Long term outcome of unilateral pallidotomy: follow up of 15 patients for 3 years.
Identifieur interne : 001575 ( PubMed/Checkpoint ); précédent : 001574; suivant : 001576Long term outcome of unilateral pallidotomy: follow up of 15 patients for 3 years.
Auteurs : P K Pal [Canada] ; A. Samii ; A. Kishore ; M. Schulzer ; E. Mak ; S. Yardley ; I M Turnbull ; D B CalneSource :
- Journal of neurology, neurosurgery, and psychiatry [ 0022-3050 ] ; 2000.
English descriptors
- KwdEn :
- MESH :
- classification : Dyskinesias, Tremor.
- pathology : Dyskinesias, Tremor.
- surgery : Globus Pallidus, Parkinson Disease.
- Activities of Daily Living, Adult, Aged, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Treatment Outcome.
Abstract
With the advent of new antiparkinsonian drug therapy and promising results from subthalamic and pallidal stimulation, this study evaluated the long term efficacy of unilateral pallidotomy, a technique which has gained popularity over the past decade for the management of advanced Parkinson's disease.
PubMed: 10945808
Affiliations:
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pubmed:10945808Le document en format XML
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<author><name sortKey="Yardley, S" sort="Yardley, S" uniqKey="Yardley S" first="S" last="Yardley">S. Yardley</name>
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<author><name sortKey="Turnbull, I M" sort="Turnbull, I M" uniqKey="Turnbull I" first="I M" last="Turnbull">I M Turnbull</name>
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<term>Aged</term>
<term>Disease Progression</term>
<term>Dyskinesias (classification)</term>
<term>Dyskinesias (pathology)</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Globus Pallidus (surgery)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (surgery)</term>
<term>Treatment Outcome</term>
<term>Tremor (classification)</term>
<term>Tremor (pathology)</term>
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<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Dyskinesias</term>
<term>Tremor</term>
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<term>Tremor</term>
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<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Globus Pallidus</term>
<term>Parkinson Disease</term>
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<term>Adult</term>
<term>Aged</term>
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<term>Female</term>
<term>Follow-Up Studies</term>
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<front><div type="abstract" xml:lang="en">With the advent of new antiparkinsonian drug therapy and promising results from subthalamic and pallidal stimulation, this study evaluated the long term efficacy of unilateral pallidotomy, a technique which has gained popularity over the past decade for the management of advanced Parkinson's disease.</div>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10945808</PMID>
<DateCreated><Year>2000</Year>
<Month>09</Month>
<Day>14</Day>
</DateCreated>
<DateCompleted><Year>2000</Year>
<Month>09</Month>
<Day>14</Day>
</DateCompleted>
<DateRevised><Year>2014</Year>
<Month>06</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-3050</ISSN>
<JournalIssue CitedMedium="Print"><Volume>69</Volume>
<Issue>3</Issue>
<PubDate><Year>2000</Year>
<Month>Sep</Month>
</PubDate>
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<Title>Journal of neurology, neurosurgery, and psychiatry</Title>
<ISOAbbreviation>J. Neurol. Neurosurg. Psychiatr.</ISOAbbreviation>
</Journal>
<ArticleTitle>Long term outcome of unilateral pallidotomy: follow up of 15 patients for 3 years.</ArticleTitle>
<Pagination><MedlinePgn>337-44</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">With the advent of new antiparkinsonian drug therapy and promising results from subthalamic and pallidal stimulation, this study evaluated the long term efficacy of unilateral pallidotomy, a technique which has gained popularity over the past decade for the management of advanced Parkinson's disease.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The 15 patients reported here are part of the original cohort of 24 patients who underwent posteroventral pallidotomy for motor fluctuations and disabling dyskinesias 3 years ago as part of a prospective study. Evaluation scales included the unified Parkinson's disease rating scale, the Goetz dyskinesia scale, and the Purdue pegboard test.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">When compared with the prepallidotomy scores, the reduction in the limb dyskinesias and off state tremor scores persisted on the side contralateral to pallidotomy at the end of 3 years (dyskinesias were reduced by 64% (p<0.01) and tremor by 63% (p<0.05). Other measures tended to deteriorate. The dosage of antiparkinsonian medications did not change significantly from 3 months prepallidotomy to 3 years postpallidotomy.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Although unilateral pallidotomy is useful in controlling the contralateral dyskinesias and tremor 3 years after surgery, all other early benefits disappear and activities of daily living continue to worsen.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pal</LastName>
<ForeName>P K</ForeName>
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<AffiliationInfo><Affiliation>Neurodegenerative Disorders Centre, M 36 Purdy Pavilion, Vancouver Hospital and Health Sciences Centre, 2221 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5.</Affiliation>
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<Author ValidYN="Y"><LastName>Kishore</LastName>
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<Author ValidYN="Y"><LastName>Turnbull</LastName>
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