations are discussed.
PubMed: 9495899
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Does thalamotomy alter the course of Parkinson's disease?</title><author><name sortKey="Tasker, R R" sort="Tasker, R R" uniqKey="Tasker R" first="R R" last="Tasker">R R Tasker</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgery, University of Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Surgery, University of Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9495899</idno><idno type="pmid">9495899</idno><idno type="wicri:Area/PubMed/Corpus">001776</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001776</idno><idno type="wicri:Area/PubMed/Curation">001776</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001776</idno><idno type="wicri:Area/PubMed/Checkpoint">001776</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001776</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Ablative therapy for movement disorders. Does thalamotomy alter the course of Parkinson's disease?</title><author><name sortKey="Tasker, R R" sort="Tasker, R R" uniqKey="Tasker R" first="R R" last="Tasker">R R Tasker</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgery, University of Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Surgery, University of Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><title level="j">Neurosurgery clinics of North America</title><idno type="ISSN">1042-3680</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans</term><term>Parkinson Disease (surgery)</term><term>Stereotaxic Techniques</term><term>Thalamic Nuclei (surgery)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term><term>Thalamic Nuclei</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Stereotaxic Techniques</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although there is no confirmed evidence that therapy alters the course of Parkinson's disease, some follow-up of patients who have undergone thalamotomy has suggested it might slow or even halt the progress of the disease. A retrospective semiquantitative assessment of 55 patients undergoing bilateral thalamotomy and 31 undergoing unilateral operation confirms the previously held notion that postencephalitic disease or clinical onset below age 40 may progress so slowly as to appear arrested after thalamotomy. Patients left with no tremor and minimal rigidity after completion of unilateral or bilateral surgery, whether their disease is of youthful onset, postencephalitic or not, may also appear to follow stable courses postoperatively. This occurs in patients whose tremor and rigidity have been controlled by bilateral thalamotomy and also in those in whom unilateral tremor and rigidity have been controlled by unilateral surgery in the absence of significant tremor and rigidity on the other side of the body. Possible explanations are discussed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9495899</PMID><DateCreated><Year>1998</Year><Month>04</Month><Day>23</Day></DateCreated><DateCompleted><Year>1998</Year><Month>04</Month><Day>23</Day></DateCompleted><DateRevised><Year>2005</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1042-3680</ISSN><JournalIssue CitedMedium="Print"><Volume>9</Volume><Issue>2</Issue><PubDate><Year>1998</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Neurosurgery clinics of North America</Title><ISOAbbreviation>Neurosurg. Clin. N. Am.</ISOAbbreviation></Journal><ArticleTitle>Ablative therapy for movement disorders. Does thalamotomy alter the course of Parkinson's disease?</ArticleTitle><Pagination><MedlinePgn>375-80</MedlinePgn></Pagination><Abstract><AbstractText>Although there is no confirmed evidence that therapy alters the course of Parkinson's disease, some follow-up of patients who have undergone thalamotomy has suggested it might slow or even halt the progress of the disease. A retrospective semiquantitative assessment of 55 patients undergoing bilateral thalamotomy and 31 undergoing unilateral operation confirms the previously held notion that postencephalitic disease or clinical onset below age 40 may progress so slowly as to appear arrested after thalamotomy. Patients left with no tremor and minimal rigidity after completion of unilateral or bilateral surgery, whether their disease is of youthful onset, postencephalitic or not, may also appear to follow stable courses postoperatively. This occurs in patients whose tremor and rigidity have been controlled by bilateral thalamotomy and also in those in whom unilateral tremor and rigidity have been controlled by unilateral surgery in the absence of significant tremor and rigidity on the other side of the body. Possible explanations are discussed.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tasker</LastName><ForeName>R R</ForeName><Initials>RR</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurosurg Clin N Am</MedlineTA><NlmUniqueID>9008004</NlmUniqueID><ISSNLinking>1042-3680</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013238" MajorTopicYN="Y">Stereotaxic Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013787" MajorTopicYN="N">Thalamic Nuclei</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><NumberOfReferences>16</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1998</Year><Month>4</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1998</Year><Month>4</Month><Day>29</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1998</Year><Month>4</Month><Day>29</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9495899</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Tasker, R R" sort="Tasker, R R" uniqKey="Tasker R" first="R R" last="Tasker">R R Tasker</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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