[Recent discoveries on the function and plasticity of central dopamine pathways].
Identifieur interne : 000C54 ( PubMed/Checkpoint ); précédent : 000C53; suivant : 000C55[Recent discoveries on the function and plasticity of central dopamine pathways].
Auteurs : Dominic Thibault [Canada] ; Christian Kortleven ; Caroline Fasano ; Gregory Dal Bo ; Louis-Eric TrudeauSource :
- Medecine sciences : M/S [ 0767-0974 ] ; 2010.
English descriptors
- KwdEn :
- Animals, Brain (cytology), Brain (physiology), Dopamine (physiology), Glutamic Acid (physiology), Humans, Models, Neurological, Nerve Tissue Proteins (physiology), Neural Pathways (anatomy & histology), Neural Pathways (physiology), Neuronal Plasticity (physiology), Neurons (physiology), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Receptors, Dopamine (physiology), Schizophrenia (pathology), Schizophrenia (physiopathology), Signal Transduction (physiology), Substantia Nigra (cytology), Substantia Nigra (physiology), Synaptic Transmission (physiology), Ventral Tegmental Area (cytology), Ventral Tegmental Area (physiology).
- MESH :
- chemical , physiology : Dopamine, Glutamic Acid, Nerve Tissue Proteins, Receptors, Dopamine.
- anatomy & histology : Neural Pathways.
- cytology : Brain, Substantia Nigra, Ventral Tegmental Area.
- pathology : Parkinson Disease, Schizophrenia.
- physiology : Brain, Neural Pathways, Neuronal Plasticity, Neurons, Signal Transduction, Substantia Nigra, Synaptic Transmission, Ventral Tegmental Area.
- physiopathology : Parkinson Disease, Schizophrenia.
- Animals, Humans, Models, Neurological.
Abstract
Despite the fact that the neurotransmitter dopamine was discovered more than 50 years ago, we still have limited knowledge of its physiological and pathological roles. Recent work has unveiled novel and surprising properties of dopamine neurons and of other key players involved in regulating the dopamine system. For example, the integration of the dopamine signal by its receptors depends on many proteins of diverse signaling pathways and also of other types of receptors that interact with and regulate dopamine receptors: many new promising interactions have been reported during the past few years. Also, we are beginning to discover that chronic treatment with dopamine receptor ligands or other molecules affecting dopaminergic pathways induce long-term molecular, structural and functional rearrangements that could ultimately force us to revisit the mechanism of action of established therapeutic agents. Finally, the discovery of glutamate co-release by dopamine neurons is leading us to reconsider some keys aspects of dopamine neuron physiology.
DOI: 10.1051/medsci/2010262165
PubMed: 20188048
Affiliations:
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Fasano</name></author><author><name sortKey="Dal Bo, Gregory" sort="Dal Bo, Gregory" uniqKey="Dal Bo G" first="Gregory" last="Dal Bo">Gregory Dal Bo</name></author><author><name sortKey="Trudeau, Louis Eric" sort="Trudeau, Louis Eric" uniqKey="Trudeau L" first="Louis-Eric" last="Trudeau">Louis-Eric Trudeau</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20188048</idno><idno type="pmid">20188048</idno><idno type="doi">10.1051/medsci/2010262165</idno><idno type="wicri:Area/PubMed/Corpus">000D78</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D78</idno><idno type="wicri:Area/PubMed/Curation">000D78</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D78</idno><idno type="wicri:Area/PubMed/Checkpoint">000D78</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" 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Recent work has unveiled novel and surprising properties of dopamine neurons and of other key players involved in regulating the dopamine system. For example, the integration of the dopamine signal by its receptors depends on many proteins of diverse signaling pathways and also of other types of receptors that interact with and regulate dopamine receptors: many new promising interactions have been reported during the past few years. Also, we are beginning to discover that chronic treatment with dopamine receptor ligands or other molecules affecting dopaminergic pathways induce long-term molecular, structural and functional rearrangements that could ultimately force us to revisit the mechanism of action of established therapeutic agents. 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Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><VernacularTitle>Découvertes récentes sur la fonction et la plasticité des voies dopaminergiques du cerveau.</VernacularTitle></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Med Sci (Paris)</MedlineTA><NlmUniqueID>8710980</NlmUniqueID><ISSNLinking>0767-0974</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009419">Nerve Tissue Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011954">Receptors, Dopamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>3KX376GY7L</RegistryNumber><NameOfSubstance UI="D018698">Glutamic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>VTD58H1Z2X</RegistryNumber><NameOfSubstance 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PubStatus="medline"><Year>2010</Year><Month>6</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20188048</ArticleId><ArticleId IdType="pii">00/00/0E/F8/</ArticleId><ArticleId IdType="doi">10.1051/medsci/2010262165</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Dal Bo, Gregory" sort="Dal Bo, Gregory" uniqKey="Dal Bo G" first="Gregory" last="Dal Bo">Gregory Dal Bo</name><name sortKey="Fasano, Caroline" sort="Fasano, Caroline" uniqKey="Fasano C" first="Caroline" last="Fasano">Caroline Fasano</name><name sortKey="Kortleven, Christian" sort="Kortleven, Christian" uniqKey="Kortleven C" first="Christian" last="Kortleven">Christian Kortleven</name><name sortKey="Trudeau, Louis Eric" sort="Trudeau, Louis Eric" uniqKey="Trudeau L" first="Louis-Eric" last="Trudeau">Louis-Eric Trudeau</name></noCountry><country name="Canada"><noRegion><name sortKey="Thibault, Dominic" sort="Thibault, Dominic" uniqKey="Thibault D" first="Dominic" last="Thibault">Dominic Thibault</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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