La maladie de Parkinson au Canada (serveur d'exploration)

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Long term outcome of unilateral pallidotomy: follow up of 15 patients for 3 years.

Identifieur interne : 001575 ( PubMed/Checkpoint ); précédent : 001574; suivant : 001576

Long term outcome of unilateral pallidotomy: follow up of 15 patients for 3 years.

Auteurs : P K Pal [Canada] ; A. Samii ; A. Kishore ; M. Schulzer ; E. Mak ; S. Yardley ; I M Turnbull ; D B Calne

Source :

RBID : pubmed:10945808

English descriptors

Abstract

With the advent of new antiparkinsonian drug therapy and promising results from subthalamic and pallidal stimulation, this study evaluated the long term efficacy of unilateral pallidotomy, a technique which has gained popularity over the past decade for the management of advanced Parkinson's disease.

PubMed: 10945808


Affiliations:


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pubmed:10945808

Le document en format XML

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<div type="abstract" xml:lang="en">With the advent of new antiparkinsonian drug therapy and promising results from subthalamic and pallidal stimulation, this study evaluated the long term efficacy of unilateral pallidotomy, a technique which has gained popularity over the past decade for the management of advanced Parkinson's disease.</div>
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<ArticleTitle>Long term outcome of unilateral pallidotomy: follow up of 15 patients for 3 years.</ArticleTitle>
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<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">With the advent of new antiparkinsonian drug therapy and promising results from subthalamic and pallidal stimulation, this study evaluated the long term efficacy of unilateral pallidotomy, a technique which has gained popularity over the past decade for the management of advanced Parkinson's disease.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The 15 patients reported here are part of the original cohort of 24 patients who underwent posteroventral pallidotomy for motor fluctuations and disabling dyskinesias 3 years ago as part of a prospective study. Evaluation scales included the unified Parkinson's disease rating scale, the Goetz dyskinesia scale, and the Purdue pegboard test.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">When compared with the prepallidotomy scores, the reduction in the limb dyskinesias and off state tremor scores persisted on the side contralateral to pallidotomy at the end of 3 years (dyskinesias were reduced by 64% (p<0.01) and tremor by 63% (p<0.05). Other measures tended to deteriorate. The dosage of antiparkinsonian medications did not change significantly from 3 months prepallidotomy to 3 years postpallidotomy.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Although unilateral pallidotomy is useful in controlling the contralateral dyskinesias and tremor 3 years after surgery, all other early benefits disappear and activities of daily living continue to worsen.</AbstractText>
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