ParkinsonCanadaV1, PubMed, Checkpoint, bibRecord, 001474

Deep brain stimulation for Parkinson's disease: disrupting the disruption.

Identifieur interne : 001474 ( PubMed/Checkpoint ); précédent : 001473; suivant : 001475

Deep brain stimulation for Parkinson's disease: disrupting the disruption.

Auteurs : Andres M. Lozano [Canada] ; Jonathan Dostrovsky ; Robert Chen ; Peter Ashby

Source :

The Lancet. Neurology [ 1474-4422 ] ; 2002.

RBID : pubmed:12849455

English descriptors

KwdEn :
- Animals, Brain (physiopathology), Disease Models, Animal, Electric Stimulation Therapy, Haplorhini, Humans, Parkinson Disease (physiopathology), Parkinson Disease (therapy), Rats.
MESH :
- physiopathology : Brain, Parkinson Disease.
- therapy : Parkinson Disease.
- Animals, Disease Models, Animal, Electric Stimulation Therapy, Haplorhini, Humans, Rats.

Abstract

Many people are disabled by Parkinson's disease (PD) despite the drug treatments that are currently available. For these patients, neurosurgery has the potential to help restore their function. The most effective neurosurgical procedures to date use electrical stimulation--deep brain stimulation (DBS)--of small targets in the brain by use of a pacemaker-like device to deliver constant stimulation. Although these operations can produce striking results, the mechanism by which delivery of electrical stimulation to targets deep in the brain can restore function in the motor system is not clear. This type of surgery probably works by interfering with and shutting down abnormal brain activity in areas where the current is delivered, such as the thalamus, globus pallidus, or the subthalamic nucleus. With this abnormal neuronal activity neutralised, motor areas of the brain can resume their function and normal movements are reinstated. Current research is aimed at elucidating how DBS works and using this information to develop better treatments for patients with PD and other neurological disorders.

PubMed: 12849455

Affiliations:

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pubmed:12849455

Le document en format XML

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<front><div type="abstract" xml:lang="en">Many people are disabled by Parkinson's disease (PD) despite the drug treatments that are currently available. For these patients, neurosurgery has the potential to help restore their function. The most effective neurosurgical procedures to date use electrical stimulation--deep brain stimulation (DBS)--of small targets in the brain by use of a pacemaker-like device to deliver constant stimulation. Although these operations can produce striking results, the mechanism by which delivery of electrical stimulation to targets deep in the brain can restore function in the motor system is not clear. This type of surgery probably works by interfering with and shutting down abnormal brain activity in areas where the current is delivered, such as the thalamus, globus pallidus, or the subthalamic nucleus. With this abnormal neuronal activity neutralised, motor areas of the brain can resume their function and normal movements are reinstated. Current research is aimed at elucidating how DBS works and using this information to develop better treatments for patients with PD and other neurological disorders.</div>
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<Abstract><AbstractText>Many people are disabled by Parkinson's disease (PD) despite the drug treatments that are currently available. For these patients, neurosurgery has the potential to help restore their function. The most effective neurosurgical procedures to date use electrical stimulation--deep brain stimulation (DBS)--of small targets in the brain by use of a pacemaker-like device to deliver constant stimulation. Although these operations can produce striking results, the mechanism by which delivery of electrical stimulation to targets deep in the brain can restore function in the motor system is not clear. This type of surgery probably works by interfering with and shutting down abnormal brain activity in areas where the current is delivered, such as the thalamus, globus pallidus, or the subthalamic nucleus. With this abnormal neuronal activity neutralised, motor areas of the brain can resume their function and normal movements are reinstated. Current research is aimed at elucidating how DBS works and using this information to develop better treatments for patients with PD and other neurological disorders.</AbstractText>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Deep brain stimulation for Parkinson's disease: disrupting the disruption.

Deep brain stimulation for Parkinson's disease: disrupting the disruption.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki