Genetic factors involved in the pathogenesis of Parkinson's disease.
Identifieur interne : 000F57 ( PubMed/Checkpoint ); précédent : 000F56; suivant : 000F58Genetic factors involved in the pathogenesis of Parkinson's disease.
Auteurs : Frank J S. Lee [Canada] ; Fang LiuSource :
- Brain research reviews [ 0165-0173 ] ; 2008.
English descriptors
- KwdEn :
- Animals, Dopamine (metabolism), Humans, Intracellular Signaling Peptides and Proteins (genetics), Membrane Proteins (genetics), Neoplasm Proteins (genetics), Oncogene Proteins (genetics), Parkinson Disease (genetics), Parkinson Disease (pathology), Protein Deglycase DJ-1, Protein Kinases (genetics), Ubiquitin Thiolesterase (genetics), Ubiquitin-Protein Ligases (genetics), alpha-Synuclein (genetics).
- MESH :
- chemical , genetics : Intracellular Signaling Peptides and Proteins, Membrane Proteins, Neoplasm Proteins, Oncogene Proteins, Protein Kinases, Ubiquitin Thiolesterase, Ubiquitin-Protein Ligases, alpha-Synuclein.
- chemical , metabolism : Dopamine.
- genetics : Parkinson Disease.
- pathology : Parkinson Disease.
- Animals, Humans, Protein Deglycase DJ-1.
Abstract
Parkinson's disease (PD) is a neurodegenerative disease characterized by a loss of nigrostriatal dopaminergic neurons. Recently, PD research has been stimulated by the identification of genes that are implicated in rare familial forms of PD. However, despite these discoveries, the primary cause of PD is still unclear. Various pathogenic mechanisms may be involved including mitochondrial dysfunction, proteasomal dysfunction/protein aggregation, oxidative damage, environmental factors and genetic disposition. Furthermore, dopamine has also been implicated in contributing to the pathogenesis of PD. This review will focus on the genes that have been identified to be associated with PD and how they may impair dopamine metabolism. Understanding the role of these PD-related genes in dopamine neurobiology may provide insight into the underpinning pathogenic mechanisms of PD.
DOI: 10.1016/j.brainresrev.2008.02.001
PubMed: 18313759
Affiliations:
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Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuroscience, Centre for Addiction and Mental Health, Clarke Division, Toronto, Ontario, Canada M5T 1R8.</nlm:affiliation><country>Canada</country><wicri:regionArea>Department of Neuroscience, Centre for Addiction and Mental Health, Clarke Division, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Fang" sort="Liu, Fang" uniqKey="Liu F" first="Fang" last="Liu">Fang Liu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18313759</idno><idno type="pmid">18313759</idno><idno type="doi">10.1016/j.brainresrev.2008.02.001</idno><idno type="wicri:Area/PubMed/Corpus">000F59</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F59</idno><idno type="wicri:Area/PubMed/Curation">000F59</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F59</idno><idno type="wicri:Area/PubMed/Checkpoint">000F59</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F59</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic factors involved in the pathogenesis of Parkinson's disease.</title><author><name sortKey="Lee, Frank J S" sort="Lee, Frank J S" uniqKey="Lee F" first="Frank J S" last="Lee">Frank J S. Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neuroscience, Centre for Addiction and Mental Health, Clarke Division, Toronto, Ontario, Canada M5T 1R8.</nlm:affiliation><country>Canada</country><wicri:regionArea>Department of Neuroscience, Centre for Addiction and Mental Health, Clarke Division, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Fang" sort="Liu, Fang" uniqKey="Liu F" first="Fang" last="Liu">Fang Liu</name></author></analytic><series><title level="j">Brain research reviews</title><idno type="ISSN">0165-0173</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Dopamine (metabolism)</term><term>Humans</term><term>Intracellular Signaling Peptides and Proteins (genetics)</term><term>Membrane Proteins (genetics)</term><term>Neoplasm Proteins (genetics)</term><term>Oncogene Proteins (genetics)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (pathology)</term><term>Protein Deglycase DJ-1</term><term>Protein Kinases (genetics)</term><term>Ubiquitin Thiolesterase (genetics)</term><term>Ubiquitin-Protein Ligases (genetics)</term><term>alpha-Synuclein (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Intracellular Signaling Peptides and Proteins</term><term>Membrane Proteins</term><term>Neoplasm Proteins</term><term>Oncogene Proteins</term><term>Protein Kinases</term><term>Ubiquitin Thiolesterase</term><term>Ubiquitin-Protein Ligases</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Protein Deglycase DJ-1</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a neurodegenerative disease characterized by a loss of nigrostriatal dopaminergic neurons. Recently, PD research has been stimulated by the identification of genes that are implicated in rare familial forms of PD. However, despite these discoveries, the primary cause of PD is still unclear. Various pathogenic mechanisms may be involved including mitochondrial dysfunction, proteasomal dysfunction/protein aggregation, oxidative damage, environmental factors and genetic disposition. Furthermore, dopamine has also been implicated in contributing to the pathogenesis of PD. This review will focus on the genes that have been identified to be associated with PD and how they may impair dopamine metabolism. Understanding the role of these PD-related genes in dopamine neurobiology may provide insight into the underpinning pathogenic mechanisms of PD.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18313759</PMID><DateCreated><Year>2008</Year><Month>08</Month><Day>25</Day></DateCreated><DateCompleted><Year>2008</Year><Month>12</Month><Day>18</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0165-0173</ISSN><JournalIssue CitedMedium="Print"><Volume>58</Volume><Issue>2</Issue><PubDate><Year>2008</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Brain research reviews</Title><ISOAbbreviation>Brain Res Rev</ISOAbbreviation></Journal><ArticleTitle>Genetic factors involved in the pathogenesis of Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>354-64</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.brainresrev.2008.02.001</ELocationID><Abstract><AbstractText>Parkinson's disease (PD) is a neurodegenerative disease characterized by a loss of nigrostriatal dopaminergic neurons. Recently, PD research has been stimulated by the identification of genes that are implicated in rare familial forms of PD. However, despite these discoveries, the primary cause of PD is still unclear. Various pathogenic mechanisms may be involved including mitochondrial dysfunction, proteasomal dysfunction/protein aggregation, oxidative damage, environmental factors and genetic disposition. Furthermore, dopamine has also been implicated in contributing to the pathogenesis of PD. This review will focus on the genes that have been identified to be associated with PD and how they may impair dopamine metabolism. Understanding the role of these PD-related genes in dopamine neurobiology may provide insight into the underpinning pathogenic mechanisms of PD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Frank J S</ForeName><Initials>FJ</Initials><AffiliationInfo><Affiliation>Department of Neuroscience, Centre for Addiction and Mental Health, Clarke Division, Toronto, Ontario, Canada M5T 1R8.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Fang</ForeName><Initials>F</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2008</Year><Month>02</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Brain Res 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MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044767" MajorTopicYN="N">Ubiquitin-Protein Ligases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051844" MajorTopicYN="N">alpha-Synuclein</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList><NumberOfReferences>128</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2007</Year><Month>06</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2008</Year><Month>01</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2008</Year><Month>02</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>3</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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