Dysfunction of the default mode network in Parkinson disease: a functional magnetic resonance imaging study.
Identifieur interne : 000E64 ( PubMed/Checkpoint ); précédent : 000E63; suivant : 000E65Dysfunction of the default mode network in Parkinson disease: a functional magnetic resonance imaging study.
Auteurs : Thilo Van Eimeren [Canada] ; Oury Monchi ; Benedicte Ballanger ; Antonio P. StrafellaSource :
- Archives of neurology [ 1538-3687 ] ; 2009.
English descriptors
- KwdEn :
- Aged, Brain Mapping, Cerebral Cortex (blood supply), Cerebral Cortex (physiopathology), Female, Humans, Image Processing, Computer-Assisted (methods), Magnetic Resonance Imaging (methods), Male, Middle Aged, Nerve Net (blood supply), Nerve Net (pathology), Neural Pathways (blood supply), Neural Pathways (pathology), Neural Pathways (physiopathology), Neuropsychological Tests, Oxygen (blood), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Problem Solving (physiology), Statistics as Topic.
- MESH :
- chemical , blood : Oxygen.
- blood supply : Cerebral Cortex, Nerve Net, Neural Pathways.
- methods : Image Processing, Computer-Assisted, Magnetic Resonance Imaging.
- pathology : Nerve Net, Neural Pathways, Parkinson Disease.
- physiology : Problem Solving.
- physiopathology : Cerebral Cortex, Neural Pathways, Parkinson Disease.
- Aged, Brain Mapping, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Statistics as Topic.
Abstract
To examine the integrity of the default mode network in patients with Parkinson disease (PD). Previous functional neuroimaging experiments have studied executive deficits in patients with PD with regard to task-related brain activation. However, recent studies suggest that executive performance also relies on the integrity of the default mode network (ie, medial prefrontal cortex, posterior cingulate cortex, precuneus, and lateral parietal and medial temporal cortices), characterized by a deactivation of these cortical areas during the performance of executive tasks.
DOI: 10.1001/archneurol.2009.97
PubMed: 19597090
Affiliations:
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Strafella</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19597090</idno><idno type="pmid">19597090</idno><idno type="doi">10.1001/archneurol.2009.97</idno><idno type="wicri:Area/PubMed/Corpus">000E60</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E60</idno><idno type="wicri:Area/PubMed/Curation">000E60</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E60</idno><idno type="wicri:Area/PubMed/Checkpoint">000E60</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E60</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Dysfunction of the default mode network in Parkinson disease: a functional magnetic resonance imaging study.</title><author><name sortKey="Van Eimeren, Thilo" sort="Van Eimeren, Thilo" uniqKey="Van Eimeren T" first="Thilo" last="Van Eimeren">Thilo Van Eimeren</name><affiliation wicri:level="1"><nlm:affiliation>Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute, and Movement Disorders Centre, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario M5T 1R8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute, and Movement Disorders Centre, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario M5T 1R8</wicri:regionArea><wicri:noRegion>Ontario M5T 1R8</wicri:noRegion></affiliation></author><author><name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name></author><author><name sortKey="Ballanger, Benedicte" sort="Ballanger, Benedicte" uniqKey="Ballanger B" first="Benedicte" last="Ballanger">Benedicte Ballanger</name></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P" last="Strafella">Antonio P. Strafella</name></author></analytic><series><title level="j">Archives of neurology</title><idno type="eISSN">1538-3687</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Cerebral Cortex (blood supply)</term><term>Cerebral Cortex (physiopathology)</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted (methods)</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Nerve Net (blood supply)</term><term>Nerve Net (pathology)</term><term>Neural Pathways (blood supply)</term><term>Neural Pathways (pathology)</term><term>Neural Pathways (physiopathology)</term><term>Neuropsychological Tests</term><term>Oxygen (blood)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Problem Solving (physiology)</term><term>Statistics as Topic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Oxygen</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Cerebral Cortex</term><term>Nerve Net</term><term>Neural Pathways</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Nerve Net</term><term>Neural Pathways</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Problem Solving</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebral Cortex</term><term>Neural Pathways</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Statistics as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To examine the integrity of the default mode network in patients with Parkinson disease (PD). Previous functional neuroimaging experiments have studied executive deficits in patients with PD with regard to task-related brain activation. However, recent studies suggest that executive performance also relies on the integrity of the default mode network (ie, medial prefrontal cortex, posterior cingulate cortex, precuneus, and lateral parietal and medial temporal cortices), characterized by a deactivation of these cortical areas during the performance of executive tasks.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19597090</PMID><DateCreated><Year>2009</Year><Month>07</Month><Day>14</Day></DateCreated><DateCompleted><Year>2009</Year><Month>07</Month><Day>31</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>22</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1538-3687</ISSN><JournalIssue CitedMedium="Internet"><Volume>66</Volume><Issue>7</Issue><PubDate><Year>2009</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Archives of neurology</Title><ISOAbbreviation>Arch. Neurol.</ISOAbbreviation></Journal><ArticleTitle>Dysfunction of the default mode network in Parkinson disease: a functional magnetic resonance imaging study.</ArticleTitle><Pagination><MedlinePgn>877-83</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1001/archneurol.2009.97</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To examine the integrity of the default mode network in patients with Parkinson disease (PD). Previous functional neuroimaging experiments have studied executive deficits in patients with PD with regard to task-related brain activation. However, recent studies suggest that executive performance also relies on the integrity of the default mode network (ie, medial prefrontal cortex, posterior cingulate cortex, precuneus, and lateral parietal and medial temporal cortices), characterized by a deactivation of these cortical areas during the performance of executive tasks.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">We used functional magnetic resonance imaging to investigate cortical deactivations during a card-sorting task (retrieval and manipulation of short-term memory contents) compared with a simple sensory-motor matching task. In addition, a functional connectivity analysis was performed.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">Tertiary outpatient clinic.</AbstractText><AbstractText Label="PARTICIPANTS" NlmCategory="METHODS">Seven patients with mild to moderate PD (not taking medication) and 7 healthy controls.</AbstractText><AbstractText Label="MAIN OUTCOME MEASURE" NlmCategory="METHODS">Cortical deactivations.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Both groups showed comparable deactivation of the medial prefrontal cortex but different deactivation in the posterior cingulate cortex and the precuneus. Compared with controls, patients with PD not only showed less deactivation of the posterior cingulate cortex and the precuneus, they even demonstrated a reversed pattern of activation and deactivation. Connectivity analysis yielded that in contrast to healthy individuals, medial prefrontal cortex and the rostral ventromedial caudate nucleus were functionally disconnected in PD.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">We describe specific malfunctioning of the default mode network during an executive task in PD. This finding is plausibly linked to dopamine depletion and may critically contribute to the understanding of executive deficits in PD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>van Eimeren</LastName><ForeName>Thilo</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute, and Movement Disorders Centre, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario M5T 1R8, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monchi</LastName><ForeName>Oury</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Ballanger</LastName><ForeName>Benedicte</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Strafella</LastName><ForeName>Antonio P</ForeName><Initials>AP</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>64423</GrantID><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Arch Neurol</MedlineTA><NlmUniqueID>0372436</NlmUniqueID><ISSNLinking>0003-9942</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>S88TT14065</RegistryNumber><NameOfSubstance UI="D010100">Oxygen</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Hum Brain Mapp. 2008 Nov;29(11):1265-75</RefSource><PMID Version="1">17894392</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci Methods. 2008 Mar 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IdType="mid">CAMS1533</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Ballanger, Benedicte" sort="Ballanger, Benedicte" uniqKey="Ballanger B" first="Benedicte" last="Ballanger">Benedicte Ballanger</name><name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P" last="Strafella">Antonio P. Strafella</name></noCountry><country name="Canada"><noRegion><name sortKey="Van Eimeren, Thilo" sort="Van Eimeren, Thilo" uniqKey="Van Eimeren T" first="Thilo" last="Van Eimeren">Thilo Van Eimeren</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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