LINGO1 rs9652490 is associated with essential tremor and Parkinson disease.
Identifieur interne : 000C97 ( PubMed/Checkpoint ); précédent : 000C96; suivant : 000C98LINGO1 rs9652490 is associated with essential tremor and Parkinson disease.
Auteurs : Carles Vilari O-Güell [États-Unis] ; Owen A. Ross ; Christian Wider ; Barbara Jasinska-Myga ; Stephanie A. Cobb ; Alexandra I. Soto-Ortolaza ; Jennifer M. Kachergus ; Brett H. Keeling ; Justus C. Dachsel ; Heather L. Melrose ; Bahareh Behrouz ; Zbigniew K. Wszolek ; Ryan J. Uitti ; Jan O. Aasly ; Alex Rajput ; Matthew J. FarrerSource :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2010.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Essential Tremor (genetics), Female, Gene Frequency, Genome-Wide Association Study, Genotype, Humans, International Cooperation, Male, Membrane Proteins (genetics), Middle Aged, Nerve Tissue Proteins (genetics), Parkinson Disease (genetics), Polymorphism, Genetic (genetics).
- MESH :
- chemical , genetics : Membrane Proteins, Nerve Tissue Proteins.
- genetics : Essential Tremor, Parkinson Disease, Polymorphism, Genetic.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Female, Gene Frequency, Genome-Wide Association Study, Genotype, Humans, International Cooperation, Male, Middle Aged.
Abstract
Recently, a variant in LINGO1 (rs9652490) was found to associate with increased risk of essential tremor. We set out to replicate this association in an independent case-control series of essential tremor from North America. In addition, given the clinical and pathological overlap between essential tremor and Parkinson disease, we also evaluate the effect of LINGO1 rs9652490 in two case-control series of Parkinson disease. Our study demonstrates a significant association between LINGO1 rs9652490 and essential tremor (P = 0.014) and Parkinson disease (P = 0.0003), thus providing the first evidence of a genetic link between both diseases.
DOI: 10.1016/j.parkreldis.2009.08.006
PubMed: 19720553
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:19720553Le document en format XML
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<front><div type="abstract" xml:lang="en">Recently, a variant in LINGO1 (rs9652490) was found to associate with increased risk of essential tremor. We set out to replicate this association in an independent case-control series of essential tremor from North America. In addition, given the clinical and pathological overlap between essential tremor and Parkinson disease, we also evaluate the effect of LINGO1 rs9652490 in two case-control series of Parkinson disease. Our study demonstrates a significant association between LINGO1 rs9652490 and essential tremor (P = 0.014) and Parkinson disease (P = 0.0003), thus providing the first evidence of a genetic link between both diseases.</div>
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<Abstract><AbstractText>Recently, a variant in LINGO1 (rs9652490) was found to associate with increased risk of essential tremor. We set out to replicate this association in an independent case-control series of essential tremor from North America. In addition, given the clinical and pathological overlap between essential tremor and Parkinson disease, we also evaluate the effect of LINGO1 rs9652490 in two case-control series of Parkinson disease. Our study demonstrates a significant association between LINGO1 rs9652490 and essential tremor (P = 0.014) and Parkinson disease (P = 0.0003), thus providing the first evidence of a genetic link between both diseases.</AbstractText>
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