Posterior cingulate metabolic changes occur in Parkinson's disease patients without dementia.
Identifieur interne : 001290 ( PubMed/Checkpoint ); précédent : 001289; suivant : 001291Posterior cingulate metabolic changes occur in Parkinson's disease patients without dementia.
Auteurs : R M Camicioli [Canada] ; J R Korzan ; S L Foster ; N J Fisher ; D J Emery ; A C Bastos ; C C HanstockSource :
- Neuroscience letters [ 0304-3940 ] ; 2004.
English descriptors
- KwdEn :
- Aged, Aspartic Acid (analogs & derivatives), Aspartic Acid (metabolism), Case-Control Studies, Choline (metabolism), Cognition (physiology), Creatine (metabolism), Female, Gyrus Cinguli (metabolism), Gyrus Cinguli (pathology), Humans, Magnetic Resonance Imaging (methods), Magnetic Resonance Spectroscopy (methods), Male, Mental Status Schedule, Middle Aged, Parkinson Disease (metabolism), Parkinson Disease (pathology).
- MESH :
- chemical , analogs & derivatives : Aspartic Acid.
- chemical , metabolism : Aspartic Acid, Choline, Creatine.
- metabolism : Gyrus Cinguli, Parkinson Disease.
- methods : Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy.
- pathology : Gyrus Cinguli, Parkinson Disease.
- physiology : Cognition.
- Aged, Case-Control Studies, Female, Humans, Male, Mental Status Schedule, Middle Aged.
Abstract
The basis for cognitive deficits in Parkinson's disease (PD) is unknown. Hippocampal atrophy has been shown in Alzheimer's disease (AD) and PD. N-Acetyl aspartate (NAA)/creatine (Cr) ratio in the posterior cingulate gyrus (PCG) is decreased in AD, but unknown in PD. Volumetric magnetic resonance (MR) imaging (at 1.5 T) determined corrected HC volume and MR spectroscopy (MRS) PCG metabolites in 12 non-demented mild to moderately affected PD patients (six male, six female) and ten controls (five male, five female). Age (PD=60.6 years, control=62.2; P=0.62), education (PD=14.1 years, controls=13.8; P=0.89) and global cognition (Mini-Mental State Exam score: PD=28.7, controls=29.6; P=0.14) did not differ. Only recall (CVLT-II, P=0.046) and NAA/Cr (PD=1.53, controls=1.78; P=0.03) were decreased in PD. Memory correlated with NAA/Cr (r=0.65, P=0.02) in PD. In conclusion, cingulate metabolic changes occur in PD.
PubMed: 14700725
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L" uniqKey="Foster S" first="S L" last="Foster">S L Foster</name></author><author><name sortKey="Fisher, N J" sort="Fisher, N J" uniqKey="Fisher N" first="N J" last="Fisher">N J Fisher</name></author><author><name sortKey="Emery, D J" sort="Emery, D J" uniqKey="Emery D" first="D J" last="Emery">D J Emery</name></author><author><name sortKey="Bastos, A C" sort="Bastos, A C" uniqKey="Bastos A" first="A C" last="Bastos">A C Bastos</name></author><author><name sortKey="Hanstock, C C" sort="Hanstock, C C" uniqKey="Hanstock C" first="C C" last="Hanstock">C C Hanstock</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:14700725</idno><idno type="pmid">14700725</idno><idno type="wicri:Area/PubMed/Corpus">001374</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001374</idno><idno type="wicri:Area/PubMed/Curation">001374</idno><idno type="wicri:explorRef" 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AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Korzan, J R" sort="Korzan, J R" uniqKey="Korzan J" first="J R" last="Korzan">J R Korzan</name></author><author><name sortKey="Foster, S L" sort="Foster, S L" uniqKey="Foster S" first="S L" last="Foster">S L Foster</name></author><author><name sortKey="Fisher, N J" sort="Fisher, N J" uniqKey="Fisher N" first="N J" last="Fisher">N J Fisher</name></author><author><name sortKey="Emery, D J" sort="Emery, D J" uniqKey="Emery D" first="D J" last="Emery">D J Emery</name></author><author><name sortKey="Bastos, A C" sort="Bastos, A C" uniqKey="Bastos A" first="A C" last="Bastos">A C Bastos</name></author><author><name sortKey="Hanstock, C C" sort="Hanstock, C C" uniqKey="Hanstock C" first="C C" last="Hanstock">C C Hanstock</name></author></analytic><series><title level="j">Neuroscience letters</title><idno type="ISSN">0304-3940</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aspartic Acid (analogs & derivatives)</term><term>Aspartic Acid (metabolism)</term><term>Case-Control Studies</term><term>Choline (metabolism)</term><term>Cognition (physiology)</term><term>Creatine (metabolism)</term><term>Female</term><term>Gyrus Cinguli (metabolism)</term><term>Gyrus Cinguli (pathology)</term><term>Humans</term><term>Magnetic Resonance Imaging (methods)</term><term>Magnetic Resonance Spectroscopy (methods)</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Aspartic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Aspartic Acid</term><term>Choline</term><term>Creatine</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Gyrus Cinguli</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term><term>Magnetic Resonance Spectroscopy</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Gyrus Cinguli</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cognition</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The basis for cognitive deficits in Parkinson's disease (PD) is unknown. Hippocampal atrophy has been shown in Alzheimer's disease (AD) and PD. N-Acetyl aspartate (NAA)/creatine (Cr) ratio in the posterior cingulate gyrus (PCG) is decreased in AD, but unknown in PD. Volumetric magnetic resonance (MR) imaging (at 1.5 T) determined corrected HC volume and MR spectroscopy (MRS) PCG metabolites in 12 non-demented mild to moderately affected PD patients (six male, six female) and ten controls (five male, five female). Age (PD=60.6 years, control=62.2; P=0.62), education (PD=14.1 years, controls=13.8; P=0.89) and global cognition (Mini-Mental State Exam score: PD=28.7, controls=29.6; P=0.14) did not differ. Only recall (CVLT-II, P=0.046) and NAA/Cr (PD=1.53, controls=1.78; P=0.03) were decreased in PD. Memory correlated with NAA/Cr (r=0.65, P=0.02) in PD. In conclusion, cingulate metabolic changes occur in PD.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">14700725</PMID><DateCreated><Year>2003</Year><Month>12</Month><Day>31</Day></DateCreated><DateCompleted><Year>2004</Year><Month>03</Month><Day>08</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0304-3940</ISSN><JournalIssue CitedMedium="Print"><Volume>354</Volume><Issue>3</Issue><PubDate><Year>2004</Year><Month>Jan</Month><Day>16</Day></PubDate></JournalIssue><Title>Neuroscience letters</Title><ISOAbbreviation>Neurosci. Lett.</ISOAbbreviation></Journal><ArticleTitle>Posterior cingulate metabolic changes occur in Parkinson's disease patients without dementia.</ArticleTitle><Pagination><MedlinePgn>177-80</MedlinePgn></Pagination><Abstract><AbstractText>The basis for cognitive deficits in Parkinson's disease (PD) is unknown. Hippocampal atrophy has been shown in Alzheimer's disease (AD) and PD. N-Acetyl aspartate (NAA)/creatine (Cr) ratio in the posterior cingulate gyrus (PCG) is decreased in AD, but unknown in PD. Volumetric magnetic resonance (MR) imaging (at 1.5 T) determined corrected HC volume and MR spectroscopy (MRS) PCG metabolites in 12 non-demented mild to moderately affected PD patients (six male, six female) and ten controls (five male, five female). Age (PD=60.6 years, control=62.2; P=0.62), education (PD=14.1 years, controls=13.8; P=0.89) and global cognition (Mini-Mental State Exam score: PD=28.7, controls=29.6; P=0.14) did not differ. Only recall (CVLT-II, P=0.046) and NAA/Cr (PD=1.53, controls=1.78; P=0.03) were decreased in PD. Memory correlated with NAA/Cr (r=0.65, P=0.02) in PD. In conclusion, cingulate metabolic changes occur in PD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Camicioli</LastName><ForeName>R M</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>Department of Medicine (Neurology Division), Room E-223, Glenrose Rehabilitation Hospital, 10230-111th Avenue, University of Alberta, Edmonton, AB, Canada T5G 0B7. richard.camicioli@ualberta.ca</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Korzan</LastName><ForeName>J R</ForeName><Initials>JR</Initials></Author><Author ValidYN="Y"><LastName>Foster</LastName><ForeName>S L</ForeName><Initials>SL</Initials></Author><Author ValidYN="Y"><LastName>Fisher</LastName><ForeName>N J</ForeName><Initials>NJ</Initials></Author><Author ValidYN="Y"><LastName>Emery</LastName><ForeName>D J</ForeName><Initials>DJ</Initials></Author><Author ValidYN="Y"><LastName>Bastos</LastName><ForeName>A C</ForeName><Initials>AC</Initials></Author><Author ValidYN="Y"><LastName>Hanstock</LastName><ForeName>C C</ForeName><Initials>CC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>Neurosci Lett</MedlineTA><NlmUniqueID>7600130</NlmUniqueID><ISSNLinking>0304-3940</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>30KYC7MIAI</RegistryNumber><NameOfSubstance UI="D001224">Aspartic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>997-55-7</RegistryNumber><NameOfSubstance UI="C000179">N-acetylaspartate</NameOfSubstance></Chemical><Chemical><RegistryNumber>MU72812GK0</RegistryNumber><NameOfSubstance UI="D003401">Creatine</NameOfSubstance></Chemical><Chemical><RegistryNumber>N91BDP6H0X</RegistryNumber><NameOfSubstance UI="D002794">Choline</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001224" MajorTopicYN="N">Aspartic Acid</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002794" MajorTopicYN="N">Choline</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003071" MajorTopicYN="N">Cognition</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003401" MajorTopicYN="N">Creatine</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006179" MajorTopicYN="N">Gyrus Cinguli</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009682" MajorTopicYN="N">Magnetic Resonance Spectroscopy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008609" MajorTopicYN="N">Mental Status Schedule</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>1</Month><Day>1</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>3</Month><Day>9</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>1</Month><Day>1</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">14700725</ArticleId><ArticleId IdType="pii">S030439400301187X</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Bastos, A C" sort="Bastos, A C" uniqKey="Bastos A" first="A C" last="Bastos">A C Bastos</name><name sortKey="Emery, D J" sort="Emery, D J" uniqKey="Emery D" first="D J" last="Emery">D J Emery</name><name sortKey="Fisher, N J" sort="Fisher, N J" uniqKey="Fisher N" first="N J" last="Fisher">N J Fisher</name><name sortKey="Foster, S L" sort="Foster, S L" uniqKey="Foster S" first="S L" last="Foster">S L Foster</name><name sortKey="Hanstock, C C" sort="Hanstock, C C" uniqKey="Hanstock C" first="C C" last="Hanstock">C C Hanstock</name><name sortKey="Korzan, J R" sort="Korzan, J R" uniqKey="Korzan J" first="J R" last="Korzan">J R Korzan</name></noCountry><country name="Canada"><noRegion><name sortKey="Camicioli, R M" sort="Camicioli, R M" uniqKey="Camicioli R" first="R M" last="Camicioli">R M Camicioli</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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