ParkinsonCanadaV1, PubMed, Checkpoint, bibRecord, 001215

Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC.

Identifieur interne : 001215 ( PubMed/Checkpoint ); précédent : 001214; suivant : 001216

Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC.

Auteurs : Thomas J. Montine [États-Unis] ; Ke Li ; Daniel P. Perl ; Douglas Galasko

Source :

Neurology [ 1526-632X ] ; 2005.

RBID : pubmed:16157919

Descripteurs français

Wicri :
- geographic : Canada.

English descriptors

KwdEn :
- Aged, Alzheimer Disease (chemically induced), Alzheimer Disease (metabolism), Alzheimer Disease (physiopathology), Amino Acids, Diamino (analysis), Amino Acids, Diamino (metabolism), Amyotrophic Lateral Sclerosis (chemically induced), Amyotrophic Lateral Sclerosis (metabolism), Amyotrophic Lateral Sclerosis (physiopathology), Brain (metabolism), Brain (pathology), Brain (physiopathology), Brain Chemistry (physiology), Canada, Environmental Exposure, Female, Guam, Humans, Male, Middle Aged, Parkinsonian Disorders (chemically induced), Parkinsonian Disorders (metabolism), Parkinsonian Disorders (physiopathology), Reproducibility of Results.
MESH :
- chemical , analysis : Amino Acids, Diamino.
- geographic : Canada, Guam.
- chemically induced : Alzheimer Disease, Amyotrophic Lateral Sclerosis, Parkinsonian Disorders.
- metabolism : Alzheimer Disease, Amino Acids, Diamino, Amyotrophic Lateral Sclerosis, Brain, Parkinsonian Disorders.
- pathology : Brain.
- physiology : Brain Chemistry.
- physiopathology : Alzheimer Disease, Amyotrophic Lateral Sclerosis, Brain, Parkinsonian Disorders.
- Aged, Environmental Exposure, Female, Humans, Male, Middle Aged, Reproducibility of Results.

Abstract

High levels of beta-methylamino-l-alanine (BMAA), a putative neurotoxin, have been reported in brain samples from Chamorros and patients with Alzheimer disease (AD) from western Canada. The authors assayed free BMAA in the brains of five control subjects and five patients with AD from the US Pacific Northwest as well as Chamorros with and without Parkinson-dementia complex. In contrast to others, they detected no free BMAA in any of these samples.

DOI: 10.1212/01.wnl.0000174523.62022.52
PubMed: 16157919

Affiliations:

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pubmed:16157919

Le document en format XML

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<author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J" last="Montine">Thomas J. Montine</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98104, USA. tmontine@u.washington.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98104</wicri:regionArea>
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<settlement type="city">Seattle</settlement>
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<orgName type="university">Université de Washington</orgName>
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<author><name sortKey="Li, Ke" sort="Li, Ke" uniqKey="Li K" first="Ke" last="Li">Ke Li</name>
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<author><name sortKey="Perl, Daniel P" sort="Perl, Daniel P" uniqKey="Perl D" first="Daniel P" last="Perl">Daniel P. Perl</name>
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<term>Amino Acids, Diamino (analysis)</term>
<term>Amino Acids, Diamino (metabolism)</term>
<term>Amyotrophic Lateral Sclerosis (chemically induced)</term>
<term>Amyotrophic Lateral Sclerosis (metabolism)</term>
<term>Amyotrophic Lateral Sclerosis (physiopathology)</term>
<term>Brain (metabolism)</term>
<term>Brain (pathology)</term>
<term>Brain (physiopathology)</term>
<term>Brain Chemistry (physiology)</term>
<term>Canada</term>
<term>Environmental Exposure</term>
<term>Female</term>
<term>Guam</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinsonian Disorders (chemically induced)</term>
<term>Parkinsonian Disorders (metabolism)</term>
<term>Parkinsonian Disorders (physiopathology)</term>
<term>Reproducibility of Results</term>
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<term>Guam</term>
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<term>Parkinsonian Disorders</term>
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<term>Amino Acids, Diamino</term>
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<term>Parkinsonian Disorders</term>
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<term>Parkinsonian Disorders</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">High levels of beta-methylamino-l-alanine (BMAA), a putative neurotoxin, have been reported in brain samples from Chamorros and patients with Alzheimer disease (AD) from western Canada. The authors assayed free BMAA in the brains of five control subjects and five patients with AD from the US Pacific Northwest as well as Chamorros with and without Parkinson-dementia complex. In contrast to others, they detected no free BMAA in any of these samples.</div>
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<Abstract><AbstractText>High levels of beta-methylamino-l-alanine (BMAA), a putative neurotoxin, have been reported in brain samples from Chamorros and patients with Alzheimer disease (AD) from western Canada. The authors assayed free BMAA in the brains of five control subjects and five patients with AD from the US Pacific Northwest as well as Chamorros with and without Parkinson-dementia complex. In contrast to others, they detected no free BMAA in any of these samples.</AbstractText>
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<name sortKey="Perl, Daniel P" sort="Perl, Daniel P" uniqKey="Perl D" first="Daniel P" last="Perl">Daniel P. Perl</name>
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<country name="États-Unis"><region name="Washington (État)"><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J" last="Montine">Thomas J. Montine</name>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC.

Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki