Astrocytes and neurons: different roles in regulating adenosine levels.
Identifieur interne : 001249 ( PubMed/Checkpoint ); précédent : 001248; suivant : 001250Astrocytes and neurons: different roles in regulating adenosine levels.
Auteurs : Fiona E. Parkinson [Canada] ; Wei Xiong ; Christina R. ZamzowSource :
- Neurological research [ 0161-6412 ] ; 2005.
English descriptors
- KwdEn :
- Adenosine (metabolism), Affinity Labels (pharmacology), Animals, Astrocytes (metabolism), Brain Ischemia (metabolism), Cells, Cultured, Deoxyglucose (pharmacology), Dipyridamole (pharmacology), Disease Models, Animal, Dose-Response Relationship, Drug, Drug Interactions, Glucose (deficiency), Hypoxia (metabolism), Inosine (pharmacology), Models, Biological, Neurons (metabolism), Oligomycins (pharmacology), Phosphodiesterase Inhibitors (pharmacology), Prosencephalon (cytology), Purines (metabolism), Rats, Thioinosine (analogs & derivatives), Thioinosine (pharmacology), Tritium (metabolism).
- MESH :
- chemical , analogs & derivatives : Thioinosine.
- chemical , deficiency : Glucose.
- chemical , metabolism : Adenosine, Purines, Tritium.
- chemical , pharmacology : Affinity Labels, Deoxyglucose, Dipyridamole, Inosine, Oligomycins, Phosphodiesterase Inhibitors, Thioinosine.
- cytology : Prosencephalon.
- metabolism : Astrocytes, Brain Ischemia, Hypoxia, Neurons.
- Animals, Cells, Cultured, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Interactions, Models, Biological, Rats.
Abstract
Adenosine is an endogenous nucleoside that signals through G-protein coupled receptors. Extracellular adenosine is required for receptor activation and two pathways have been identified for formation and cellular release of adenosine. The CLASSICAL pathway relies on intracellular formation of adenosine from adenine nucleotides and cellular efflux of adenosine via equilibrative nucleoside transporters (ENTs). The ALTERNATE pathway involves cellular release of adenine nucleotides, hydrolysis via ecto-5'-nucleotidases and extracellular formation of adenosine.
DOI: 10.1179/016164105X21878
PubMed: 15829178
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Astrocytes and neurons: different roles in regulating adenosine levels.</title><author><name sortKey="Parkinson, Fiona E" sort="Parkinson, Fiona E" uniqKey="Parkinson F" first="Fiona E" last="Parkinson">Fiona E. Parkinson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Therapeutics, University of Manitoba, A203-753 McDermot Avenue, Winnipeg MB Canada R3E 0T6. parkins@ms.umanitoba.ca</nlm:affiliation><country wicri:rule="url">Canada</country></affiliation></author><author><name sortKey="Xiong, Wei" sort="Xiong, Wei" uniqKey="Xiong W" first="Wei" last="Xiong">Wei Xiong</name></author><author><name sortKey="Zamzow, Christina R" sort="Zamzow, Christina R" uniqKey="Zamzow C" first="Christina R" last="Zamzow">Christina R. Zamzow</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:15829178</idno><idno type="pmid">15829178</idno><idno type="doi">10.1179/016164105X21878</idno><idno type="wicri:Area/PubMed/Corpus">001282</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001282</idno><idno type="wicri:Area/PubMed/Curation">001282</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001282</idno><idno type="wicri:Area/PubMed/Checkpoint">001282</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001282</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Astrocytes and neurons: different roles in regulating adenosine levels.</title><author><name sortKey="Parkinson, Fiona E" sort="Parkinson, Fiona E" uniqKey="Parkinson F" first="Fiona E" last="Parkinson">Fiona E. Parkinson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Therapeutics, University of Manitoba, A203-753 McDermot Avenue, Winnipeg MB Canada R3E 0T6. parkins@ms.umanitoba.ca</nlm:affiliation><country wicri:rule="url">Canada</country></affiliation></author><author><name sortKey="Xiong, Wei" sort="Xiong, Wei" uniqKey="Xiong W" first="Wei" last="Xiong">Wei Xiong</name></author><author><name sortKey="Zamzow, Christina R" sort="Zamzow, Christina R" uniqKey="Zamzow C" first="Christina R" last="Zamzow">Christina R. Zamzow</name></author></analytic><series><title level="j">Neurological research</title><idno type="ISSN">0161-6412</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine (metabolism)</term><term>Affinity Labels (pharmacology)</term><term>Animals</term><term>Astrocytes (metabolism)</term><term>Brain Ischemia (metabolism)</term><term>Cells, Cultured</term><term>Deoxyglucose (pharmacology)</term><term>Dipyridamole (pharmacology)</term><term>Disease Models, Animal</term><term>Dose-Response Relationship, Drug</term><term>Drug Interactions</term><term>Glucose (deficiency)</term><term>Hypoxia (metabolism)</term><term>Inosine (pharmacology)</term><term>Models, Biological</term><term>Neurons (metabolism)</term><term>Oligomycins (pharmacology)</term><term>Phosphodiesterase Inhibitors (pharmacology)</term><term>Prosencephalon (cytology)</term><term>Purines (metabolism)</term><term>Rats</term><term>Thioinosine (analogs & derivatives)</term><term>Thioinosine (pharmacology)</term><term>Tritium (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Thioinosine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Glucose</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adenosine</term><term>Purines</term><term>Tritium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Affinity Labels</term><term>Deoxyglucose</term><term>Dipyridamole</term><term>Inosine</term><term>Oligomycins</term><term>Phosphodiesterase Inhibitors</term><term>Thioinosine</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Prosencephalon</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Astrocytes</term><term>Brain Ischemia</term><term>Hypoxia</term><term>Neurons</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Disease Models, Animal</term><term>Dose-Response Relationship, Drug</term><term>Drug Interactions</term><term>Models, Biological</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Adenosine is an endogenous nucleoside that signals through G-protein coupled receptors. Extracellular adenosine is required for receptor activation and two pathways have been identified for formation and cellular release of adenosine. The CLASSICAL pathway relies on intracellular formation of adenosine from adenine nucleotides and cellular efflux of adenosine via equilibrative nucleoside transporters (ENTs). The ALTERNATE pathway involves cellular release of adenine nucleotides, hydrolysis via ecto-5'-nucleotidases and extracellular formation of adenosine.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15829178</PMID><DateCreated><Year>2005</Year><Month>04</Month><Day>14</Day></DateCreated><DateCompleted><Year>2005</Year><Month>05</Month><Day>27</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0161-6412</ISSN><JournalIssue CitedMedium="Print"><Volume>27</Volume><Issue>2</Issue><PubDate><Year>2005</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Neurological research</Title><ISOAbbreviation>Neurol. Res.</ISOAbbreviation></Journal><ArticleTitle>Astrocytes and neurons: different roles in regulating adenosine levels.</ArticleTitle><Pagination><MedlinePgn>153-60</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Adenosine is an endogenous nucleoside that signals through G-protein coupled receptors. Extracellular adenosine is required for receptor activation and two pathways have been identified for formation and cellular release of adenosine. The CLASSICAL pathway relies on intracellular formation of adenosine from adenine nucleotides and cellular efflux of adenosine via equilibrative nucleoside transporters (ENTs). The ALTERNATE pathway involves cellular release of adenine nucleotides, hydrolysis via ecto-5'-nucleotidases and extracellular formation of adenosine.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A rat model of cerebral ischemia and primary cultures of rat forebrain astrocytes and neurons were used.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Using a rat model of cerebral ischemia, the ENT1 inhibitor nitrobenzylmercaptopurine ribonucleoside (NBMPR) significantly increased post-ischemic forebrain adenosine levels and significantly decreased hippocampal neuron injury relative to saline-treatment. NBMPR-induced increases in adenosine receptor activation were not detected, suggesting that altering the intracellular:extracellular distribution of adenosine can affect ischemic outcome. Using primary cultures of rat forebrain astrocytes and neurons, adenosine release was evoked by ischemic-like conditions. Dipyridamole, an inhibitor of ENTs, was more effective at inhibiting adenosine release from neurons than from astrocytes. In contrast, alpha , beta-methylene ADP, an inhibitor of ecto-5'-nucleotidase, was effective at inhibiting adenosine release from astrocytes, but not from neurons. Thus, during ischemic-like conditions, neurons released adenosine via the CLASSICAL pathway, while astrocytes released adenosine via the ALTERNATE pathway.</AbstractText><AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">These cell type differences in pathways for adenosine formation during ischemia may allow transport inhibitors to block simultaneously adenosine release from neurons and adenosine uptake into astrocytes. In principle, this could improve neuronal ATP levels without decreasing adenosine receptor activation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Parkinson</LastName><ForeName>Fiona E</ForeName><Initials>FE</Initials><AffiliationInfo><Affiliation>Department of Pharmacology and Therapeutics, University of Manitoba, A203-753 McDermot Avenue, Winnipeg MB Canada R3E 0T6. parkins@ms.umanitoba.ca</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiong</LastName><ForeName>Wei</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Zamzow</LastName><ForeName>Christina R</ForeName><Initials>CR</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Neurol Res</MedlineTA><NlmUniqueID>7905298</NlmUniqueID><ISSNLinking>0161-6412</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000345">Affinity Labels</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009840">Oligomycins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010726">Phosphodiesterase Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011687">Purines</NameOfSubstance></Chemical><Chemical><RegistryNumber>10028-17-8</RegistryNumber><NameOfSubstance UI="D014316">Tritium</NameOfSubstance></Chemical><Chemical><RegistryNumber>38048-32-7</RegistryNumber><NameOfSubstance UI="C001789">4-nitrobenzylthioinosine</NameOfSubstance></Chemical><Chemical><RegistryNumber>46S541971T</RegistryNumber><NameOfSubstance UI="D013868">Thioinosine</NameOfSubstance></Chemical><Chemical><RegistryNumber>5A614L51CT</RegistryNumber><NameOfSubstance UI="D007288">Inosine</NameOfSubstance></Chemical><Chemical><RegistryNumber>64ALC7F90C</RegistryNumber><NameOfSubstance UI="D004176">Dipyridamole</NameOfSubstance></Chemical><Chemical><RegistryNumber>9G2MP84A8W</RegistryNumber><NameOfSubstance UI="D003847">Deoxyglucose</NameOfSubstance></Chemical><Chemical><RegistryNumber>IY9XDZ35W2</RegistryNumber><NameOfSubstance UI="D005947">Glucose</NameOfSubstance></Chemical><Chemical><RegistryNumber>K72T3FS567</RegistryNumber><NameOfSubstance UI="D000241">Adenosine</NameOfSubstance></Chemical><Chemical><RegistryNumber>W60KTZ3IZY</RegistryNumber><NameOfSubstance UI="C030985">purine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000241" MajorTopicYN="N">Adenosine</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000345" MajorTopicYN="N">Affinity Labels</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001253" MajorTopicYN="N">Astrocytes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002545" MajorTopicYN="N">Brain Ischemia</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003847" MajorTopicYN="N">Deoxyglucose</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004176" MajorTopicYN="N">Dipyridamole</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004347" MajorTopicYN="N">Drug Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005947" MajorTopicYN="N">Glucose</DescriptorName><QualifierName UI="Q000172" MajorTopicYN="N">deficiency</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000860" MajorTopicYN="N">Hypoxia</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007288" MajorTopicYN="N">Inosine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009474" MajorTopicYN="N">Neurons</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009840" MajorTopicYN="N">Oligomycins</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010726" MajorTopicYN="N">Phosphodiesterase Inhibitors</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016548" MajorTopicYN="N">Prosencephalon</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011687" MajorTopicYN="N">Purines</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013868" MajorTopicYN="N">Thioinosine</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014316" MajorTopicYN="N">Tritium</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>4</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>5</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>4</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15829178</ArticleId><ArticleId IdType="doi">10.1179/016164105X21878</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Xiong, Wei" sort="Xiong, Wei" uniqKey="Xiong W" first="Wei" last="Xiong">Wei Xiong</name><name sortKey="Zamzow, Christina R" sort="Zamzow, Christina R" uniqKey="Zamzow C" first="Christina R" last="Zamzow">Christina R. Zamzow</name></noCountry><country name="Canada"><noRegion><name sortKey="Parkinson, Fiona E" sort="Parkinson, Fiona E" uniqKey="Parkinson F" first="Fiona E" last="Parkinson">Fiona E. Parkinson</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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